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The map label for this gene is frr

Identifier: 17546126

GI number: 17546126

Start: 1506711

End: 1507271

Strand: Direct

Name: frr

Synonym: RSc1407

Alternate gene names: 17546126

Gene position: 1506711-1507271 (Clockwise)

Preceding gene: 17546125

Following gene: 17546127

Centisome position: 40.54

GC content: 60.07

Gene sequence:

>561_bases
ATGAGCGTGGCCGATATCAAGAAGAGTGCCGAGCAGAAGATGCAGAAGTCGATCGACGCCTTCAAGGCCGATCTCGCGAA
GGTTCGTACCGGTCGCGCCCACACGGGTCTGCTTGACCACGTGCAGGTCGATTACTATGGTTCGATGGTACCCATCAGTC
AGGTCGCCAATCTGGGCCTGGCCGATGCACGTACGATCAGTGTGCAGCCGTGGGAAAAGAAGATGGTGTCGGCCGTCGAA
AGGGCCATCCGCGACGCGGACCTGGGCCTGAACCCGGCGACCATGGGCGAAGTGATTCGCGTACCGATGCCCCCGCTGAC
CGAGGAGCGCCGCAAGGAACTGACCAAGGTGGTCAAGTCCGAGGGCGAAGATGCCAAGGTCGCGGTGCGCAACGTGCGCC
GCGACGCCAACGAGCAGTTCAAGAAGCTGGTCAAGGACAAAGCCATCTCCGAAGATGACGAGCGCCGCGGCCAGGATGAA
GTCCAAAAACTGACCGATCGCTTCGTGGCCGAGGTGGACAAGCTTGTCGCCGAAAAGGACAAGGAAATCATGACGGTTTG
A

Upstream 100 bases:

>100_bases
TCCATGTAAAATTGCCTATTGTCTTTCAGGTGCTGCCGGCGCCGGGCGCGATGCCTCGGTCGCACATTTGGCGGGACCGC
CGTTATCGTTCGGAGGAAGT

Downstream 100 bases:

>100_bases
GGCCGTCTCCCACCTGCCGGCGCATTGTGTGTCGGCCATGGGAACCCATTCATGCATATCAGCTCGACACTGGCGGTGCC
TGACACCGCCGATACGCCAC

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MSVADIKKSAEQKMQKSIDAFKADLAKVRTGRAHTGLLDHVQVDYYGSMVPISQVANLGLADARTISVQPWEKKMVSAVE
RAIRDADLGLNPATMGEVIRVPMPPLTEERRKELTKVVKSEGEDAKVAVRNVRRDANEQFKKLVKDKAISEDDERRGQDE
VQKLTDRFVAEVDKLVAEKDKEIMTV

Sequences:

>Translated_186_residues
MSVADIKKSAEQKMQKSIDAFKADLAKVRTGRAHTGLLDHVQVDYYGSMVPISQVANLGLADARTISVQPWEKKMVSAVE
RAIRDADLGLNPATMGEVIRVPMPPLTEERRKELTKVVKSEGEDAKVAVRNVRRDANEQFKKLVKDKAISEDDERRGQDE
VQKLTDRFVAEVDKLVAEKDKEIMTV
>Mature_185_residues
SVADIKKSAEQKMQKSIDAFKADLAKVRTGRAHTGLLDHVQVDYYGSMVPISQVANLGLADARTISVQPWEKKMVSAVER
AIRDADLGLNPATMGEVIRVPMPPLTEERRKELTKVVKSEGEDAKVAVRNVRRDANEQFKKLVKDKAISEDDERRGQDEV
QKLTDRFVAEVDKLVAEKDKEIMTV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=174, Percent_Identity=31.0344827586207, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI291042689, Length=150, Percent_Identity=32, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1786368, Length=182, Percent_Identity=53.2967032967033, Blast_Score=207, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24661488, Length=173, Percent_Identity=30.635838150289, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_RALSO (Q8XZI8)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519528.1
- ProteinModelPortal:   Q8XZI8
- SMR:   Q8XZI8
- GeneID:   1220231
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1407
- NMPDR:   fig|267608.1.peg.1407
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- ProtClustDB:   PRK00083
- BioCyc:   RSOL267608:RSC1407-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20845; Mature: 20714

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVADIKKSAEQKMQKSIDAFKADLAKVRTGRAHTGLLDHVQVDYYGSMVPISQVANLGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHCCCCCCHHHHHHCCC
ADARTISVQPWEKKMVSAVERAIRDADLGLNPATMGEVIRVPMPPLTEERRKELTKVVKS
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
EGEDAKVAVRNVRRDANEQFKKLVKDKAISEDDERRGQDEVQKLTDRFVAEVDKLVAEKD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHC
KEIMTV
HHHCCC
>Mature Secondary Structure 
SVADIKKSAEQKMQKSIDAFKADLAKVRTGRAHTGLLDHVQVDYYGSMVPISQVANLGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHCCCCCCHHHHHHCCC
ADARTISVQPWEKKMVSAVERAIRDADLGLNPATMGEVIRVPMPPLTEERRKELTKVVKS
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
EGEDAKVAVRNVRRDANEQFKKLVKDKAISEDDERRGQDEVQKLTDRFVAEVDKLVAEKD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHC
KEIMTV
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852