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The map label for this gene is kefBC [H]

Identifier: 17545133

GI number: 17545133

Start: 441171

End: 443150

Strand: Direct

Name: kefBC [H]

Synonym: RSc0414

Alternate gene names: 17545133

Gene position: 441171-443150 (Clockwise)

Preceding gene: 17545120

Following gene: 17545136

Centisome position: 11.87

GC content: 69.7

Gene sequence:

>1980_bases
ATGCATTCGCCGCTGGAACTCACCCTCGTATTGTTGGCCGCCGCCGTGATCGGCGTGGTGCTGTTCCGCATGCTGCAACT
GCCGCCGATGCTGGCCTACCTGGTGGTCGGCGTGGTGATCGGCCCGAATGCGACCGGGCTGGAGTCCGATTCGGCGCAGA
CGCGCTATCTGGCCGAGTTCGGCGTGGTGTTCCTGATGTTCTCGATCGGGCTGGAGTTCAGCCTGGCCAAGCTGCGCTCG
ATGCGCCGGCTGGTGCTGGGGCTGGGCGCCTCGCAGGTGGTGCTGACCATGCTGCTGACGGTGCCGGCCTCGTTGCTGCT
CTCGCGCTGGTACCCGCTGTCGTGGCAGGCGAGCCTGGCGCTGGGCGGCGCGCTGGCGATGTCGTCCACCGCCATCGTCT
CCAAGATGCTGGCCGAGCGGCTGCAGCTGGAGACGGAGCACGGCCGCAACATCATCAGCGTGCTGCTGTTCCAGGATCTG
GCCGTGGTGCTGCTGCTGATCGTGGTGCCGTCGCTCGGCAAGAACCCGACCGACCTGGTGCTGACGCTGTCCATCGCGGC
GGTGAAGATCATCGTCGCGCTGGTGCTGATCCTGTTCCTGGGGCAGAAGCTGCTGTCGCGCTGGTTCCACCTGGTGGCCG
CGCGCCGCTCGCAGGAGCTGTTCATGCTGAACCTGCTGCTGGTGACGCTGGGCATGGCGGCGCTGACCGAGCGGCTGGGC
CTGTCGATGGCGCTGGGCGCCTTCCTGGCCGGCATGCTGGTGTCGGAAACGCCGTACCGGCTGCAGGTGGAGGAGGACAT
CAAGCCCTTCCGCGACGTGCTGCTGGGGCTGTTCTTCGTCACCGTGGGCATGCTGCTCGACCCGCGCGTGGTGATCGGGC
ACTGGGGGCTGGTGATCGGGCTGGTGATCGGGCCGGTGCTGTTCAAGTTCGCGCTGATCGCCTTGCTGGCGCGCGCCTTC
GGCTCGGGCGGCGGCACGGCGATCCGCACGGCGCTGGGCCTGGCGCAGGCCGGCGAGTTCGGCTTCGTGCTGCTCAACCA
GATCGACGGGATGCGGCTGATCGATCCGCTGCTCAGCCAGGCGATCCTGGCGGCGATGCTGCTGTCGATGCTGCTGGCGC
CATTCCTGATCCAGTACAGCGATGCGATCGCCATGCGGCTGTCGCGCACGGACTGGCTGATGCAGTCGCTGGCGATGACC
AAGATCGCCGCGCAGAGCCTGCAGACCGAGCGCCACGTCATCATCTGCGGCTACGGGCGCAGCGGCCAGAACCTGGCGCA
CATGCTGGAGCAGGAGGACATCAGCTATGTCGCCCTCGACCTGGACCCCGACCGCGTGCGCGATGCGGCGGCGGCCGGCG
AGCGCGTGGTCTACGGCGATGCGGCGCGGCGCGAGTCGCTGGTGGCGGCCGGGGTCCACCGCGCGGCGGCGGTTGCCGTC
ACCTATGCCGACACGGCCTCGGCGCTGAAGGTGCTGCACCACGTGCAGGCGCTGGCGCCGACCTTGCCCGTCATCGTGCG
CACCATCGACGATGCCGATCTCGACCGGCTGCAGCAGGCCGGCGCCGCCGAAGTGGTGCCGGAGATCATCGAGGGCAGCC
TGATGCTGGCCTCGCACGCGCTGGTGCTGCTGGGCGTGCCGCTGCGGCGCGTGGTGCGCCGCGCGCAGGAAATGCGCGAT
GCGCGCTACGGCCTGCTGCGCGGCTACTTCCACGGCCAGGATGACGACGAGGACATGCTCGAGCGCGACGCCGTGCGCCT
GCACTCGGTGCCGCTGATCAAGGGCTCGCCCGCGATCGGCCGCCCGCTGGGCACGCTGGGGCTGGAAACCTTCAAGACCT
CGGTGACGGCGATCCGGCGCCAGGGTATCCGCGCGCTCGACCCGGAGCCGAACACCCTGCTCGAGCTGGGCGACATCGTC
GTGCTGCGCGGCACGCCCGACGGCCTGCAGCAGGCCGAGGAGCGCCTGTCGCCCCGCTGA

Upstream 100 bases:

>100_bases
CGGTTTTGCAAGGTGCGGCGTGCCGCTTGTCGCACGCACCGTTCCGATGCCGGGGCATCGTCCCGCGTTGCCAACCCTTT
CGCCTGATTTTTCGCGTCGC

Downstream 100 bases:

>100_bases
TGTGCGGGTGCGTTATTTCGCCACGACTTCGAGCAGCGGCCCGCGCGAGCGCCGCTGCAGCGGCGGCTCGGCCAGGCTCG
GCGGCAGGCCGGCCAGCACC

Product: glutathione-regulated potassium-efflux system K+/H+ antiporter transmembrane protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVVIGPNATGLESDSAQTRYLAEFGVVFLMFSIGLEFSLAKLRS
MRRLVLGLGASQVVLTMLLTVPASLLLSRWYPLSWQASLALGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDL
AVVLLLIVVPSLGKNPTDLVLTLSIAAVKIIVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
LSMALGAFLAGMLVSETPYRLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVIGHWGLVIGLVIGPVLFKFALIALLARAF
GSGGGTAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLSQAILAAMLLSMLLAPFLIQYSDAIAMRLSRTDWLMQSLAMT
KIAAQSLQTERHVIICGYGRSGQNLAHMLEQEDISYVALDLDPDRVRDAAAAGERVVYGDAARRESLVAAGVHRAAAVAV
TYADTASALKVLHHVQALAPTLPVIVRTIDDADLDRLQQAGAAEVVPEIIEGSLMLASHALVLLGVPLRRVVRRAQEMRD
ARYGLLRGYFHGQDDDEDMLERDAVRLHSVPLIKGSPAIGRPLGTLGLETFKTSVTAIRRQGIRALDPEPNTLLELGDIV
VLRGTPDGLQQAEERLSPR

Sequences:

>Translated_659_residues
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVVIGPNATGLESDSAQTRYLAEFGVVFLMFSIGLEFSLAKLRS
MRRLVLGLGASQVVLTMLLTVPASLLLSRWYPLSWQASLALGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDL
AVVLLLIVVPSLGKNPTDLVLTLSIAAVKIIVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
LSMALGAFLAGMLVSETPYRLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVIGHWGLVIGLVIGPVLFKFALIALLARAF
GSGGGTAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLSQAILAAMLLSMLLAPFLIQYSDAIAMRLSRTDWLMQSLAMT
KIAAQSLQTERHVIICGYGRSGQNLAHMLEQEDISYVALDLDPDRVRDAAAAGERVVYGDAARRESLVAAGVHRAAAVAV
TYADTASALKVLHHVQALAPTLPVIVRTIDDADLDRLQQAGAAEVVPEIIEGSLMLASHALVLLGVPLRRVVRRAQEMRD
ARYGLLRGYFHGQDDDEDMLERDAVRLHSVPLIKGSPAIGRPLGTLGLETFKTSVTAIRRQGIRALDPEPNTLLELGDIV
VLRGTPDGLQQAEERLSPR
>Mature_659_residues
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVVIGPNATGLESDSAQTRYLAEFGVVFLMFSIGLEFSLAKLRS
MRRLVLGLGASQVVLTMLLTVPASLLLSRWYPLSWQASLALGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDL
AVVLLLIVVPSLGKNPTDLVLTLSIAAVKIIVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
LSMALGAFLAGMLVSETPYRLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVIGHWGLVIGLVIGPVLFKFALIALLARAF
GSGGGTAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLSQAILAAMLLSMLLAPFLIQYSDAIAMRLSRTDWLMQSLAMT
KIAAQSLQTERHVIICGYGRSGQNLAHMLEQEDISYVALDLDPDRVRDAAAAGERVVYGDAARRESLVAAGVHRAAAVAV
TYADTASALKVLHHVQALAPTLPVIVRTIDDADLDRLQQAGAAEVVPEIIEGSLMLASHALVLLGVPLRRVVRRAQEMRD
ARYGLLRGYFHGQDDDEDMLERDAVRLHSVPLIKGSPAIGRPLGTLGLETFKTSVTAIRRQGIRALDPEPNTLLELGDIV
VLRGTPDGLQQAEERLSPR

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=340, Percent_Identity=29.4117647058824, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1786232, Length=559, Percent_Identity=33.0948121645796, Blast_Score=246, Evalue=4e-66,
Organism=Escherichia coli, GI1789749, Length=562, Percent_Identity=33.2740213523132, Blast_Score=232, Evalue=5e-62,
Organism=Escherichia coli, GI1786685, Length=543, Percent_Identity=30.5709023941068, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 71314; Mature: 71314

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVVIGPNATGLESDSAQTRYLAEF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GVVFLMFSIGLEFSLAKLRSMRRLVLGLGASQVVLTMLLTVPASLLLSRWYPLSWQASLA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDLAVVLLLIVVPSLGKNPTDLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LTLSIAAVKIIVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LSMALGAFLAGMLVSETPYRLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVIGHWGLVIG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LVIGPVLFKFALIALLARAFGSGGGTAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLSQ
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHH
AILAAMLLSMLLAPFLIQYSDAIAMRLSRTDWLMQSLAMTKIAAQSLQTERHVIICGYGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
SGQNLAHMLEQEDISYVALDLDPDRVRDAAAAGERVVYGDAARRESLVAAGVHRAAAVAV
CCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHEEE
TYADTASALKVLHHVQALAPTLPVIVRTIDDADLDRLQQAGAAEVVPEIIEGSLMLASHA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCCHHHHHHHH
LVLLGVPLRRVVRRAQEMRDARYGLLRGYFHGQDDDEDMLERDAVRLHSVPLIKGSPAIG
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RPLGTLGLETFKTSVTAIRRQGIRALDPEPNTLLELGDIVVLRGTPDGLQQAEERLSPR
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEECCEEEECCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVVIGPNATGLESDSAQTRYLAEF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GVVFLMFSIGLEFSLAKLRSMRRLVLGLGASQVVLTMLLTVPASLLLSRWYPLSWQASLA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDLAVVLLLIVVPSLGKNPTDLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LTLSIAAVKIIVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LSMALGAFLAGMLVSETPYRLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVIGHWGLVIG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LVIGPVLFKFALIALLARAFGSGGGTAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLSQ
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHH
AILAAMLLSMLLAPFLIQYSDAIAMRLSRTDWLMQSLAMTKIAAQSLQTERHVIICGYGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
SGQNLAHMLEQEDISYVALDLDPDRVRDAAAAGERVVYGDAARRESLVAAGVHRAAAVAV
CCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHEEE
TYADTASALKVLHHVQALAPTLPVIVRTIDDADLDRLQQAGAAEVVPEIIEGSLMLASHA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCCHHHHHHHH
LVLLGVPLRRVVRRAQEMRDARYGLLRGYFHGQDDDEDMLERDAVRLHSVPLIKGSPAIG
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RPLGTLGLETFKTSVTAIRRQGIRALDPEPNTLLELGDIVVLRGTPDGLQQAEERLSPR
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEECCEEEECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]