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The map label for this gene is ubiE [H]

Identifier: 17545177

GI number: 17545177

Start: 489163

End: 489894

Strand: Direct

Name: ubiE [H]

Synonym: RSc0458

Alternate gene names: 17545177

Gene position: 489163-489894 (Clockwise)

Preceding gene: 17545176

Following gene: 17545178

Centisome position: 13.16

GC content: 64.21

Gene sequence:

>732_bases
ATGAGCCAAACCCACTTCGGATTCCAGCAGGTCGACGAGCGCGAGAAGGCAGGTAAGGTCGCCGGCGTGTTCCATTCCGT
CGCCAGCAAGTACGACGTGATGAACGACCTGATGTCCGGCGGCATGCACCGGCTGTGGAAGATGTTCACCATCGCCCAGG
CCGCCGTGCGCCCGGGCTACAAGGTGCTCGACATCGCCGGCGGCACCGGTGACCTGGCCAAGGCCTTCGCGCGCCAGGCC
GGCCCCACCGGCGAGGTGTGGCTGACCGACATCAACGAATCGATGCTGCGCGTGGGCCGTGACCGCCTGCTCGATGCCGG
CGTGCTCACGCCCACCTGCCTGTGCGATGCCGAGCACATTCCCTTTCCGAACGCTTACTTCGATGTCGTGACAGTTGCGT
TCGGCTTGCGCAACATGACGCACAAGGATCGTGCGCTGGCCGAGATGCGTCGCGTGGTCAAGCCAGGCGGCAAGGTGATG
GTGCTGGAGTTCTCCAAGGTGTGGCAGCCGCTGGAGAAGGCCTACGACGTGTACTCGTTCAAGGTGCTGCCGTGGCTGGG
CAGCAAGGTCGCCGGCGATGCCGAGAGCTACCGCTATCTGGCCGAGTCCATCCGCATGCACCCGGATCAGGAAACGCTCA
AGCAGATGATGGAACAGGCCGGGTTGGACTCGGTCGAATACTTCAATCTGACGGCGGGTGTCGTCGCGCTGCACGTCGGC
CGGCGTCTCTGA

Upstream 100 bases:

>100_bases
CGCACCGATGGCGCCCGGCGCCGGCCATGCCTGCGGCCACGGCCACTGATTCCGATTCACTCCGCGGCGCAGGCGCGCCG
CATCGCAACCCCATTCCGTC

Downstream 100 bases:

>100_bases
TCCGTTGGATGGGCGATGTGGCGCGCTGCGGCGTCATGCCACGATCCGTCACATTGAATTCCGGCGGGGGCGTCATCATC
TGATGGGGCGTCACTGCCAC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSQTHFGFQQVDEREKAGKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQAAVRPGYKVLDIAGGTGDLAKAFARQA
GPTGEVWLTDINESMLRVGRDRLLDAGVLTPTCLCDAEHIPFPNAYFDVVTVAFGLRNMTHKDRALAEMRRVVKPGGKVM
VLEFSKVWQPLEKAYDVYSFKVLPWLGSKVAGDAESYRYLAESIRMHPDQETLKQMMEQAGLDSVEYFNLTAGVVALHVG
RRL

Sequences:

>Translated_243_residues
MSQTHFGFQQVDEREKAGKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQAAVRPGYKVLDIAGGTGDLAKAFARQA
GPTGEVWLTDINESMLRVGRDRLLDAGVLTPTCLCDAEHIPFPNAYFDVVTVAFGLRNMTHKDRALAEMRRVVKPGGKVM
VLEFSKVWQPLEKAYDVYSFKVLPWLGSKVAGDAESYRYLAESIRMHPDQETLKQMMEQAGLDSVEYFNLTAGVVALHVG
RRL
>Mature_242_residues
SQTHFGFQQVDEREKAGKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQAAVRPGYKVLDIAGGTGDLAKAFARQAG
PTGEVWLTDINESMLRVGRDRLLDAGVLTPTCLCDAEHIPFPNAYFDVVTVAFGLRNMTHKDRALAEMRRVVKPGGKVMV
LEFSKVWQPLEKAYDVYSFKVLPWLGSKVAGDAESYRYLAESIRMHPDQETLKQMMEQAGLDSVEYFNLTAGVVALHVGR
RL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=278, Percent_Identity=44.9640287769784, Blast_Score=229, Evalue=2e-60,
Organism=Escherichia coli, GI48994983, Length=243, Percent_Identity=63.3744855967078, Blast_Score=313, Evalue=7e-87,
Organism=Caenorhabditis elegans, GI17557039, Length=242, Percent_Identity=45.4545454545455, Blast_Score=218, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6323526, Length=258, Percent_Identity=40.6976744186046, Blast_Score=165, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24641702, Length=256, Percent_Identity=47.265625, Blast_Score=226, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27076; Mature: 26944

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure 
SQTHFGFQQVDEREKAGKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQAAVRPGY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KVLDIAGGTGDLAKAFARQAGPTGEVWLTDINESMLRVGRDRLLDAGVLTPTCLCDAEHI
EEEEECCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
PFPNAYFDVVTVAFGLRNMTHKDRALAEMRRVVKPGGKVMVLEFSKVWQPLEKAYDVYSF
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHE
KVLPWLGSKVAGDAESYRYLAESIRMHPDQETLKQMMEQAGLDSVEYFNLTAGVVALHVG
EEHHHHCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RRL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA