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The map label for this gene is coxA [H]

Identifier: 17545082

GI number: 17545082

Start: 393098

End: 394702

Strand: Direct

Name: coxA [H]

Synonym: RSc0363

Alternate gene names: 17545082

Gene position: 393098-394702 (Clockwise)

Preceding gene: 17545081

Following gene: 17545083

Centisome position: 10.58

GC content: 64.3

Gene sequence:

>1605_bases
ATGAGCACTGCGATAACGCACCCGCAAGATCACGCGCACGGTCATGGAGACGACCACGCGCACGACCATCCGCATGGCTG
GCGCCGTTGGCTGTTCGCGACCAACCACAAGGACATCGGCACGCTGTACCTGCTGTTCTCCTTCACGATGCTGCTCTCGG
GCGGCACGCTGGCACTGCTGATCCGCCTGGAGCTGTTCGAGCCGGGCCTGCAGTTCTTCCATCCGGAGCTGTTCAACCAG
TTCACCACGCTGCACGGCCTGGTCATGGTGTTCGGCGCGATCATGCCGGCCTTCGTCGGCTTCGCGAACTGGATGATCCC
GCTGCAGGTCGGCGCGTCCGACATGGCCTTCGCGCGGATGAACAACTTCAGCTTCTGGCTGCTGCCCCCCGCGGCCATCC
TGCTGGTCGGCTCGTTCTTCGTGCCGGGCGGCGCCACCGCCGCCGGCTGGACGCTCTACGCGCCGCTGTCGGTGCAGATG
GGGCCCGGCATGGACATGGCGATCTTCGCGGTGCACATCATGGGCGCCTCGTCGATCATGGGCGCGATCAACATCATCGT
GACCATCCTGAACATGCGCGCCCCCGGCATGACGCTGATGAAGATGCCGATGTTCTGCTGGACGTGGCTGATCACGGCCT
ACCTGCTGATCGCCGTGATGCCGGTGCTGGCCGGCGCGATCACCATGGTGCTGACCGACCGCCACTTCGGCACGAGCTTC
TTCTCGGCCGCCGGCGGTGGCGATCCGGTGATGTACCAGCACATCTTCTGGTTCTTCGGGCATCCCGAGGTCTACATCAT
GATCCTGCCGGCGTTCGGCATCGTCAGCCAGATCGTGCCGGCCTTCGCGCGCAAGCCGCTGTTCGGCTACAGCTCGATGG
TGTACGCCACCGCCTCGATCGCCATCCTGTCGTTCATCGTGTGGGCGCACCACATGTTCACGACCGGCATGCCCGTCACC
GGCCAGCTGTTTTTCATGTACGCGACCATGCTGATCGCGGTGCCGACCGGCGTGAAGATCTTCAACTGGATCGCCACCAT
GTGGCGCGGCTCGATGACCTTCGAGACGCCGATGCTGTTCGCGCTCGGCTTCATCTTCGTGTTCACCATCGGCGGGTTCA
CGGGCCTGATCCTGGCCGTGGCGCCGATCGACATCCAGCTGCAGGACACCTACTACGTGGTGGCGCACTTCCACTACGTG
CTGGTGGCGGGCTCGCTGTTCGCGCTGTTCGCGGGCTTCTACTACTGGGGGCCGAAGTGGTCGGGCTACATGTACAACGA
GACGCGCGGCCAGATCCACTTCTGGGGTTCGATGATCTTCTTCAACCTCACCTTCTTCCCGATGCACTTCCTGGGCCTGG
CCGGCATGCCGCGCCGCTATGCGGACTACCCGCAGCAGTTCGCCGACTTCAACGCGATCGCGTCGATCGGCGCGCTGGGC
TTCGGCCTGATGCAGGTGTATTTCTTCTTCTTCGTGGTGCTGCCGTCGTATCGCGGCGGCGAGAAGGCCGCCGACAAGCC
GTGGGATGGCGCCGAGGGCCTGGAGTGGACCGTGCCCTCGCCGGCGCCGTTCCACACCTTTGAAGAACCGCCGCACGTCA
AGTGA

Upstream 100 bases:

>100_bases
CGGCGAAGACCGCTGCCCCGCAGGCCAGCGTCGCGGCACCCGCCCGCAACGCCGGCTGACCGACCGTCTGCGTGACGAAA
CGACACCAAGGAGTTTTGCG

Downstream 100 bases:

>100_bases
AACAGGACACGCGGGGCTGGCCGATGCCCGGTCCCGGCCCCGCGCACCTCCGGACAACGATGCCGAATCCAGGAAACAGC
CCGACGCCCGAGCAGCGCGC

Product: cytochrome C oxidase polypeptide I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MSTAITHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGTLALLIRLELFEPGLQFFHPELFNQ
FTTLHGLVMVFGAIMPAFVGFANWMIPLQVGASDMAFARMNNFSFWLLPPAAILLVGSFFVPGGATAAGWTLYAPLSVQM
GPGMDMAIFAVHIMGASSIMGAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASIAILSFIVWAHHMFTTGMPVT
GQLFFMYATMLIAVPTGVKIFNWIATMWRGSMTFETPMLFALGFIFVFTIGGFTGLILAVAPIDIQLQDTYYVVAHFHYV
LVAGSLFALFAGFYYWGPKWSGYMYNETRGQIHFWGSMIFFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALG
FGLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK

Sequences:

>Translated_534_residues
MSTAITHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGTLALLIRLELFEPGLQFFHPELFNQ
FTTLHGLVMVFGAIMPAFVGFANWMIPLQVGASDMAFARMNNFSFWLLPPAAILLVGSFFVPGGATAAGWTLYAPLSVQM
GPGMDMAIFAVHIMGASSIMGAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASIAILSFIVWAHHMFTTGMPVT
GQLFFMYATMLIAVPTGVKIFNWIATMWRGSMTFETPMLFALGFIFVFTIGGFTGLILAVAPIDIQLQDTYYVVAHFHYV
LVAGSLFALFAGFYYWGPKWSGYMYNETRGQIHFWGSMIFFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALG
FGLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK
>Mature_533_residues
STAITHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGTLALLIRLELFEPGLQFFHPELFNQF
TTLHGLVMVFGAIMPAFVGFANWMIPLQVGASDMAFARMNNFSFWLLPPAAILLVGSFFVPGGATAAGWTLYAPLSVQMG
PGMDMAIFAVHIMGASSIMGAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSFF
SAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASIAILSFIVWAHHMFTTGMPVTG
QLFFMYATMLIAVPTGVKIFNWIATMWRGSMTFETPMLFALGFIFVFTIGGFTGLILAVAPIDIQLQDTYYVVAHFHYVL
VAGSLFALFAGFYYWGPKWSGYMYNETRGQIHFWGSMIFFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALGF
GLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=514, Percent_Identity=51.9455252918288, Blast_Score=480, Evalue=1e-135,
Organism=Escherichia coli, GI1786634, Length=516, Percent_Identity=41.6666666666667, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6226519, Length=530, Percent_Identity=47.5471698113208, Blast_Score=490, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=51.0835913312694, Blast_Score=336, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=47.5806451612903, Blast_Score=222, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59552; Mature: 59421

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAITHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGTLALL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCEEEH
IRLELFEPGLQFFHPELFNQFTTLHGLVMVFGAIMPAFVGFANWMIPLQVGASDMAFARM
EEHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHH
NNFSFWLLPPAAILLVGSFFVPGGATAAGWTLYAPLSVQMGPGMDMAIFAVHIMGASSIM
CCCEEEEECHHHHHHHHHHCCCCCCCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHHHH
GAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASI
HHCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AILSFIVWAHHMFTTGMPVTGQLFFMYATMLIAVPTGVKIFNWIATMWRGSMTFETPMLF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHH
ALGFIFVFTIGGFTGLILAVAPIDIQLQDTYYVVAHFHYVLVAGSLFALFAGFYYWGPKW
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGYMYNETRGQIHFWGSMIFFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALG
CCEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHH
FGLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STAITHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGTLALL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCEEEH
IRLELFEPGLQFFHPELFNQFTTLHGLVMVFGAIMPAFVGFANWMIPLQVGASDMAFARM
EEHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHH
NNFSFWLLPPAAILLVGSFFVPGGATAAGWTLYAPLSVQMGPGMDMAIFAVHIMGASSIM
CCCEEEEECHHHHHHHHHHCCCCCCCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHHHH
GAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASI
HHCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AILSFIVWAHHMFTTGMPVTGQLFFMYATMLIAVPTGVKIFNWIATMWRGSMTFETPMLF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHH
ALGFIFVFTIGGFTGLILAVAPIDIQLQDTYYVVAHFHYVLVAGSLFALFAGFYYWGPKW
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGYMYNETRGQIHFWGSMIFFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALG
CCEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHH
FGLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]