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The map label for this gene is 17544920

Identifier: 17544920

GI number: 17544920

Start: 223245

End: 224603

Strand: Direct

Name: 17544920

Synonym: RSc0201

Alternate gene names: NA

Gene position: 223245-224603 (Clockwise)

Preceding gene: 17544919

Following gene: 17544921

Centisome position: 6.01

GC content: 64.68

Gene sequence:

>1359_bases
GTGCAGTTGCAGTTTCTCGGGGCCACCGAAACGGTGACCGGCTCGAAATACGTGCTGGAGACCGGTGCGCGTCGCGTGAT
GGTCGACTGCGGGCTGTTCCAGGGTTACAAGTCATTGCGACTGCGCAACTGGGACACGCTGGCCGTCAACCCGCACCACA
TTGATGCCGTCGTTCTCACGCATGCCCACATCGATCACAGCGGCTACTTGCCGCTGCTGGTCCGCAATGGCTTTCGGGGT
CCCGTCTACTGCACGAAGGGCACGGCCGAGCTGTGCAACATCCTGTTGCCGGACAGCGCGCGGCTCGCTGTTGAAGATGC
CCAGTACGCCAATGCGCAGGGTTTCTCGCGCCACCATCCCGCCTTGCCCCTCTACGACGAGCAAGACGCCGCCAAGGCGT
TGCGCAGACTTCATCCGGTGGGCTATGGGGAGCGCTTCTCCGTGGTCGATGGGGTCGAGGCGGAGTTTCACCGTGCCGGG
CACATCATTGGCGCGGCCACGGTGACGTTGTTGGCAGAGGGGCGACGCACCGTCTTCTCGGGCGATTTGGGAAGACAGGT
CGATCCCGTCATGCGGCCGCCCGAACCTGTGGCCGAGGCCGATACCCTGCTGGTCGAGTCCACGTATGGGGATCGATTGC
ATCCACCGGGTGATCCGCTCGATGAACTCGAGCGCATCGTGCACCGAACCATCGAGCAGGGGGGCACGCTGCTGATTCCG
GCCTTTGCCGTCGGTCGCACACAGGCGCTGCTGTTCTGCCTTTACACGTTGATCCGCACCCACCGGATTCCCCACGTGCC
GATCTACCTTGACAGCCCAATGGCCGAGCGCGCCACCGAGGTGTTTGCCCGCCACGTTGAGGAACTGCATATCGATGCAG
CGGACTGCCAGGCGGCCTGCGCTCTGGCGGTTCCGGTGCAAAGCCCGCAGCAGTCGATGCACCTGGGCAACGATCGCGCG
CCGAAGATCATTCTTGCGGCCAGTGGCATGGCCACGGGCGGTCGCGTTCTGCATCACCTCAAGAGCTTCGGCGGTGGCAA
GCGCAACGCCATCCTGATGTCAGGGTTTCAGGCTGCCGGCACGCGCGGGGCAGCGCTGCTGGCGGGGCAGCGACAATTGC
GCGTGCATGGTCGCGAGATTGCGATTCGTGCCACGGTTGAACAGATCGCCAATCTCTCCGCCCACGCCGACGCCAACGAG
CTGATGGCGTGGCTGCGCGGATTCTCACGCGCACCGGAGCAGACGTTCATCGTCCACGGCGAACCGGCGGCCAGCGACGC
CTTGCGCCAGCGCATCGAACGCGAGTTGCAGTGGCCGGTGCGCATGCCTGAGTACCGGCAGTCCTATGCGCTGAGCTGA

Upstream 100 bases:

>100_bases
GGAAGCGACTTACGAGAGCGGGCTGCTGCGCGTGACACTGCCCAAGAAGGAAGTCTCGCCGCAGCAACGCATCACCATTC
GCTGAGCACGGGAGCGGCAC

Downstream 100 bases:

>100_bases
GCATGGGCCCCCTGACGCCAGCTTGCACGGTCAACGGCAACGCACAAAGGCGCGTCGTCCTTGCCTTGCCAGGCAACCAG
GCTGCAGCCGCAAGACTGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MQLQFLGATETVTGSKYVLETGARRVMVDCGLFQGYKSLRLRNWDTLAVNPHHIDAVVLTHAHIDHSGYLPLLVRNGFRG
PVYCTKGTAELCNILLPDSARLAVEDAQYANAQGFSRHHPALPLYDEQDAAKALRRLHPVGYGERFSVVDGVEAEFHRAG
HIIGAATVTLLAEGRRTVFSGDLGRQVDPVMRPPEPVAEADTLLVESTYGDRLHPPGDPLDELERIVHRTIEQGGTLLIP
AFAVGRTQALLFCLYTLIRTHRIPHVPIYLDSPMAERATEVFARHVEELHIDAADCQAACALAVPVQSPQQSMHLGNDRA
PKIILAASGMATGGRVLHHLKSFGGGKRNAILMSGFQAAGTRGAALLAGQRQLRVHGREIAIRATVEQIANLSAHADANE
LMAWLRGFSRAPEQTFIVHGEPAASDALRQRIERELQWPVRMPEYRQSYALS

Sequences:

>Translated_452_residues
MQLQFLGATETVTGSKYVLETGARRVMVDCGLFQGYKSLRLRNWDTLAVNPHHIDAVVLTHAHIDHSGYLPLLVRNGFRG
PVYCTKGTAELCNILLPDSARLAVEDAQYANAQGFSRHHPALPLYDEQDAAKALRRLHPVGYGERFSVVDGVEAEFHRAG
HIIGAATVTLLAEGRRTVFSGDLGRQVDPVMRPPEPVAEADTLLVESTYGDRLHPPGDPLDELERIVHRTIEQGGTLLIP
AFAVGRTQALLFCLYTLIRTHRIPHVPIYLDSPMAERATEVFARHVEELHIDAADCQAACALAVPVQSPQQSMHLGNDRA
PKIILAASGMATGGRVLHHLKSFGGGKRNAILMSGFQAAGTRGAALLAGQRQLRVHGREIAIRATVEQIANLSAHADANE
LMAWLRGFSRAPEQTFIVHGEPAASDALRQRIERELQWPVRMPEYRQSYALS
>Mature_452_residues
MQLQFLGATETVTGSKYVLETGARRVMVDCGLFQGYKSLRLRNWDTLAVNPHHIDAVVLTHAHIDHSGYLPLLVRNGFRG
PVYCTKGTAELCNILLPDSARLAVEDAQYANAQGFSRHHPALPLYDEQDAAKALRRLHPVGYGERFSVVDGVEAEFHRAG
HIIGAATVTLLAEGRRTVFSGDLGRQVDPVMRPPEPVAEADTLLVESTYGDRLHPPGDPLDELERIVHRTIEQGGTLLIP
AFAVGRTQALLFCLYTLIRTHRIPHVPIYLDSPMAERATEVFARHVEELHIDAADCQAACALAVPVQSPQQSMHLGNDRA
PKIILAASGMATGGRVLHHLKSFGGGKRNAILMSGFQAAGTRGAALLAGQRQLRVHGREIAIRATVEQIANLSAHADANE
LMAWLRGFSRAPEQTFIVHGEPAASDALRQRIERELQWPVRMPEYRQSYALS

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=462, Percent_Identity=27.7056277056277, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI7706427, Length=445, Percent_Identity=26.9662921348315, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32564696, Length=463, Percent_Identity=25.9179265658747, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI32566029, Length=444, Percent_Identity=27.4774774774775, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323307, Length=431, Percent_Identity=27.3781902552204, Blast_Score=145, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24648013, Length=450, Percent_Identity=27.1111111111111, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI21358523, Length=471, Percent_Identity=26.7515923566879, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 49614; Mature: 49614

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLQFLGATETVTGSKYVLETGARRVMVDCGLFQGYKSLRLRNWDTLAVNPHHIDAVVLT
CEEEEECCCCCCCCCHHEECCCCCEEEEEHHHHHHHHHHEECCCCEEEECCCCCEEEEEE
HAHIDHSGYLPLLVRNGFRGPVYCTKGTAELCNILLPDSARLAVEDAQYANAQGFSRHHP
EEEECCCCCCEEEEECCCCCCEEEECCHHHHHHEECCCCCCEEECCCHHCCCCCCCCCCC
ALPLYDEQDAAKALRRLHPVGYGERFSVVDGVEAEFHRAGHIIGAATVTLLAEGRRTVFS
CCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEC
GDLGRQVDPVMRPPEPVAEADTLLVESTYGDRLHPPGDPLDELERIVHRTIEQGGTLLIP
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
AFAVGRTQALLFCLYTLIRTHRIPHVPIYLDSPMAERATEVFARHVEELHIDAADCQAAC
EHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHCEE
ALAVPVQSPQQSMHLGNDRAPKIILAASGMATGGRVLHHLKSFGGGKRNAILMSGFQAAG
EEEECCCCCHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCHHCC
TRGAALLAGQRQLRVHGREIAIRATVEQIANLSAHADANELMAWLRGFSRAPEQTFIVHG
CCCEEEEECCCEEEECCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
EPAASDALRQRIERELQWPVRMPEYRQSYALS
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MQLQFLGATETVTGSKYVLETGARRVMVDCGLFQGYKSLRLRNWDTLAVNPHHIDAVVLT
CEEEEECCCCCCCCCHHEECCCCCEEEEEHHHHHHHHHHEECCCCEEEECCCCCEEEEEE
HAHIDHSGYLPLLVRNGFRGPVYCTKGTAELCNILLPDSARLAVEDAQYANAQGFSRHHP
EEEECCCCCCEEEEECCCCCCEEEECCHHHHHHEECCCCCCEEECCCHHCCCCCCCCCCC
ALPLYDEQDAAKALRRLHPVGYGERFSVVDGVEAEFHRAGHIIGAATVTLLAEGRRTVFS
CCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEC
GDLGRQVDPVMRPPEPVAEADTLLVESTYGDRLHPPGDPLDELERIVHRTIEQGGTLLIP
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
AFAVGRTQALLFCLYTLIRTHRIPHVPIYLDSPMAERATEVFARHVEELHIDAADCQAAC
EHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHCEE
ALAVPVQSPQQSMHLGNDRAPKIILAASGMATGGRVLHHLKSFGGGKRNAILMSGFQAAG
EEEECCCCCHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCHHCC
TRGAALLAGQRQLRVHGREIAIRATVEQIANLSAHADANELMAWLRGFSRAPEQTFIVHG
CCCEEEEECCCEEEECCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
EPAASDALRQRIERELQWPVRMPEYRQSYALS
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA