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The map label for this gene is mvaB [H]

Identifier: 17544980

GI number: 17544980

Start: 293804

End: 294733

Strand: Reverse

Name: mvaB [H]

Synonym: RSc0261

Alternate gene names: 17544980

Gene position: 294733-293804 (Counterclockwise)

Preceding gene: 17544981

Following gene: 17544979

Centisome position: 7.93

GC content: 69.46

Gene sequence:

>930_bases
ATGACGTTCCCGCATTTTGTGAAGGTAGTCGAGGTCGGCCCGCGCGACGGCCTGCAGAACGAGAAGTCGCCGGTGTCCAC
CGAGGCCAAGGTGGAGCTGGTGAACCGCCTGTCCGACGCCGGCTTCGTCAACGTGGAGGCCGCGTCGTTCGTGTCGCCCC
GGTGGGTGCCCCAGATGGCCGACGGCGCCGACGTGATGGCGCGCATCCAGCGCCGGCCCGGCACGCTGTATTCCGCGCTG
ACGCCCAACATGAAGGGTTTCGAGGCCGCCGCCGCCGCGCTCGCCGATGAAGTGGTGATCTTCAGCGCGGCCAGCGAGGC
GTTCTCGCAGAAGAACATCAACTGCTCGATCGCTGAATCGATCGAACGGTTCGTGCCGGTGGCCCGGGCCGCCAAGGACG
CGGGCATCCGGCTGCGCGGGTCGATCTCGTGCGCGCTGGGCTGTCCGTACCAGGGCGAGGTGCCGGTGGCGTCGGTCGTC
GATGTGGTCAAGCGGCTGGCGGCGCTCGGCTGCGATGAGATCGACATCGCCGACACCATCGGCGTGGGCACCGCCGGCCG
CGTCAAGGCGGTGATGGAAGCCGCCGCCGCCGCCTTCCCGCTCGACCGGCTGTCGGGCCATTTCCATGACACCTACGGCC
AGGCGCTGGCCAATATCCTGGCGAGCCTGGAAGTGGGCGTTGCCATCTTCCACGCGTCGGTGGCGGGGCTGGGCGGCTGC
CCGTACGCCAAAGGGGCGACCGGCAACGTCGCCACCGAAGACGTGCTGTACCTGCTGCATGGCTTGGGGCTGCGCACCGG
CATCGACCTGGACAAGGTGGTGCTGGCCGGCGACTTCATCTCCCAGGCCATCGGCCGGCCGACCGCCTCGCGCGCCGGCC
GCGCCCTGCTGCTCAAGCTGCAGGACCAGATCGCCCAGGCCTGCATCTGA

Upstream 100 bases:

>100_bases
CTGCGCGAGGTCAGCATTGCCCAGATCGCGCGCAAGATCCGCGCGCTGGAAGCCGGCGAGCCGATCGCCGGCATCGTCGA
TCTGCAACGAGGTTACTGAG

Downstream 100 bases:

>100_bases
CGCCAACGCTCAATGACGACGATGACGACCGCCCCCGACACCCACGCCCCCCTGCCCGAATCCGCCCAGCGCGTGGCCGA
CCACCTGCGCGCGCTCGGCT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTFPHFVKVVEVGPRDGLQNEKSPVSTEAKVELVNRLSDAGFVNVEAASFVSPRWVPQMADGADVMARIQRRPGTLYSAL
TPNMKGFEAAAAALADEVVIFSAASEAFSQKNINCSIAESIERFVPVARAAKDAGIRLRGSISCALGCPYQGEVPVASVV
DVVKRLAALGCDEIDIADTIGVGTAGRVKAVMEAAAAAFPLDRLSGHFHDTYGQALANILASLEVGVAIFHASVAGLGGC
PYAKGATGNVATEDVLYLLHGLGLRTGIDLDKVVLAGDFISQAIGRPTASRAGRALLLKLQDQIAQACI

Sequences:

>Translated_309_residues
MTFPHFVKVVEVGPRDGLQNEKSPVSTEAKVELVNRLSDAGFVNVEAASFVSPRWVPQMADGADVMARIQRRPGTLYSAL
TPNMKGFEAAAAALADEVVIFSAASEAFSQKNINCSIAESIERFVPVARAAKDAGIRLRGSISCALGCPYQGEVPVASVV
DVVKRLAALGCDEIDIADTIGVGTAGRVKAVMEAAAAAFPLDRLSGHFHDTYGQALANILASLEVGVAIFHASVAGLGGC
PYAKGATGNVATEDVLYLLHGLGLRTGIDLDKVVLAGDFISQAIGRPTASRAGRALLLKLQDQIAQACI
>Mature_308_residues
TFPHFVKVVEVGPRDGLQNEKSPVSTEAKVELVNRLSDAGFVNVEAASFVSPRWVPQMADGADVMARIQRRPGTLYSALT
PNMKGFEAAAAALADEVVIFSAASEAFSQKNINCSIAESIERFVPVARAAKDAGIRLRGSISCALGCPYQGEVPVASVVD
VVKRLAALGCDEIDIADTIGVGTAGRVKAVMEAAAAAFPLDRLSGHFHDTYGQALANILASLEVGVAIFHASVAGLGGCP
YAKGATGNVATEDVLYLLHGLGLRTGIDLDKVVLAGDFISQAIGRPTASRAGRALLLKLQDQIAQACI

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=294, Percent_Identity=56.8027210884354, Blast_Score=357, Evalue=7e-99,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=55.2901023890785, Blast_Score=346, Evalue=1e-95,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=55.2901023890785, Blast_Score=346, Evalue=1e-95,
Organism=Homo sapiens, GI260654708, Length=134, Percent_Identity=53.7313432835821, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17510563, Length=293, Percent_Identity=48.8054607508532, Blast_Score=294, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24582381, Length=289, Percent_Identity=53.6332179930796, Blast_Score=332, Evalue=2e-91,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32231; Mature: 32100

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFPHFVKVVEVGPRDGLQNEKSPVSTEAKVELVNRLSDAGFVNVEAASFVSPRWVPQMA
CCCCHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCC
DGADVMARIQRRPGTLYSALTPNMKGFEAAAAALADEVVIFSAASEAFSQKNINCSIAES
CCHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCHHHHH
IERFVPVARAAKDAGIRLRGSISCALGCPYQGEVPVASVVDVVKRLAALGCDEIDIADTI
HHHHHHHHHHHHCCCEEEEECEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTAGRVKAVMEAAAAAFPLDRLSGHFHDTYGQALANILASLEVGVAIFHASVAGLGGC
CCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYLLHGLGLRTGIDLDKVVLAGDFISQAIGRPTASRAGRALLLKL
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHH
QDQIAQACI
HHHHHHHCC
>Mature Secondary Structure 
TFPHFVKVVEVGPRDGLQNEKSPVSTEAKVELVNRLSDAGFVNVEAASFVSPRWVPQMA
CCCHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCC
DGADVMARIQRRPGTLYSALTPNMKGFEAAAAALADEVVIFSAASEAFSQKNINCSIAES
CCHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCHHHHH
IERFVPVARAAKDAGIRLRGSISCALGCPYQGEVPVASVVDVVKRLAALGCDEIDIADTI
HHHHHHHHHHHHCCCEEEEECEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTAGRVKAVMEAAAAAFPLDRLSGHFHDTYGQALANILASLEVGVAIFHASVAGLGGC
CCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYLLHGLGLRTGIDLDKVVLAGDFISQAIGRPTASRAGRALLLKL
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHH
QDQIAQACI
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]