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The map label for this gene is mdrB [H]

Identifier: 17544782

GI number: 17544782

Start: 69714

End: 70856

Strand: Direct

Name: mdrB [H]

Synonym: RSc0063

Alternate gene names: 17544782

Gene position: 69714-70856 (Clockwise)

Preceding gene: 17544781

Following gene: 17544784

Centisome position: 1.88

GC content: 65.97

Gene sequence:

>1143_bases
ATGGACAAGCGCCGCGCATTCAACGTCATCAAGTCGCTCTTCACCGGCTTCGACAAGCCGCTGGCGCTGATCGTCTTCCT
GCTGCTCGGCACGGGGCTGATCGCTCTGTACTCGGCGGCCATCGACATGCCCGGCCGGGTGGAAGACCAGGTGCGCAACA
TCCTGCTGTCGTTCGTGGTGATGTGGATCATCGCCAACCTGCCGCAGCAGACGCTGATGCGCTTTGCCGTACCGCTCTAC
ACCGCGGGCGTGGCCCTGCTGATCGGCGTGGCGATGTTCGGGCTGATCCGCAAGGGCGCGCGGCGCTGGCTCAACATCGG
CGTGGTGGTGCAGCCCTCCGAGATCATGAAGATCGCCATGCCGCTGATGCTGGCGTGGTACTTCCAGAAGCGCGAGGGGG
TGATCCACTGGTATGACTACCTCGCCGCCGCCGTGCTGCTGCTGGTGCCGGTCGGCCTGATCGCCAAGCAGCCCGACCTG
GGCACGGCGCTGCTGGTGCTGGCCGCGGGCATCTACGTGATCTACTTCGCGGGGCTGTCGTGGCGGCTGATCGTGCCGGT
GATGGTGATCGCCGTGACGGCGGTGACGCTGGTGGTGTCGTTCGAGTCGCGCATCTGCGCGCCGGGCGTCAACTGGCCGA
TCCTGCACGACTACCAGCAGCACCGCATCTGCACGCTGCTCGACCCGACCACCGATCCGCTCGGCAAGGGTTTCCACACC
ATCCAGTCGATCATCGCGATCGGCTCGGGCGGGGTGACCGGCAAGGGCTGGCTCAAGGGCACGCAGACGCACCTGGAGTT
CATCCCCGAGAAGCACACCGACTTCATCTTCGCGGTCTATTCCGAGGAGTTCGGGCTGGTGGGCAACGCGATCCTGGTGT
TCCTGTACCTGCTGCTGATCCTGCGCGGGCTGGTCATCGCCGCCAACGCGGGCACGCTGTTCGGGCGCCTGCTGGCCGGG
TCGATCACGCTGATCTTCTTCACCTACGCCTTCGTCAACATGGGCATGGTGAGCGGCATCCTGCCGGTGGTGGGCGTGCC
GCTGCCGCTTGTCAGCTACGGCGGCACCGCGCTCGTCACGCTGGGGATGGGGCTGGGCATCCTGATGAGCATCGCGCGGC
AGAAGCGCTTCGTGCAGACGTAG

Upstream 100 bases:

>100_bases
CCTCGCCCAAGGACCGCAAGCCCGCGGTCAAGCCCAATCCCAAGCCTGCGCCCAAACCGGCACGGGCCGCTCCCTGACTC
TCGCGCTTGAGGAACGCACC

Downstream 100 bases:

>100_bases
CGGCGCGCGGACCGCCCCGGCCGCCGCGGCTCAGGCCGCCACCGCCGCCTCTTCCCGCAACAGTCGCCGCAGCACCTTGC
CGGTGGCCGTGGCCGGCAGC

Product: rod shape-determining (RODA protein) transmembrane

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MDKRRAFNVIKSLFTGFDKPLALIVFLLLGTGLIALYSAAIDMPGRVEDQVRNILLSFVVMWIIANLPQQTLMRFAVPLY
TAGVALLIGVAMFGLIRKGARRWLNIGVVVQPSEIMKIAMPLMLAWYFQKREGVIHWYDYLAAAVLLLVPVGLIAKQPDL
GTALLVLAAGIYVIYFAGLSWRLIVPVMVIAVTAVTLVVSFESRICAPGVNWPILHDYQQHRICTLLDPTTDPLGKGFHT
IQSIIAIGSGGVTGKGWLKGTQTHLEFIPEKHTDFIFAVYSEEFGLVGNAILVFLYLLLILRGLVIAANAGTLFGRLLAG
SITLIFFTYAFVNMGMVSGILPVVGVPLPLVSYGGTALVTLGMGLGILMSIARQKRFVQT

Sequences:

>Translated_380_residues
MDKRRAFNVIKSLFTGFDKPLALIVFLLLGTGLIALYSAAIDMPGRVEDQVRNILLSFVVMWIIANLPQQTLMRFAVPLY
TAGVALLIGVAMFGLIRKGARRWLNIGVVVQPSEIMKIAMPLMLAWYFQKREGVIHWYDYLAAAVLLLVPVGLIAKQPDL
GTALLVLAAGIYVIYFAGLSWRLIVPVMVIAVTAVTLVVSFESRICAPGVNWPILHDYQQHRICTLLDPTTDPLGKGFHT
IQSIIAIGSGGVTGKGWLKGTQTHLEFIPEKHTDFIFAVYSEEFGLVGNAILVFLYLLLILRGLVIAANAGTLFGRLLAG
SITLIFFTYAFVNMGMVSGILPVVGVPLPLVSYGGTALVTLGMGLGILMSIARQKRFVQT
>Mature_380_residues
MDKRRAFNVIKSLFTGFDKPLALIVFLLLGTGLIALYSAAIDMPGRVEDQVRNILLSFVVMWIIANLPQQTLMRFAVPLY
TAGVALLIGVAMFGLIRKGARRWLNIGVVVQPSEIMKIAMPLMLAWYFQKREGVIHWYDYLAAAVLLLVPVGLIAKQPDL
GTALLVLAAGIYVIYFAGLSWRLIVPVMVIAVTAVTLVVSFESRICAPGVNWPILHDYQQHRICTLLDPTTDPLGKGFHT
IQSIIAIGSGGVTGKGWLKGTQTHLEFIPEKHTDFIFAVYSEEFGLVGNAILVFLYLLLILRGLVIAANAGTLFGRLLAG
SITLIFFTYAFVNMGMVSGILPVVGVPLPLVSYGGTALVTLGMGLGILMSIARQKRFVQT

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=348, Percent_Identity=50.5747126436782, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1786277, Length=379, Percent_Identity=28.4960422163588, Blast_Score=152, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 41462; Mature: 41462

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRRAFNVIKSLFTGFDKPLALIVFLLLGTGLIALYSAAIDMPGRVEDQVRNILLSFVV
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
MWIIANLPQQTLMRFAVPLYTAGVALLIGVAMFGLIRKGARRWLNIGVVVQPSEIMKIAM
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHH
PLMLAWYFQKREGVIHWYDYLAAAVLLLVPVGLIAKQPDLGTALLVLAAGIYVIYFAGLS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
WRLIVPVMVIAVTAVTLVVSFESRICAPGVNWPILHDYQQHRICTLLDPTTDPLGKGFHT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCEEEEECCCCCCCCCHHHH
IQSIIAIGSGGVTGKGWLKGTQTHLEFIPEKHTDFIFAVYSEEFGLVGNAILVFLYLLLI
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
LRGLVIAANAGTLFGRLLAGSITLIFFTYAFVNMGMVSGILPVVGVPLPLVSYGGTALVT
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHH
LGMGLGILMSIARQKRFVQT
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKRRAFNVIKSLFTGFDKPLALIVFLLLGTGLIALYSAAIDMPGRVEDQVRNILLSFVV
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
MWIIANLPQQTLMRFAVPLYTAGVALLIGVAMFGLIRKGARRWLNIGVVVQPSEIMKIAM
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHH
PLMLAWYFQKREGVIHWYDYLAAAVLLLVPVGLIAKQPDLGTALLVLAAGIYVIYFAGLS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
WRLIVPVMVIAVTAVTLVVSFESRICAPGVNWPILHDYQQHRICTLLDPTTDPLGKGFHT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCEEEEECCCCCCCCCHHHH
IQSIIAIGSGGVTGKGWLKGTQTHLEFIPEKHTDFIFAVYSEEFGLVGNAILVFLYLLLI
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
LRGLVIAANAGTLFGRLLAGSITLIFFTYAFVNMGMVSGILPVVGVPLPLVSYGGTALVT
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHH
LGMGLGILMSIARQKRFVQT
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]