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The map label for this gene is degS [H]

Identifier: 17544910

GI number: 17544910

Start: 212253

End: 213629

Strand: Direct

Name: degS [H]

Synonym: RSc0191

Alternate gene names: 17544910

Gene position: 212253-213629 (Clockwise)

Preceding gene: 17544908

Following gene: 17544911

Centisome position: 5.71

GC content: 63.11

Gene sequence:

>1377_bases
ATGTTTGTGTTCATCTCAGCCTTTTTGGTGGCGTTTGTGGCGGGGCAAGACAGCCATTCCTCGAAGGCGTCGCGCAGGCG
CCTGTTGCTATCGCATTCCGCCCCGGCCGAGTTGGTGGCGGGCGGGCTGGCCATTCTGCTGCTGGCCGCATCGGTCGCAT
GGCTTGCTATAGCGTTTCAGGCCAGGGATGCGCCCTTTGTATTGCTGGCCCTGGCAAGTATTGCCGCTGTCCTGGCTCTC
GCCTTTTATTGGCTGCGGCTTCGCATGCTGCGCGCCGCTGTGGCGCGGGACTTGACCGACCTGGAGAAGAGCGAGGCTCG
GCTGGCGGGCATCATCCGCTCTTCCATGGAGGCGATCATTTCCGTGGACGATGCCCAGCGCATCGTGCTGTTCAATCCTA
TGGCGGAAACCCTGTTCGGATGCCCGGCCAATCACGCCATTGGCCGTCCGCTGTCCGACTTCATGCCGGAGCGGTTTCGC
GGCGCGCACGAAGCACACGTGCGGCGCTTTGGGGTGACCGGCGTATCGGAGCGTCAGATGGGCAAGCAGCGCCCGCTCTT
TGCTCTGCACGCGGATGGCCGTGAATTTCCAATCGAAGCCTCCATCTCGCAAATCGAGGTGAACGGCGGCAAGCTCTTTA
CCGTGATGCTGCGCGACACCACCGAGCGTGTCCGGGCGGAAGCGGCGCTGCGGCGCTCGCAGGAGGAGCTGCAGCATTTG
TCGGACAGCATTCTGGCTTCGCGGGAGGAGGAGCGGCATCGCATCGCCCGCGAGCTGCATGACGATCTGGGACAGCGCCT
GAGCGCGCTCAAGATGGATATCTCACTGCTGGCGGCGGATCTCCAGGCCGAAGGCGGCGACAGAACGCTGATCGCCCAGA
CGGAGGCCATGCAGCGAGTGATCGACGAGACGATCTCGGCGGTGCGGCAAATTTCCGCCGACCTTCGTCCACCGCTGCTC
GACGAGTTGGAGCTGGTACCGGCCATCGAGTGGATCGCCAAAAATTTCCGCCAGCGCTTCGGCTTGATCGTCAACGTGCA
CGCCCAGGAGATGCCGATGCAGGAGCGAGCGGCAATTTCTGTCTTTCGGATCGTGCAGGAAGCACTGAACAACGTGGTGC
GCCACGCCGATGCCACCCGCGTTGAGATCGAGTTTGTGCGGCTGGACGATATGCTCGAGTTGTCGATCCAGGATAACGGC
CGTGGTTGGAGCGGGGTACCACCGGCCCCGGGCGAGCGCAAGCCGCTGGGGTTGCTTGGTATTCGCGAGCGCGCGCGTCT
GCTAGGCGGCCAGGCCACGATCGCACACACGCCTGACAGCGGCTTTCGCTTGAGCGTACGTTTTCCCGCTACTCAAGAAG
TGACTGAGGAGACCTGA

Upstream 100 bases:

>100_bases
GATGCGCCGCGACACTGTCAGGGAACCCTGACAGCGACGCCGGGTTTTTCCTGGGGTGGCTTCATCACATGGCCAGTGTC
TCCAGTCGCCGGAATGGGCT

Downstream 100 bases:

>100_bases
TCATGATCCGCGTGATGATTGCCGACGATCACGCCGTGATGCGCGATGGCGTGCGCCATATTCTGGAGCGCGCCGGAGAT
TTCGAGGTTGCGTGCGAAGC

Product: transmembrane two component system sensor kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MFVFISAFLVAFVAGQDSHSSKASRRRLLLSHSAPAELVAGGLAILLLAASVAWLAIAFQARDAPFVLLALASIAAVLAL
AFYWLRLRMLRAAVARDLTDLEKSEARLAGIIRSSMEAIISVDDAQRIVLFNPMAETLFGCPANHAIGRPLSDFMPERFR
GAHEAHVRRFGVTGVSERQMGKQRPLFALHADGREFPIEASISQIEVNGGKLFTVMLRDTTERVRAEAALRRSQEELQHL
SDSILASREEERHRIARELHDDLGQRLSALKMDISLLAADLQAEGGDRTLIAQTEAMQRVIDETISAVRQISADLRPPLL
DELELVPAIEWIAKNFRQRFGLIVNVHAQEMPMQERAAISVFRIVQEALNNVVRHADATRVEIEFVRLDDMLELSIQDNG
RGWSGVPPAPGERKPLGLLGIRERARLLGGQATIAHTPDSGFRLSVRFPATQEVTEET

Sequences:

>Translated_458_residues
MFVFISAFLVAFVAGQDSHSSKASRRRLLLSHSAPAELVAGGLAILLLAASVAWLAIAFQARDAPFVLLALASIAAVLAL
AFYWLRLRMLRAAVARDLTDLEKSEARLAGIIRSSMEAIISVDDAQRIVLFNPMAETLFGCPANHAIGRPLSDFMPERFR
GAHEAHVRRFGVTGVSERQMGKQRPLFALHADGREFPIEASISQIEVNGGKLFTVMLRDTTERVRAEAALRRSQEELQHL
SDSILASREEERHRIARELHDDLGQRLSALKMDISLLAADLQAEGGDRTLIAQTEAMQRVIDETISAVRQISADLRPPLL
DELELVPAIEWIAKNFRQRFGLIVNVHAQEMPMQERAAISVFRIVQEALNNVVRHADATRVEIEFVRLDDMLELSIQDNG
RGWSGVPPAPGERKPLGLLGIRERARLLGGQATIAHTPDSGFRLSVRFPATQEVTEET
>Mature_458_residues
MFVFISAFLVAFVAGQDSHSSKASRRRLLLSHSAPAELVAGGLAILLLAASVAWLAIAFQARDAPFVLLALASIAAVLAL
AFYWLRLRMLRAAVARDLTDLEKSEARLAGIIRSSMEAIISVDDAQRIVLFNPMAETLFGCPANHAIGRPLSDFMPERFR
GAHEAHVRRFGVTGVSERQMGKQRPLFALHADGREFPIEASISQIEVNGGKLFTVMLRDTTERVRAEAALRRSQEELQHL
SDSILASREEERHRIARELHDDLGQRLSALKMDISLLAADLQAEGGDRTLIAQTEAMQRVIDETISAVRQISADLRPPLL
DELELVPAIEWIAKNFRQRFGLIVNVHAQEMPMQERAAISVFRIVQEALNNVVRHADATRVEIEFVRLDDMLELSIQDNG
RGWSGVPPAPGERKPLGLLGIRERARLLGGQATIAHTPDSGFRLSVRFPATQEVTEET

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=223, Percent_Identity=34.5291479820628, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787474, Length=246, Percent_Identity=30.8943089430894, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788812, Length=203, Percent_Identity=26.6009852216749, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50709; Mature: 50709

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVFISAFLVAFVAGQDSHSSKASRRRLLLSHSAPAELVAGGLAILLLAASVAWLAIAFQ
CEEHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARDAPFVLLALASIAAVLALAFYWLRLRMLRAAVARDLTDLEKSEARLAGIIRSSMEAII
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
SVDDAQRIVLFNPMAETLFGCPANHAIGRPLSDFMPERFRGAHEAHVRRFGVTGVSERQM
EECCCCEEEEECCHHHHHHCCCCCCCCCCCHHHHCHHHHCCHHHHHHHHHCCCCCCHHHC
GKQRPLFALHADGREFPIEASISQIEVNGGKLFTVMLRDTTERVRAEAALRRSQEELQHL
CCCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
SDSILASREEERHRIARELHDDLGQRLSALKMDISLLAADLQAEGGDRTLIAQTEAMQRV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
IDETISAVRQISADLRPPLLDELELVPAIEWIAKNFRQRFGLIVNVHAQEMPMQERAAIS
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHCCHHHHHHHH
VFRIVQEALNNVVRHADATRVEIEFVRLDDMLELSIQDNGRGWSGVPPAPGERKPLGLLG
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCHHH
IRERARLLGGQATIAHTPDSGFRLSVRFPATQEVTEET
HHHHHHHHCCCEEEEECCCCCCEEEEECCCCHHHCCCC
>Mature Secondary Structure
MFVFISAFLVAFVAGQDSHSSKASRRRLLLSHSAPAELVAGGLAILLLAASVAWLAIAFQ
CEEHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARDAPFVLLALASIAAVLALAFYWLRLRMLRAAVARDLTDLEKSEARLAGIIRSSMEAII
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
SVDDAQRIVLFNPMAETLFGCPANHAIGRPLSDFMPERFRGAHEAHVRRFGVTGVSERQM
EECCCCEEEEECCHHHHHHCCCCCCCCCCCHHHHCHHHHCCHHHHHHHHHCCCCCCHHHC
GKQRPLFALHADGREFPIEASISQIEVNGGKLFTVMLRDTTERVRAEAALRRSQEELQHL
CCCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
SDSILASREEERHRIARELHDDLGQRLSALKMDISLLAADLQAEGGDRTLIAQTEAMQRV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
IDETISAVRQISADLRPPLLDELELVPAIEWIAKNFRQRFGLIVNVHAQEMPMQERAAIS
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHCCHHHHHHHH
VFRIVQEALNNVVRHADATRVEIEFVRLDDMLELSIQDNGRGWSGVPPAPGERKPLGLLG
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCHHH
IRERARLLGGQATIAHTPDSGFRLSVRFPATQEVTEET
HHHHHHHHCCCEEEEECCCCCCEEEEECCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]