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The map label for this gene is hom [H]

Identifier: 17546046

GI number: 17546046

Start: 1412538

End: 1413857

Strand: Direct

Name: hom [H]

Synonym: RSc1327

Alternate gene names: 17546046

Gene position: 1412538-1413857 (Clockwise)

Preceding gene: 17546045

Following gene: 17546047

Centisome position: 38.01

GC content: 67.58

Gene sequence:

>1320_bases
ATGAAACCCATCAAGATCGGCCTGCTCGGGCTCGGTACCGTCGGTGGCGGTACGCTCAAGGTTCTGCAACGGAACCAGGA
AGAAATCCGGCGCCGCGCCGGGCGCGGCATCGAGGTCGCCCTGATTGCGGTGCGCAACGTCGAGCGCGCCCGCGCCATCG
TGCAGGAAACCGGCGCGAGCGTGCCGGTGGTGGACGACCCGGTTGCGGTGGTGGATTCGCCCGAGATCGACATCGTGGTG
GAGCTGATCGGCGGCTATGACCTGACGCGCGAACTGGTGCTGCGCGCCATCGCCAACGGCAAGCACGTGGTCACGGCCAA
CAAGGCGCTGCTGGCGGTGCACGGCAACGAGATCTTCAAGGCCGCCCAGGACAAGGGCGTGATGGTGGCGTTCGAGGCCG
CGGTGGCCGGCGGCATCCCCATCATCAAGGCGCTGCGCGAGGGGCTGACGGGTAACCGCATCGAGTGGATCGCCGGCATC
ATCAACGGCACCACCAACTTCATCCTGTCGGAGATGCGCGACAAGGGCCTGGACTTCGGCACGGTGCTCGCGGAGGCCCA
GCGCCTGGGCTATGCCGAGGCCGATCCGACCTTCGACATCGAGGGCTTCGATGCAGCCCACAAGCTCACGCTGATGAGCG
CCATCGCCTTCGGCGTGCCGGTGCAGTTCGAGCGCGCCTATGTGGAGGGCATCACCAAGCTGGAGGCGGTCGATATCCGC
TACGCGGAGGAGCTCGGCTACCGCATCAAGCTGCTCGGCCTGACGCGCCGCGCCGAGGCGGGCATCGAGCTGCGCGTGCA
CCCGACGCTGGTGCCGGCCACGCGCCTGATCGCCAACGTGGAAGGCGCGATGAACGCCGTGGTGGTGCAGGGCGATGCCG
TCGGCCCGACGCTGTACTACGGCAAGGGTGCCGGCGCCGAGCCGACCGCTTCGGCCGTGGTGGCCGATCTGGTGGACGTG
ACGCGCCTGCACACCGCCGATCCGGAGCACCGCGTGCCGCACTTGGCGTTCCAGCCGGATGCGCTGTCCAACACGCCGCT
GCTGCCGATCGAAGAAGTGCGCTCGGCCTACTACCTGCGCATGCGCGTGGCCGACGAGACCGGTGTGCTGGCCGACATCA
CCCGCATCCTGGCCGAGTCCGGCATCTCGATCGACGCGATGCTGCAGAAGGAATCGCGCGAGGGCGAGCCGCAGACCGAC
ATCATCATGCTGTCGCACGTGGTGGTGGAGAAGCAGGTCAATGCCGCCATCGCCGCCATCGAGGCGCTGCCGACCGTGCT
GTCCAAGGTCACGCGTCTGCGCATGGAAGAATTGAACTGA

Upstream 100 bases:

>100_bases
GGCCGCCTGAACTCGGTCATCCGCCAGATCCGTCGTTGCGGGGCAGACCGAAGTGTCTGCCCTGTCCGTTTTTTGCCTTT
CCGCTTTTACAACACGTCTC

Downstream 100 bases:

>100_bases
CGCGCCCGACGTTTCCGAGATCGCCATGAGCATGCAATACCGTTCCACGCGCGGCCACGCCGAGCCGCAGAGCTTCTCCC
GCATCCTGCTGGGCGGCCTG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVALIAVRNVERARAIVQETGASVPVVDDPVAVVDSPEIDIVV
ELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFKAAQDKGVMVAFEAAVAGGIPIIKALREGLTGNRIEWIAGI
INGTTNFILSEMRDKGLDFGTVLAEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
YAEELGYRIKLLGLTRRAEAGIELRVHPTLVPATRLIANVEGAMNAVVVQGDAVGPTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDALSNTPLLPIEEVRSAYYLRMRVADETGVLADITRILAESGISIDAMLQKESREGEPQTD
IIMLSHVVVEKQVNAAIAAIEALPTVLSKVTRLRMEELN

Sequences:

>Translated_439_residues
MKPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVALIAVRNVERARAIVQETGASVPVVDDPVAVVDSPEIDIVV
ELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFKAAQDKGVMVAFEAAVAGGIPIIKALREGLTGNRIEWIAGI
INGTTNFILSEMRDKGLDFGTVLAEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
YAEELGYRIKLLGLTRRAEAGIELRVHPTLVPATRLIANVEGAMNAVVVQGDAVGPTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDALSNTPLLPIEEVRSAYYLRMRVADETGVLADITRILAESGISIDAMLQKESREGEPQTD
IIMLSHVVVEKQVNAAIAAIEALPTVLSKVTRLRMEELN
>Mature_439_residues
MKPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVALIAVRNVERARAIVQETGASVPVVDDPVAVVDSPEIDIVV
ELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFKAAQDKGVMVAFEAAVAGGIPIIKALREGLTGNRIEWIAGI
INGTTNFILSEMRDKGLDFGTVLAEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
YAEELGYRIKLLGLTRRAEAGIELRVHPTLVPATRLIANVEGAMNAVVVQGDAVGPTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDALSNTPLLPIEEVRSAYYLRMRVADETGVLADITRILAESGISIDAMLQKESREGEPQTD
IIMLSHVVVEKQVNAAIAAIEALPTVLSKVTRLRMEELN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=359, Percent_Identity=23.9554317548747, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786183, Length=245, Percent_Identity=25.7142857142857, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=314, Percent_Identity=27.0700636942675, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47167; Mature: 47167

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVALIAVRNVERARAIVQETGAS
CCCEEEEEEEECCCCCCHHHHHHCCHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHCCCC
VPVVDDPVAVVDSPEIDIVVELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFK
CCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHH
AAQDKGVMVAFEAAVAGGIPIIKALREGLTGNRIEWIAGIINGTTNFILSEMRDKGLDFG
HHCCCCEEEEEECHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHH
TVLAEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGLTRRAEAGIELRVHPTLVPATRLIANVEGAMNAVVVQGDAVGPTLYY
HHHHCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDALSNTPLLPIEEVRSAYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHEEEEE
MRVADETGVLADITRILAESGISIDAMLQKESREGEPQTDIIMLSHVVVEKQVNAAIAAI
EEECCCCCHHHHHHHHHHHCCCCEEHHEEHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHH
EALPTVLSKVTRLRMEELN
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVALIAVRNVERARAIVQETGAS
CCCEEEEEEEECCCCCCHHHHHHCCHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHCCCC
VPVVDDPVAVVDSPEIDIVVELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFK
CCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHH
AAQDKGVMVAFEAAVAGGIPIIKALREGLTGNRIEWIAGIINGTTNFILSEMRDKGLDFG
HHCCCCEEEEEECHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHH
TVLAEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGLTRRAEAGIELRVHPTLVPATRLIANVEGAMNAVVVQGDAVGPTLYY
HHHHCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDALSNTPLLPIEEVRSAYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHEEEEE
MRVADETGVLADITRILAESGISIDAMLQKESREGEPQTDIIMLSHVVVEKQVNAAIAAI
EEECCCCCHHHHHHHHHHHCCCCEEHHEEHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHH
EALPTVLSKVTRLRMEELN
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]