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The map label for this gene is pyrH [H]

Identifier: 17546125

GI number: 17546125

Start: 1505835

End: 1506545

Strand: Direct

Name: pyrH [H]

Synonym: RSc1406

Alternate gene names: 17546125

Gene position: 1505835-1506545 (Clockwise)

Preceding gene: 161621733

Following gene: 17546126

Centisome position: 40.52

GC content: 64.7

Gene sequence:

>711_bases
ATGCCTGCCTACAAGCGCGTTCTACTCAAACTTTCCGGCGAAGCCCTGATGGGCGACGATGCCTTCGGCATCAATCGCAG
CACCATCGAAGGGATGGTCAACGACATCGCCGAAATCGTGAGGCTGGGCGTGCAGGTGGCCGTGGTGATCGGCGGCGGCA
ACATCTTCCGCGGCGTCGCGGGCGGCGCTGCCGGCATGGATCGCGCCACGGCCGACTACATGGGCATGCTGGCCACCATG
ATGAACGCGCTGGCACTGCAGGATGCCATGCGCCACGCCAACATCGAGGGTCGCGTGCAGTCCGCGCTGCGCATGGACCA
GGTGGTCGAGCCGTACATCCGTCCGCGCGCGATCCGTCAGCTGGAGGAGGGCAAGGTCGTCATCTTCGCGGCCGGTACCG
GCAATCCGTTCTTCACCACCGACACCGCCGCCGCGCTGCGCGGCTCGGAGATCGGCGCGGAGATCGTACTCAAGGCCACC
AAGGTCGATGGCGTCTATACCGCTGATCCGAAGAAGGACCCCAGCGCGACCCGCTATACCACCATCAGCTTCGACGAGGC
CATCTCGCGCAACCTGCAGGTGATGGATGCGACCGCCTTTGCGCTGTGCCGCGACCAGAAGCTGCCGATCAAGGTCTTCT
CGATCCAGAAGCCGAACGCGCTCAAGCGCGTCATCATGGGTGAGGACGAGGGCACGCTGGTGCACGTCTGA

Upstream 100 bases:

>100_bases
CGGTTGTTGTGGCCGCCGTGTTTCGTTCAGACGGCCAGCCCCTGCGCTGGCGCGTTTTCCCCTTTCCTGCTCCCGTACAG
GAATCGTCAAAAGGATATTC

Downstream 100 bases:

>100_bases
GCGGCCTCGCATCCGCCTTTCCCAGCCGCCCGCCAGGTCGATGCAAATGGCTCTGGCGTGCGGCTTCCATGTAAAATTGC
CTATTGTCTTTCAGGTGCTG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MPAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVRLGVQVAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATM
MNALALQDAMRHANIEGRVQSALRMDQVVEPYIRPRAIRQLEEGKVVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKAT
KVDGVYTADPKKDPSATRYTTISFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPNALKRVIMGEDEGTLVHV

Sequences:

>Translated_236_residues
MPAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVRLGVQVAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATM
MNALALQDAMRHANIEGRVQSALRMDQVVEPYIRPRAIRQLEEGKVVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKAT
KVDGVYTADPKKDPSATRYTTISFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPNALKRVIMGEDEGTLVHV
>Mature_235_residues
PAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVRLGVQVAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATMM
NALALQDAMRHANIEGRVQSALRMDQVVEPYIRPRAIRQLEEGKVVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKATK
VDGVYTADPKKDPSATRYTTISFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPNALKRVIMGEDEGTLVHV

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=57.0815450643777, Blast_Score=281, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25363; Mature: 25232

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVRLGVQVAVVIGGGNIFRGVA
CCHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEHHCC
GGAAGMDRATADYMGMLATMMNALALQDAMRHANIEGRVQSALRMDQVVEPYIRPRAIRQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHH
LEEGKVVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKATKVDGVYTADPKKDPSATRYT
HCCCCEEEEEECCCCCCEECCHHHHHCCCCCCCEEEEEEEECCCEEECCCCCCCCCCEEE
TISFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPNALKRVIMGEDEGTLVHV
EEEHHHHHHCCCEEEHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCEEEC
>Mature Secondary Structure 
PAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVRLGVQVAVVIGGGNIFRGVA
CHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEHHCC
GGAAGMDRATADYMGMLATMMNALALQDAMRHANIEGRVQSALRMDQVVEPYIRPRAIRQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHH
LEEGKVVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKATKVDGVYTADPKKDPSATRYT
HCCCCEEEEEECCCCCCEECCHHHHHCCCCCCCEEEEEEEECCCEEECCCCCCCCCCEEE
TISFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPNALKRVIMGEDEGTLVHV
EEEHHHHHHCCCEEEHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA