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The map label for this gene is clpB

Identifier: 17546054

GI number: 17546054

Start: 1420990

End: 1423578

Strand: Direct

Name: clpB

Synonym: RSc1335

Alternate gene names: 17546054

Gene position: 1420990-1423578 (Clockwise)

Preceding gene: 17546053

Following gene: 17546055

Centisome position: 38.24

GC content: 67.48

Gene sequence:

>2589_bases
ATGCGTTTGGACAAACTGACCACCCGCTTCCAGGAAGCGTTGGCCGACGCGCAAAGCCTGGCGTTGGGCAACGACAATCC
GTATATCGAACCGCTCCATCTGCTGCTGGCGATGCTGCGCCAGCCCGACGGGGCCACCAAGAACCTGCTGGCGCGCGCGG
GCGTCAACGCCAAGGGGCTCGAGATCGCGCTCGACAACGCGATCAAGCGCCTGCCGCAAGTGCAGGGCGGCGAACAGGTG
CAGGTCGGCCGGGACCTGGGCAGCCTGCTGCAGGCCACGGAGAAAGAGGGCATCAAGCGCGGTGACCAGTTCATCGCGAG
CGAGCTGTTCCTGCTGGCCGTGGCCGACGACAAGGGCGAGGCCGGCCGCGTCGCGCGCGAGCACGGGCTGGCGCGCCGTG
CGCTGGAGGCGGCCATCGATGCCGTGCGCGGCGGCCAGACCGTCGGCAGCGCCGAGGCCGAGAGCCAGCGCGAGGCGCTC
AAGAAGTACACCATCGACCTGACCGAGCAGGCGCGCATCGGCAAGCTCGACCCGGTCATTGGCCGCGACGACGAGATCCG
CCGCGCGATCCAGATCCTGCAGCGCCGCACCAAGAACAACCCGGTGCTGATCGGCGAGCCGGGCGTGGGCAAGACCGCCA
TCGTCGAGGGCCTGGCGCAGCGCATCATCAACGGCGAGGTGCCCGAGAGCCTGAAGAACAAGCGCGTGCTGGTGCTCGAC
ATGGCGGGCCTGCTGGCCGGCGCCAAGTACCGCGGCGAGTTCGAGGAGCGGCTGAAGGCCGTGCTCAACGATATCGCCAA
GGAAGAGGGCCAGACCATCCTCTTCATCGACGAGATCCACACCATGGTGGGCGCGGGCAAGGCCGAGGGCGCGATCGATG
CCGGCAACATGCTCAAGCCGGCGCTGGCGCGCGGCGAGCTGCACTGCATCGGCGCGACCACGCTGGATGAGTACCGCAAG
TACATCGAAAAGGATGCCGCGCTGGAGCGCCGCTTCCAGAAGGTGTTGGTCGACGAGCCGAGCGTGGAGGCGACCATCGC
CATCCTGCGCGGCCTGCAGGAGAAATACGAGCTGCACCACGGCGTGGAGATCACCGACCCGGCGATCGTGGCGGCGGCCG
AGCTGAGCCATCGCTACATCACCGACCGCTTCCTGCCCGACAAGGCCATCGACCTGATCGACGAGGCGGCCGCGCGCATC
AAGATGGAAATCGACTCGAAACCCGAGGCGATGGACAAGCTCGACCGCCGGCTGATCCAGCTGAAGATCGAGCGCGAGGC
GGTGAAGAAGGAAACCGACGAGGCGTCGCAGAAGCGGCTGGAGCTGATCGAGCAGGAAATCGAGCGGCTGCAGAAGGAGT
ACGCCGACCTCGAAGAGATCTGGAAGGCCGAGAAGGGCGCGGCGCAGGGCGCGGCGGCGGTGAAGGAAGAGATCGACCGG
GTCAAGCTGGAGATCGCCCGGCTGCAGCGCGAGGGCAAGCTCGACAAGGTGGCCGAGCTGCAGTACGGCAGGCTGCCCGA
GCTGGAAGGCAAGCTGAAGGCCGCCACCGCGGCGGAAGCCAGCGGCCAGAGGCCGCCCAACAAGCTGCTGCGCACGCAGG
TGGGCGCCGAAGAGATTGCCGAGGTGGTCAGCCGCGCCACGGGCATCCCCGTGTCGAAGATGATGCAGGGCGAGCGCGAC
AAGCTGCTGCGCATGGAAGACCGCCTGCACGAGCGCGTGGTCGGCCAGGACGAGGCGGTGCGGCTGGTGTCGGACGCCAT
CCGGCGCTCGCGCGCGGGCATCGCGGACGAGAACAAGCCTTACGGCTCGTTCCTGTTCCTGGGCCCGACGGGCGTGGGCA
AGACCGAACTGTGCAAGGCGCTGGCCGGCTTCCTGTTCGACTCGGAGGAGCACCTGATCCGCATCGACATGAGTGAGTTC
ATGGAGAAGCATTCGGTGAGCCGCCTGATCGGCGCGCCGCCGGGCTACGTCGGCTACGAGGAGGGCGGCTACCTGACCGA
GGCCGTGCGCCGCAAGCCGTACAGCGTGGTGCTGCTGGACGAGGTCGAGAAGGCGCATCCGGATGTGTTCAACATCCTGC
TGCAGGTGCTGGACGACGGCCGCCTGACCGATGGCCAGGGCCGCACGGTGGACTTCAAGAACACGGTGATCGTGATGACG
TCCAACCTGGGCTCGCAGCTGATCCAGCAGATGGCGTCCGAGTCGCCCGATGTGATCAAAGGTGCGGTGTGGCAGGAGGT
GAAGACGCATTTCCGGCCCGAGTTCCTGAACCGCATCGACGAGGTGGTGGTGTTCCACGCGCTCGACCAGGGCCACATCG
AGTCGATCGCGCGCATCCAGCTGCAGCGGCTGGCGGCCCGCCTGGCGCACATGGACCTGACGCTGGAGATCAGCGACCCG
GCGGTCGCCAAGCTGGCCTCGGCGGGGTACGACCCGGTGTTCGGCGCGCGGCCGCTCAAGCGCGCGATCCAGCAGCAGAT
CGAGAACCCGGTCGCGCGGATGATCCTGGAAGGCCGGTTCACGCCGAAGGACGTGGTGCCGGTGGATTACCACGACGGCC
ACTTCACCTTCGATCGTGTCGTGCGCTGA

Upstream 100 bases:

>100_bases
ACACAAAACGCCATCAAAAGCGGCCCGCCCCGGGCTTGAAATGCCACCGACGCTCCCTATCTTTCGGAACAGTGAACGAT
TTTCCGCAAGGGGTTTTTTC

Downstream 100 bases:

>100_bases
GCCGCGACGCCTCCTTGAACAGCCCGGCAGCCGCCGGGCTTTTTCTTTGCGCGGGCGCGGCTGTGACGGCGCCGCGCCAC
CGGGGGCCGGGCATGGCGGC

Product: ATP-dependent protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 862; Mature: 862

Protein sequence:

>862_residues
MRLDKLTTRFQEALADAQSLALGNDNPYIEPLHLLLAMLRQPDGATKNLLARAGVNAKGLEIALDNAIKRLPQVQGGEQV
QVGRDLGSLLQATEKEGIKRGDQFIASELFLLAVADDKGEAGRVAREHGLARRALEAAIDAVRGGQTVGSAEAESQREAL
KKYTIDLTEQARIGKLDPVIGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAIDAGNMLKPALARGELHCIGATTLDEYRK
YIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARI
KMEIDSKPEAMDKLDRRLIQLKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLEEIWKAEKGAAQGAAAVKEEIDR
VKLEIARLQREGKLDKVAELQYGRLPELEGKLKAATAAEASGQRPPNKLLRTQVGAEEIAEVVSRATGIPVSKMMQGERD
KLLRMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEF
MEKHSVSRLIGAPPGYVGYEEGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFKNTVIVMT
SNLGSQLIQQMASESPDVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQGHIESIARIQLQRLAARLAHMDLTLEISDP
AVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGRFTPKDVVPVDYHDGHFTFDRVVR

Sequences:

>Translated_862_residues
MRLDKLTTRFQEALADAQSLALGNDNPYIEPLHLLLAMLRQPDGATKNLLARAGVNAKGLEIALDNAIKRLPQVQGGEQV
QVGRDLGSLLQATEKEGIKRGDQFIASELFLLAVADDKGEAGRVAREHGLARRALEAAIDAVRGGQTVGSAEAESQREAL
KKYTIDLTEQARIGKLDPVIGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAIDAGNMLKPALARGELHCIGATTLDEYRK
YIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARI
KMEIDSKPEAMDKLDRRLIQLKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLEEIWKAEKGAAQGAAAVKEEIDR
VKLEIARLQREGKLDKVAELQYGRLPELEGKLKAATAAEASGQRPPNKLLRTQVGAEEIAEVVSRATGIPVSKMMQGERD
KLLRMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEF
MEKHSVSRLIGAPPGYVGYEEGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFKNTVIVMT
SNLGSQLIQQMASESPDVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQGHIESIARIQLQRLAARLAHMDLTLEISDP
AVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGRFTPKDVVPVDYHDGHFTFDRVVR
>Mature_862_residues
MRLDKLTTRFQEALADAQSLALGNDNPYIEPLHLLLAMLRQPDGATKNLLARAGVNAKGLEIALDNAIKRLPQVQGGEQV
QVGRDLGSLLQATEKEGIKRGDQFIASELFLLAVADDKGEAGRVAREHGLARRALEAAIDAVRGGQTVGSAEAESQREAL
KKYTIDLTEQARIGKLDPVIGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAIDAGNMLKPALARGELHCIGATTLDEYRK
YIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARI
KMEIDSKPEAMDKLDRRLIQLKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLEEIWKAEKGAAQGAAAVKEEIDR
VKLEIARLQREGKLDKVAELQYGRLPELEGKLKAATAAEASGQRPPNKLLRTQVGAEEIAEVVSRATGIPVSKMMQGERD
KLLRMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEF
MEKHSVSRLIGAPPGYVGYEEGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFKNTVIVMT
SNLGSQLIQQMASESPDVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQGHIESIARIQLQRLAARLAHMDLTLEISDP
AVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGRFTPKDVVPVDYHDGHFTFDRVVR

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=38.9261744966443, Blast_Score=210, Evalue=5e-54,
Organism=Escherichia coli, GI1788943, Length=863, Percent_Identity=66.5121668597914, Blast_Score=1143, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=391, Percent_Identity=41.6879795396419, Blast_Score=279, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6320464, Length=704, Percent_Identity=53.4090909090909, Blast_Score=746, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=858, Percent_Identity=43.006993006993, Blast_Score=666, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_RALSO (Q8XZR0)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519456.1
- ProteinModelPortal:   Q8XZR0
- GeneID:   1220159
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1335
- NMPDR:   fig|267608.1.peg.1335
- HOGENOM:   HBG413133
- OMA:   WHLLMSI
- ProtClustDB:   CLSK896938
- BioCyc:   RSOL267608:RSC1335-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382
- TIGRFAMs:   TIGR03346

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 95561; Mature: 95561

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDKLTTRFQEALADAQSLALGNDNPYIEPLHLLLAMLRQPDGATKNLLARAGVNAKGL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCH
EIALDNAIKRLPQVQGGEQVQVGRDLGSLLQATEKEGIKRGDQFIASELFLLAVADDKGE
HHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCC
AGRVAREHGLARRALEAAIDAVRGGQTVGSAEAESQREALKKYTIDLTEQARIGKLDPVI
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEEEE
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAIDAGNMLKP
HHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHH
ALARGELHCIGATTLDEYRKYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHH
HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARIKMEIDSKPEAMDKLDRRLIQ
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHH
LKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLEEIWKAEKGAAQGAAAVKEEIDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VKLEIARLQREGKLDKVAELQYGRLPELEGKLKAATAAEASGQRPPNKLLRTQVGAEEIA
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCHHHHH
EVVSRATGIPVSKMMQGERDKLLRMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKP
HHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
YGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEFMEKHSVSRLIGAPPGYVGYE
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCC
EGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFKNTVIVMT
CCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEE
SNLGSQLIQQMASESPDVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQGHIESIARIQ
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LQRLAARLAHMDLTLEISDPAVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGRF
HHHHHHHHHHCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
TPKDVVPVDYHDGHFTFDRVVR
CCCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MRLDKLTTRFQEALADAQSLALGNDNPYIEPLHLLLAMLRQPDGATKNLLARAGVNAKGL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCH
EIALDNAIKRLPQVQGGEQVQVGRDLGSLLQATEKEGIKRGDQFIASELFLLAVADDKGE
HHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCC
AGRVAREHGLARRALEAAIDAVRGGQTVGSAEAESQREALKKYTIDLTEQARIGKLDPVI
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPESLKNKRVLVLD
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEEEE
MAGLLAGAKYRGEFEERLKAVLNDIAKEEGQTILFIDEIHTMVGAGKAEGAIDAGNMLKP
HHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHH
ALARGELHCIGATTLDEYRKYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHH
HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARIKMEIDSKPEAMDKLDRRLIQ
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHH
LKIEREAVKKETDEASQKRLELIEQEIERLQKEYADLEEIWKAEKGAAQGAAAVKEEIDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VKLEIARLQREGKLDKVAELQYGRLPELEGKLKAATAAEASGQRPPNKLLRTQVGAEEIA
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCHHHHH
EVVSRATGIPVSKMMQGERDKLLRMEDRLHERVVGQDEAVRLVSDAIRRSRAGIADENKP
HHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
YGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEFMEKHSVSRLIGAPPGYVGYE
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCC
EGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFKNTVIVMT
CCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEE
SNLGSQLIQQMASESPDVIKGAVWQEVKTHFRPEFLNRIDEVVVFHALDQGHIESIARIQ
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LQRLAARLAHMDLTLEISDPAVAKLASAGYDPVFGARPLKRAIQQQIENPVARMILEGRF
HHHHHHHHHHCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
TPKDVVPVDYHDGHFTFDRVVR
CCCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852