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The map label for this gene is nrdZ [H]

Identifier: 17544914

GI number: 17544914

Start: 216164

End: 218017

Strand: Direct

Name: nrdZ [H]

Synonym: RSc0195

Alternate gene names: 17544914

Gene position: 216164-218017 (Clockwise)

Preceding gene: 17544913

Following gene: 17544915

Centisome position: 5.82

GC content: 63.48

Gene sequence:

>1854_bases
ATGCGACGTCGGCTGCGCGGCACGCCGGGGATGTGGATGCAGGCTGGGATGCTGACCGAGCCGGAAGAGTTGTCGCCCGT
CTGCGCTGCTGTGCTGGCGGATCGCTATCTTGCTCCCGGAGAGACGACGCCCGAACAGGTCTTCAGACGGGTCGCGCACG
CGCTGGCAGCCGCAGAGGCACCAGACCGGCGCACGCATTTTGCGCGTTTGTTCTACGTCAACATGCTGCACGGCGCCATC
GGAGCGGGGCGCATCATGGCGAATGCTGGCGTGGACAGACAGGCCACGATGGTGAATTGCTTCGTTCATCCCATCGTTGG
CCCCGGCGCGCAGGTGGCAGGCGCTGCCGACATCGACCGGGCATTGAAGCAGGCACAAGTCACTCTGCGCATGGGCGGCG
GCGTGGGCTACGACTTCTCGGCCGTTGCCCCAATGGATGCACTGCAAACGGGGGAAGACGGCGGGACCGGTAGCGTCTGC
GAAGTCATCGAGCGTTTCGACCACACTTGCGCGGCGCTTGCACTGGCCAACACTCGCGGTGGCGCGCAGATGGCCGTGCT
GCGCTGTAACCATCCGGACCTTGCCGCATTCGTCGCGGCAAAACGTGGGCGCAAGCGCTGGACGACCTTCAACGTATCGG
TTGCCGTCACGGACGCCTTCATGCAGGCGGTCGCCGATGATGCACAGTGGCGCTTACAACATCGTGCCGAGCCTAGTGCA
CAGAGGCGCGCCGCCGGCGCCCACCTGCTGGACAACGGCCACTGGTGCTATGCAACGGTGCCCGCACGGCAACTGTGGGA
CATGCTTGTCGAAGCCGCGCATCACAGCGCCGAGCCTGGGCTGCTGTTCATCGACACGATCAACGCCGCCAACGACCTTG
CCGAACTCGAAACCATTGCCGCGACCAACCCTTGCGGCGAACAGCCTCTGCCGGCTTGGGGGAGTTGCGTGCTCGGCCCG
ATCAACCTGTCCAGATGGATCCAGCATCCGTTCGGAGTGGGCGGGCAGCCGATGTTCGACTTTGTCAGTTTTGGGCGAGC
GGTGCACATCCAGGTCCGGATGCTCGATAACGCGATCGACATCACGCGCTGGCCCTTGATCGAGCACATGAGGGAAGCCC
ACGCCAAACGCAGGATCGGCGTGGGTGTGACCGGTTTGGCCGATGCGCTGACGATGATGGGGCTGCCGTATCAAGCGCCC
GAGGCTCGGAACTTGGCTGTCCAGATCGGGCGATGCCTGCGCGATAACGCTTACGCGGCGTCTGCGGCGTTGGCGCAGGA
GCGCAGTCCGTATCCGCTGTTCCGAGCTGAGCGTAGCCTTGCACCGGGGCATTTCGTTGCCACGCTACCTGGAGCTGTGC
GCGAAACCATCGCGCGCCACGGATTACGCAATAGCCATCTGCTGTCTTTGGCGCCCACCGGCAGTGTGAGCTTGGCCTTT
GGCGGAAACTGCTCCAGTGGTATCGAACCCGCCTTCGACTGGGCGTATCAGCGGCGGGTGCGCATCCACCACGGCCAGCC
GCAGCTCTACCGAATTGAGAATCACGCTTACCGATGCTTTCAGGCGATGCACGGAGAGCATGCGGTATTGCCTAGCTACT
TTGTGACCGCAAACCAGGTCGACGGCGATGACCATCTGAAGATGGTCGCCGCGCTGCAGCCGTTCATCGATGCCTCGATC
TCAAAAACGATTCTCATTTCAGGCGGGGTGTCGCCAGCGCAGGTTGGGGCATTGCTCTTTCGAGCGTGGCAACTGCGGCT
CAAAGGCATCACGATCTTCCGGCCGGATCCCGCATCGGATGAGGTGCTTTCCGTGTTGCCGGCTGCCGATGGCCGGCCGG
TATGCTTCTGCTGA

Upstream 100 bases:

>100_bases
CCGGTTCAAGCTCGACGACATCCTCGCCGCCTACGACACATTCCGCAATGCGGGGGAAACGCATGCACTCAAGGTCATCA
TCGCCACGTAGGGTACTGAC

Downstream 100 bases:

>100_bases
GTGCGCCACGCCACTCTTCGCCAATGCCTTCCACGATTGTTCACCTGCCACGTTTTTACCGCCTCCGGAAATGGGGTTTC
ACACAAGGGCGGAAGTGGAG

Product: ribonucleotide reductase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MRRRLRGTPGMWMQAGMLTEPEELSPVCAAVLADRYLAPGETTPEQVFRRVAHALAAAEAPDRRTHFARLFYVNMLHGAI
GAGRIMANAGVDRQATMVNCFVHPIVGPGAQVAGAADIDRALKQAQVTLRMGGGVGYDFSAVAPMDALQTGEDGGTGSVC
EVIERFDHTCAALALANTRGGAQMAVLRCNHPDLAAFVAAKRGRKRWTTFNVSVAVTDAFMQAVADDAQWRLQHRAEPSA
QRRAAGAHLLDNGHWCYATVPARQLWDMLVEAAHHSAEPGLLFIDTINAANDLAELETIAATNPCGEQPLPAWGSCVLGP
INLSRWIQHPFGVGGQPMFDFVSFGRAVHIQVRMLDNAIDITRWPLIEHMREAHAKRRIGVGVTGLADALTMMGLPYQAP
EARNLAVQIGRCLRDNAYAASAALAQERSPYPLFRAERSLAPGHFVATLPGAVRETIARHGLRNSHLLSLAPTGSVSLAF
GGNCSSGIEPAFDWAYQRRVRIHHGQPQLYRIENHAYRCFQAMHGEHAVLPSYFVTANQVDGDDHLKMVAALQPFIDASI
SKTILISGGVSPAQVGALLFRAWQLRLKGITIFRPDPASDEVLSVLPAADGRPVCFC

Sequences:

>Translated_617_residues
MRRRLRGTPGMWMQAGMLTEPEELSPVCAAVLADRYLAPGETTPEQVFRRVAHALAAAEAPDRRTHFARLFYVNMLHGAI
GAGRIMANAGVDRQATMVNCFVHPIVGPGAQVAGAADIDRALKQAQVTLRMGGGVGYDFSAVAPMDALQTGEDGGTGSVC
EVIERFDHTCAALALANTRGGAQMAVLRCNHPDLAAFVAAKRGRKRWTTFNVSVAVTDAFMQAVADDAQWRLQHRAEPSA
QRRAAGAHLLDNGHWCYATVPARQLWDMLVEAAHHSAEPGLLFIDTINAANDLAELETIAATNPCGEQPLPAWGSCVLGP
INLSRWIQHPFGVGGQPMFDFVSFGRAVHIQVRMLDNAIDITRWPLIEHMREAHAKRRIGVGVTGLADALTMMGLPYQAP
EARNLAVQIGRCLRDNAYAASAALAQERSPYPLFRAERSLAPGHFVATLPGAVRETIARHGLRNSHLLSLAPTGSVSLAF
GGNCSSGIEPAFDWAYQRRVRIHHGQPQLYRIENHAYRCFQAMHGEHAVLPSYFVTANQVDGDDHLKMVAALQPFIDASI
SKTILISGGVSPAQVGALLFRAWQLRLKGITIFRPDPASDEVLSVLPAADGRPVCFC
>Mature_617_residues
MRRRLRGTPGMWMQAGMLTEPEELSPVCAAVLADRYLAPGETTPEQVFRRVAHALAAAEAPDRRTHFARLFYVNMLHGAI
GAGRIMANAGVDRQATMVNCFVHPIVGPGAQVAGAADIDRALKQAQVTLRMGGGVGYDFSAVAPMDALQTGEDGGTGSVC
EVIERFDHTCAALALANTRGGAQMAVLRCNHPDLAAFVAAKRGRKRWTTFNVSVAVTDAFMQAVADDAQWRLQHRAEPSA
QRRAAGAHLLDNGHWCYATVPARQLWDMLVEAAHHSAEPGLLFIDTINAANDLAELETIAATNPCGEQPLPAWGSCVLGP
INLSRWIQHPFGVGGQPMFDFVSFGRAVHIQVRMLDNAIDITRWPLIEHMREAHAKRRIGVGVTGLADALTMMGLPYQAP
EARNLAVQIGRCLRDNAYAASAALAQERSPYPLFRAERSLAPGHFVATLPGAVRETIARHGLRNSHLLSLAPTGSVSLAF
GGNCSSGIEPAFDWAYQRRVRIHHGQPQLYRIENHAYRCFQAMHGEHAVLPSYFVTANQVDGDDHLKMVAALQPFIDASI
SKTILISGGVSPAQVGALLFRAWQLRLKGITIFRPDPASDEVLSVLPAADGRPVCFC

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=566, Percent_Identity=25.0883392226148, Blast_Score=142, Evalue=9e-34,
Organism=Escherichia coli, GI2367133, Length=360, Percent_Identity=25, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555242, Length=606, Percent_Identity=24.9174917491749, Blast_Score=142, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6320914, Length=446, Percent_Identity=24.2152466367713, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322123, Length=552, Percent_Identity=24.4565217391304, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17352481, Length=542, Percent_Identity=23.6162361623616, Blast_Score=121, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 66827; Mature: 66827

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRLRGTPGMWMQAGMLTEPEELSPVCAAVLADRYLAPGETTPEQVFRRVAHALAAAEA
CCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
PDRRTHFARLFYVNMLHGAIGAGRIMANAGVDRQATMVNCFVHPIVGPGAQVAGAADIDR
CCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHEEEEEEECCCCCCCCCCCHHHHHH
ALKQAQVTLRMGGGVGYDFSAVAPMDALQTGEDGGTGSVCEVIERFDHTCAALALANTRG
HHHHHEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCC
GAQMAVLRCNHPDLAAFVAAKRGRKRWTTFNVSVAVTDAFMQAVADDAQWRLQHRAEPSA
CCEEEEEEECCCCHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHCCHHHHHHHCCCCCH
QRRAAGAHLLDNGHWCYATVPARQLWDMLVEAAHHSAEPGLLFIDTINAANDLAELETIA
HHHHCCCCEEECCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
ATNPCGEQPLPAWGSCVLGPINLSRWIQHPFGVGGQPMFDFVSFGRAVHIQVRMLDNAID
CCCCCCCCCCCCCCCEEECCCCHHHHHCCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCC
ITRWPLIEHMREAHAKRRIGVGVTGLADALTMMGLPYQAPEARNLAVQIGRCLRDNAYAA
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHH
SAALAQERSPYPLFRAERSLAPGHFVATLPGAVRETIARHGLRNSHLLSLAPTGSVSLAF
HHHHHHCCCCCCHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEECCCCCEEEEE
GGNCSSGIEPAFDWAYQRRVRIHHGQPQLYRIENHAYRCFQAMHGEHAVLPSYFVTANQV
CCCCCCCCCHHHHHHHHCEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCEEEEECCC
DGDDHLKMVAALQPFIDASISKTILISGGVSPAQVGALLFRAWQLRLKGITIFRPDPASD
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCH
EVLSVLPAADGRPVCFC
HHHHHHCCCCCCCEECC
>Mature Secondary Structure
MRRRLRGTPGMWMQAGMLTEPEELSPVCAAVLADRYLAPGETTPEQVFRRVAHALAAAEA
CCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
PDRRTHFARLFYVNMLHGAIGAGRIMANAGVDRQATMVNCFVHPIVGPGAQVAGAADIDR
CCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHEEEEEEECCCCCCCCCCCHHHHHH
ALKQAQVTLRMGGGVGYDFSAVAPMDALQTGEDGGTGSVCEVIERFDHTCAALALANTRG
HHHHHEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCC
GAQMAVLRCNHPDLAAFVAAKRGRKRWTTFNVSVAVTDAFMQAVADDAQWRLQHRAEPSA
CCEEEEEEECCCCHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHCCHHHHHHHCCCCCH
QRRAAGAHLLDNGHWCYATVPARQLWDMLVEAAHHSAEPGLLFIDTINAANDLAELETIA
HHHHCCCCEEECCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
ATNPCGEQPLPAWGSCVLGPINLSRWIQHPFGVGGQPMFDFVSFGRAVHIQVRMLDNAID
CCCCCCCCCCCCCCCEEECCCCHHHHHCCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCC
ITRWPLIEHMREAHAKRRIGVGVTGLADALTMMGLPYQAPEARNLAVQIGRCLRDNAYAA
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHH
SAALAQERSPYPLFRAERSLAPGHFVATLPGAVRETIARHGLRNSHLLSLAPTGSVSLAF
HHHHHHCCCCCCHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEECCCCCEEEEE
GGNCSSGIEPAFDWAYQRRVRIHHGQPQLYRIENHAYRCFQAMHGEHAVLPSYFVTANQV
CCCCCCCCCHHHHHHHHCEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCEEEEECCC
DGDDHLKMVAALQPFIDASISKTILISGGVSPAQVGALLFRAWQLRLKGITIFRPDPASD
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCH
EVLSVLPAADGRPVCFC
HHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]