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The map label for this gene is glmU [H]

Identifier: 17544896

GI number: 17544896

Start: 199354

End: 200721

Strand: Direct

Name: glmU [H]

Synonym: RSc0177

Alternate gene names: 17544896

Gene position: 199354-200721 (Clockwise)

Preceding gene: 17544894

Following gene: 17544897

Centisome position: 5.36

GC content: 68.79

Gene sequence:

>1368_bases
GTGAACATCGTCATCCTTGCCGCCGGGCTGGGCAAACGCATGCGCTCCGCCCTCCCGAAAGTCCTGCATCCCCTGGCCGG
CAAACCGCTGCTGGCACACGTCATTGAGACGGCCCGATCATTGTCGCCGACACGGCTGGTGGTGGTGGTCGGCCACGGCG
GCGACCGCGTGCGCGACATGGTCGGCGCGCCCGATGTCACCTTCGCGACGCAGGACCAGCAACTGGGCACCGGCCACGCC
GTCATGCAGGCGCTCGACCAGCTTGACGACACCGTGCCCACCCTGGTGCTGTACGGCGACGTGCCGCTCACCCGCGCCGA
GACGCTCAACGCGCTGGTCGGCGCCGCCGGCCAGGACCACCTGGGCGTGCTGACCGTCCACCTCGACGATCCGACCGGCT
ACGGCCGCATCGTGCGCGACGCCACTGGCCGCATCACGCGCATCGTCGAGCAGAAGGACGCCAACGAAACGCAACTGGCC
ATCCACGAAGTCAACACCGGCATCCTGGTCTGCCCGACGGCCAGGCTCAAGACCTGGCTGGCCACGCTACGCAACGACAA
TGCCCAGGGCGAGTACTACCTGACCGATGTGATCGAGCGTGCCGCCAGCGAGGGCCTGCCGATCACCTCCGCGCATCCGC
TGGCCGAGTGGGAGACGCTGGGCGTCAACAGCAAGGTGCAGCTGGCGGAGCTCGAGCGCATCCACCAGCGCAACCTCGCG
CAGCAACTGCTGGAAGACGGCGTGACGCTGATCGACCCGGCGCGCATCGACATCCGCGGCAGGCTGACGTGCGGGCGCGA
TGTCGTCATCGACATCGACTGCATCTTCGAAGGCAACGTGACGCTGGGCGACGGCGTGCGCATCGGTGCCCATGCCGTGA
TCCGCGACGCCGCCATCCAGGCCGGCGCCGAGATCCTGCCGTTCTGCCACATCGAGCAGGCCACGGTGGGCGCGCAGTCG
CGCATCGGTCCGTACGCGCGGCTGCGCCCGGGCACCGAACTGGCCGAGGACGTGCACATCGGCAACTTCGTCGAGGTCAA
GAACAGCCAGATCGCCGCGCACAGCAAGGCCAACCACCTCGCCTACGTGGGCGATGCCACGGTGGGCTCGCGCGTGAACA
TCGGCGCGGGCACCATCACCTGCAACTACGACGGCGCCAACAAGTTCCGCACCATCATCGAGGACGACGCCTTCATCGGC
TCGGACACGCAGCTGGTGGCGCCGGTGCGGGTGGGACGCGGCGCCACGCTGGGCGCCGGCACCACGCTGACCAAGGATGC
GCCGGAAGGCCAGCTGACGGTCTCGCGTGCGCGGCAGACCACCGTCAACGGCTGGCAACGGCCGGTCAAGCAGAAGAAGG
ACGCCTGA

Upstream 100 bases:

>100_bases
AACCCGATGGCAGGCGGCGGACGGCCGCTCCAGGACGGTTGGTCCGGTCCGTGAACGCAAGCCGCAGGCTATCGCTTCGA
GTCACTCTAGGAATCTCCTT

Downstream 100 bases:

>100_bases
GCAGCGGTTTTCCTGCGCCGAACAGCGGATGCCGTTGCGGCGCCTGAGCATCGATACTGAATGAAGATCGAGTGCAGCGC
GCTGCGCGCTGTGCTCCAAC

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MNIVILAAGLGKRMRSALPKVLHPLAGKPLLAHVIETARSLSPTRLVVVVGHGGDRVRDMVGAPDVTFATQDQQLGTGHA
VMQALDQLDDTVPTLVLYGDVPLTRAETLNALVGAAGQDHLGVLTVHLDDPTGYGRIVRDATGRITRIVEQKDANETQLA
IHEVNTGILVCPTARLKTWLATLRNDNAQGEYYLTDVIERAASEGLPITSAHPLAEWETLGVNSKVQLAELERIHQRNLA
QQLLEDGVTLIDPARIDIRGRLTCGRDVVIDIDCIFEGNVTLGDGVRIGAHAVIRDAAIQAGAEILPFCHIEQATVGAQS
RIGPYARLRPGTELAEDVHIGNFVEVKNSQIAAHSKANHLAYVGDATVGSRVNIGAGTITCNYDGANKFRTIIEDDAFIG
SDTQLVAPVRVGRGATLGAGTTLTKDAPEGQLTVSRARQTTVNGWQRPVKQKKDA

Sequences:

>Translated_455_residues
MNIVILAAGLGKRMRSALPKVLHPLAGKPLLAHVIETARSLSPTRLVVVVGHGGDRVRDMVGAPDVTFATQDQQLGTGHA
VMQALDQLDDTVPTLVLYGDVPLTRAETLNALVGAAGQDHLGVLTVHLDDPTGYGRIVRDATGRITRIVEQKDANETQLA
IHEVNTGILVCPTARLKTWLATLRNDNAQGEYYLTDVIERAASEGLPITSAHPLAEWETLGVNSKVQLAELERIHQRNLA
QQLLEDGVTLIDPARIDIRGRLTCGRDVVIDIDCIFEGNVTLGDGVRIGAHAVIRDAAIQAGAEILPFCHIEQATVGAQS
RIGPYARLRPGTELAEDVHIGNFVEVKNSQIAAHSKANHLAYVGDATVGSRVNIGAGTITCNYDGANKFRTIIEDDAFIG
SDTQLVAPVRVGRGATLGAGTTLTKDAPEGQLTVSRARQTTVNGWQRPVKQKKDA
>Mature_455_residues
MNIVILAAGLGKRMRSALPKVLHPLAGKPLLAHVIETARSLSPTRLVVVVGHGGDRVRDMVGAPDVTFATQDQQLGTGHA
VMQALDQLDDTVPTLVLYGDVPLTRAETLNALVGAAGQDHLGVLTVHLDDPTGYGRIVRDATGRITRIVEQKDANETQLA
IHEVNTGILVCPTARLKTWLATLRNDNAQGEYYLTDVIERAASEGLPITSAHPLAEWETLGVNSKVQLAELERIHQRNLA
QQLLEDGVTLIDPARIDIRGRLTCGRDVVIDIDCIFEGNVTLGDGVRIGAHAVIRDAAIQAGAEILPFCHIEQATVGAQS
RIGPYARLRPGTELAEDVHIGNFVEVKNSQIAAHSKANHLAYVGDATVGSRVNIGAGTITCNYDGANKFRTIIEDDAFIG
SDTQLVAPVRVGRGATLGAGTTLTKDAPEGQLTVSRARQTTVNGWQRPVKQKKDA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=452, Percent_Identity=54.8672566371681, Blast_Score=483, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48671; Mature: 48671

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVILAAGLGKRMRSALPKVLHPLAGKPLLAHVIETARSLSPTRLVVVVGHGGDRVRDM
CEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHH
VGAPDVTFATQDQQLGTGHAVMQALDQLDDTVPTLVLYGDVPLTRAETLNALVGAAGQDH
HCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCC
LGVLTVHLDDPTGYGRIVRDATGRITRIVEQKDANETQLAIHEVNTGILVCPTARLKTWL
EEEEEEEECCCCCCCCEEHHHCCHHHHHHHHCCCCCCEEEEEECCCCEEEECHHHHHHHH
ATLRNDNAQGEYYLTDVIERAASEGLPITSAHPLAEWETLGVNSKVQLAELERIHQRNLA
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHH
QQLLEDGVTLIDPARIDIRGRLTCGRDVVIDIDCIFEGNVTLGDGVRIGAHAVIRDAAIQ
HHHHHCCCEEECCCEEEEEEEEEECCEEEEEEEEEEECCEEECCCCEECHHHHHHHHHHH
AGAEILPFCHIEQATVGAQSRIGPYARLRPGTELAEDVHIGNFVEVKNSQIAAHSKANHL
CCCCCCCEEEECHHHCCCHHHCCCCCCCCCCCHHHHHCCCCCEEEECCCEEEECCCCCCE
AYVGDATVGSRVNIGAGTITCNYDGANKFRTIIEDDAFIGSDTQLVAPVRVGRGATLGAG
EEEECCCCCCEEECCCEEEEEECCCCHHHHHHHCCCCEECCCCEEEEEEECCCCCEECCC
TTLTKDAPEGQLTVSRARQTTVNGWQRPVKQKKDA
CEECCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIVILAAGLGKRMRSALPKVLHPLAGKPLLAHVIETARSLSPTRLVVVVGHGGDRVRDM
CEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHH
VGAPDVTFATQDQQLGTGHAVMQALDQLDDTVPTLVLYGDVPLTRAETLNALVGAAGQDH
HCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCC
LGVLTVHLDDPTGYGRIVRDATGRITRIVEQKDANETQLAIHEVNTGILVCPTARLKTWL
EEEEEEEECCCCCCCCEEHHHCCHHHHHHHHCCCCCCEEEEEECCCCEEEECHHHHHHHH
ATLRNDNAQGEYYLTDVIERAASEGLPITSAHPLAEWETLGVNSKVQLAELERIHQRNLA
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHH
QQLLEDGVTLIDPARIDIRGRLTCGRDVVIDIDCIFEGNVTLGDGVRIGAHAVIRDAAIQ
HHHHHCCCEEECCCEEEEEEEEEECCEEEEEEEEEEECCEEECCCCEECHHHHHHHHHHH
AGAEILPFCHIEQATVGAQSRIGPYARLRPGTELAEDVHIGNFVEVKNSQIAAHSKANHL
CCCCCCCEEEECHHHCCCHHHCCCCCCCCCCCHHHHHCCCCCEEEECCCEEEECCCCCCE
AYVGDATVGSRVNIGAGTITCNYDGANKFRTIIEDDAFIGSDTQLVAPVRVGRGATLGAG
EEEECCCCCCEEECCCEEEEEECCCCHHHHHHHCCCCEECCCCEEEEEEECCCCCEECCC
TTLTKDAPEGQLTVSRARQTTVNGWQRPVKQKKDA
CEECCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA