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The map label for this gene is ghrA [H]

Identifier: 17544981

GI number: 17544981

Start: 294735

End: 295676

Strand: Reverse

Name: ghrA [H]

Synonym: RSc0262

Alternate gene names: 17544981

Gene position: 295676-294735 (Counterclockwise)

Preceding gene: 17544982

Following gene: 17544980

Centisome position: 7.96

GC content: 70.7

Gene sequence:

>942_bases
ATGCACATCCAGATCTACACCCCCGACGGCAAGCCCCAGCCCTGGCTGGACGGCTTCGCGCAAGCGCTGCCCGGGGCGCG
GCTGTCGGTCTGGACGCAAGGCGCGGCGCACGATGCCGACTACGCCGTGGTCTGGCAGCCGCCCGCCGACATGCTGCGCG
GCCGCACCGACCTGCGCGCGGTGTTCAACCTGGGCGCCGGCGTCGATGCCATCCTGGGCCTGCTCGCGCAATCGCCCGAT
GCGCTGCCCGAGAGCGTGCCGATCGTGCGCCTGGACGACGCCGGCATGGCCTCGCAGATGAGCGAATATGTCACCCACGC
CGTGCTGCGCTTCTTCCGCCGGCTGGACGAGTACGAGCGCCTGCAGCAGGCGAAGATCTGGCGCTTCCTGAAGCCGTTCG
ATCGCGACGCGTTCGTGGTCGGCGTGTTGGGCCTGGGCGTGCTGGGCACGCACATCGCGCGCACGCTGGCGGGCTTCGGT
TTTCCGGTGCGCGGGTGGAGCCGCTCGGCCAAGTCGGTGGAAGGCATCGACTGCCGCGCGGGCGCCGACGCCCTGCCCGG
CTTCCTGGCCGGCACGCGCGTGCTGATCAACGTGCTGCCGCTGACGGCCGATACCGAGAACGTGCTCGATGCCGCGCTGT
TCGACCAGCTCGAAGCCGGCGCGTATCTCGTCAACGTGGCGCGCGGCAAGCACCTGGTCGAGGACGACCTGCTCGCGGCC
GTCGCGCGCGGGCAGATCGCCGGCGCGGCGCTCGACGTCTTCCGCACCGAGCCGCTGCCCGCCGATCATCCCTTCTGGAC
CGAACCGCGCATCCGCATCACGCCGCACATCTCGGCGCTGACGCTGCGCGAGGTCAGCATTGCCCAGATCGCGCGCAAGA
TCCGCGCGCTGGAAGCCGGCGAGCCGATCGCCGGCATCGTCGATCTGCAACGAGGTTACTGA

Upstream 100 bases:

>100_bases
GCGCACCTCTGGCCCGGACCGCACTGAAACCCGTCACCGCGCGCATCAGCGCCCCCTGCTACACTCCTTGACGTATACGT
CAACCACCACGCGGCGCCCC

Downstream 100 bases:

>100_bases
GATGACGTTCCCGCATTTTGTGAAGGTAGTCGAGGTCGGCCCGCGCGACGGCCTGCAGAACGAGAAGTCGCCGGTGTCCA
CCGAGGCCAAGGTGGAGCTG

Product: 2-hydroxyacid dehydrogenase oxidoreductase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MHIQIYTPDGKPQPWLDGFAQALPGARLSVWTQGAAHDADYAVVWQPPADMLRGRTDLRAVFNLGAGVDAILGLLAQSPD
ALPESVPIVRLDDAGMASQMSEYVTHAVLRFFRRLDEYERLQQAKIWRFLKPFDRDAFVVGVLGLGVLGTHIARTLAGFG
FPVRGWSRSAKSVEGIDCRAGADALPGFLAGTRVLINVLPLTADTENVLDAALFDQLEAGAYLVNVARGKHLVEDDLLAA
VARGQIAGAALDVFRTEPLPADHPFWTEPRIRITPHISALTLREVSIAQIARKIRALEAGEPIAGIVDLQRGY

Sequences:

>Translated_313_residues
MHIQIYTPDGKPQPWLDGFAQALPGARLSVWTQGAAHDADYAVVWQPPADMLRGRTDLRAVFNLGAGVDAILGLLAQSPD
ALPESVPIVRLDDAGMASQMSEYVTHAVLRFFRRLDEYERLQQAKIWRFLKPFDRDAFVVGVLGLGVLGTHIARTLAGFG
FPVRGWSRSAKSVEGIDCRAGADALPGFLAGTRVLINVLPLTADTENVLDAALFDQLEAGAYLVNVARGKHLVEDDLLAA
VARGQIAGAALDVFRTEPLPADHPFWTEPRIRITPHISALTLREVSIAQIARKIRALEAGEPIAGIVDLQRGY
>Mature_313_residues
MHIQIYTPDGKPQPWLDGFAQALPGARLSVWTQGAAHDADYAVVWQPPADMLRGRTDLRAVFNLGAGVDAILGLLAQSPD
ALPESVPIVRLDDAGMASQMSEYVTHAVLRFFRRLDEYERLQQAKIWRFLKPFDRDAFVVGVLGLGVLGTHIARTLAGFG
FPVRGWSRSAKSVEGIDCRAGADALPGFLAGTRVLINVLPLTADTENVLDAALFDQLEAGAYLVNVARGKHLVEDDLLAA
VARGQIAGAALDVFRTEPLPADHPFWTEPRIRITPHISALTLREVSIAQIARKIRALEAGEPIAGIVDLQRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=222, Percent_Identity=29.7297297297297, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI23308577, Length=270, Percent_Identity=27.4074074074074, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87081824, Length=313, Percent_Identity=47.6038338658147, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI87082289, Length=247, Percent_Identity=28.7449392712551, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=231, Percent_Identity=26.4069264069264, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574286, Length=173, Percent_Identity=34.1040462427746, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45552429, Length=175, Percent_Identity=33.7142857142857, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585514, Length=175, Percent_Identity=33.7142857142857, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574282, Length=175, Percent_Identity=33.7142857142857, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574284, Length=175, Percent_Identity=33.7142857142857, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551003, Length=175, Percent_Identity=33.7142857142857, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585516, Length=299, Percent_Identity=26.4214046822742, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28571528, Length=174, Percent_Identity=29.8850574712644, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34024; Mature: 34024

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIQIYTPDGKPQPWLDGFAQALPGARLSVWTQGAAHDADYAVVWQPPADMLRGRTDLRA
CEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCHHHHCCCHHHHH
VFNLGAGVDAILGLLAQSPDALPESVPIVRLDDAGMASQMSEYVTHAVLRFFRRLDEYER
HHHCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQQAKIWRFLKPFDRDAFVVGVLGLGVLGTHIARTLAGFGFPVRGWSRSAKSVEGIDCRA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GADALPGFLAGTRVLINVLPLTADTENVLDAALFDQLEAGAYLVNVARGKHLVEDDLLAA
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
VARGQIAGAALDVFRTEPLPADHPFWTEPRIRITPHISALTLREVSIAQIARKIRALEAG
HHHCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
EPIAGIVDLQRGY
CCCCHHHCCCCCC
>Mature Secondary Structure
MHIQIYTPDGKPQPWLDGFAQALPGARLSVWTQGAAHDADYAVVWQPPADMLRGRTDLRA
CEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCHHHHCCCHHHHH
VFNLGAGVDAILGLLAQSPDALPESVPIVRLDDAGMASQMSEYVTHAVLRFFRRLDEYER
HHHCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQQAKIWRFLKPFDRDAFVVGVLGLGVLGTHIARTLAGFGFPVRGWSRSAKSVEGIDCRA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GADALPGFLAGTRVLINVLPLTADTENVLDAALFDQLEAGAYLVNVARGKHLVEDDLLAA
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
VARGQIAGAALDVFRTEPLPADHPFWTEPRIRITPHISALTLREVSIAQIARKIRALEAG
HHHCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
EPIAGIVDLQRGY
CCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA