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The map label for this gene is adh [H]

Identifier: 17544913

GI number: 17544913

Start: 215117

End: 216154

Strand: Direct

Name: adh [H]

Synonym: RSc0194

Alternate gene names: 17544913

Gene position: 215117-216154 (Clockwise)

Preceding gene: 17544911

Following gene: 17544914

Centisome position: 5.79

GC content: 62.14

Gene sequence:

>1038_bases
GTGAAAGCACTGGTCTATGAAGGTCCAGGCAAGATCTCGCTCGAGAACAAGCCGAAACCCGAACTGCAGGCGCCCGGCGA
CGCAGTGGTCCGCGTGACGTTGACCACGATCTGTGGCACCGATCTGCATATCATCAAGGGCGATGTCCCGACCTGTGAGC
CGGGCCGCACGCTTGGCCATGAAGGTGTTGGCGTGATCGAGTCAGTCGGGGCCGCCGTAACGTCTCTCAAGCCCGGTGAT
CACGTGCTGATCTCGTGTATTTCGTCCTGCGGGAAATGCGCGAATTGTCGGCGCGGCATGTATTCCCATTGCGAAACAGG
CGGCTGGATTCTCGGCCATCGCATCGATGGCGTGCAGGCCGAGTATGTGCGGGTACCGCACGCAGAAACCAGCCTGTACA
AGGTACCGCCGGGTGTTGATGAAGAGGCGCTGGTCATGCTGTCAGATATCTTCCCGACCGGCTTCGAATGCGGCGTCTTG
AACGGCCGAGTGCAGCCGGGCAGCACCGTGGCGATCGTCGGAGCAGGGCCCATCGGGCTGGCGTCGTTGCTGACGGCCCA
GTTCTATTCGCCCGCCCGGATCATCATGATCGATACCAACGTCGCGCGGCTGGAGGTGGCGAGCGGGCTGGGCGCAAGTG
ACTGCATCAACGTCACCCGTGAAAATGCTGCCGCCGCGGTAAAGCGGCTGACGGATGGCATGGGCGTCGACTGCGCAATC
GAGGCGGTCGGGGTACCTGCCACATTCGAACTGTGTCAGGAGCTGGTCGCGCCGGGCGGCGTGATCGCCAATATCGGCGT
GCATGGCGTAAAGGCCGACCTGCATCTGGAAACGCTGTGGAGCCAGAACATCGCCATCACCACGCGACTGGTCGACACGG
TCAGCACGCCGATGCTGTTGAAGACCGTGCGGGCAGGGAAACTCCTGCCGGGGCAACTCATCACGCACCGGTTCAAGCTC
GACGACATCCTCGCCGCCTACGACACATTCCGCAATGCGGGGGAAACGCATGCACTCAAGGTCATCATCGCCACGTAG

Upstream 100 bases:

>100_bases
CGCCAGAGGGATGGCTGATGCGCTGCTATCCTGTTTTAAATCAATAGCCGCTCAAGACCATTGCCTAGCATGAAATCATC
GGTCTCTTTTGGGGCACGCC

Downstream 100 bases:

>100_bases
GGTACTGACATGCGACGTCGGCTGCGCGGCACGCCGGGGATGTGGATGCAGGCTGGGATGCTGACCGAGCCGGAAGAGTT
GTCGCCCGTCTGCGCTGCTG

Product: zinc-dependent alcohol dehydrogenase oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKALVYEGPGKISLENKPKPELQAPGDAVVRVTLTTICGTDLHIIKGDVPTCEPGRTLGHEGVGVIESVGAAVTSLKPGD
HVLISCISSCGKCANCRRGMYSHCETGGWILGHRIDGVQAEYVRVPHAETSLYKVPPGVDEEALVMLSDIFPTGFECGVL
NGRVQPGSTVAIVGAGPIGLASLLTAQFYSPARIIMIDTNVARLEVASGLGASDCINVTRENAAAAVKRLTDGMGVDCAI
EAVGVPATFELCQELVAPGGVIANIGVHGVKADLHLETLWSQNIAITTRLVDTVSTPMLLKTVRAGKLLPGQLITHRFKL
DDILAAYDTFRNAGETHALKVIIAT

Sequences:

>Translated_345_residues
MKALVYEGPGKISLENKPKPELQAPGDAVVRVTLTTICGTDLHIIKGDVPTCEPGRTLGHEGVGVIESVGAAVTSLKPGD
HVLISCISSCGKCANCRRGMYSHCETGGWILGHRIDGVQAEYVRVPHAETSLYKVPPGVDEEALVMLSDIFPTGFECGVL
NGRVQPGSTVAIVGAGPIGLASLLTAQFYSPARIIMIDTNVARLEVASGLGASDCINVTRENAAAAVKRLTDGMGVDCAI
EAVGVPATFELCQELVAPGGVIANIGVHGVKADLHLETLWSQNIAITTRLVDTVSTPMLLKTVRAGKLLPGQLITHRFKL
DDILAAYDTFRNAGETHALKVIIAT
>Mature_345_residues
MKALVYEGPGKISLENKPKPELQAPGDAVVRVTLTTICGTDLHIIKGDVPTCEPGRTLGHEGVGVIESVGAAVTSLKPGD
HVLISCISSCGKCANCRRGMYSHCETGGWILGHRIDGVQAEYVRVPHAETSLYKVPPGVDEEALVMLSDIFPTGFECGVL
NGRVQPGSTVAIVGAGPIGLASLLTAQFYSPARIIMIDTNVARLEVASGLGASDCINVTRENAAAAVKRLTDGMGVDCAI
EAVGVPATFELCQELVAPGGVIANIGVHGVKADLHLETLWSQNIAITTRLVDTVSTPMLLKTVRAGKLLPGQLITHRFKL
DDILAAYDTFRNAGETHALKVIIAT

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=338, Percent_Identity=27.5147928994083, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=28.686327077748, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI34577061, Length=359, Percent_Identity=29.2479108635098, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=28.1501340482574, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4501939, Length=330, Percent_Identity=26.0606060606061, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI156523966, Length=330, Percent_Identity=26.0606060606061, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI71565154, Length=359, Percent_Identity=27.0194986072423, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI71743840, Length=236, Percent_Identity=31.3559322033898, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI262073058, Length=236, Percent_Identity=31.3559322033898, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI71565152, Length=340, Percent_Identity=25.8823529411765, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1786825, Length=388, Percent_Identity=29.1237113402062, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1787863, Length=346, Percent_Identity=28.0346820809249, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1790045, Length=330, Percent_Identity=29.0909090909091, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788073, Length=314, Percent_Identity=28.9808917197452, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87082125, Length=310, Percent_Identity=30.6451612903226, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786552, Length=352, Percent_Identity=31.8181818181818, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788407, Length=347, Percent_Identity=28.2420749279539, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788075, Length=358, Percent_Identity=25.9776536312849, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87081918, Length=234, Percent_Identity=33.7606837606838, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI226510992, Length=334, Percent_Identity=25.4491017964072, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790718, Length=322, Percent_Identity=24.5341614906832, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=338, Percent_Identity=29.585798816568, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=349, Percent_Identity=28.9398280802292, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71997431, Length=349, Percent_Identity=28.6532951289398, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17562876, Length=350, Percent_Identity=25.4285714285714, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=343, Percent_Identity=27.1137026239067, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=337, Percent_Identity=26.7062314540059, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=337, Percent_Identity=26.7062314540059, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=26.9541778975741, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=301, Percent_Identity=27.2425249169435, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=341, Percent_Identity=24.0469208211144, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=300, Percent_Identity=28.3333333333333, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=262, Percent_Identity=28.6259541984733, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=281, Percent_Identity=29.1814946619217, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=292, Percent_Identity=28.0821917808219, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=278, Percent_Identity=28.0575539568345, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137530, Length=346, Percent_Identity=29.7687861271676, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17737897, Length=348, Percent_Identity=30.4597701149425, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17737895, Length=331, Percent_Identity=29.0030211480363, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45550770, Length=333, Percent_Identity=22.5225225225225, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221457811, Length=333, Percent_Identity=22.5225225225225, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45551930, Length=333, Percent_Identity=22.5225225225225, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36232; Mature: 36232

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVYEGPGKISLENKPKPELQAPGDAVVRVTLTTICGTDLHIIKGDVPTCEPGRTLGH
CCEEEEECCCEEEECCCCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCC
EGVGVIESVGAAVTSLKPGDHVLISCISSCGKCANCRRGMYSHCETGGWILGHRIDGVQA
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEEECCCCE
EYVRVPHAETSLYKVPPGVDEEALVMLSDIFPTGFECGVLNGRVQPGSTVAIVGAGPIGL
EEEECCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHH
ASLLTAQFYSPARIIMIDTNVARLEVASGLGASDCINVTRENAAAAVKRLTDGMGVDCAI
HHHHHHHHCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
EAVGVPATFELCQELVAPGGVIANIGVHGVKADLHLETLWSQNIAITTRLVDTVSTPMLL
EEECCCHHHHHHHHHHCCCCEEEECCCEEEEEEEEEEEHHCCCEEEEEEHHHHHCCHHHH
KTVRAGKLLPGQLITHRFKLDDILAAYDTFRNAGETHALKVIIAT
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
>Mature Secondary Structure
MKALVYEGPGKISLENKPKPELQAPGDAVVRVTLTTICGTDLHIIKGDVPTCEPGRTLGH
CCEEEEECCCEEEECCCCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCC
EGVGVIESVGAAVTSLKPGDHVLISCISSCGKCANCRRGMYSHCETGGWILGHRIDGVQA
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEEECCCCE
EYVRVPHAETSLYKVPPGVDEEALVMLSDIFPTGFECGVLNGRVQPGSTVAIVGAGPIGL
EEEECCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHH
ASLLTAQFYSPARIIMIDTNVARLEVASGLGASDCINVTRENAAAAVKRLTDGMGVDCAI
HHHHHHHHCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
EAVGVPATFELCQELVAPGGVIANIGVHGVKADLHLETLWSQNIAITTRLVDTVSTPMLL
EEECCCHHHHHHHHHHCCCCEEEECCCEEEEEEEEEEEHHCCCEEEEEEHHHHHCCHHHH
KTVRAGKLLPGQLITHRFKLDDILAAYDTFRNAGETHALKVIIAT
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]