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The map label for this gene is tyrB [H]

Identifier: 17545729

GI number: 17545729

Start: 1060385

End: 1061581

Strand: Reverse

Name: tyrB [H]

Synonym: RSc1010

Alternate gene names: 17545729

Gene position: 1061581-1060385 (Counterclockwise)

Preceding gene: 17545732

Following gene: 17545728

Centisome position: 28.56

GC content: 66.67

Gene sequence:

>1197_bases
ATGTCGCTTTTTTCCGCCGTCGAGCTGGCCCCGCGCGACCCCATCCTGGGGCTGAATGAAGCTTTCAACGCCGATGCCCG
CAGCACCAAAGTCAACCTGGGCGTGGGCGTGTACTTCACCGACGAAGGAAAAATCCCGGTACTGCGCGCCGTGCAGGAAG
CCGAGAAGGCCCGCCTGGCCATGGCCGCGCCGCGCGGCTACCTGCCGATCGAAGGCATCGCCGCCTACGACCAGGCCGTG
CAGAAGCTGCTGTTCGGCGCCGATTCGCCGCTGCTGGCCGAAGGCCGCGTGGTGACGGCCCAGGCACTGGGCGGCACCGG
CGCACTGAAGATCGGCGCCGATTTCCTCAAACGCCTGTACCCGGACGCCAAGGTCGCCATCTCCGACCCGAGCTGGGAAA
ACCACCGCGCGCTGTTCGAGGCCGCCGGCTTCCCGGTCGTGAACTATCCGTACTACGACGCCCCGACGCACGGCCTGAAC
TTCGCCGCCATGCTCGAAGCGCTCAACGGCTACGCGCCCAACACCATCGTCGTGCTGCACGCCTGCTGCCACAACCCGAC
CGGCGTGGACCTGACCACCGAGCAGTGGAAGCAGGTGGTCGAAGTCATCAAGGCCAAGCAGCTGATCCCGTTCCTCGACA
TGGCCTACCAGGGCTTCGCCGACGGCATCGCCCAGGACGGCCTGGCCGTGAGCCTGTTCGCCGAATCGGGCCTGCAGTTC
TTCGTGTCGAGCTCGTTCTCCAAGTCGTTCTCGCTGTACGGCGAGCGCGTCGGCGCTCTGTCGATCGTCACCACCAGCAA
GGACGAGGCAGCCCGCGTGATGTCGCAGGTCAAGCGCGTGATCCGCACCAACTACTCCAACCCGCCGACGCACGGCGGCA
CGGTGGTCGCCAGCGTGCTGACCAGCCCCGAGCTGCGCGCGATGTGGGAGCAGGAACTGGGCGAGATGCGCGACCGCATC
AAGTCGATGCGCCACGCGCTGGTCGACAAGCTTGCCGCCAAGGGCGTGAAGACCGACTTCTCGTTCGTGAAGGCGCAGCG
CGGCATGTTCTCGTATTCGGGCCTGTCCGCCGCCCAGGTGGACCGCCTGCGCAACGAGCACGGCATCTACGCGGTGTCGA
CCGGCCGCATCTGCGTGGCCGCGCTGAACTCGCACAACATCGACGCCGTGGTCAACGCCATCGCCGAAGTGCTCTGA

Upstream 100 bases:

>100_bases
GCATCTGGCGCCGGCAGCCCTGCCGGCCGCTTGCGGTGCGCAGCCTGCTGCATCCCACCGAATTCCGAACCAACCGAACG
TCATCGAACGTCAACACATC

Downstream 100 bases:

>100_bases
GAGCCCGTTTGAAAATTCCCCGCGGTTGTGATGTAAATGCGGGATGTGGAAAAAAGAACATCGAGAGCGTGAGGCGAAGC
TAGCTCGCAAGACAAAGCGT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSLFSAVELAPRDPILGLNEAFNADARSTKVNLGVGVYFTDEGKIPVLRAVQEAEKARLAMAAPRGYLPIEGIAAYDQAV
QKLLFGADSPLLAEGRVVTAQALGGTGALKIGADFLKRLYPDAKVAISDPSWENHRALFEAAGFPVVNYPYYDAPTHGLN
FAAMLEALNGYAPNTIVVLHACCHNPTGVDLTTEQWKQVVEVIKAKQLIPFLDMAYQGFADGIAQDGLAVSLFAESGLQF
FVSSSFSKSFSLYGERVGALSIVTTSKDEAARVMSQVKRVIRTNYSNPPTHGGTVVASVLTSPELRAMWEQELGEMRDRI
KSMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLSAAQVDRLRNEHGIYAVSTGRICVAALNSHNIDAVVNAIAEVL

Sequences:

>Translated_398_residues
MSLFSAVELAPRDPILGLNEAFNADARSTKVNLGVGVYFTDEGKIPVLRAVQEAEKARLAMAAPRGYLPIEGIAAYDQAV
QKLLFGADSPLLAEGRVVTAQALGGTGALKIGADFLKRLYPDAKVAISDPSWENHRALFEAAGFPVVNYPYYDAPTHGLN
FAAMLEALNGYAPNTIVVLHACCHNPTGVDLTTEQWKQVVEVIKAKQLIPFLDMAYQGFADGIAQDGLAVSLFAESGLQF
FVSSSFSKSFSLYGERVGALSIVTTSKDEAARVMSQVKRVIRTNYSNPPTHGGTVVASVLTSPELRAMWEQELGEMRDRI
KSMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLSAAQVDRLRNEHGIYAVSTGRICVAALNSHNIDAVVNAIAEVL
>Mature_397_residues
SLFSAVELAPRDPILGLNEAFNADARSTKVNLGVGVYFTDEGKIPVLRAVQEAEKARLAMAAPRGYLPIEGIAAYDQAVQ
KLLFGADSPLLAEGRVVTAQALGGTGALKIGADFLKRLYPDAKVAISDPSWENHRALFEAAGFPVVNYPYYDAPTHGLNF
AAMLEALNGYAPNTIVVLHACCHNPTGVDLTTEQWKQVVEVIKAKQLIPFLDMAYQGFADGIAQDGLAVSLFAESGLQFF
VSSSFSKSFSLYGERVGALSIVTTSKDEAARVMSQVKRVIRTNYSNPPTHGGTVVASVLTSPELRAMWEQELGEMRDRIK
SMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLSAAQVDRLRNEHGIYAVSTGRICVAALNSHNIDAVVNAIAEVL

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=396, Percent_Identity=43.9393939393939, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI4504067, Length=405, Percent_Identity=43.2098765432099, Blast_Score=324, Evalue=8e-89,
Organism=Homo sapiens, GI117414139, Length=403, Percent_Identity=29.5285359801489, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1790488, Length=399, Percent_Identity=52.3809523809524, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=46.7171717171717, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71981858, Length=398, Percent_Identity=41.9597989949749, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI25147133, Length=397, Percent_Identity=41.5617128463476, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17569539, Length=401, Percent_Identity=40.3990024937656, Blast_Score=308, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI17569537, Length=400, Percent_Identity=33.75, Blast_Score=220, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17550384, Length=268, Percent_Identity=36.1940298507463, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI25147136, Length=213, Percent_Identity=38.9671361502347, Blast_Score=171, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6323055, Length=406, Percent_Identity=39.9014778325123, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6322743, Length=434, Percent_Identity=32.9493087557604, Blast_Score=243, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=42.713567839196, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=42.713567839196, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI19920542, Length=391, Percent_Identity=42.7109974424552, Blast_Score=327, Evalue=6e-90,
Organism=Drosophila melanogaster, GI24654046, Length=400, Percent_Identity=40.75, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI19922362, Length=400, Percent_Identity=40.75, Blast_Score=312, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 42932; Mature: 42800

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFSAVELAPRDPILGLNEAFNADARSTKVNLGVGVYFTDEGKIPVLRAVQEAEKARLA
CCCHHHHHCCCCCCCCCCHHHCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHH
MAAPRGYLPIEGIAAYDQAVQKLLFGADSPLLAEGRVVTAQALGGTGALKIGADFLKRLY
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCEEEEEEECCCCCCHHHHHHHHHHHC
PDAKVAISDPSWENHRALFEAAGFPVVNYPYYDAPTHGLNFAAMLEALNGYAPNTIVVLH
CCCEEEECCCCCCHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEE
ACCHNPTGVDLTTEQWKQVVEVIKAKQLIPFLDMAYQGFADGIAQDGLAVSLFAESGLQF
EHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHH
FVSSSFSKSFSLYGERVGALSIVTTSKDEAARVMSQVKRVIRTNYSNPPTHGGTVVASVL
HHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TSPELRAMWEQELGEMRDRIKSMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLSAAQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHH
DRLRNEHGIYAVSTGRICVAALNSHNIDAVVNAIAEVL
HHHHCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SLFSAVELAPRDPILGLNEAFNADARSTKVNLGVGVYFTDEGKIPVLRAVQEAEKARLA
CCHHHHHCCCCCCCCCCHHHCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHH
MAAPRGYLPIEGIAAYDQAVQKLLFGADSPLLAEGRVVTAQALGGTGALKIGADFLKRLY
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCEEEEEEECCCCCCHHHHHHHHHHHC
PDAKVAISDPSWENHRALFEAAGFPVVNYPYYDAPTHGLNFAAMLEALNGYAPNTIVVLH
CCCEEEECCCCCCHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEE
ACCHNPTGVDLTTEQWKQVVEVIKAKQLIPFLDMAYQGFADGIAQDGLAVSLFAESGLQF
EHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHH
FVSSSFSKSFSLYGERVGALSIVTTSKDEAARVMSQVKRVIRTNYSNPPTHGGTVVASVL
HHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TSPELRAMWEQELGEMRDRIKSMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLSAAQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHH
DRLRNEHGIYAVSTGRICVAALNSHNIDAVVNAIAEVL
HHHHCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043; 8808952 [H]