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The map label for this gene is adhP [C]

Identifier: 17544900

GI number: 17544900

Start: 204493

End: 205059

Strand: Reverse

Name: adhP [C]

Synonym: RSc0181

Alternate gene names: 17544900

Gene position: 205059-204493 (Counterclockwise)

Preceding gene: 17544902

Following gene: 17544899

Centisome position: 5.52

GC content: 63.32

Gene sequence:

>567_bases
ATGTCCGACTCGATGCAGGCCATGGTTCTGGAAGGTGTGCGGGCGCCGTTGAAATTGCGGAACATGCCCATGCCGGTTCC
TGGTCCGGGTGAGGTTCGAATCGCCGTGTCTGCCTGCGGGGTATGCCGCACTGACTTGCACATCGTGGATGGCGAACCTC
CCAATCCCAAACCTTCACTCATACCCGGCCATGAGATTGTGGGGACCGTCGAGTCATGTGGCGCAGGCGTGACTTCCCCG
GTGCCAGGCGACCGCATTGGCGTACCCTGGCTCGGCTGGACTTGCGGGGCCTGCCCGTTCTGCCTGCGCGGGCATGAGAA
CCTGTGCGACTACCTTGCTTTCACCGGTGACACACGCGATGGCGGCTACGCTCAGTACGTGGTCTGCGATGCCCGGTACT
GCCTGCCCATTCCCGAGAGGTATGACGATGCACATGCTGCCCCGCTCCTGTGTGCCGGCCTGATCGGCTACCGCACATTG
CGCATGGCGGGCGATGCGCGGCGGTTGGGTATCTACGGCTTCGGTGCCGCCGCTCACCTGATCACTCAGATTGCCGTGGC
GGAGTAA

Upstream 100 bases:

>100_bases
CGCTTCCATTGATCTGTCGCAGTTGTTCGCCCTCTCTCTTAGCCGATCGCCCCGCGCCGCTCGTCCATACAGAAGGCGTA
CTTCGCGTTCGGAGGCCTCT

Downstream 100 bases:

>100_bases
CGCGAAGTCTTCGCCTTTACGCGCCCAGGAGACACTGCCGCACAGCGGCTGGCGCTGGAGACAGGAGCCTGTTGGGCGGG
GCCGAGTCATCGATCGGCTC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSDSMQAMVLEGVRAPLKLRNMPMPVPGPGEVRIAVSACGVCRTDLHIVDGEPPNPKPSLIPGHEIVGTVESCGAGVTSP
VPGDRIGVPWLGWTCGACPFCLRGHENLCDYLAFTGDTRDGGYAQYVVCDARYCLPIPERYDDAHAAPLLCAGLIGYRTL
RMAGDARRLGIYGFGAAAHLITQIAVAE

Sequences:

>Translated_188_residues
MSDSMQAMVLEGVRAPLKLRNMPMPVPGPGEVRIAVSACGVCRTDLHIVDGEPPNPKPSLIPGHEIVGTVESCGAGVTSP
VPGDRIGVPWLGWTCGACPFCLRGHENLCDYLAFTGDTRDGGYAQYVVCDARYCLPIPERYDDAHAAPLLCAGLIGYRTL
RMAGDARRLGIYGFGAAAHLITQIAVAE
>Mature_187_residues
SDSMQAMVLEGVRAPLKLRNMPMPVPGPGEVRIAVSACGVCRTDLHIVDGEPPNPKPSLIPGHEIVGTVESCGAGVTSPV
PGDRIGVPWLGWTCGACPFCLRGHENLCDYLAFTGDTRDGGYAQYVVCDARYCLPIPERYDDAHAAPLLCAGLIGYRTLR
MAGDARRLGIYGFGAAAHLITQIAVAE

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=104, Percent_Identity=39.4230769230769, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI34577061, Length=104, Percent_Identity=40.3846153846154, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI4501929, Length=104, Percent_Identity=39.4230769230769, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI262073058, Length=111, Percent_Identity=37.8378378378378, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI71743840, Length=111, Percent_Identity=37.8378378378378, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI71565154, Length=100, Percent_Identity=39, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI71565152, Length=98, Percent_Identity=36.734693877551, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI87081918, Length=134, Percent_Identity=38.8059701492537, Blast_Score=104, Evalue=3e-24,
Organism=Escherichia coli, GI1786518, Length=157, Percent_Identity=38.8535031847134, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082401, Length=136, Percent_Identity=32.3529411764706, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1787863, Length=142, Percent_Identity=35.2112676056338, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=160, Percent_Identity=31.875, Blast_Score=70, Evalue=6e-14,
Organism=Escherichia coli, GI226510992, Length=121, Percent_Identity=29.7520661157025, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788073, Length=138, Percent_Identity=31.1594202898551, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87082125, Length=152, Percent_Identity=30.9210526315789, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1790045, Length=147, Percent_Identity=30.6122448979592, Blast_Score=61, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562582, Length=164, Percent_Identity=32.3170731707317, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=159, Percent_Identity=31.4465408805031, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=159, Percent_Identity=30.188679245283, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=159, Percent_Identity=33.9622641509434, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=159, Percent_Identity=31.4465408805031, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=107, Percent_Identity=35.5140186915888, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=162, Percent_Identity=37.037037037037, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323729, Length=161, Percent_Identity=36.6459627329193, Blast_Score=112, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324486, Length=162, Percent_Identity=36.4197530864198, Blast_Score=111, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319621, Length=162, Percent_Identity=37.037037037037, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323980, Length=162, Percent_Identity=35.8024691358025, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=151, Percent_Identity=32.4503311258278, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=103, Percent_Identity=34.9514563106796, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737895, Length=110, Percent_Identity=35.4545454545455, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=143, Percent_Identity=32.1678321678322, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 19936; Mature: 19805

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSMQAMVLEGVRAPLKLRNMPMPVPGPGEVRIAVSACGVCRTDLHIVDGEPPNPKPSL
CCCCHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEEECCEECCCEEEECCCCCCCCCCC
IPGHEIVGTVESCGAGVTSPVPGDRIGVPWLGWTCGACPFCLRGHENLCDYLAFTGDTRD
CCCHHHEECHHHCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHCCCHHHHHHHHCCCCCCC
GGYAQYVVCDARYCLPIPERYDDAHAAPLLCAGLIGYRTLRMAGDARRLGIYGFGAAAHL
CCEEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHH
ITQIAVAE
HHHHHHCC
>Mature Secondary Structure 
SDSMQAMVLEGVRAPLKLRNMPMPVPGPGEVRIAVSACGVCRTDLHIVDGEPPNPKPSL
CCCHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEEECCEECCCEEEECCCCCCCCCCC
IPGHEIVGTVESCGAGVTSPVPGDRIGVPWLGWTCGACPFCLRGHENLCDYLAFTGDTRD
CCCHHHEECHHHCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHCCCHHHHHHHHCCCCCCC
GGYAQYVVCDARYCLPIPERYDDAHAAPLLCAGLIGYRTLRMAGDARRLGIYGFGAAAHL
CCEEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHH
ITQIAVAE
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]