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The map label for this gene is prs [H]

Identifier: 17544921

GI number: 17544921

Start: 224606

End: 225568

Strand: Direct

Name: prs [H]

Synonym: RSc0202

Alternate gene names: 17544921

Gene position: 224606-225568 (Clockwise)

Preceding gene: 17544920

Following gene: 17544922

Centisome position: 6.04

GC content: 62.62

Gene sequence:

>963_bases
ATGGGCCCCCTGACGCCAGCTTGCACGGTCAACGGCAACGCACAAAGGCGCGTCGTCCTTGCCTTGCCAGGCAACCAGGC
TGCAGCCGCAAGACTGGCAGCGCCACTGGCTGCCGAGATCGGGCAAGCCGAGATGAAGCGTTTTCCAGATGGTGAATTCC
ACGTGCGGTTGCAAACGCCGGTGTGCGACGCCGAGGTCGCCATCGTCTGCACGCTAGACCGGCCAGACGAGAAGGTCTTG
CCGCTGCTGTGGCTTGCCATTGCAGCTCATCAAGGTGGGGCGCGCCGCGTTGGGCTGGTCGCACCTTACCTGGCCTATAT
GCGGCAGGACGCCATTTTTCAGTCGGGCGAGATATGTGCAGCACGTCACTTTGCTGAGCTGCTGACGCGGTACTTCGATT
GGCTGGTTGCAGTCGATCCGCACCTGCATCGCATTCCGGAACTGTCGGACATCTATGGCATGCCAGTAACCGTTGCACAG
GCGGCTCCGGCCATGGCTGCTTGGGTGCGGGCCCATGTCAGCGATCCGCTGTTTATCGGCCCTGATGACGAAAGCCGGCA
GTGGGTCGAGCACGTGGCAGGCCTGTGCAGCGCCCCCTGGACTGTCCTGAGCAAGACACGCTACAGCGCGTGGGACGTGG
CGGTGTCGGCTATCGGATCCAATCCGCGCTCGCAGCACACGCCCGTCTTGATCGACGACATCATTTCCACCGGGCGAACC
CTAATCGCGGCAGCTCACCAGTTGCATAGTGCGGGGCTGCGACGTCCATTGTGCGTGGCGGTCCATGCCGTGTTTGCCAC
CGACGCCTACAGCGAACTGAGTGCCGTGGCCGCCGACGTGATCACCTGCGACACCATCGCTCACCCGTCCAACCGCATTG
CGCTGTCGGAACCCGTTGCAGCTGCGATTTCGACCATGTTTGATCTACCTCTGCCCGCGGCTATTCAGCGCCTTGCTCGG
TAA

Upstream 100 bases:

>100_bases
AACCGGCGGCCAGCGACGCCTTGCGCCAGCGCATCGAACGCGAGTTGCAGTGGCCGGTGCGCATGCCTGAGTACCGGCAG
TCCTATGCGCTGAGCTGAGC

Downstream 100 bases:

>100_bases
CGGCTGGATTTCTACGCTGACGATGGCAAGACCCCAACCCGAGAGACGCATCATGAAACAGATCGAGTTTCCAACCGGTG
AACCAACCTATTGCGCGACT

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MGPLTPACTVNGNAQRRVVLALPGNQAAAARLAAPLAAEIGQAEMKRFPDGEFHVRLQTPVCDAEVAIVCTLDRPDEKVL
PLLWLAIAAHQGGARRVGLVAPYLAYMRQDAIFQSGEICAARHFAELLTRYFDWLVAVDPHLHRIPELSDIYGMPVTVAQ
AAPAMAAWVRAHVSDPLFIGPDDESRQWVEHVAGLCSAPWTVLSKTRYSAWDVAVSAIGSNPRSQHTPVLIDDIISTGRT
LIAAAHQLHSAGLRRPLCVAVHAVFATDAYSELSAVAADVITCDTIAHPSNRIALSEPVAAAISTMFDLPLPAAIQRLAR

Sequences:

>Translated_320_residues
MGPLTPACTVNGNAQRRVVLALPGNQAAAARLAAPLAAEIGQAEMKRFPDGEFHVRLQTPVCDAEVAIVCTLDRPDEKVL
PLLWLAIAAHQGGARRVGLVAPYLAYMRQDAIFQSGEICAARHFAELLTRYFDWLVAVDPHLHRIPELSDIYGMPVTVAQ
AAPAMAAWVRAHVSDPLFIGPDDESRQWVEHVAGLCSAPWTVLSKTRYSAWDVAVSAIGSNPRSQHTPVLIDDIISTGRT
LIAAAHQLHSAGLRRPLCVAVHAVFATDAYSELSAVAADVITCDTIAHPSNRIALSEPVAAAISTMFDLPLPAAIQRLAR
>Mature_319_residues
GPLTPACTVNGNAQRRVVLALPGNQAAAARLAAPLAAEIGQAEMKRFPDGEFHVRLQTPVCDAEVAIVCTLDRPDEKVLP
LLWLAIAAHQGGARRVGLVAPYLAYMRQDAIFQSGEICAARHFAELLTRYFDWLVAVDPHLHRIPELSDIYGMPVTVAQA
APAMAAWVRAHVSDPLFIGPDDESRQWVEHVAGLCSAPWTVLSKTRYSAWDVAVSAIGSNPRSQHTPVLIDDIISTGRTL
IAAAHQLHSAGLRRPLCVAVHAVFATDAYSELSAVAADVITCDTIAHPSNRIALSEPVAAAISTMFDLPLPAAIQRLAR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=275, Percent_Identity=25.0909090909091, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI84875539, Length=278, Percent_Identity=25.1798561151079, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4506127, Length=274, Percent_Identity=25.5474452554745, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI28557709, Length=276, Percent_Identity=25.7246376811594, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787458, Length=264, Percent_Identity=28.030303030303, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25149168, Length=296, Percent_Identity=24.6621621621622, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554704, Length=296, Percent_Identity=24.6621621621622, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17554702, Length=296, Percent_Identity=24.6621621621622, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71989924, Length=296, Percent_Identity=24.6621621621622, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321776, Length=260, Percent_Identity=23.4615384615385, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319403, Length=262, Percent_Identity=22.9007633587786, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355239, Length=264, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551540, Length=290, Percent_Identity=22.7586206896552, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34384; Mature: 34253

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPLTPACTVNGNAQRRVVLALPGNQAAAARLAAPLAAEIGQAEMKRFPDGEFHVRLQTP
CCCCCCCEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECC
VCDAEVAIVCTLDRPDEKVLPLLWLAIAAHQGGARRVGLVAPYLAYMRQDAIFQSGEICA
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
ARHFAELLTRYFDWLVAVDPHLHRIPELSDIYGMPVTVAQAAPAMAAWVRAHVSDPLFIG
HHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEC
PDDESRQWVEHVAGLCSAPWTVLSKTRYSAWDVAVSAIGSNPRSQHTPVLIDDIISTGRT
CCCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHH
LIAAAHQLHSAGLRRPLCVAVHAVFATDAYSELSAVAADVITCDTIAHPSNRIALSEPVA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHH
AAISTMFDLPLPAAIQRLAR
HHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure 
GPLTPACTVNGNAQRRVVLALPGNQAAAARLAAPLAAEIGQAEMKRFPDGEFHVRLQTP
CCCCCCEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECC
VCDAEVAIVCTLDRPDEKVLPLLWLAIAAHQGGARRVGLVAPYLAYMRQDAIFQSGEICA
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
ARHFAELLTRYFDWLVAVDPHLHRIPELSDIYGMPVTVAQAAPAMAAWVRAHVSDPLFIG
HHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEC
PDDESRQWVEHVAGLCSAPWTVLSKTRYSAWDVAVSAIGSNPRSQHTPVLIDDIISTGRT
CCCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHH
LIAAAHQLHSAGLRRPLCVAVHAVFATDAYSELSAVAADVITCDTIAHPSNRIALSEPVA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHH
AAISTMFDLPLPAAIQRLAR
HHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]