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The map label for this gene is pilH [H]

Identifier: 17545388

GI number: 17545388

Start: 713495

End: 713863

Strand: Direct

Name: pilH [H]

Synonym: RSc0669

Alternate gene names: 17545388

Gene position: 713495-713863 (Clockwise)

Preceding gene: 17545387

Following gene: 17545389

Centisome position: 19.2

GC content: 60.16

Gene sequence:

>369_bases
ATGGCAATCAAAAAGATTCTGGTGGTTGATGACTCCCCCACCGAAGCACTGTTCCTGTCGGAAATCCTGAGCAAGAACGG
TTTCAAGGTGTCGGTCGCGGCCGACAGCGACCAGGCCATGGCCAAGCTGGAAGGCGAGCCTTTCGACCTGGTCCTGATGG
ACGTGGTGATGCCCGGCCAGAACGGCTACCAGGCCACCCGCGCGATCAAGAAGGACGATCGCTTCAAGGACATCCCGGTG
ATCATCTGCACCACCAAGGGCCTGGAGACCGACCGCGTGTGGGGCATGCGCCAGGGCGCGTCGGACTACATCGTCAAGCC
GGTCAAGGCAGAAGAGCTGCTCGAAAAGATCGCCAAGCTGCCGCAGTAA

Upstream 100 bases:

>100_bases
TTCTCGCGGGAAGCGCTGCTGGAGGCGGTCCAGGCGCATCTGCCGGCAGCCGCTGGCGCCGCGCAATGACGGCACCTCTT
TAGAAAGAAGGACTGTTTGT

Downstream 100 bases:

>100_bases
CCGCGCGCAGATGTTTAACCCGCGCGACGCCTGACGGCGCGCAACGACCGCATCCGACATGAGCGAGACGCGCACCAACC
TGACTTCCCGCCAGCGGCTG

Product: twitching motility two-component response regulator transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 122; Mature: 121

Protein sequence:

>122_residues
MAIKKILVVDDSPTEALFLSEILSKNGFKVSVAADSDQAMAKLEGEPFDLVLMDVVMPGQNGYQATRAIKKDDRFKDIPV
IICTTKGLETDRVWGMRQGASDYIVKPVKAEELLEKIAKLPQ

Sequences:

>Translated_122_residues
MAIKKILVVDDSPTEALFLSEILSKNGFKVSVAADSDQAMAKLEGEPFDLVLMDVVMPGQNGYQATRAIKKDDRFKDIPV
IICTTKGLETDRVWGMRQGASDYIVKPVKAEELLEKIAKLPQ
>Mature_121_residues
AIKKILVVDDSPTEALFLSEILSKNGFKVSVAADSDQAMAKLEGEPFDLVLMDVVMPGQNGYQATRAIKKDDRFKDIPVI
ICTTKGLETDRVWGMRQGASDYIVKPVKAEELLEKIAKLPQ

Specific function: May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction) [H]

COG id: COG0784

COG function: function code T; FOG: CheY-like receiver

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=115, Percent_Identity=40, Blast_Score=87, Evalue=2e-19,
Organism=Escherichia coli, GI1789809, Length=113, Percent_Identity=38.0530973451327, Blast_Score=81, Evalue=2e-17,
Organism=Escherichia coli, GI1788394, Length=113, Percent_Identity=33.6283185840708, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1787229, Length=117, Percent_Identity=29.0598290598291, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI2367329, Length=115, Percent_Identity=40.8695652173913, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI87082012, Length=119, Percent_Identity=30.2521008403361, Blast_Score=67, Evalue=3e-13,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=30.1724137931034, Blast_Score=67, Evalue=4e-13,
Organism=Escherichia coli, GI1788191, Length=117, Percent_Identity=32.4786324786325, Blast_Score=62, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=108, Percent_Identity=29.6296296296296, Blast_Score=60, Evalue=4e-11,
Organism=Escherichia coli, GI1790863, Length=113, Percent_Identity=30.0884955752212, Blast_Score=60, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=108, Percent_Identity=32.4074074074074, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 13483; Mature: 13352

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKKILVVDDSPTEALFLSEILSKNGFKVSVAADSDQAMAKLEGEPFDLVLMDVVMPGQ
CCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCCCCEEEEEEEEECCC
NGYQATRAIKKDDRFKDIPVIICTTKGLETDRVWGMRQGASDYIVKPVKAEELLEKIAKL
CCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHCC
PQ
CC
>Mature Secondary Structure 
AIKKILVVDDSPTEALFLSEILSKNGFKVSVAADSDQAMAKLEGEPFDLVLMDVVMPGQ
CCEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCCCCEEEEEEEEECCC
NGYQATRAIKKDDRFKDIPVIICTTKGLETDRVWGMRQGASDYIVKPVKAEELLEKIAKL
CCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHCC
PQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7908398; 10984043 [H]