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The map label for this gene is coxB [H]

Identifier: 17545081

GI number: 17545081

Start: 391884

End: 393056

Strand: Direct

Name: coxB [H]

Synonym: RSc0362

Alternate gene names: 17545081

Gene position: 391884-393056 (Clockwise)

Preceding gene: 17545080

Following gene: 17545082

Centisome position: 10.54

GC content: 65.3

Gene sequence:

>1173_bases
ATGCCGGGCGGCCCCGCGGTGCGACAGCTGAATCTTGCCCCTCCGGTCACCAAGATCGCGGCGGAGATCCACTGGCTGCA
CTACATGATGCTGATCATCTGTATCGTGATCTTCGTCGGTGTGTTCGGGGTGATGTTCTATTCGATTTTCAAGCACCGCA
AATCGCTGGGTCACAAGCCGGCGACCTTCCACGAAAGCACCACCGTCGAAATCATCTGGACCATCGTGCCGTTCCTGATC
GTGATCGGGATGGCGCTGCCGGCCACCCGGGCCGTGGTCGCGATGAAGGACACCACCAACTCCGACCTCACCATCAAGGC
CACCGGCTACCAGTGGAAGTGGGGCTATGACTACCTGAAAGGCGAAGGCGAGGGCATCTCGTTCCTGTCCACCCTCGCCA
CGCCGCGCGACCAGATCGACAACCTGGCGCCGAAGAGCGACACCTATCTCATCGAGGTCGACAACGAGCTGGTCGTGCCG
GTCAACCGCAAGGTGCGCATCGTCACCACCGCCAACGACGTGATCCACTCGTGGATGATCCCGGCCTTCGGCGTCAAGCA
GGACGCGATCCCGGGCTTCGTGCGCGATACGTGGTTCAAGGCCGAGAAGGTCGGCGTGTACCGGGGCCAGTGCGCCGAGC
TGTGCGGCAAGGAACATGCCTTCATGCCGATCGTCGTGCGCGTGGTGTCCGACGCGGACTACACCAGCTGGGTCGACGGC
AAGAAGAAGGAGATGGCCGCCAAGGCCGACGACCCCAACAAGACCTACACGCTCGACGAGCTGAAGACGCGCGGCGAGAA
GGTCTACACCGCCAACTGCGCCGTGTGCCATCAGCCGAACGGCAAGGGCGGTGGCGCGTTCCCGGCCCTGGACGGCTCCA
AGATCGCGACCGGCCCGCTGGCCGACCACGTGAGCATCGTGCTGCACGGCAAGGGCGCCATGCCGCCCTGGGCCTCGGCG
CTCAACGACGTGGAGATCGCATCCGTCATTACCTACGAGCGGAACAACTGGGGCAATCACACCAATGACGTGCTGCAGCC
GACCCAGGTGAAGGAGGCGCGCGGCGGCAAGATGCCCGAGGGCGGCGGTGCCGGCAAGACCGCGGCGGCCGAAGCGGCGA
AGACCGCTGCCCCGCAGGCCAGCGTCGCGGCACCCGCCCGCAACGCCGGCTGA

Upstream 100 bases:

>100_bases
TGGGTAGACAAAAATGAAAATGTTCAATAAGACATTGGCAGGTTTGCTGGCGGCAGGCTCCCTCCTTGCCCTCGGTCAAA
CAGCCCTGGCAGTGGAAGAC

Downstream 100 bases:

>100_bases
CCGACCGTCTGCGTGACGAAACGACACCAAGGAGTTTTGCGATGAGCACTGCGATAACGCACCCGCAAGATCACGCGCAC
GGTCATGGAGACGACCACGC

Product: cytochrome C oxidase polypeptide II precursor (cytochrome AA3 subunit 2) transmembrane protein

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MPGGPAVRQLNLAPPVTKIAAEIHWLHYMMLIICIVIFVGVFGVMFYSIFKHRKSLGHKPATFHESTTVEIIWTIVPFLI
VIGMALPATRAVVAMKDTTNSDLTIKATGYQWKWGYDYLKGEGEGISFLSTLATPRDQIDNLAPKSDTYLIEVDNELVVP
VNRKVRIVTTANDVIHSWMIPAFGVKQDAIPGFVRDTWFKAEKVGVYRGQCAELCGKEHAFMPIVVRVVSDADYTSWVDG
KKKEMAAKADDPNKTYTLDELKTRGEKVYTANCAVCHQPNGKGGGAFPALDGSKIATGPLADHVSIVLHGKGAMPPWASA
LNDVEIASVITYERNNWGNHTNDVLQPTQVKEARGGKMPEGGGAGKTAAAEAAKTAAPQASVAAPARNAG

Sequences:

>Translated_390_residues
MPGGPAVRQLNLAPPVTKIAAEIHWLHYMMLIICIVIFVGVFGVMFYSIFKHRKSLGHKPATFHESTTVEIIWTIVPFLI
VIGMALPATRAVVAMKDTTNSDLTIKATGYQWKWGYDYLKGEGEGISFLSTLATPRDQIDNLAPKSDTYLIEVDNELVVP
VNRKVRIVTTANDVIHSWMIPAFGVKQDAIPGFVRDTWFKAEKVGVYRGQCAELCGKEHAFMPIVVRVVSDADYTSWVDG
KKKEMAAKADDPNKTYTLDELKTRGEKVYTANCAVCHQPNGKGGGAFPALDGSKIATGPLADHVSIVLHGKGAMPPWASA
LNDVEIASVITYERNNWGNHTNDVLQPTQVKEARGGKMPEGGGAGKTAAAEAAKTAAPQASVAAPARNAG
>Mature_389_residues
PGGPAVRQLNLAPPVTKIAAEIHWLHYMMLIICIVIFVGVFGVMFYSIFKHRKSLGHKPATFHESTTVEIIWTIVPFLIV
IGMALPATRAVVAMKDTTNSDLTIKATGYQWKWGYDYLKGEGEGISFLSTLATPRDQIDNLAPKSDTYLIEVDNELVVPV
NRKVRIVTTANDVIHSWMIPAFGVKQDAIPGFVRDTWFKAEKVGVYRGQCAELCGKEHAFMPIVVRVVSDADYTSWVDGK
KKEMAAKADDPNKTYTLDELKTRGEKVYTANCAVCHQPNGKGGGAFPALDGSKIATGPLADHVSIVLHGKGAMPPWASAL
NDVEIASVITYERNNWGNHTNDVLQPTQVKEARGGKMPEGGGAGKTAAAEAAKTAAPQASVAAPARNAG

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=165, Percent_Identity=40, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6226540, Length=219, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 42199; Mature: 42068

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGGPAVRQLNLAPPVTKIAAEIHWLHYMMLIICIVIFVGVFGVMFYSIFKHRKSLGHKP
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ATFHESTTVEIIWTIVPFLIVIGMALPATRAVVAMKDTTNSDLTIKATGYQWKWGYDYLK
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCEEEECCCHHHC
GEGEGISFLSTLATPRDQIDNLAPKSDTYLIEVDNELVVPVNRKVRIVTTANDVIHSWMI
CCCCCHHHHHHHCCCHHHHHCCCCCCCEEEEEECCEEEEECCCEEEEEEEHHHHHHHHHC
PAFGVKQDAIPGFVRDTWFKAEKVGVYRGQCAELCGKEHAFMPIVVRVVSDADYTSWVDG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCHHHCCC
KKKEMAAKADDPNKTYTLDELKTRGEKVYTANCAVCHQPNGKGGGAFPALDGSKIATGPL
CHHHHHCCCCCCCCCEEHHHHHHCCCEEEEECEEEEECCCCCCCCCCCCCCCCCEECCCC
ADHVSIVLHGKGAMPPWASALNDVEIASVITYERNNWGNHTNDVLQPTQVKEARGGKMPE
CCCEEEEEECCCCCCHHHHHHCCCEEEEEEEEECCCCCCCCHHCCCCCHHHHHCCCCCCC
GGGAGKTAAAEAAKTAAPQASVAAPARNAG
CCCCCCHHHHHHHHHCCCCCHHCCCCCCCC
>Mature Secondary Structure 
PGGPAVRQLNLAPPVTKIAAEIHWLHYMMLIICIVIFVGVFGVMFYSIFKHRKSLGHKP
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ATFHESTTVEIIWTIVPFLIVIGMALPATRAVVAMKDTTNSDLTIKATGYQWKWGYDYLK
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCEEEECCCHHHC
GEGEGISFLSTLATPRDQIDNLAPKSDTYLIEVDNELVVPVNRKVRIVTTANDVIHSWMI
CCCCCHHHHHHHCCCHHHHHCCCCCCCEEEEEECCEEEEECCCEEEEEEEHHHHHHHHHC
PAFGVKQDAIPGFVRDTWFKAEKVGVYRGQCAELCGKEHAFMPIVVRVVSDADYTSWVDG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCHHHCCC
KKKEMAAKADDPNKTYTLDELKTRGEKVYTANCAVCHQPNGKGGGAFPALDGSKIATGPL
CHHHHHCCCCCCCCCEEHHHHHHCCCEEEEECEEEEECCCCCCCCCCCCCCCCCEECCCC
ADHVSIVLHGKGAMPPWASALNDVEIASVITYERNNWGNHTNDVLQPTQVKEARGGKMPE
CCCEEEEEECCCCCCHHHHHHCCCEEEEEEEEECCCCCCCCHHCCCCCHHHHHCCCCCCC
GGGAGKTAAAEAAKTAAPQASVAAPARNAG
CCCCCCHHHHHHHHHCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2820725; 7651515; 9380672 [H]