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The map label for this gene is lrp [H]

Identifier: 17545480

GI number: 17545480

Start: 804749

End: 805279

Strand: Direct

Name: lrp [H]

Synonym: RSc0761

Alternate gene names: 17545480

Gene position: 804749-805279 (Clockwise)

Preceding gene: 17545476

Following gene: 17545481

Centisome position: 21.65

GC content: 68.74

Gene sequence:

>531_bases
ATGCAACTCGATACCACCGATCTGCGCATTCTCCAGGTCCTGCAGGAGGATGGCCGCATCAGCAACCAGGACCTGGCCGA
GCGCGTGGCGCTGTCGCCGTCGGCCTGCCTGCGGCGGGTGCGGATGCTGGAGGAGGGGGGCGCCATCACCGGCTATCGCG
CGCGGCTCGGGCGGGCGGCGCTCGGGCTGGAGCTGGAGGCCATCGTGCAGGTGTCGATGCGGCAGGATGTGTCCGGCTGG
CACGAGACCTTCATGGAGGCGGTGCAGCAGTGGCCGGAGATCGTCGCGGCGTACATCATCACCGGGGACTGCAACTACAT
CCTGCGCGTGCAGGCGCCCAACCTGCAGCACTATTCCGAGTTCATCATCGAGCGGCTGTACAAGACGCCGGGCGTGATGG
ACATTCGCTCGAACATCGTGCTGCGCACGCTCAAGGAGCGCGAGGGCGGGCTGGCCCTGCTGATGGAGGCGCGCGGCGTG
CGGCCGCTGGAGGCGGGGGCCGGCAAGCGTGGCAAGGCGGGCAGTTCCTGA

Upstream 100 bases:

>100_bases
GAAAACCGTGCGAAATGGGTTTGCATATTCGTGCGTGCGATTTTGCTGAATTCGCATAAAATTCAACATAATTGACAGAT
CGCACCATTTTCTTCGACCT

Downstream 100 bases:

>100_bases
CGCGGATCAATCCCCTACTGGCCGTGTGCGCGGATAGTCGGTCTGTGTTGTCGACCGGAGCCGGGCCATGGCCAAGAAAT
TTCCACTGCATCCCGTGCAC

Product: transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MQLDTTDLRILQVLQEDGRISNQDLAERVALSPSACLRRVRMLEEGGAITGYRARLGRAALGLELEAIVQVSMRQDVSGW
HETFMEAVQQWPEIVAAYIITGDCNYILRVQAPNLQHYSEFIIERLYKTPGVMDIRSNIVLRTLKEREGGLALLMEARGV
RPLEAGAGKRGKAGSS

Sequences:

>Translated_176_residues
MQLDTTDLRILQVLQEDGRISNQDLAERVALSPSACLRRVRMLEEGGAITGYRARLGRAALGLELEAIVQVSMRQDVSGW
HETFMEAVQQWPEIVAAYIITGDCNYILRVQAPNLQHYSEFIIERLYKTPGVMDIRSNIVLRTLKEREGGLALLMEARGV
RPLEAGAGKRGKAGSS
>Mature_176_residues
MQLDTTDLRILQVLQEDGRISNQDLAERVALSPSACLRRVRMLEEGGAITGYRARLGRAALGLELEAIVQVSMRQDVSGW
HETFMEAVQQWPEIVAAYIITGDCNYILRVQAPNLQHYSEFIIERLYKTPGVMDIRSNIVLRTLKEREGGLALLMEARGV
RPLEAGAGKRGKAGSS

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=144, Percent_Identity=39.5833333333333, Blast_Score=111, Evalue=2e-26,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=32.1678321678322, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19595; Mature: 19595

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLDTTDLRILQVLQEDGRISNQDLAERVALSPSACLRRVRMLEEGGAITGYRARLGRAA
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LGLELEAIVQVSMRQDVSGWHETFMEAVQQWPEIVAAYIITGDCNYILRVQAPNLQHYSE
HCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHH
FIIERLYKTPGVMDIRSNIVLRTLKEREGGLALLMEARGVRPLEAGAGKRGKAGSS
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQLDTTDLRILQVLQEDGRISNQDLAERVALSPSACLRRVRMLEEGGAITGYRARLGRAA
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LGLELEAIVQVSMRQDVSGWHETFMEAVQQWPEIVAAYIITGDCNYILRVQAPNLQHYSE
HCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHH
FIIERLYKTPGVMDIRSNIVLRTLKEREGGLALLMEARGVRPLEAGAGKRGKAGSS
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]