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The map label for this gene is yngE [H]

Identifier: 17544988

GI number: 17544988

Start: 302096

End: 303703

Strand: Reverse

Name: yngE [H]

Synonym: RSc0269

Alternate gene names: 17544988

Gene position: 303703-302096 (Counterclockwise)

Preceding gene: 17544989

Following gene: 17544987

Centisome position: 8.17

GC content: 68.84

Gene sequence:

>1608_bases
ATGCCGACACTCGAGACCAAGCTCAACCCACGTGCCGACGACTTCAAGGCCAACGCCGACGCCATGCGTGCGCTGGTGGC
CGACCTGCGCGACAAGGTCGCCCGCATCGCCCGGGGCGGCGGCGACGATGCGCGCGCCAAGCACCTCGCGCGCGGCAAGC
TGCTGCCGCGCGAGCGCGTGCAGCAGCTGCTCGACCCCGGCACGCCGTTCCTGGAGTTCTCGCAGCTGGCGGCCCACGGC
ATGTACGACGACGCCGCGCCCGGCGCCGGCATCATCACCGGCATCGGCCGCATCTCGGGGCGGGAATGCGTGATCGTGTG
CAACGACGCCACCGTCAAGGGCGGCACCTACTACCCGATGACGGTGAAGAAACACCTGCGCGCGCAGGAGATCGCCGAGC
AGAACCACCTGCCCTGCGTCTACCTGGTCGACTCGGGCGGCGCCAACCTGCCCAACCAGGACGACGTCTTCCCCGACCGC
GACCACTTCGGCCGCATCTTCTACAACCAGGCCAACCTGTCGGCCAAGGGCATCCCGCAGATCGCGGTGGTGATGGGCTC
GTGCACGGCCGGCGGCGCCTACGTGCCGGCCATGAGCGACGAATCGATCATCGTCAAGGAACAGGGCACCATCTTTCTGG
CCGGCCCGCCGCTGGTGAAGGCCGCCACCGGCGAGGTGGTGAGCGCCGAAGACCTGGGCGGCGCCGACGTGCACACGCGC
CTGTCGGGCGTGGCCGACTACTTCGCCAACAACGACGCGCACGCGCTGGCCCAGGCCCGCGGCATCGTCGCCCACCTGAA
CCGCCGCAAGCCCGAGCAGGTGCAGATTCATGCGCCGGTCGAGCCGCGCTACGCGGCCGAAGAACTCTACGGCGTGATCC
CGACCGACACGCGCAAGCCGTTCGACGTGCGCGAAGTCATCGCCCGCATCGTCGACGATTCGGCCTTCGATGAATTCAAG
GCGCGCTACGGCACCACGCTGGTGTGCGGCTTCGCCCGCATCTGGGGGTATCCGGTCGGCATCATCGCCAACAACGGCAT
CCTGTTCTCGGAGGCGGCGCTCAAGGGGGCGCACTTCATCGAGCTGTGCTGCCAGCGCAAGATCCCGCTGGTGTTCCTGC
AGAACATCACCGGCTTCATGGTCGGGCGCAAGTACGAGAACGAGGGCATCGCCAAGAACGGCGCCAAGATGGTGACGGCG
GTGGCCACCGCCCAGGTGCCCAAGTTCACGGTCATCATCGGCGGCTCGTTCGGGGCGGGCAACTACGGCATGTGCGGGCG
CGCGTATTCGCCGCGATTCCTGTGGATGTGGCCGAACGCGCGCATCTCGGTGATGGGCGGCGAGCAGGCCGCGAGCGTGC
TCGCCACCGTGCGCCGCGACGGCATCGAGGCCCGCGGCGGCCACTGGAGCACGGACGAGGAAGCCGCCTTCAAGGCACCG
ATCCGCGAGCAGTACGAGCGCCAGGGCCATCCGTACTACGCCAGCGCGCGCCTGTGGGACGACGGCGTGATCGACCCGGC
CGATACGCGCAGCGTGCTGGGCCTGGGGCTGTCGGCCAGCCTGAACGCGCCGATCGGCGAGATGAATTTCGGCGTGTTCC
GCATGTAG

Upstream 100 bases:

>100_bases
AGCCGCTTCGTCCGCCTGGACGCGGGCGGCGCCGAATCCCCGCAAGGCCGCTGGCTGTACGTTGACGGCGACCTGACCTG
ACCCCGACCCGACCGCCGCC

Downstream 100 bases:

>100_bases
GCGGGCCGCCACGGTACTGAATGGAGAGCGACGTGAACCACGCACATCGGCCGGGATGGCGCCGCGCATGGGCCGTGCTC
GGCTGCGCCCTGCTGCTCGC

Product: propionyl-CoA carboxylase (beta subunit) protein

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPTLETKLNPRADDFKANADAMRALVADLRDKVARIARGGGDDARAKHLARGKLLPRERVQQLLDPGTPFLEFSQLAAHG
MYDDAAPGAGIITGIGRISGRECVIVCNDATVKGGTYYPMTVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDR
DHFGRIFYNQANLSAKGIPQIAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTR
LSGVADYFANNDAHALAQARGIVAHLNRRKPEQVQIHAPVEPRYAAEELYGVIPTDTRKPFDVREVIARIVDDSAFDEFK
ARYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTA
VATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEARGGHWSTDEEAAFKAP
IREQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGEMNFGVFRM

Sequences:

>Translated_535_residues
MPTLETKLNPRADDFKANADAMRALVADLRDKVARIARGGGDDARAKHLARGKLLPRERVQQLLDPGTPFLEFSQLAAHG
MYDDAAPGAGIITGIGRISGRECVIVCNDATVKGGTYYPMTVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDR
DHFGRIFYNQANLSAKGIPQIAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTR
LSGVADYFANNDAHALAQARGIVAHLNRRKPEQVQIHAPVEPRYAAEELYGVIPTDTRKPFDVREVIARIVDDSAFDEFK
ARYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTA
VATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEARGGHWSTDEEAAFKAP
IREQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGEMNFGVFRM
>Mature_534_residues
PTLETKLNPRADDFKANADAMRALVADLRDKVARIARGGGDDARAKHLARGKLLPRERVQQLLDPGTPFLEFSQLAAHGM
YDDAAPGAGIITGIGRISGRECVIVCNDATVKGGTYYPMTVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDRD
HFGRIFYNQANLSAKGIPQIAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTRL
SGVADYFANNDAHALAQARGIVAHLNRRKPEQVQIHAPVEPRYAAEELYGVIPTDTRKPFDVREVIARIVDDSAFDEFKA
RYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTAV
ATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEARGGHWSTDEEAAFKAPI
REQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGEMNFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=68.5823754789272, Blast_Score=728, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=491, Percent_Identity=33.6048879837067, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI295821216, Length=511, Percent_Identity=32.2896281800391, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=62.1212121212121, Blast_Score=155, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.2270168855535, Blast_Score=717, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=524, Percent_Identity=33.7786259541985, Blast_Score=250, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI25147362, Length=485, Percent_Identity=34.4329896907216, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=64.8451730418944, Blast_Score=736, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57867; Mature: 57735

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLETKLNPRADDFKANADAMRALVADLRDKVARIARGGGDDARAKHLARGKLLPRERV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHH
QQLLDPGTPFLEFSQLAAHGMYDDAAPGAGIITGIGRISGRECVIVCNDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEHHHCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDRDHFGRIFYNQANLSAKGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCEEECCCCCCCHHHHH
LSGVADYFANNDAHALAQARGIVAHLNRRKPEQVQIHAPVEPRYAAEELYGVIPTDTRKP
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCCC
FDVREVIARIVDDSAFDEFKARYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFI
CCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEEEHHHHCCHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTAVATAQVPKFTVIIGGSFGAG
HHHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCCCEEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEARGGHWSTDEEAAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCH
IREQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGEMNFGVFRM
HHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEC
>Mature Secondary Structure 
PTLETKLNPRADDFKANADAMRALVADLRDKVARIARGGGDDARAKHLARGKLLPRERV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHH
QQLLDPGTPFLEFSQLAAHGMYDDAAPGAGIITGIGRISGRECVIVCNDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEHHHCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDRDHFGRIFYNQANLSAKGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCEEECCCCCCCHHHHH
LSGVADYFANNDAHALAQARGIVAHLNRRKPEQVQIHAPVEPRYAAEELYGVIPTDTRKP
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCCC
FDVREVIARIVDDSAFDEFKARYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFI
CCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEEEHHHHCCHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTAVATAQVPKFTVIIGGSFGAG
HHHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCCCEEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEARGGHWSTDEEAAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCH
IREQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGEMNFGVFRM
HHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]