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The map label for this gene is caiD [C]

Identifier: 17546017

GI number: 17546017

Start: 1384111

End: 1385241

Strand: Direct

Name: caiD [C]

Synonym: RSc1298

Alternate gene names: 17546017

Gene position: 1384111-1385241 (Clockwise)

Preceding gene: 17546015

Following gene: 17546018

Centisome position: 37.24

GC content: 71.09

Gene sequence:

>1131_bases
ATGGAATCCACCGCATCGACCGCTTCCTCGACTGTTTCCGCCGCCACGCAGACCGACACCCAGGCCCACGTGATCGCCGA
GGTGCACGGCGGCATCGGCTGGCTGACGCTGAACCGGCCGCAGGCGCTCAATGCGCTGTCGCTGGAGATGATTCGCGCGC
TGTCGCATGCGCTGATGGCGTGGCAGCACGATCCGGCGGTGCGCGCCGTGATCCTGCGCGGCGAGGGCGGCAAGGCGCTG
TGCGCCGGGGGCGACATCCGTTTTTTCCACCGCGCCGCCACCGCGCGCGATCCGCAACTGATCACCTTCTTCGCCGAGGA
ATACCGCCTCAACCACCTGATCTTCCGCTACGCCAAGCCCTATATCGCGCTGATGGACGGCGTGGTGATGGGCGGCGGCA
TGGGCATCTCGCAGGGCGCTTCGCTGCGCGTGGTGACCGGGCGCACGCGCATGGCCATGCCTGAGACCAACATCGGCCTG
TTTCCCGATGTCGGGGGTGGCTGGTTCCTGGCGCGCCTGCCGGGGCACGTGGGCGAATACCTGGGGGTGACCGGGCAGGT
GATCGACGCGGCGGACGCGTTGTCGGTCGGCCTGGCCGATTGCCATGTGCCGGCGGACACTCTGGCCGCCGTGGTCCGCC
GCCTGCGCGACGGCACCTGGCAGCGCGCCGAGCAGATCGCCGCCTGCTTCGCCGAGGCCGCGACCGATCCCGACGCGACC
CGGGCCGTGATCGCGCCGCACCGTGCCGCCATCGACGCGTGCTTTAGCCAGGCCACGGTGCCCGCCATCCTCGCCGACCT
GGCCGGCAGCCCCGATGCCGGCTGGGCTGCGCAGACCGGGCAGCAGATGGCCCGGCGCTCACCGCTGATGATGGCGGTCA
CGCTCGAGCAGATCCGCCGCGGCCGCCACACCACGCTCGCCGACGAACTGCGCCGCGAACTGGACATGATGGCGCGCGTG
TTCGACGCTGGCGACGGCATCGAAGGCATCCGCGCGCTGGCCGTCGACAAGGACCATGCGCCCCGGTGGCAGCACGCCAG
CGTCGACGCCGTGCGCGAAGACGAGGTGGCCGCGTTCTTCGCATCGCCGTGGCGGCGCGAGCAGCATCCGCTGCTGGGGC
TGTCGGACTAG

Upstream 100 bases:

>100_bases
CGTCCGCAAAGAGGGCCGGCTAGAGCCCTTCCTCGCAAACCTGCCGGCTCGTGTACAGTGCGAGCCGTCATTCCCGTAAC
GACAGGCACAGACGCGAGAC

Downstream 100 bases:

>100_bases
AACCGGTAAACTTGCGCGCCTGAACCGAATTACCGAATTGCCGTGTCTGCTGAACGCTCTACGCCGAATCCGCGTCGCCT
GTCCGTTGCCCCGATGATGG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MESTASTASSTVSAATQTDTQAHVIAEVHGGIGWLTLNRPQALNALSLEMIRALSHALMAWQHDPAVRAVILRGEGGKAL
CAGGDIRFFHRAATARDPQLITFFAEEYRLNHLIFRYAKPYIALMDGVVMGGGMGISQGASLRVVTGRTRMAMPETNIGL
FPDVGGGWFLARLPGHVGEYLGVTGQVIDAADALSVGLADCHVPADTLAAVVRRLRDGTWQRAEQIAACFAEAATDPDAT
RAVIAPHRAAIDACFSQATVPAILADLAGSPDAGWAAQTGQQMARRSPLMMAVTLEQIRRGRHTTLADELRRELDMMARV
FDAGDGIEGIRALAVDKDHAPRWQHASVDAVREDEVAAFFASPWRREQHPLLGLSD

Sequences:

>Translated_376_residues
MESTASTASSTVSAATQTDTQAHVIAEVHGGIGWLTLNRPQALNALSLEMIRALSHALMAWQHDPAVRAVILRGEGGKAL
CAGGDIRFFHRAATARDPQLITFFAEEYRLNHLIFRYAKPYIALMDGVVMGGGMGISQGASLRVVTGRTRMAMPETNIGL
FPDVGGGWFLARLPGHVGEYLGVTGQVIDAADALSVGLADCHVPADTLAAVVRRLRDGTWQRAEQIAACFAEAATDPDAT
RAVIAPHRAAIDACFSQATVPAILADLAGSPDAGWAAQTGQQMARRSPLMMAVTLEQIRRGRHTTLADELRRELDMMARV
FDAGDGIEGIRALAVDKDHAPRWQHASVDAVREDEVAAFFASPWRREQHPLLGLSD
>Mature_376_residues
MESTASTASSTVSAATQTDTQAHVIAEVHGGIGWLTLNRPQALNALSLEMIRALSHALMAWQHDPAVRAVILRGEGGKAL
CAGGDIRFFHRAATARDPQLITFFAEEYRLNHLIFRYAKPYIALMDGVVMGGGMGISQGASLRVVTGRTRMAMPETNIGL
FPDVGGGWFLARLPGHVGEYLGVTGQVIDAADALSVGLADCHVPADTLAAVVRRLRDGTWQRAEQIAACFAEAATDPDAT
RAVIAPHRAAIDACFSQATVPAILADLAGSPDAGWAAQTGQQMARRSPLMMAVTLEQIRRGRHTTLADELRRELDMMARV
FDAGDGIEGIRALAVDKDHAPRWQHASVDAVREDEVAAFFASPWRREQHPLLGLSD

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=351, Percent_Identity=37.3219373219373, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI37594469, Length=302, Percent_Identity=38.4105960264901, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI194097323, Length=242, Percent_Identity=30.5785123966942, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI68989263, Length=237, Percent_Identity=26.5822784810127, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI20127408, Length=238, Percent_Identity=27.3109243697479, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4502327, Length=184, Percent_Identity=28.804347826087, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI221142681, Length=188, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787660, Length=196, Percent_Identity=30.6122448979592, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788597, Length=197, Percent_Identity=28.4263959390863, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=361, Percent_Identity=38.2271468144044, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI25144160, Length=361, Percent_Identity=38.2271468144044, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17540714, Length=180, Percent_Identity=29.4444444444444, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=187, Percent_Identity=28.3422459893048, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=182, Percent_Identity=29.1208791208791, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=343, Percent_Identity=29.1545189504373, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI28571729, Length=358, Percent_Identity=36.3128491620112, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI28571730, Length=358, Percent_Identity=36.3128491620112, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI20129971, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24653477, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24653139, Length=220, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 40384; Mature: 40384

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTASTASSTVSAATQTDTQAHVIAEVHGGIGWLTLNRPQALNALSLEMIRALSHALMA
CCCCHHHHHHHHHHHHCCCCHHEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
WQHDPAVRAVILRGEGGKALCAGGDIRFFHRAATARDPQLITFFAEEYRLNHLIFRYAKP
HCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCH
YIALMDGVVMGGGMGISQGASLRVVTGRTRMAMPETNIGLFPDVGGGWFLARLPGHVGEY
HHHHHHHHHCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCCCCEEEECCCHHHHHH
LGVTGQVIDAADALSVGLADCHVPADTLAAVVRRLRDGTWQRAEQIAACFAEAATDPDAT
HCCCCHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
RAVIAPHRAAIDACFSQATVPAILADLAGSPDAGWAAQTGQQMARRSPLMMAVTLEQIRR
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHC
GRHTTLADELRRELDMMARVFDAGDGIEGIRALAVDKDHAPRWQHASVDAVREDEVAAFF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
ASPWRREQHPLLGLSD
HCCCCCCCCCCCCCCC
>Mature Secondary Structure
MESTASTASSTVSAATQTDTQAHVIAEVHGGIGWLTLNRPQALNALSLEMIRALSHALMA
CCCCHHHHHHHHHHHHCCCCHHEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
WQHDPAVRAVILRGEGGKALCAGGDIRFFHRAATARDPQLITFFAEEYRLNHLIFRYAKP
HCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCH
YIALMDGVVMGGGMGISQGASLRVVTGRTRMAMPETNIGLFPDVGGGWFLARLPGHVGEY
HHHHHHHHHCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCCCCEEEECCCHHHHHH
LGVTGQVIDAADALSVGLADCHVPADTLAAVVRRLRDGTWQRAEQIAACFAEAATDPDAT
HCCCCHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
RAVIAPHRAAIDACFSQATVPAILADLAGSPDAGWAAQTGQQMARRSPLMMAVTLEQIRR
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHC
GRHTTLADELRRELDMMARVFDAGDGIEGIRALAVDKDHAPRWQHASVDAVREDEVAAFF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
ASPWRREQHPLLGLSD
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA