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The map label for this gene is dehH [C]

Identifier: 17544975

GI number: 17544975

Start: 288087

End: 289013

Strand: Direct

Name: dehH [C]

Synonym: RSc0256

Alternate gene names: 17544975

Gene position: 288087-289013 (Clockwise)

Preceding gene: 17544972

Following gene: 17544976

Centisome position: 7.75

GC content: 70.87

Gene sequence:

>927_bases
ATGACAGCATCGCCCACCCTCGAAGTCGCGATCGCCGCCGCCGACCGAGCCCTGTTCCCCGGCTTCCGCCCATTCAGGCA
AGCGGCCAACGGCGTGGAGATCGCCGGGGTCATCGGCGGAAGCGGCCCGCCGCTGCTGTTGCTGCACGGGCATCCGCAGA
GCCACGTGATCTGGCACAAGGTGGCGCGCGAGCTGGCCCGCGAGCACACCGTGGTCGCCACCGACCTGCGCGGCTACGGC
GCCTCGTCCAAGCCGGCCGGCAGCGCCACGCACGTCGAGTACAGCAAGCGCGCGATGGCGCAGGATCAGGTGGACGTCAT
GCGCGCGCTCGGCTTCGAGCGCTTCGGCCTGTGCGCCCACGATCGCGGCGCGCGTGTCGCCCATCGCTTGTGCGTCGATC
ATGCCGGGCGCGTCGAGCGCGCGATGCTGCTCGACATCGCCCCCACGCTGGCGATGTACGAACAGACCAACATGGCCTTC
GCCGCCGCCTACTGGCACTGGTTCTTCCTGATCCAGCCGGCGCCGTTTCCCGAGACGCTCATCCATGCCACGCCCGATTT
CTACATCGGCAAGCTGATGGGGCTGCGGCATGCCGGCCTTGCGCCCTTCGCGCCGGAAGCCATGGCCGCCTATGCCGCCG
CCATGCGCGAACCGGCCTGCGTGCACGCCATGTGCGAGGACTACCGCGCCGCCGCCACCATCGACCTGGAGCACGATCGC
GCCGACCGCGCGGCCGGCCGACGCATCGCGGTGCCGCTGCGCGTGCTGTGGGGGCAGCATGGCGTGATCCAGCGGTGCTT
CGAGCCTCTGGCGCTGTGGCGCGCTGTGGCCGAGGACGTCAGCGGCGGCACGGTGCCGTGCGGGCACTATGTGCCGGAGG
AGGCGCCGGACGCATTGCTGGCGGAGATGCGGGCGTTTTTCGGCTGA

Upstream 100 bases:

>100_bases
GGCCGGACGGCATCCGCCGGGCGCCAACATGCATGCCGGCGCTGCGCTAGCATGCGAACGATCCCTCATATCGCCGCATC
CCACCCGCCGGGAGACCCGC

Downstream 100 bases:

>100_bases
GGTGGTCAGTCGGGGGCGACCTCGCTGCTGCGTTTTGCGTGCCGTGTTTTCGGGGGGGCGGACGGGGGCGGAGCGCCCGC
CATGGGACCATGGGGCGCCA

Product: haloacetate dehalogenase H-1 protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTASPTLEVAIAAADRALFPGFRPFRQAANGVEIAGVIGGSGPPLLLLHGHPQSHVIWHKVARELAREHTVVATDLRGYG
ASSKPAGSATHVEYSKRAMAQDQVDVMRALGFERFGLCAHDRGARVAHRLCVDHAGRVERAMLLDIAPTLAMYEQTNMAF
AAAYWHWFFLIQPAPFPETLIHATPDFYIGKLMGLRHAGLAPFAPEAMAAYAAAMREPACVHAMCEDYRAAATIDLEHDR
ADRAAGRRIAVPLRVLWGQHGVIQRCFEPLALWRAVAEDVSGGTVPCGHYVPEEAPDALLAEMRAFFG

Sequences:

>Translated_308_residues
MTASPTLEVAIAAADRALFPGFRPFRQAANGVEIAGVIGGSGPPLLLLHGHPQSHVIWHKVARELAREHTVVATDLRGYG
ASSKPAGSATHVEYSKRAMAQDQVDVMRALGFERFGLCAHDRGARVAHRLCVDHAGRVERAMLLDIAPTLAMYEQTNMAF
AAAYWHWFFLIQPAPFPETLIHATPDFYIGKLMGLRHAGLAPFAPEAMAAYAAAMREPACVHAMCEDYRAAATIDLEHDR
ADRAAGRRIAVPLRVLWGQHGVIQRCFEPLALWRAVAEDVSGGTVPCGHYVPEEAPDALLAEMRAFFG
>Mature_307_residues
TASPTLEVAIAAADRALFPGFRPFRQAANGVEIAGVIGGSGPPLLLLHGHPQSHVIWHKVARELAREHTVVATDLRGYGA
SSKPAGSATHVEYSKRAMAQDQVDVMRALGFERFGLCAHDRGARVAHRLCVDHAGRVERAMLLDIAPTLAMYEQTNMAFA
AAYWHWFFLIQPAPFPETLIHATPDFYIGKLMGLRHAGLAPFAPEAMAAYAAAMREPACVHAMCEDYRAAATIDLEHDRA
DRAAGRRIAVPLRVLWGQHGVIQRCFEPLALWRAVAEDVSGGTVPCGHYVPEEAPDALLAEMRAFFG

Specific function: Catalyzes the hydrolytic defluorination of fluoroacetate to produce glycolate. Has low activity towards chloroacetate [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=296, Percent_Identity=26.0135135135135, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI13376164, Length=296, Percent_Identity=26.0135135135135, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI218777837, Length=233, Percent_Identity=25.3218884120172, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562298, Length=195, Percent_Identity=24.6153846153846, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.3 [H]

Molecular weight: Translated: 33547; Mature: 33416

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASPTLEVAIAAADRALFPGFRPFRQAANGVEIAGVIGGSGPPLLLLHGHPQSHVIWHK
CCCCCCEEEEEEECCHHHCCCCHHHHHHCCCEEEEEEECCCCCCEEEEECCCCCHHHHHH
VARELAREHTVVATDLRGYGASSKPAGSATHVEYSKRAMAQDQVDVMRALGFERFGLCAH
HHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCC
DRGARVAHRLCVDHAGRVERAMLLDIAPTLAMYEQTNMAFAAAYWHWFFLIQPAPFPETL
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEEECCCCCCHHH
IHATPDFYIGKLMGLRHAGLAPFAPEAMAAYAAAMREPACVHAMCEDYRAAATIDLEHDR
HHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCH
ADRAAGRRIAVPLRVLWGQHGVIQRCFEPLALWRAVAEDVSGGTVPCGHYVPEEAPDALL
HHHHCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
AEMRAFFG
HHHHHHCC
>Mature Secondary Structure 
TASPTLEVAIAAADRALFPGFRPFRQAANGVEIAGVIGGSGPPLLLLHGHPQSHVIWHK
CCCCCEEEEEEECCHHHCCCCHHHHHHCCCEEEEEEECCCCCCEEEEECCCCCHHHHHH
VARELAREHTVVATDLRGYGASSKPAGSATHVEYSKRAMAQDQVDVMRALGFERFGLCAH
HHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCC
DRGARVAHRLCVDHAGRVERAMLLDIAPTLAMYEQTNMAFAAAYWHWFFLIQPAPFPETL
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEEECCCCCCHHH
IHATPDFYIGKLMGLRHAGLAPFAPEAMAAYAAAMREPACVHAMCEDYRAAATIDLEHDR
HHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCH
ADRAAGRRIAVPLRVLWGQHGVIQRCFEPLALWRAVAEDVSGGTVPCGHYVPEEAPDALL
HHHHCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
AEMRAFFG
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA