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The map label for this gene is pyrR

Identifier: 17545396

GI number: 17545396

Start: 725416

End: 725940

Strand: Direct

Name: pyrR

Synonym: RSc0677

Alternate gene names: 17545396

Gene position: 725416-725940 (Clockwise)

Preceding gene: 17545395

Following gene: 17545397

Centisome position: 19.52

GC content: 69.14

Gene sequence:

>525_bases
ATGACATCGCAACAGATCGATGCCGAGGCGCTCTACCAGAGCCTCGTCGCGCAGCTTCGTACGCGGATGGCCGGCACGCC
CGCCGGCGATTGGTCGGTGGCCGGCATTGTCAGCGGGGGCGCCTGGATCGCGGCGCGCCTGGCGCTCGATCTGGGCCTGC
GGGAGTATGGCATCGTCAATGTCGCCCTGCATCGCGACGACTACGCCAAGAAGGGCCTGCACGCCCAGGCCCAGCCGACC
ACGCTGCCGTTCGAGGTGGAAGAGCGCCGCATTCTGCTGGTGGACGATGTGCTCGCCACCGGCCGCACCATCCGTGCCGC
CATCAACGAATTGTTCGACTATGGCCGTCCGGCCGCGGTGGAGCTGGCCGTGCTGGTCGACCGCGGCGAGCGTCAGCTGC
CCATCGCGCCCGACTATATCGGCGAGCGCATCGCGCTGGCGGCCGACGAGTCGCTGGTGCTGCGCCAGGAGGGCGAGGGC
GCATCAGCACGCTTCACCTTCACGCGCGAGCCCAAGACCGCCTGA

Upstream 100 bases:

>100_bases
ACTCGTCGATTGCCGCACAGGATGCCGGCGCCACCGACGACGTGCTCGATGCCGAGGCCGCGCGCATCATCCTCCAACAA
TTCTTCGACGAATCACACGC

Downstream 100 bases:

>100_bases
TGCCGGGCATCGCGTACCGCTTCTGCTCTGACCGCTTTCGTTTGTCTTCGCCTTCCGTCCGCCTTTGTCCCCTGTCATGA
CCAAGACTTTCGCCAACCCG

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase; UPRTase

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTSQQIDAEALYQSLVAQLRTRMAGTPAGDWSVAGIVSGGAWIAARLALDLGLREYGIVNVALHRDDYAKKGLHAQAQPT
TLPFEVEERRILLVDDVLATGRTIRAAINELFDYGRPAAVELAVLVDRGERQLPIAPDYIGERIALAADESLVLRQEGEG
ASARFTFTREPKTA

Sequences:

>Translated_174_residues
MTSQQIDAEALYQSLVAQLRTRMAGTPAGDWSVAGIVSGGAWIAARLALDLGLREYGIVNVALHRDDYAKKGLHAQAQPT
TLPFEVEERRILLVDDVLATGRTIRAAINELFDYGRPAAVELAVLVDRGERQLPIAPDYIGERIALAADESLVLRQEGEG
ASARFTFTREPKTA
>Mature_173_residues
TSQQIDAEALYQSLVAQLRTRMAGTPAGDWSVAGIVSGGAWIAARLALDLGLREYGIVNVALHRDDYAKKGLHAQAQPTT
LPFEVEERRILLVDDVLATGRTIRAAINELFDYGRPAAVELAVLVDRGERQLPIAPDYIGERIALAADESLVLRQEGEGA
SARFTFTREPKTA

Specific function: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR_RALSO (Q8Y1L3)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518798.1
- ProteinModelPortal:   Q8Y1L3
- SMR:   Q8Y1L3
- GeneID:   1219482
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0677
- NMPDR:   fig|267608.1.peg.677
- HOGENOM:   HBG641958
- OMA:   VAFHRDD
- ProtClustDB:   PRK05205
- BioCyc:   RSOL267608:RSC0677-MONOMER
- BRENDA:   2.4.2.9
- GO:   GO:0006350
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 18929; Mature: 18798

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQQIDAEALYQSLVAQLRTRMAGTPAGDWSVAGIVSGGAWIAARLALDLGLREYGIVN
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHCCHHCCEEE
VALHRDDYAKKGLHAQAQPTTLPFEVEERRILLVDDVLATGRTIRAAINELFDYGRPAAV
EEEECCHHHHCCCCCCCCCCCCCEEECCCEEEEEECHHHCCHHHHHHHHHHHHCCCCCCE
ELAVLVDRGERQLPIAPDYIGERIALAADESLVLRQEGEGASARFTFTREPKTA
EEEEEEECCCCCCCCCHHHHCCEEEEECCCEEEEEECCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
TSQQIDAEALYQSLVAQLRTRMAGTPAGDWSVAGIVSGGAWIAARLALDLGLREYGIVN
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHCCHHCCEEE
VALHRDDYAKKGLHAQAQPTTLPFEVEERRILLVDDVLATGRTIRAAINELFDYGRPAAV
EEEECCHHHHCCCCCCCCCCCCCEEECCCEEEEEECHHHCCHHHHHHHHHHHHCCCCCCE
ELAVLVDRGERQLPIAPDYIGERIALAADESLVLRQEGEGASARFTFTREPKTA
EEEEEEECCCCCCCCCHHHHCCEEEEECCCEEEEEECCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852