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The map label for this gene is apt [H]

Identifier: 17545136

GI number: 17545136

Start: 444221

End: 444916

Strand: Direct

Name: apt [H]

Synonym: RSc0417

Alternate gene names: 17545136

Gene position: 444221-444916 (Clockwise)

Preceding gene: 17545133

Following gene: 17545137

Centisome position: 11.95

GC content: 67.82

Gene sequence:

>696_bases
ATGGCGGCTGCCGTGCACCGTGCCTGCCGCATTGTGGTGCGGCGCCATCCGGGCCGGGTGGTAGCCGGCTACCGCATCGC
CTTTTCTCTTTCTGTTTCAGCAATGACCGACGCCAGCATCTCTCCGTCCTCGCCCGTTCCTGCCTCGACCGAACTGGGCG
ATGTGACGCGCTACCTGCGCGAGCGCATCCGCACCGTGCCCGACTGGCCGCAGCTGGGGGTGATGTTCCGCGACATCACG
CCGCTGCTGCAGGACCCGAAGAGCCTGCGCGTGCTGGTGGACGTGTTCGTCCATCGCTATATGGGACAGGGGCTGAACCT
GGTGGCGGGCATCGATGCGCGCGGCTTCATCCTCGGCTCCATCGTCGCGTACGAGCTGAACCTGGGCTTCGTGCCGATCC
GCAAGAAGGGCAAGCTGCCGTTCACCACCGTGGCCGAGGAGTACATGCTGGAGTACGGCAGCGCCACGGTGGAGATCCAC
GCCGACGCCTGCAAGCCCGGCGACCGCGTGCTGCTGATCGACGACCTGATCGCCACCGGCGGCACCATGATGGCCGGCAA
GCGCCTGCTGGAGCGGCTGGGCGCGACGGTGGTGGAGGGCGCGGCCATCGTCGACCTGCCCGAACTGGGTGGCTCGCGCC
TGCTGATGGACGGCGGCCTGCCGCTCTTTACCGTGTGCCGCTTCGACGGGCATTGA

Upstream 100 bases:

>100_bases
CCTGGAAGGGCACCATGACTTCGTAGTCTTCGACATAGTCGCCCACCAGCATCAGAATCTTCTTCGCCATCGTCGTCTCC
TGTATGGTTGCAGTTTGTGC

Downstream 100 bases:

>100_bases
TGGCCGCCGGCGATGCCCTGGCCGCATCCCTTGGTGTCACCGCAACAAGACGCCGCCGCGCGCCGCGCGGTGGTGTGGCC
TTTTGATGAGAGGACAACGA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MAAAVHRACRIVVRRHPGRVVAGYRIAFSLSVSAMTDASISPSSPVPASTELGDVTRYLRERIRTVPDWPQLGVMFRDIT
PLLQDPKSLRVLVDVFVHRYMGQGLNLVAGIDARGFILGSIVAYELNLGFVPIRKKGKLPFTTVAEEYMLEYGSATVEIH
ADACKPGDRVLLIDDLIATGGTMMAGKRLLERLGATVVEGAAIVDLPELGGSRLLMDGGLPLFTVCRFDGH

Sequences:

>Translated_231_residues
MAAAVHRACRIVVRRHPGRVVAGYRIAFSLSVSAMTDASISPSSPVPASTELGDVTRYLRERIRTVPDWPQLGVMFRDIT
PLLQDPKSLRVLVDVFVHRYMGQGLNLVAGIDARGFILGSIVAYELNLGFVPIRKKGKLPFTTVAEEYMLEYGSATVEIH
ADACKPGDRVLLIDDLIATGGTMMAGKRLLERLGATVVEGAAIVDLPELGGSRLLMDGGLPLFTVCRFDGH
>Mature_230_residues
AAAVHRACRIVVRRHPGRVVAGYRIAFSLSVSAMTDASISPSSPVPASTELGDVTRYLRERIRTVPDWPQLGVMFRDITP
LLQDPKSLRVLVDVFVHRYMGQGLNLVAGIDARGFILGSIVAYELNLGFVPIRKKGKLPFTTVAEEYMLEYGSATVEIHA
DACKPGDRVLLIDDLIATGGTMMAGKRLLERLGATVVEGAAIVDLPELGGSRLLMDGGLPLFTVCRFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=176, Percent_Identity=44.3181818181818, Blast_Score=147, Evalue=7e-36,
Organism=Homo sapiens, GI71773201, Length=127, Percent_Identity=47.244094488189, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1786675, Length=175, Percent_Identity=47.4285714285714, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=174, Percent_Identity=43.1034482758621, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=180, Percent_Identity=32.7777777777778, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320649, Length=175, Percent_Identity=29.1428571428571, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136334, Length=164, Percent_Identity=40.8536585365854, Blast_Score=127, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 25045; Mature: 24913

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAVHRACRIVVRRHPGRVVAGYRIAFSLSVSAMTDASISPSSPVPASTELGDVTRYLR
CCHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEHEECCCCCCCCCCCCCCHHHHHHHHHH
ERIRTVPDWPQLGVMFRDITPLLQDPKSLRVLVDVFVHRYMGQGLNLVAGIDARGFILGS
HHHHCCCCCHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHH
IVAYELNLGFVPIRKKGKLPFTTVAEEYMLEYGSATVEIHADACKPGDRVLLIDDLIATG
EEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEHHHHCC
GTMMAGKRLLERLGATVVEGAAIVDLPELGGSRLLMDGGLPLFTVCRFDGH
CHHHHHHHHHHHHCHHHHCCEEEEECCCCCCCEEEEECCCCEEEEEEECCC
>Mature Secondary Structure 
AAAVHRACRIVVRRHPGRVVAGYRIAFSLSVSAMTDASISPSSPVPASTELGDVTRYLR
CHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEHEECCCCCCCCCCCCCCHHHHHHHHHH
ERIRTVPDWPQLGVMFRDITPLLQDPKSLRVLVDVFVHRYMGQGLNLVAGIDARGFILGS
HHHHCCCCCHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHH
IVAYELNLGFVPIRKKGKLPFTTVAEEYMLEYGSATVEIHADACKPGDRVLLIDDLIATG
EEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEHHHHCC
GTMMAGKRLLERLGATVVEGAAIVDLPELGGSRLLMDGGLPLFTVCRFDGH
CHHHHHHHHHHHHCHHHHCCEEEEECCCCCCCEEEEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]