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The map label for this gene is dxr

Identifier: 17546129

GI number: 17546129

Start: 1508933

End: 1510114

Strand: Direct

Name: dxr

Synonym: RSc1410

Alternate gene names: 17546129

Gene position: 1508933-1510114 (Clockwise)

Preceding gene: 17546128

Following gene: 17546130

Centisome position: 40.6

GC content: 69.88

Gene sequence:

>1182_bases
ATGATGCGCATTACCGTTCTTGGCGCCACCGGCTCCATCGGCGACAGCACGCTCGACGTGGTGCGCCGCCATCCCGACCG
TTACCGCGTGTTCGCACTGACCGCCAACACGCAGGTCGATAAGCTTGCCGCGCTGTGCCGCGTGTTCCGTCCGGCGATGG
CGGTGGTCGGCTCGGCCACCGCGGCCGAGGTGCTGCGGGACCAGCTCGGCGCGGAGGCCACCGGCATCGACATCCGCTTC
GGCCCCGAGGCGCTGGAAGAGGCCGCCGCCCACCCCGATTGCGATGCCGTGATGGCCGCCATCGTCGGCGCGGCCGGCCT
GCGCCCGACGCTGGCGGCCGTGCGCGCGGGCAAGCGTGTGCTGCTGGCCAACAAGGAAGCGCTGGTGATGTCCGGCGCGC
TCTTCATGGACGCGGTGCGCCAGCATGGCGCCACCGTGCTGCCGATCGACAGCGAGCATAACGCCATCTTCCAGTGCCTG
CCCCAGCAGCGTCCGAGCTTCGGGCACGGTGTGGCGCGCATCGTGCTGACGGCGTCGGGCGGCCCGTTCCGCACGCGCGC
CGTCGAGACGCTGGCCGAGGTCACGCCCGATCAGGCCTGCGCCCATCCGAACTGGGTGATGGGCCGCAAGATTTCCGTCG
ACTCCGCCACCATGATGAACAAGGGGCTGGAGGTGATCGAGGCGCACTGGCTGTTCAACGTGCCGGTCGAGCGGCTCGAG
GTGCTGATCCACCCGCAGAGCGTGATCCATTCGATGGTCGCTTACGATGACGGTTCGGTCCTGGCGCAACTGGGCAACCC
CGACATGCGGACGCCGATCGCCTACGGGCTTGCGTACCCCGAGCGCATCGAGGCCGGCGTGCCGCTGCTGGATCTGGCCG
CGACCGGCACGCTTGCGTTCGAAGCGCCCGATCTGCACCGCTTCCCGTGTCTGGCCCTGGCTTTCGACGCACTGCGCGCC
GGCGGCACGGCGCCTGCGGTGCTGAATGCGGCCAACGAGGTGGCGGTCGAGGCATTTTTGCAGCGCCGTATCCGCTTCAC
CGAGATTGCCGCGGTGGTGGGCGACACGCTGGCGCGCACCGCCATCGGGCCGGCGGATTCGCTGGACACGGTGTTTGCCG
CCGATGCGCAGGCGCGCCGCCGCGCCGAGCACTATATCGCTGCCTCGTGCCTGCAGTCGTGA

Upstream 100 bases:

>100_bases
GCCGCCTGCTGCCCGGCCATGGCGGGGTGCTCGACCGCATCGACGCACTGCTGCCGGTGCTGCCGCTGGCTGTATTGTTG
ACCTGAGGCGCTTTCCGGAC

Downstream 100 bases:

>100_bases
GGCCTCAGGCCCACGTGCAAGCGGCCTGTCAGCGCAAGCGGGTAACATAATGCGTTCGCGCGGGCGGTGTCCGCGCTGGC
GTGTCGACGCATCCGGAGAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MMRITVLGATGSIGDSTLDVVRRHPDRYRVFALTANTQVDKLAALCRVFRPAMAVVGSATAAEVLRDQLGAEATGIDIRF
GPEALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRVLLANKEALVMSGALFMDAVRQHGATVLPIDSEHNAIFQCL
PQQRPSFGHGVARIVLTASGGPFRTRAVETLAEVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVPVERLE
VLIHPQSVIHSMVAYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLAATGTLAFEAPDLHRFPCLALAFDALRA
GGTAPAVLNAANEVAVEAFLQRRIRFTEIAAVVGDTLARTAIGPADSLDTVFAADAQARRRAEHYIAASCLQS

Sequences:

>Translated_393_residues
MMRITVLGATGSIGDSTLDVVRRHPDRYRVFALTANTQVDKLAALCRVFRPAMAVVGSATAAEVLRDQLGAEATGIDIRF
GPEALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRVLLANKEALVMSGALFMDAVRQHGATVLPIDSEHNAIFQCL
PQQRPSFGHGVARIVLTASGGPFRTRAVETLAEVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVPVERLE
VLIHPQSVIHSMVAYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLAATGTLAFEAPDLHRFPCLALAFDALRA
GGTAPAVLNAANEVAVEAFLQRRIRFTEIAAVVGDTLARTAIGPADSLDTVFAADAQARRRAEHYIAASCLQS
>Mature_393_residues
MMRITVLGATGSIGDSTLDVVRRHPDRYRVFALTANTQVDKLAALCRVFRPAMAVVGSATAAEVLRDQLGAEATGIDIRF
GPEALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRVLLANKEALVMSGALFMDAVRQHGATVLPIDSEHNAIFQCL
PQQRPSFGHGVARIVLTASGGPFRTRAVETLAEVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVPVERLE
VLIHPQSVIHSMVAYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLAATGTLAFEAPDLHRFPCLALAFDALRA
GGTAPAVLNAANEVAVEAFLQRRIRFTEIAAVVGDTLARTAIGPADSLDTVFAADAQARRRAEHYIAASCLQS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=393, Percent_Identity=54.70737913486, Blast_Score=406, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_RALSO (Q8XZI5)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519531.1
- ProteinModelPortal:   Q8XZI5
- SMR:   Q8XZI5
- GeneID:   1220234
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1410
- NMPDR:   fig|267608.1.peg.1410
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   RSOL267608:RSC1410-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41763; Mature: 41763

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 179-179 BINDING 202-202 BINDING 224-224

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRITVLGATGSIGDSTLDVVRRHPDRYRVFALTANTQVDKLAALCRVFRPAMAVVGSAT
CEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHH
AAEVLRDQLGAEATGIDIRFGPEALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRV
HHHHHHHHHCCCCCCEEEEECHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCEE
LLANKEALVMSGALFMDAVRQHGATVLPIDSEHNAIFQCLPQQRPSFGHGVARIVLTASG
EEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCCCCCCCEEEEEEEECC
GPFRTRAVETLAEVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVPVERLE
CCCHHHHHHHHHHCCCHHHCCCCCCCCCCEECCCHHHHHHCCHHHHHHHHEECCCHHHHH
VLIHPQSVIHSMVAYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLAATGTLAF
EEECCHHHHHHHHHCCCCHHEEECCCCCCCCCHHHHCCCHHHHHCCCCEEEHHCCCEEEE
EAPDLHRFPCLALAFDALRAGGTAPAVLNAANEVAVEAFLQRRIRFTEIAAVVGDTLART
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGPADSLDTVFAADAQARRRAEHYIAASCLQS
HCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMRITVLGATGSIGDSTLDVVRRHPDRYRVFALTANTQVDKLAALCRVFRPAMAVVGSAT
CEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHH
AAEVLRDQLGAEATGIDIRFGPEALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRV
HHHHHHHHHCCCCCCEEEEECHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCEE
LLANKEALVMSGALFMDAVRQHGATVLPIDSEHNAIFQCLPQQRPSFGHGVARIVLTASG
EEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCCCCCCCEEEEEEEECC
GPFRTRAVETLAEVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVPVERLE
CCCHHHHHHHHHHCCCHHHCCCCCCCCCCEECCCHHHHHHCCHHHHHHHHEECCCHHHHH
VLIHPQSVIHSMVAYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLAATGTLAF
EEECCHHHHHHHHHCCCCHHEEECCCCCCCCCHHHHCCCHHHHHCCCCEEEHHCCCEEEE
EAPDLHRFPCLALAFDALRAGGTAPAVLNAANEVAVEAFLQRRIRFTEIAAVVGDTLART
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGPADSLDTVFAADAQARRRAEHYIAASCLQS
HCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852