Click here to switch to the map view.

The map label for this gene is iolG

Identifier: 17545965

GI number: 17545965

Start: 1321305

End: 1322318

Strand: Direct

Name: iolG

Synonym: RSc1246

Alternate gene names: 17545965

Gene position: 1321305-1322318 (Clockwise)

Preceding gene: 17545964

Following gene: 17545966

Centisome position: 35.55

GC content: 66.77

Gene sequence:

>1014_bases
ATGACTCTGCAAATTGGGGTGATCGGCTGCGGCGCGATCGGCCAGGACCACATCCGGCGGCTGACGCGCACGTTGTCGGG
CGCGCGCGTGGTGGCCGTGACCGACATCGATCCGACGCAGGCACACGCCGCCGTGGCGAATCACGGCCTGAATGCCGAGG
TGTACGCGAACGGCGGCGATCTGATCGAGGCGCCGGACGTGCAGGCGGTGCTGGTCACGTCGTGGGGGCCGACGCACGAG
GAATTTGTCCTGAAGGCGATCGCGCAAGGCAAGCCGGTGTTCTGCGAGAAGCCGCTGGCGGTGACCGCCGACGGTTGCAT
GCGGATCGTCGCGGCCGAGCAGGCGCACGGCAGCAGGCTGGTGCAGGTGGGCTTCATGCGCCCATACGACGCCGGCTATC
GTGCGCTCAAGCAGGTGATCGACAGCGGCACGATCGGCGCACCGCTGATGCTGCATTGCGCGCACCGCAACCCGTCGGTC
GGCGACCGCTACATGACCGACATGGCGATCACCGACACGCTGATCCACGAACTCGACGTGCTGCGCTGGCTGACCGGCGA
CGACTATGTCAGCGCGCAGGTCGTCTATCCGAGGAAGACGCGCCACGCGTCTTCGCATCTCGCCGATCCGCAGATCGTGC
TGCTGGAGACGGCGCAGGGCGTGCGCATCGACGTGGAGATTTTCGTCAACTGCCAGTATGGCTACGACATCCAGTGCGAG
GTGGTTGGCGAGAACGGGATTGCCACGCTGCCGGACCCGCAGGCGGTGTCGCTCAAACATGCGGCCAGGCATGCGATCGC
GATCCTGACCGATTGGAAGGACCGCTTCATCGCCGCGTACGACATCGAGCTGCAGGCCTTCATCGATGGCGTGCAAGGGG
GCGCATTGACCGGCCCATCGGCGTGGGATGGCTATGCCGCGGCGGTTGCCGCCGACGCCTGCGTGCGGGCACAGAAGAGC
GGCGCGATCGAGCGCATCGAGATGGCGGCGAGGCCGGCGTTCTATCGTGGCTGA

Upstream 100 bases:

>100_bases
GAAGTGATGGAGGCGGAGAACAGCGAGGCGTTGCTTGCCGAGAGCATGCACTACATCCACCACGCATTGTCTTGACACGC
TGGACGACAGGGAAAACGGT

Downstream 100 bases:

>100_bases
GTCCGGCCGCGGCCACAACGAATGGAATCCACCGATATGACGATGAAAATCGGCTGTGCGCCCTGCTGCTGGGGCGTGGA
CGACGTGAGGAATCCGCACC

Product: oxidoreductase myo-inositol 2-dehydrogenase signal peptide protein

Products: NA

Alternate protein names: Myo-inositol 2-dehydrogenase; MI 2-dehydrogenase

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTLQIGVIGCGAIGQDHIRRLTRTLSGARVVAVTDIDPTQAHAAVANHGLNAEVYANGGDLIEAPDVQAVLVTSWGPTHE
EFVLKAIAQGKPVFCEKPLAVTADGCMRIVAAEQAHGSRLVQVGFMRPYDAGYRALKQVIDSGTIGAPLMLHCAHRNPSV
GDRYMTDMAITDTLIHELDVLRWLTGDDYVSAQVVYPRKTRHASSHLADPQIVLLETAQGVRIDVEIFVNCQYGYDIQCE
VVGENGIATLPDPQAVSLKHAARHAIAILTDWKDRFIAAYDIELQAFIDGVQGGALTGPSAWDGYAAAVAADACVRAQKS
GAIERIEMAARPAFYRG

Sequences:

>Translated_337_residues
MTLQIGVIGCGAIGQDHIRRLTRTLSGARVVAVTDIDPTQAHAAVANHGLNAEVYANGGDLIEAPDVQAVLVTSWGPTHE
EFVLKAIAQGKPVFCEKPLAVTADGCMRIVAAEQAHGSRLVQVGFMRPYDAGYRALKQVIDSGTIGAPLMLHCAHRNPSV
GDRYMTDMAITDTLIHELDVLRWLTGDDYVSAQVVYPRKTRHASSHLADPQIVLLETAQGVRIDVEIFVNCQYGYDIQCE
VVGENGIATLPDPQAVSLKHAARHAIAILTDWKDRFIAAYDIELQAFIDGVQGGALTGPSAWDGYAAAVAADACVRAQKS
GAIERIEMAARPAFYRG
>Mature_336_residues
TLQIGVIGCGAIGQDHIRRLTRTLSGARVVAVTDIDPTQAHAAVANHGLNAEVYANGGDLIEAPDVQAVLVTSWGPTHEE
FVLKAIAQGKPVFCEKPLAVTADGCMRIVAAEQAHGSRLVQVGFMRPYDAGYRALKQVIDSGTIGAPLMLHCAHRNPSVG
DRYMTDMAITDTLIHELDVLRWLTGDDYVSAQVVYPRKTRHASSHLADPQIVLLETAQGVRIDVEIFVNCQYGYDIQCEV
VGENGIATLPDPQAVSLKHAARHAIAILTDWKDRFIAAYDIELQAFIDGVQGGALTGPSAWDGYAAAVAADACVRAQKSG
AIERIEMAARPAFYRG

Specific function: Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IOLG_RALSO (Q8XZZ9)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519367.1
- ProteinModelPortal:   Q8XZZ9
- SMR:   Q8XZZ9
- GeneID:   1220069
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1246
- NMPDR:   fig|267608.1.peg.1246
- HOGENOM:   HBG612336
- OMA:   DWKDRFI
- ProtClustDB:   CLSK896889
- BioCyc:   RSOL267608:RSC1246-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01671
- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C

EC number: =1.1.1.18

Molecular weight: Translated: 36236; Mature: 36104

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQIGVIGCGAIGQDHIRRLTRTLSGARVVAVTDIDPTQAHAAVANHGLNAEVYANGGD
CEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCCC
LIEAPDVQAVLVTSWGPTHEEFVLKAIAQGKPVFCEKPLAVTADGCMRIVAAEQAHGSRL
EEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCEECCCCEEECCHHEEEEEECCCCCCEE
VQVGFMRPYDAGYRALKQVIDSGTIGAPLMLHCAHRNPSVGDRYMTDMAITDTLIHELDV
EEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LRWLTGDDYVSAQVVYPRKTRHASSHLADPQIVLLETAQGVRIDVEIFVNCQYGYDIQCE
HHHCCCCCEEEEEEECCCCCCCCHHHCCCCEEEEEECCCCCEEEEEEEEEEECCCEEEEE
VVGENGIATLPDPQAVSLKHAARHAIAILTDWKDRFIAAYDIELQAFIDGVQGGALTGPS
EECCCCEEECCCCCCCHHHHHHCEEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCC
AWDGYAAAVAADACVRAQKSGAIERIEMAARPAFYRG
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLQIGVIGCGAIGQDHIRRLTRTLSGARVVAVTDIDPTQAHAAVANHGLNAEVYANGGD
EEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCCC
LIEAPDVQAVLVTSWGPTHEEFVLKAIAQGKPVFCEKPLAVTADGCMRIVAAEQAHGSRL
EEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCEECCCCEEECCHHEEEEEECCCCCCEE
VQVGFMRPYDAGYRALKQVIDSGTIGAPLMLHCAHRNPSVGDRYMTDMAITDTLIHELDV
EEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LRWLTGDDYVSAQVVYPRKTRHASSHLADPQIVLLETAQGVRIDVEIFVNCQYGYDIQCE
HHHCCCCCEEEEEEECCCCCCCCHHHCCCCEEEEEECCCCCEEEEEEEEEEECCCEEEEE
VVGENGIATLPDPQAVSLKHAARHAIAILTDWKDRFIAAYDIELQAFIDGVQGGALTGPS
EECCCCEEECCCCCCCHHHHHHCEEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCC
AWDGYAAAVAADACVRAQKSGAIERIEMAARPAFYRG
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852