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The map label for this gene is sucD [H]

Identifier: 17545274

GI number: 17545274

Start: 600028

End: 600909

Strand: Direct

Name: sucD [H]

Synonym: RSc0555

Alternate gene names: 17545274

Gene position: 600028-600909 (Clockwise)

Preceding gene: 17545273

Following gene: 17545275

Centisome position: 16.15

GC content: 64.51

Gene sequence:

>882_bases
ATGTCGATTCTGATCAACAAAGACACCAAGGTCATCACCCAGGGGATCACCGGCAAGACCGGGCAATTCCACACCCGCGG
CTGCCGCGACTACGCCAACGGCAAGAACGCTTTCGTGGCGGGCGTGAACCCGAAGAAGGCCGGCGAAGATTTCGAAGGCA
TTCCCATCTACGCCAGCGTCAAGGAAGCCAAGGACCAGACCGGCGCGACCGTCTCGGTCATCTACGTGCCGCCCGCCGGC
GCCGCTGCCGCCATCTGGGAAGCCGTCGACGCCGACCTGGACCTGGTGGTCTGCATCACCGAAGGCATCCCCGTCCGCGA
CATGATGGAAGTCAAGGACAAGATGCGTAAGCAGAACAAGACGACCCTGCTGCTGGGTCCGAACTGCCCGGGCCTGATCA
CGCCGGACGAAATCAAGATCGGCATCATGCCGGGCCACATTCACCGCAAGGGCCGCATCGGCGTGGTGTCGCGCTCGGGC
ACGCTGACGTACGAAGCCGTGGGCCAGCTGACCGCGCTGGGCCTGGGCCAGTCGTCGGCTGTCGGCATCGGCGGCGACCC
GATCAACGGCCTGAAGCACATCGACGTCATGAAGATGTTCAACGACGATCCGGACACGGACGCCGTGGTCATGATCGGTG
AGATCGGCGGTCCGGACGAAGCCAACGCCGCGCGCTGGATCAAGGACAACATGAAGAAGCCGGTGGTCGGCTTCATCGCG
GGCGTGACCGCGCCTCCGGGCAAGCGCATGGGCCACGCCGGCGCGCTGATCTCGGGCGGCGCCGACACCGCGCAGGCCAA
GCTCGACATTATGGAAGAGTGCGGCATCAAGGCCACCAAGAACCCGTCCGAAATGGGCCGGCTGCTGAAGGCACTGCTGT
AA

Upstream 100 bases:

>100_bases
AGCCGCCGGCAAGTAAGCCGCCCGCTGAACGAACCATACGCGAACGCGAGCGGCACCCGGCCACCGGGAGGCGGCTCGCA
GCCAAGCAAAGGATTACAGC

Downstream 100 bases:

>100_bases
TCGGCAGGGTTTGAGGTTGTGCGAGAACGGGAGGCCTGGCCTCCCGTTTTTGTTTGGGCGGCCGCGCCGCCGCGTGCACA
CTCGGTGTGAGGCGTGTATA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSILINKDTKVITQGITGKTGQFHTRGCRDYANGKNAFVAGVNPKKAGEDFEGIPIYASVKEAKDQTGATVSVIYVPPAG
AAAAIWEAVDADLDLVVCITEGIPVRDMMEVKDKMRKQNKTTLLLGPNCPGLITPDEIKIGIMPGHIHRKGRIGVVSRSG
TLTYEAVGQLTALGLGQSSAVGIGGDPINGLKHIDVMKMFNDDPDTDAVVMIGEIGGPDEANAARWIKDNMKKPVVGFIA
GVTAPPGKRMGHAGALISGGADTAQAKLDIMEECGIKATKNPSEMGRLLKALL

Sequences:

>Translated_293_residues
MSILINKDTKVITQGITGKTGQFHTRGCRDYANGKNAFVAGVNPKKAGEDFEGIPIYASVKEAKDQTGATVSVIYVPPAG
AAAAIWEAVDADLDLVVCITEGIPVRDMMEVKDKMRKQNKTTLLLGPNCPGLITPDEIKIGIMPGHIHRKGRIGVVSRSG
TLTYEAVGQLTALGLGQSSAVGIGGDPINGLKHIDVMKMFNDDPDTDAVVMIGEIGGPDEANAARWIKDNMKKPVVGFIA
GVTAPPGKRMGHAGALISGGADTAQAKLDIMEECGIKATKNPSEMGRLLKALL
>Mature_292_residues
SILINKDTKVITQGITGKTGQFHTRGCRDYANGKNAFVAGVNPKKAGEDFEGIPIYASVKEAKDQTGATVSVIYVPPAGA
AAAIWEAVDADLDLVVCITEGIPVRDMMEVKDKMRKQNKTTLLLGPNCPGLITPDEIKIGIMPGHIHRKGRIGVVSRSGT
LTYEAVGQLTALGLGQSSAVGIGGDPINGLKHIDVMKMFNDDPDTDAVVMIGEIGGPDEANAARWIKDNMKKPVVGFIAG
VTAPPGKRMGHAGALISGGADTAQAKLDIMEECGIKATKNPSEMGRLLKALL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=288, Percent_Identity=55.5555555555556, Blast_Score=271, Evalue=4e-73,
Organism=Homo sapiens, GI38569421, Length=248, Percent_Identity=27.8225806451613, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38569423, Length=248, Percent_Identity=27.8225806451613, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1786949, Length=293, Percent_Identity=54.2662116040956, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI1786513, Length=185, Percent_Identity=29.1891891891892, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17550194, Length=289, Percent_Identity=55.7093425605536, Blast_Score=308, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17553126, Length=297, Percent_Identity=54.5454545454545, Blast_Score=301, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17557344, Length=239, Percent_Identity=26.7782426778243, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17551266, Length=254, Percent_Identity=24.4094488188976, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324716, Length=296, Percent_Identity=47.2972972972973, Blast_Score=261, Evalue=8e-71,
Organism=Drosophila melanogaster, GI21356559, Length=292, Percent_Identity=50.6849315068493, Blast_Score=287, Evalue=6e-78,
Organism=Drosophila melanogaster, GI28574296, Length=292, Percent_Identity=53.0821917808219, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI281363477, Length=250, Percent_Identity=26.8, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281363475, Length=250, Percent_Identity=26.8, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281363473, Length=250, Percent_Identity=26.8, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30783; Mature: 30652

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILINKDTKVITQGITGKTGQFHTRGCRDYANGKNAFVAGVNPKKAGEDFEGIPIYASV
CEEEEECCCEEEEECCCCCCCCCCCCCCHHHCCCCCEEEECCCCHHCCCCCCCCEEEEEH
KEAKDQTGATVSVIYVPPAGAAAAIWEAVDADLDLVVCITEGIPVRDMMEVKDKMRKQNK
HHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCC
TTLLLGPNCPGLITPDEIKIGIMPGHIHRKGRIGVVSRSGTLTYEAVGQLTALGLGQSSA
CEEEECCCCCCCCCCCCEEEEEECCCEECCCCEEEEECCCCEEHHHHHCCCEECCCCCCE
VGIGGDPINGLKHIDVMKMFNDDPDTDAVVMIGEIGGPDEANAARWIKDNMKKPVVGFIA
EECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCEEHEE
GVTAPPGKRMGHAGALISGGADTAQAKLDIMEECGIKATKNPSEMGRLLKALL
CCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SILINKDTKVITQGITGKTGQFHTRGCRDYANGKNAFVAGVNPKKAGEDFEGIPIYASV
EEEEECCCEEEEECCCCCCCCCCCCCCHHHCCCCCEEEECCCCHHCCCCCCCCEEEEEH
KEAKDQTGATVSVIYVPPAGAAAAIWEAVDADLDLVVCITEGIPVRDMMEVKDKMRKQNK
HHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCC
TTLLLGPNCPGLITPDEIKIGIMPGHIHRKGRIGVVSRSGTLTYEAVGQLTALGLGQSSA
CEEEECCCCCCCCCCCCEEEEEECCCEECCCCEEEEECCCCEEHHHHHCCCEECCCCCCE
VGIGGDPINGLKHIDVMKMFNDDPDTDAVVMIGEIGGPDEANAARWIKDNMKKPVVGFIA
EECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCEEHEE
GVTAPPGKRMGHAGALISGGADTAQAKLDIMEECGIKATKNPSEMGRLLKALL
CCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA