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The map label for this gene is gcdH [H]

Identifier: 17545475

GI number: 17545475

Start: 799647

End: 800954

Strand: Reverse

Name: gcdH [H]

Synonym: RSc0756

Alternate gene names: 17545475

Gene position: 800954-799647 (Counterclockwise)

Preceding gene: 17545477

Following gene: 17545474

Centisome position: 21.55

GC content: 65.6

Gene sequence:

>1308_bases
TTGCAAGGAAAGAGTAGAAATTGCCGTCGGCTGCGTTATGATAAACCTAAATTTCGAAACACTGTTCCGTATTACGGAAC
CACAGTGCAGAGATCCGATCCGGAGACCACCGCCATGACCGCTCGCAACGCCTTCCACTGGGCCGATCCCTTGCTGCTCG
ACGCGCAGCTCACCGACGACGAGCGCATGGTGCGCGATGCCGCCGCCGCCTACGCGCAGGACAAGCTGATGCCGCGCGTG
CTGGAATCGTTCCGGCACGAGAAGACCGACACGGCGATCTTCCGCGAGATGGGCGCGCTGGGCATGCTCGGCCCCACGAT
CCCCGAGCAGTACGGCGGCCCGGGCCTGAACTACGTCAGCTATGGCCTGATCGCGCGCGAGGTGGAGCGTGTCGACTCGG
GCTACCGCTCGATGATGAGCGTGCAGTCGTCGCTGGTGATGGTGCCCATCCACGCGTTCGGCAGCGAGGCACAGAAGCAG
AAATACCTGCCCAGGCTGGCGACCGGCGAATGGATCGGCTGCTTCGGCCTGACCGAGCCCAACCACGGCTCCGACCCGGC
TTCGATGGTCACGCGCGCGAAAAAGGTGGATGGCGGCTACTCGCTGAGCGGCGCCAAGATGTGGATCACCAACTCGCCCA
TCGCCGACGTCTTCGTGGTGTGGGCCAAGCTGCCGGACGACAACGGTGAAGACCAGATCCGCGGCTTCATCCTGGAGAAG
GGCTGGAAGGGCCTGTCCGCCCCCGCCATCCACGGCAAGGTCGGCCTGCGCACCTCGATCACCGGCGAGATCGTGCTCGA
CGAGGTGTTCGTGCCCGAAGAGAACCTGATGCCCGGCGTGCACGGCCTCAAGGGCCCGTTCACCTGCCTGAACTCCGCGC
GCTACGGCATCGCCTGGGGCGCGCTCGGCGCGGCCGAGTCCTGCTGGCACACCGCGCGCCAGTACGTGCTGGACCGCACG
CAGTTCGGCCGCCCGCTCGCCGCCAACCAGCTGATCCAGAAGAAGCTCGCCGACATGCAGACCGAGATCACGCTCGGCCT
GCAGGGCTGCCTGCGCCTGGGCCGCATGAAGGACGAAGGCACCGCCGCGGTGGAAATCACCTCGATCATGAAACGCAACT
CGTGCGGCAAGGCGCTCGACATCGCCCGCATGGCGCGCGACATGCTGGGCGGCAACGGCATCTCCGACGAGTTCGGCGTG
ATCCGTCACGTCGTGAACCTGGAGGTGGTCAACACCTACGAGGGCACGCACGATATCCACGCCCTGATCCTGGGCCGCGC
GCAGACGGGCATCCAGGCGTTCTTCTGA

Upstream 100 bases:

>100_bases
GCGCGCAGCAGTTCCAGCCCGCGCGCCAGGGCCGTGACGAAGTTCGGATCGCCTTCGCGTCCGGCGCCGGATTCGGTATC
GGGGAGACTCTCGGTACGCA

Downstream 100 bases:

>100_bases
GACGGCGCCACATCCGCGGCGGGTCGGGCACGCCCGTACATCGCCCGCCGCATCCCCCGCCTGTCCTGGGCATCGGGGTC
ACCTCCCTTTCGCGGTATAT

Product: glutaryl-CoA dehydrogenase oxidoreductase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MQGKSRNCRRLRYDKPKFRNTVPYYGTTVQRSDPETTAMTARNAFHWADPLLLDAQLTDDERMVRDAAAAYAQDKLMPRV
LESFRHEKTDTAIFREMGALGMLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIHAFGSEAQKQ
KYLPRLATGEWIGCFGLTEPNHGSDPASMVTRAKKVDGGYSLSGAKMWITNSPIADVFVVWAKLPDDNGEDQIRGFILEK
GWKGLSAPAIHGKVGLRTSITGEIVLDEVFVPEENLMPGVHGLKGPFTCLNSARYGIAWGALGAAESCWHTARQYVLDRT
QFGRPLAANQLIQKKLADMQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFGV
IRHVVNLEVVNTYEGTHDIHALILGRAQTGIQAFF

Sequences:

>Translated_435_residues
MQGKSRNCRRLRYDKPKFRNTVPYYGTTVQRSDPETTAMTARNAFHWADPLLLDAQLTDDERMVRDAAAAYAQDKLMPRV
LESFRHEKTDTAIFREMGALGMLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIHAFGSEAQKQ
KYLPRLATGEWIGCFGLTEPNHGSDPASMVTRAKKVDGGYSLSGAKMWITNSPIADVFVVWAKLPDDNGEDQIRGFILEK
GWKGLSAPAIHGKVGLRTSITGEIVLDEVFVPEENLMPGVHGLKGPFTCLNSARYGIAWGALGAAESCWHTARQYVLDRT
QFGRPLAANQLIQKKLADMQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFGV
IRHVVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
>Mature_435_residues
MQGKSRNCRRLRYDKPKFRNTVPYYGTTVQRSDPETTAMTARNAFHWADPLLLDAQLTDDERMVRDAAAAYAQDKLMPRV
LESFRHEKTDTAIFREMGALGMLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIHAFGSEAQKQ
KYLPRLATGEWIGCFGLTEPNHGSDPASMVTRAKKVDGGYSLSGAKMWITNSPIADVFVVWAKLPDDNGEDQIRGFILEK
GWKGLSAPAIHGKVGLRTSITGEIVLDEVFVPEENLMPGVHGLKGPFTCLNSARYGIAWGALGAAESCWHTARQYVLDRT
QFGRPLAANQLIQKKLADMQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFGV
IRHVVNLEVVNTYEGTHDIHALILGRAQTGIQAFF

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=399, Percent_Identity=66.6666666666667, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI7669494, Length=379, Percent_Identity=65.1715039577836, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=33.0708661417323, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=31.1827956989247, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI226958414, Length=349, Percent_Identity=33.5243553008596, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4501859, Length=392, Percent_Identity=29.0816326530612, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI76496475, Length=417, Percent_Identity=30.4556354916067, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=33.1412103746398, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI187960098, Length=397, Percent_Identity=29.4710327455919, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4557231, Length=397, Percent_Identity=29.4710327455919, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI21361497, Length=348, Percent_Identity=31.6091954022989, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=28.5714285714286, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=26.790450928382, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI87081958, Length=334, Percent_Identity=28.4431137724551, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786223, Length=341, Percent_Identity=25.8064516129032, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17534353, Length=391, Percent_Identity=62.9156010230179, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=32.0855614973262, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17508101, Length=380, Percent_Identity=32.1052631578947, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=29.8630136986301, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71985184, Length=370, Percent_Identity=31.6216216216216, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=29.8153034300792, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=272, Percent_Identity=34.1911764705882, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=33.9285714285714, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=29.973474801061, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=28.7598944591029, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=29.4117647058824, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=381, Percent_Identity=25.1968503937008, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17505929, Length=351, Percent_Identity=24.5014245014245, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17551932, Length=350, Percent_Identity=23.4285714285714, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19920834, Length=403, Percent_Identity=61.2903225806452, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=31.6216216216216, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=31.7808219178082, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=31.0160427807487, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=30.7086614173228, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=30.1587301587302, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI281363737, Length=462, Percent_Identity=29.004329004329, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 47933; Mature: 47933

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGKSRNCRRLRYDKPKFRNTVPYYGTTVQRSDPETTAMTARNAFHWADPLLLDAQLTDD
CCCCCCCCHHCCCCCCHHCCCCCCCCCEEECCCCCHHHHHHHCCHHCCCCEEEEEECCCH
ERMVRDAAAAYAQDKLMPRVLESFRHEKTDTAIFREMGALGMLGPTIPEQYGGPGLNYVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHH
YGLIAREVERVDSGYRSMMSVQSSLVMVPIHAFGSEAQKQKYLPRLATGEWIGCFGLTEP
HHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHHHHHCCCCCCCCCEEEEECCCCC
NHGSDPASMVTRAKKVDGGYSLSGAKMWITNSPIADVFVVWAKLPDDNGEDQIRGFILEK
CCCCCHHHHHHHHHHCCCCCEECCCEEEEECCCHHHEEEEEEECCCCCCHHHHHHHHHHC
GWKGLSAPAIHGKVGLRTSITGEIVLDEVFVPEENLMPGVHGLKGPFTCLNSARYGIAWG
CCCCCCCCCCCCCCCCEECCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCEEEC
ALGAAESCWHTARQYVLDRTQFGRPLAANQLIQKKLADMQTEITLGLQGCLRLGRMKDEG
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIH
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCHHEE
ALILGRAQTGIQAFF
HHEECCHHCCHHHCC
>Mature Secondary Structure
MQGKSRNCRRLRYDKPKFRNTVPYYGTTVQRSDPETTAMTARNAFHWADPLLLDAQLTDD
CCCCCCCCHHCCCCCCHHCCCCCCCCCEEECCCCCHHHHHHHCCHHCCCCEEEEEECCCH
ERMVRDAAAAYAQDKLMPRVLESFRHEKTDTAIFREMGALGMLGPTIPEQYGGPGLNYVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHH
YGLIAREVERVDSGYRSMMSVQSSLVMVPIHAFGSEAQKQKYLPRLATGEWIGCFGLTEP
HHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHHHHHCCCCCCCCCEEEEECCCCC
NHGSDPASMVTRAKKVDGGYSLSGAKMWITNSPIADVFVVWAKLPDDNGEDQIRGFILEK
CCCCCHHHHHHHHHHCCCCCEECCCEEEEECCCHHHEEEEEEECCCCCCHHHHHHHHHHC
GWKGLSAPAIHGKVGLRTSITGEIVLDEVFVPEENLMPGVHGLKGPFTCLNSARYGIAWG
CCCCCCCCCCCCCCCCEECCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCEEEC
ALGAAESCWHTARQYVLDRTQFGRPLAANQLIQKKLADMQTEITLGLQGCLRLGRMKDEG
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIH
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCHHEE
ALILGRAQTGIQAFF
HHEECCHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]