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The map label for this gene is gor [H]

Identifier: 17544733

GI number: 17544733

Start: 14967

End: 16412

Strand: Direct

Name: gor [H]

Synonym: RSc0014

Alternate gene names: 17544733

Gene position: 14967-16412 (Clockwise)

Preceding gene: 17544732

Following gene: 17544734

Centisome position: 0.4

GC content: 73.58

Gene sequence:

>1446_bases
ATGGCGTCGCCGGTCGAACCCGACGGACGCCGCATGCGCGCACATTCCGCTGTTTCCTTTGATCTGATCGTGATCGGCGC
CGGCTCGGCCGGCCTGGCCGCCGCCCGCCGCGCCGCGCAGCTTGGCGCGCGCACCCTGCTGATCGATCGCGCCGAAGTGG
GCGGTACCGGTGTCAACCGCGGCTGCATGCCCAAGAAGCTGCTGGGCTACGGCGCCGCCTGGTCGCAGTCGGCCAGCCGT
TGCCTGCATACCGCCGCGGCCCATGGCCGTGACGCCTGGCAGGATGCCGCGGCCCGCATCCGCACCGAGGTCGGGCGGCT
GCACGGGGTTTATCGCGCGCATCTGGCCGAAGCGGGCGTGCAATGGCTGGCCGGCTCAGCGTCGCTGCGCGGGCGCGGCG
CGCTCCGGCTGCTGACCGACGCCGGCAAGCGCACCATGCGCGCGCGCCAGATCGTGCTGGCGACGGGTGCCCGGCCGCAA
CCGCTGCCGGTGCCCGGCGCCGAGCTCGCCTGTACGCCGGAGGACGTGCTCACCTGGGACGCGCTCCCCGCCTCGCTGGC
GATCGTCGGGGGCGGCGTGATCGCGGTGGAGATGGCTTCGACGCTGGTGCGCTTCGGCGTGCGCGTCACGCTGCTGGTGC
GCGATCCGCGCGTGCTGCCGGATTTCGATGCGGCCCTGTCGGAGGCGGCGTTCCGGGCGCTGGCGGCGCATGGCGTCGAC
GTCGTGCCGGATGCCGATGTGGTGCGCGTGGAGCGCGACGCCGTCAATGGCGACGGCGTGGCCGTCTACGTGGCCGGGCC
GGACGGGACCGCTGCACGCGTGGTGCGCGCGCAGCGCGTGATGGCCGCCATCGGCCGTGCGCCGGCCACGGATGGGCTCG
GCCTGGAGGCGGCCGGGGTCACGCTCGATGCGCGTGGCCATATTGCGGTGGATCGGCACTTCCGTACCCGCGCGCGCGGC
GTGCATGCCATCGGCGATGTCAGCGGCAGCCCGCAACTGACGCCGGTGGCCGTCGCGCAGGGCCGCTATGTCGCCGAGCG
GCTGTTCGGCAAGGGCGCCAAGCTGCCCGACATGGAGCATGTGCCGATGGCGGTGTTCTGCGAGCCGGCCATCGCCGCCG
TCGGCCTGACCGAGGCCCAGGCGCGCGAGCGCTGGCCGGACCGGCCGGAGCGGGACGCCCGTCCCGTGGCCGAGCGCATC
GACGTGGTCGAGCGCCGCTTCGTCTCGCTGGAACAGCGCTTTGCCGGCACCGGTGCCGAGTCACTGATCAAGCTGGTCTG
CAATGCACGCAGCGGGCGCGTGCTGGGCGCGCACGTGATGGACAACGCCGCGCCTGAGATCGTGCAGGCGCTGGCGGTGG
CCGTGCGCATGGGCGTGCGGCTCAAGCACCTGCGGAGCACGGTCGGCCTGCATCCGACCGTGGCGGAGGAACTGCTCTGC
ATCTGA

Upstream 100 bases:

>100_bases
GCGGGTTTGCCGCGCTGATCGCCGCTTAGCGTGCGGTCCGCCGCAGCCGGTGGCGGGCGCGTGGCTTGCCGGGGCCGGGC
GAGCCCGCCGACACGGCGTC

Downstream 100 bases:

>100_bases
GCCCGGCCGACGGGGCGCCGATGCGGCATCGGCCCGTTTCCCGGCAGCTTGGCGTGCTGCTATTCAATTTTCCTGATGGC
ACTCTCCAAATCCATGCAGC

Product: glutathione reductase oxidoreductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MASPVEPDGRRMRAHSAVSFDLIVIGAGSAGLAAARRAAQLGARTLLIDRAEVGGTGVNRGCMPKKLLGYGAAWSQSASR
CLHTAAAHGRDAWQDAAARIRTEVGRLHGVYRAHLAEAGVQWLAGSASLRGRGALRLLTDAGKRTMRARQIVLATGARPQ
PLPVPGAELACTPEDVLTWDALPASLAIVGGGVIAVEMASTLVRFGVRVTLLVRDPRVLPDFDAALSEAAFRALAAHGVD
VVPDADVVRVERDAVNGDGVAVYVAGPDGTAARVVRAQRVMAAIGRAPATDGLGLEAAGVTLDARGHIAVDRHFRTRARG
VHAIGDVSGSPQLTPVAVAQGRYVAERLFGKGAKLPDMEHVPMAVFCEPAIAAVGLTEAQARERWPDRPERDARPVAERI
DVVERRFVSLEQRFAGTGAESLIKLVCNARSGRVLGAHVMDNAAPEIVQALAVAVRMGVRLKHLRSTVGLHPTVAEELLC
I

Sequences:

>Translated_481_residues
MASPVEPDGRRMRAHSAVSFDLIVIGAGSAGLAAARRAAQLGARTLLIDRAEVGGTGVNRGCMPKKLLGYGAAWSQSASR
CLHTAAAHGRDAWQDAAARIRTEVGRLHGVYRAHLAEAGVQWLAGSASLRGRGALRLLTDAGKRTMRARQIVLATGARPQ
PLPVPGAELACTPEDVLTWDALPASLAIVGGGVIAVEMASTLVRFGVRVTLLVRDPRVLPDFDAALSEAAFRALAAHGVD
VVPDADVVRVERDAVNGDGVAVYVAGPDGTAARVVRAQRVMAAIGRAPATDGLGLEAAGVTLDARGHIAVDRHFRTRARG
VHAIGDVSGSPQLTPVAVAQGRYVAERLFGKGAKLPDMEHVPMAVFCEPAIAAVGLTEAQARERWPDRPERDARPVAERI
DVVERRFVSLEQRFAGTGAESLIKLVCNARSGRVLGAHVMDNAAPEIVQALAVAVRMGVRLKHLRSTVGLHPTVAEELLC
I
>Mature_480_residues
ASPVEPDGRRMRAHSAVSFDLIVIGAGSAGLAAARRAAQLGARTLLIDRAEVGGTGVNRGCMPKKLLGYGAAWSQSASRC
LHTAAAHGRDAWQDAAARIRTEVGRLHGVYRAHLAEAGVQWLAGSASLRGRGALRLLTDAGKRTMRARQIVLATGARPQP
LPVPGAELACTPEDVLTWDALPASLAIVGGGVIAVEMASTLVRFGVRVTLLVRDPRVLPDFDAALSEAAFRALAAHGVDV
VPDADVVRVERDAVNGDGVAVYVAGPDGTAARVVRAQRVMAAIGRAPATDGLGLEAAGVTLDARGHIAVDRHFRTRARGV
HAIGDVSGSPQLTPVAVAQGRYVAERLFGKGAKLPDMEHVPMAVFCEPAIAAVGLTEAQARERWPDRPERDARPVAERID
VVERRFVSLEQRFAGTGAESLIKLVCNARSGRVLGAHVMDNAAPEIVQALAVAVRMGVRLKHLRSTVGLHPTVAEELLCI

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=477, Percent_Identity=33.1236897274633, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI291045266, Length=486, Percent_Identity=30.0411522633745, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI148277071, Length=465, Percent_Identity=29.0322580645161, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI33519430, Length=465, Percent_Identity=29.0322580645161, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI33519428, Length=465, Percent_Identity=29.0322580645161, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI33519426, Length=465, Percent_Identity=29.0322580645161, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI148277065, Length=465, Percent_Identity=29.0322580645161, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI22035672, Length=468, Percent_Identity=31.6239316239316, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI91199540, Length=487, Percent_Identity=28.5420944558522, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI291045268, Length=479, Percent_Identity=28.8100208768267, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1789915, Length=458, Percent_Identity=33.1877729257642, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI1786307, Length=474, Percent_Identity=27.4261603375527, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI87081717, Length=469, Percent_Identity=29.2110874200426, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87082354, Length=476, Percent_Identity=27.1008403361345, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17557007, Length=494, Percent_Identity=32.3886639676113, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71983429, Length=476, Percent_Identity=32.3529411764706, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71983419, Length=475, Percent_Identity=32.2105263157895, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI32565766, Length=470, Percent_Identity=26.8085106382979, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71982272, Length=504, Percent_Identity=27.3809523809524, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17559934, Length=296, Percent_Identity=25, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6325166, Length=488, Percent_Identity=29.0983606557377, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6321091, Length=479, Percent_Identity=26.0960334029228, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=478, Percent_Identity=25.7322175732218, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24640553, Length=487, Percent_Identity=31.4168377823409, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24640549, Length=485, Percent_Identity=31.5463917525773, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24640551, Length=491, Percent_Identity=31.5682281059063, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17737741, Length=486, Percent_Identity=30.8641975308642, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=26.0042283298097, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50601; Mature: 50470

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPVEPDGRRMRAHSAVSFDLIVIGAGSAGLAAARRAAQLGARTLLIDRAEVGGTGVNR
CCCCCCCCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEECHHCCCCCCCC
GCMPKKLLGYGAAWSQSASRCLHTAAAHGRDAWQDAAARIRTEVGRLHGVYRAHLAEAGV
CCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QWLAGSASLRGRGALRLLTDAGKRTMRARQIVLATGARPQPLPVPGAELACTPEDVLTWD
HHHCCCCCCCCCCCEEEEHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEECHHHHHECC
ALPASLAIVGGGVIAVEMASTLVRFGVRVTLLVRDPRVLPDFDAALSEAAFRALAAHGVD
CCCHHEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
VVPDADVVRVERDAVNGDGVAVYVAGPDGTAARVVRAQRVMAAIGRAPATDGLGLEAAGV
CCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEECCE
TLDARGHIAVDRHFRTRARGVHAIGDVSGSPQLTPVAVAQGRYVAERLFGKGAKLPDMEH
EEECCCCEEECCHHHHHHCCCEEEECCCCCCCCCEEEHHCCHHHHHHHHCCCCCCCCCCC
VPMAVFCEPAIAAVGLTEAQARERWPDRPERDARPVAERIDVVERRFVSLEQRFAGTGAE
CCEEEEECHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHH
SLIKLVCNARSGRVLGAHVMDNAAPEIVQALAVAVRMGVRLKHLRSTVGLHPTVAEELLC
HHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
I
C
>Mature Secondary Structure 
ASPVEPDGRRMRAHSAVSFDLIVIGAGSAGLAAARRAAQLGARTLLIDRAEVGGTGVNR
CCCCCCCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEECHHCCCCCCCC
GCMPKKLLGYGAAWSQSASRCLHTAAAHGRDAWQDAAARIRTEVGRLHGVYRAHLAEAGV
CCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QWLAGSASLRGRGALRLLTDAGKRTMRARQIVLATGARPQPLPVPGAELACTPEDVLTWD
HHHCCCCCCCCCCCEEEEHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEECHHHHHECC
ALPASLAIVGGGVIAVEMASTLVRFGVRVTLLVRDPRVLPDFDAALSEAAFRALAAHGVD
CCCHHEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
VVPDADVVRVERDAVNGDGVAVYVAGPDGTAARVVRAQRVMAAIGRAPATDGLGLEAAGV
CCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEECCE
TLDARGHIAVDRHFRTRARGVHAIGDVSGSPQLTPVAVAQGRYVAERLFGKGAKLPDMEH
EEECCCCEEECCHHHHHHCCCEEEECCCCCCCCCEEEHHCCHHHHHHHHCCCCCCCCCCC
VPMAVFCEPAIAAVGLTEAQARERWPDRPERDARPVAERIDVVERRFVSLEQRFAGTGAE
CCEEEEECHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHH
SLIKLVCNARSGRVLGAHVMDNAAPEIVQALAVAVRMGVRLKHLRSTVGLHPTVAEELLC
HHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]