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The map label for this gene is pth [H]

Identifier: 17545112

GI number: 17545112

Start: 420478

End: 421131

Strand: Reverse

Name: pth [H]

Synonym: RSc0393

Alternate gene names: 17545112

Gene position: 421131-420478 (Counterclockwise)

Preceding gene: 17545113

Following gene: 17545111

Centisome position: 11.33

GC content: 67.43

Gene sequence:

>654_bases
ATGCTTGTACGGTCACAGGGCGCATCGTTCACCCGCCTCCCTCCGAATCGCATGATCAAACTCATTGTCGGGCTCGGCAA
CCCGGGCGCCGAATACGCGGCGACGCGGCACAACGCCGGCTTCTGGCTGGTCGACCAGCTCGCACGCATGGGCCACGTGA
CACTGCGCAACGAAACGCGCTTCCACGGCTACGCGGCGCGTGCCACGCTGTGGAGCCATGAGGTCTGGCTGCTGCAGCCG
CAGACCTTCATGAACCGCTCGGGCCTCGCCACGGTGGCGCTGGCGCGCTTCTACAAAATCCTGCCCGATGAGATCCTGGT
CGTGCACGACGAACTGGACCTGCTGCCGGGTGCCGTCAAGCTGAAGCTGGGCGGCGGCTCGGGCGGGCACAATGGGTTGA
AGGACATCGCGGCCCACCTGACCACGCAGCAGTTCTGGCGGCTGCGCGTGGGCATCGGGCATCCGCGGAATCTGCTGCCG
CCCGGCACGGCGCCGTCCGGCCAGCACGATGTCGCCAACTTCGTGCTCAAGGCGCCGCGCAGGGAGGAACAGGAACTGAT
CGACCGCGCCATCGATCGCAGCCTCGATGCGCTGCCGGACCTGGTTGCCGGCAACGCCGAGCGCGCCATGATGCGCCTGC
ACACCACAGGCTGA

Upstream 100 bases:

>100_bases
GCGCCACACCGGCGCGATCGGAAGGAAAGCCCGCCGAGCCTGTCTCGCCGGGCTTTTTTTCTGCCTGCGCCGCCGTGCAT
CCGCTCACGCGAAAGCGGCT

Downstream 100 bases:

>100_bases
CGCGCCAGCCGCGCGCAGGACACCGCCATGAAGCCACCCATCCCGTCGTCCCGCCCCCGTGCGCCGATTGCGCTCGCACT
CGGCCTATGGGCCGCGGCGA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MLVRSQGASFTRLPPNRMIKLIVGLGNPGAEYAATRHNAGFWLVDQLARMGHVTLRNETRFHGYAARATLWSHEVWLLQP
QTFMNRSGLATVALARFYKILPDEILVVHDELDLLPGAVKLKLGGGSGGHNGLKDIAAHLTTQQFWRLRVGIGHPRNLLP
PGTAPSGQHDVANFVLKAPRREEQELIDRAIDRSLDALPDLVAGNAERAMMRLHTTG

Sequences:

>Translated_217_residues
MLVRSQGASFTRLPPNRMIKLIVGLGNPGAEYAATRHNAGFWLVDQLARMGHVTLRNETRFHGYAARATLWSHEVWLLQP
QTFMNRSGLATVALARFYKILPDEILVVHDELDLLPGAVKLKLGGGSGGHNGLKDIAAHLTTQQFWRLRVGIGHPRNLLP
PGTAPSGQHDVANFVLKAPRREEQELIDRAIDRSLDALPDLVAGNAERAMMRLHTTG
>Mature_217_residues
MLVRSQGASFTRLPPNRMIKLIVGLGNPGAEYAATRHNAGFWLVDQLARMGHVTLRNETRFHGYAARATLWSHEVWLLQP
QTFMNRSGLATVALARFYKILPDEILVVHDELDLLPGAVKLKLGGGSGGHNGLKDIAAHLTTQQFWRLRVGIGHPRNLLP
PGTAPSGQHDVANFVLKAPRREEQELIDRAIDRSLDALPDLVAGNAERAMMRLHTTG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=182, Percent_Identity=35.1648351648352, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1787455, Length=197, Percent_Identity=53.8071065989848, Blast_Score=169, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 23953; Mature: 23953

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVRSQGASFTRLPPNRMIKLIVGLGNPGAEYAATRHNAGFWLVDQLARMGHVTLRNETR
CCCCCCCCCCCCCCHHHEEEEEEECCCCCHHHHECCCCCCCHHHHHHHHHCCEEECCCCC
FHGYAARATLWSHEVWLLQPQTFMNRSGLATVALARFYKILPDEILVVHDELDLLPGAVK
CCCEEHHHEEEECCEEEECCHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHCCCEEE
LKLGGGSGGHNGLKDIAAHLTTQQFWRLRVGIGHPRNLLPPGTAPSGQHDVANFVLKAPR
EEECCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
REEQELIDRAIDRSLDALPDLVAGNAERAMMRLHTTG
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEECCC
>Mature Secondary Structure
MLVRSQGASFTRLPPNRMIKLIVGLGNPGAEYAATRHNAGFWLVDQLARMGHVTLRNETR
CCCCCCCCCCCCCCHHHEEEEEEECCCCCHHHHECCCCCCCHHHHHHHHHCCEEECCCCC
FHGYAARATLWSHEVWLLQPQTFMNRSGLATVALARFYKILPDEILVVHDELDLLPGAVK
CCCEEHHHEEEECCEEEECCHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHCCCEEE
LKLGGGSGGHNGLKDIAAHLTTQQFWRLRVGIGHPRNLLPPGTAPSGQHDVANFVLKAPR
EEECCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
REEQELIDRAIDRSLDALPDLVAGNAERAMMRLHTTG
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA