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The map label for this gene is norM [H]

Identifier: 17545899

GI number: 17545899

Start: 1242552

End: 1243898

Strand: Reverse

Name: norM [H]

Synonym: RSc1180

Alternate gene names: 17545899

Gene position: 1243898-1242552 (Counterclockwise)

Preceding gene: 17545900

Following gene: 17545897

Centisome position: 33.47

GC content: 68.15

Gene sequence:

>1347_bases
ATGTTCCTGGCTGACATCCGCAGCATTGCCGCGCTGGCCTGGCCGGTGCTGGTCGGCCAGCTCGCGGTGATCGCCTTCGG
CGTGCTGGATACCGCCATGGCCGGGCGTGCGTCGGCAGCGGATCTGGCCGCGATCGGGCTGGGCGGCTCGATCTATGTGA
CGGTCTACATCAGCCTGATGGGCGTCTTGCAGGCGCTCTCGCCCATTGCCGGCCAGCTCTACGGCGCGGGCCGGCACGGC
GAGATCGGCGAAGAGGTCCGCCAAGCCGCCTGGCTCGGGCTGGCGCTATCGGCCATCGGCATGCTGCTCTTGTGGTTTCC
CGCACCGCTGCTGCGGCTCGCCGACGCCTCGCCCGAGCTGACCAGCAAGGCAACCGCCTACCTCCGCTACGAAGCGCTGG
CGCTGCCCGCCGCGCTGGGTTTCCGCATCTACTCGGCGCTCAACAACGCGCTGTCGCGGCCGGTGATGGTGACGGTGCTG
CAATTGGGCGGGCTGGCCCTGAAGTTCCCGCTCAACGCCCTATTCCTGTACGGCGGCCTCGGCCTGCCCGCGATGGGCGG
CCCCGGTTGCGCGCTGGCATCGATGATCATCGGCTGGCTGTGGTGCATCGCGGGCGCGCTCATCCTGATGCGCAACCCGG
TCTACCGGCCCTTCCGGATCTTCACGCAGTTCTCGCCGCCCCACCTCGGACGCTTGTGGGGACTGGTGCGCCTGGGCGTG
CCGATGGGCCTGACCTACCTGATCGAGATCACGTCGTTCACGCTGATGGCGATCTTCATCGCGCGGATGGGAACCGTAGT
GCTGGCCGGCCACCAGATTGCGGCCAACGTGGGAGCGGTGGCCTATATGGTGCCACTGTCCCTGTCGATCGCCACATCGA
CACTGGTGGCCCAAATGATCGGCGCGCGCGATCGCGATGCCGCGCGGCGGATTGCCTGGAACGGGCTCAAGCTCGCCGCC
GCCTGCGCGATCGCTGTCGGCGGATGCGTTCTGCTGCTGCGCCGCGACCTGGTCGGCCTCTACACCCGGGATGCCACCGT
GATGGCCATCGCGGTGCCGCTACTGCCGTTCATCGCGTTCTACCAATTGTTCGATGCGCTGCAAGTCACGGCGGCGTTCA
TCCTGCGCGCCTACAAGATCGCGCTGATCCCGACGGTGATCTACGCGCTGTCGCTCTGGGGCGTGGGATTGGGAGGGGGC
TACCTGCTCGGTTTTGGCCTCCTGGGGGAATCCGCCGCCGCCCTGCGCGGCGCCGCCGGCTTCTGGGCCGCCAATGCGCT
CAGCCTTGCGGTGGCCGGCACCTTGCTCGTCGGCTATTTCAATCGCATCAGCCGCGCAGCCGACTAG

Upstream 100 bases:

>100_bases
GCCGACCGCGACGAGCACTTCCGCATGTACCGCCTGACCGAAGCCGCCAAGGCCACCCACCCGGCGCCCGTTCCGGCCAC
CTCGCGCAGGCGCAAGCTGC

Downstream 100 bases:

>100_bases
ACCGGCACCTTGCCTGAGGTCCCGGAATGCTCCCGTTCTTCCATGCCAAGAAACGGGAGCACAAAAAGAAAAACCCGCTG
CAAGCAGCGGGTTTTGATTT

Product: inner membrane transmembrane protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFLADIRSIAALAWPVLVGQLAVIAFGVLDTAMAGRASAADLAAIGLGGSIYVTVYISLMGVLQALSPIAGQLYGAGRHG
EIGEEVRQAAWLGLALSAIGMLLLWFPAPLLRLADASPELTSKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVL
QLGGLALKFPLNALFLYGGLGLPAMGGPGCALASMIIGWLWCIAGALILMRNPVYRPFRIFTQFSPPHLGRLWGLVRLGV
PMGLTYLIEITSFTLMAIFIARMGTVVLAGHQIAANVGAVAYMVPLSLSIATSTLVAQMIGARDRDAARRIAWNGLKLAA
ACAIAVGGCVLLLRRDLVGLYTRDATVMAIAVPLLPFIAFYQLFDALQVTAAFILRAYKIALIPTVIYALSLWGVGLGGG
YLLGFGLLGESAAALRGAAGFWAANALSLAVAGTLLVGYFNRISRAAD

Sequences:

>Translated_448_residues
MFLADIRSIAALAWPVLVGQLAVIAFGVLDTAMAGRASAADLAAIGLGGSIYVTVYISLMGVLQALSPIAGQLYGAGRHG
EIGEEVRQAAWLGLALSAIGMLLLWFPAPLLRLADASPELTSKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVL
QLGGLALKFPLNALFLYGGLGLPAMGGPGCALASMIIGWLWCIAGALILMRNPVYRPFRIFTQFSPPHLGRLWGLVRLGV
PMGLTYLIEITSFTLMAIFIARMGTVVLAGHQIAANVGAVAYMVPLSLSIATSTLVAQMIGARDRDAARRIAWNGLKLAA
ACAIAVGGCVLLLRRDLVGLYTRDATVMAIAVPLLPFIAFYQLFDALQVTAAFILRAYKIALIPTVIYALSLWGVGLGGG
YLLGFGLLGESAAALRGAAGFWAANALSLAVAGTLLVGYFNRISRAAD
>Mature_448_residues
MFLADIRSIAALAWPVLVGQLAVIAFGVLDTAMAGRASAADLAAIGLGGSIYVTVYISLMGVLQALSPIAGQLYGAGRHG
EIGEEVRQAAWLGLALSAIGMLLLWFPAPLLRLADASPELTSKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVL
QLGGLALKFPLNALFLYGGLGLPAMGGPGCALASMIIGWLWCIAGALILMRNPVYRPFRIFTQFSPPHLGRLWGLVRLGV
PMGLTYLIEITSFTLMAIFIARMGTVVLAGHQIAANVGAVAYMVPLSLSIATSTLVAQMIGARDRDAARRIAWNGLKLAA
ACAIAVGGCVLLLRRDLVGLYTRDATVMAIAVPLLPFIAFYQLFDALQVTAAFILRAYKIALIPTVIYALSLWGVGLGGG
YLLGFGLLGESAAALRGAAGFWAANALSLAVAGTLLVGYFNRISRAAD

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=456, Percent_Identity=23.9035087719298, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI153792564, Length=408, Percent_Identity=21.8137254901961, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI48994890, Length=437, Percent_Identity=31.8077803203661, Blast_Score=199, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321821, Length=350, Percent_Identity=26.8571428571429, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320545, Length=381, Percent_Identity=24.4094488188976, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47009; Mature: 47009

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLADIRSIAALAWPVLVGQLAVIAFGVLDTAMAGRASAADLAAIGLGGSIYVTVYISLM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHH
GVLQALSPIAGQLYGAGRHGEIGEEVRQAAWLGLALSAIGMLLLWFPAPLLRLADASPEL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
TSKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVLQLGGLALKFPLNALFLYGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEHHHHHHHHHCCC
GLPAMGGPGCALASMIIGWLWCIAGALILMRNPVYRPFRIFTQFSPPHLGRLWGLVRLGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHCC
PMGLTYLIEITSFTLMAIFIARMGTVVLAGHQIAANVGAVAYMVPLSLSIATSTLVAQMI
CHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GARDRDAARRIAWNGLKLAAACAIAVGGCVLLLRRDLVGLYTRDATVMAIAVPLLPFIAF
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YQLFDALQVTAAFILRAYKIALIPTVIYALSLWGVGLGGGYLLGFGLLGESAAALRGAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCH
FWAANALSLAVAGTLLVGYFNRISRAAD
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFLADIRSIAALAWPVLVGQLAVIAFGVLDTAMAGRASAADLAAIGLGGSIYVTVYISLM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHH
GVLQALSPIAGQLYGAGRHGEIGEEVRQAAWLGLALSAIGMLLLWFPAPLLRLADASPEL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
TSKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVLQLGGLALKFPLNALFLYGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEHHHHHHHHHCCC
GLPAMGGPGCALASMIIGWLWCIAGALILMRNPVYRPFRIFTQFSPPHLGRLWGLVRLGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHCC
PMGLTYLIEITSFTLMAIFIARMGTVVLAGHQIAANVGAVAYMVPLSLSIATSTLVAQMI
CHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GARDRDAARRIAWNGLKLAAACAIAVGGCVLLLRRDLVGLYTRDATVMAIAVPLLPFIAF
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YQLFDALQVTAAFILRAYKIALIPTVIYALSLWGVGLGGGYLLGFGLLGESAAALRGAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCH
FWAANALSLAVAGTLLVGYFNRISRAAD
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA