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The map label for this gene is ilvA [H]

Identifier: 17545168

GI number: 17545168

Start: 476953

End: 478476

Strand: Reverse

Name: ilvA [H]

Synonym: RSc0449

Alternate gene names: 17545168

Gene position: 478476-476953 (Counterclockwise)

Preceding gene: 17545170

Following gene: 17545167

Centisome position: 12.87

GC content: 66.93

Gene sequence:

>1524_bases
ATGGCCATCGACTATCTCAAGAAGATCCTGACCGCCAAGGTCTACGACGTCGCGCAGGAAACCGACCTGCAGCCCGCGCC
CAGCCTGTCGGCACGCATCGGCAACCGCGTGTACCTCAAGCGCGAAGACAACCAGCCGGTGTTCTCGTTCAAGCTGCGCG
GCGCCTACAACAAGATGGCGTCGCTGACGCCGGCCGAGCGCAAGCGGGGCGTGATTACGGCATCGGCGGGCAACCATGCG
CAGGGCGTGGCGTTCAGCGCCGCCCGGCTCGGCTGCAAGGCGGTCATCACCATGCCGGTGACGACGCCGCAGCTGAAGAT
CGACGGCGTGCGCTCGCGCGGCGGCGAGTGGGTCGAGATCGTGCTGCACGGCGAAAGCTATACGGATGCGTACGACCACG
CCGTCAAGCTGCAGGAGAAGCACGGCTACACCTTCGTCCACCCGTTCGACGATCCGGAGGTGATCGCGGGCCAGGGCACC
ATTGCCGTGGAGATCCTGCGCCAGCATCCGGAGCCGATCCACGCCATCTTCGCGGCGATCGGCGGCGGCGGGCTGGTGTC
GGGCATCGCGGCCTACGTGAAGGCGGTGCGCCCGGACATCAAGGTGATCGGCGTGCAGACGGCGGATTCCGATGCGATGG
CCTGCTCGGTGGCGGCCGGCAAGCGGGTGACGCTGCGGGACGTGGGCCTGTTCTCGGACGGCACGGCGGTCAAGCTGGTC
GGCAAGGAAACCTTCCGCCTGACCCGCGAACTGGTCGACGAGATCATCACCGTGGACACCGACGCCATCTGCGCGGCGCT
CAAGGACGTGTTCCAGGACACCCGCAGCGTGCTGGAGCCGGCGGGCGCGCTGGCGCTGGCCGGGCTCAAGCAGTACGCGG
CGGACCGCAAGCTCAAGAGCCAGTCGCTGGTGGCGATCGCGTCCGGCGCCAACATGAACTTCGACCGCCTGCGCTTCGTG
GCCGAGCGCGCCGAGGTGGGCGAGGCGCGCGAAGCCGTGTTCGCGGTGACGATTCCGGAGGAGCGCGGCAGCTTCAGGCG
CTTCTGCGAGGTGGTCGGCTGGTCGCGCAGCGTGACCGAGTTCAACTACCGCATCGCCGACAAGAACGAGGCGCACATCT
TCGTGGGCGTGCAGATCGCCTCGCGCGCCGAGGGCGACAAGATCGCCGACGGCTTCCGCAAGCACGGCTTCCCGACGCTG
GACCTGTCCAACGACGAACTGGCCAAGCAGCACATCCGCTACATGGTGGGCGGGCATTCGCCGCTGGCCGAGAACGAGCT
GCTGTACCGCTTCGAGTTTCCCGAGCGGCCCGGCGCGCTGATAAAGTTCCTCTCGAGCATGAGCCCGAACTGGAACATCA
GCCTGTTCCACTACCGCAACCAGGGCGCGGATTCGAGCAACATCCTGGTCGGCATCCAGGTGCCGAAGAACGAGAAGCGC
GCGTTCAAGGCCTTCCTCGCCACGCTCGGCTACACGTTCTGGGACGAAAGCGAGAACCCGGTCTACGGACTGTTCCTGCG
CTGA

Upstream 100 bases:

>100_bases
CCCGGGCGGCCGGGGCAGTGTACCGACCGGTCCGGCCCTGGCACAAGACGCCGCGTGATAGGCTTATGGGCTGTCCTCCG
TCCAACCCGGTCCCCGCATC

Downstream 100 bases:

>100_bases
TCCCATCCGTTGCCGTGGAGTCTTCCGCATGAGCCATCCCGAACACTCACCGCTGGGCAAGGCCTCGGCCTACAAGACGC
AGTACGACCCGAGCCTGCTG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MAIDYLKKILTAKVYDVAQETDLQPAPSLSARIGNRVYLKREDNQPVFSFKLRGAYNKMASLTPAERKRGVITASAGNHA
QGVAFSAARLGCKAVITMPVTTPQLKIDGVRSRGGEWVEIVLHGESYTDAYDHAVKLQEKHGYTFVHPFDDPEVIAGQGT
IAVEILRQHPEPIHAIFAAIGGGGLVSGIAAYVKAVRPDIKVIGVQTADSDAMACSVAAGKRVTLRDVGLFSDGTAVKLV
GKETFRLTRELVDEIITVDTDAICAALKDVFQDTRSVLEPAGALALAGLKQYAADRKLKSQSLVAIASGANMNFDRLRFV
AERAEVGEAREAVFAVTIPEERGSFRRFCEVVGWSRSVTEFNYRIADKNEAHIFVGVQIASRAEGDKIADGFRKHGFPTL
DLSNDELAKQHIRYMVGGHSPLAENELLYRFEFPERPGALIKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKR
AFKAFLATLGYTFWDESENPVYGLFLR

Sequences:

>Translated_507_residues
MAIDYLKKILTAKVYDVAQETDLQPAPSLSARIGNRVYLKREDNQPVFSFKLRGAYNKMASLTPAERKRGVITASAGNHA
QGVAFSAARLGCKAVITMPVTTPQLKIDGVRSRGGEWVEIVLHGESYTDAYDHAVKLQEKHGYTFVHPFDDPEVIAGQGT
IAVEILRQHPEPIHAIFAAIGGGGLVSGIAAYVKAVRPDIKVIGVQTADSDAMACSVAAGKRVTLRDVGLFSDGTAVKLV
GKETFRLTRELVDEIITVDTDAICAALKDVFQDTRSVLEPAGALALAGLKQYAADRKLKSQSLVAIASGANMNFDRLRFV
AERAEVGEAREAVFAVTIPEERGSFRRFCEVVGWSRSVTEFNYRIADKNEAHIFVGVQIASRAEGDKIADGFRKHGFPTL
DLSNDELAKQHIRYMVGGHSPLAENELLYRFEFPERPGALIKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKR
AFKAFLATLGYTFWDESENPVYGLFLR
>Mature_506_residues
AIDYLKKILTAKVYDVAQETDLQPAPSLSARIGNRVYLKREDNQPVFSFKLRGAYNKMASLTPAERKRGVITASAGNHAQ
GVAFSAARLGCKAVITMPVTTPQLKIDGVRSRGGEWVEIVLHGESYTDAYDHAVKLQEKHGYTFVHPFDDPEVIAGQGTI
AVEILRQHPEPIHAIFAAIGGGGLVSGIAAYVKAVRPDIKVIGVQTADSDAMACSVAAGKRVTLRDVGLFSDGTAVKLVG
KETFRLTRELVDEIITVDTDAICAALKDVFQDTRSVLEPAGALALAGLKQYAADRKLKSQSLVAIASGANMNFDRLRFVA
ERAEVGEAREAVFAVTIPEERGSFRRFCEVVGWSRSVTEFNYRIADKNEAHIFVGVQIASRAEGDKIADGFRKHGFPTLD
LSNDELAKQHIRYMVGGHSPLAENELLYRFEFPERPGALIKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKRA
FKAFLATLGYTFWDESENPVYGLFLR

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=291, Percent_Identity=33.6769759450172, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI33469958, Length=319, Percent_Identity=30.7210031347962, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI19923959, Length=320, Percent_Identity=26.875, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790207, Length=504, Percent_Identity=52.1825396825397, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1789505, Length=320, Percent_Identity=37.5, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71991565, Length=334, Percent_Identity=30.8383233532934, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17537387, Length=337, Percent_Identity=31.4540059347181, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17508781, Length=257, Percent_Identity=32.6848249027237, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320930, Length=519, Percent_Identity=47.3988439306358, Blast_Score=458, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322631, Length=306, Percent_Identity=32.6797385620915, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319788, Length=302, Percent_Identity=25.8278145695364, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21355833, Length=328, Percent_Identity=30.4878048780488, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=28.968253968254, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55667; Mature: 55536

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDYLKKILTAKVYDVAQETDLQPAPSLSARIGNRVYLKREDNQPVFSFKLRGAYNKMA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEECCCCCEEEEEECCHHHHHH
SLTPAERKRGVITASAGNHAQGVAFSAARLGCKAVITMPVTTPQLKIDGVRSRGGEWVEI
CCCHHHHHCCEEEECCCCCCCCEEEHHHHCCCEEEEEECCCCCCEEECCHHCCCCCEEEE
VLHGESYTDAYDHAVKLQEKHGYTFVHPFDDPEVIAGQGTIAVEILRQHPEPIHAIFAAI
EEECCCCCCHHHHHEEEECCCCEEEEECCCCCCEEECCCCEEEHHHHHCCCHHHHHHHHH
GGGGLVSGIAAYVKAVRPDIKVIGVQTADSDAMACSVAAGKRVTLRDVGLFSDGTAVKLV
CCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCEEEEEECCEECCCCEEEEE
GKETFRLTRELVDEIITVDTDAICAALKDVFQDTRSVLEPAGALALAGLKQYAADRKLKS
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
QSLVAIASGANMNFDRLRFVAERAEVGEAREAVFAVTIPEERGSFRRFCEVVGWSRSVTE
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCHHHHHHHHHCCCCCEEE
FNYRIADKNEAHIFVGVQIASRAEGDKIADGFRKHGFPTLDLSNDELAKQHIRYMVGGHS
EEEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCC
PLAENELLYRFEFPERPGALIKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKR
CCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHH
AFKAFLATLGYTFWDESENPVYGLFLR
HHHHHHHHHCCCEECCCCCCEEEEEEC
>Mature Secondary Structure 
AIDYLKKILTAKVYDVAQETDLQPAPSLSARIGNRVYLKREDNQPVFSFKLRGAYNKMA
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEECCCCCEEEEEECCHHHHHH
SLTPAERKRGVITASAGNHAQGVAFSAARLGCKAVITMPVTTPQLKIDGVRSRGGEWVEI
CCCHHHHHCCEEEECCCCCCCCEEEHHHHCCCEEEEEECCCCCCEEECCHHCCCCCEEEE
VLHGESYTDAYDHAVKLQEKHGYTFVHPFDDPEVIAGQGTIAVEILRQHPEPIHAIFAAI
EEECCCCCCHHHHHEEEECCCCEEEEECCCCCCEEECCCCEEEHHHHHCCCHHHHHHHHH
GGGGLVSGIAAYVKAVRPDIKVIGVQTADSDAMACSVAAGKRVTLRDVGLFSDGTAVKLV
CCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCEEEEEECCEECCCCEEEEE
GKETFRLTRELVDEIITVDTDAICAALKDVFQDTRSVLEPAGALALAGLKQYAADRKLKS
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
QSLVAIASGANMNFDRLRFVAERAEVGEAREAVFAVTIPEERGSFRRFCEVVGWSRSVTE
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCHHHHHHHHHCCCCCEEE
FNYRIADKNEAHIFVGVQIASRAEGDKIADGFRKHGFPTLDLSNDELAKQHIRYMVGGHS
EEEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCC
PLAENELLYRFEFPERPGALIKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKR
CCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHH
AFKAFLATLGYTFWDESENPVYGLFLR
HHHHHHHHHCCCEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA