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The map label for this gene is acrR [H]

Identifier: 17544731

GI number: 17544731

Start: 13346

End: 14005

Strand: Direct

Name: acrR [H]

Synonym: RSc0012

Alternate gene names: 17544731

Gene position: 13346-14005 (Clockwise)

Preceding gene: 17544726

Following gene: 17544732

Centisome position: 0.36

GC content: 65.61

Gene sequence:

>660_bases
ATGGTCAGACGAACCAAGGAAGAAGCGCTGGAAACGCGCAACCGCATCCTCGACGCGGCGGAAGAGGTGTTCTATGTGCG
TGGCGTGGCGCGCACGTCGCTATCCGACATCGCGCAGGCGGCCGGTGTCACGCGCGGCGCCATCTACTGGCATTTCCGCA
ACAAGGCCGATGTGTTCGCCGCCATGTGCGAGCGCGTCAAGCTGCCGATGGAGACCCTGTGCTCGCCGCTGGGCGTCGAA
CCCAACGATCCGCTGGGCGAGCTGCGCAATGTGGCCAATTTCGTGCTGCAGCAGCTGGTGGAAGACATGCACTGGCGCCG
GGTCTTCGAGATCATGTTCAACAAGTGCGAGTTCGTGGAGGACACGAGCCCGATCCTCAAGCGCCAGCAGGAGTCCTTCG
AGGAGGGGCTTGCACGCCTGACCCACATCATCGGGCAGGCGGCCCGGCGCGGGCAGCTGCCGCCCGACCTGGATGTGCCG
CTGGCGGTGGCGCATTTCCACGCCTCGTTCGGCGGCATCATGGGCGACTACCTGTTCTATCCGGACGCCTCCAGCCTCGC
CGTCAAGCGCGAGCGCTTCGTCGATGCCTGCATCGACACACTCAAGTACTCGCCCGCGCTGCGCCTGGCGCAGCCCGTCG
TCGCCGAGGCTTGTGCATGA

Upstream 100 bases:

>100_bases
GTTGTGCAATGCGCAACAGTCAGTTGTCAGTATTTGTGCGCTGCACAAAAGCGGAACGAAAGCTGCCGGCCGTGCTGGAG
CCGGCTTCCCGAAGGGCATC

Downstream 100 bases:

>100_bases
CCCTGCCCGCCTTCGACCAGATGGTGTTCGCCGGCGGCGGCAATCGCTGCTGGTGGCAGGCCGGCTGGTGGGACACCGTG
CAGCCCGGGCTGGGCCTGCG

Product: AcrAB operon repressor transcription regulator protein

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MVRRTKEEALETRNRILDAAEEVFYVRGVARTSLSDIAQAAGVTRGAIYWHFRNKADVFAAMCERVKLPMETLCSPLGVE
PNDPLGELRNVANFVLQQLVEDMHWRRVFEIMFNKCEFVEDTSPILKRQQESFEEGLARLTHIIGQAARRGQLPPDLDVP
LAVAHFHASFGGIMGDYLFYPDASSLAVKRERFVDACIDTLKYSPALRLAQPVVAEACA

Sequences:

>Translated_219_residues
MVRRTKEEALETRNRILDAAEEVFYVRGVARTSLSDIAQAAGVTRGAIYWHFRNKADVFAAMCERVKLPMETLCSPLGVE
PNDPLGELRNVANFVLQQLVEDMHWRRVFEIMFNKCEFVEDTSPILKRQQESFEEGLARLTHIIGQAARRGQLPPDLDVP
LAVAHFHASFGGIMGDYLFYPDASSLAVKRERFVDACIDTLKYSPALRLAQPVVAEACA
>Mature_219_residues
MVRRTKEEALETRNRILDAAEEVFYVRGVARTSLSDIAQAAGVTRGAIYWHFRNKADVFAAMCERVKLPMETLCSPLGVE
PNDPLGELRNVANFVLQQLVEDMHWRRVFEIMFNKCEFVEDTSPILKRQQESFEEGLARLTHIIGQAARRGQLPPDLDVP
LAVAHFHASFGGIMGDYLFYPDASSLAVKRERFVDACIDTLKYSPALRLAQPVVAEACA

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=213, Percent_Identity=36.150234741784, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789664, Length=209, Percent_Identity=30.622009569378, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24656; Mature: 24656

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRTKEEALETRNRILDAAEEVFYVRGVARTSLSDIAQAAGVTRGAIYWHFRNKADVFA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
AMCERVKLPMETLCSPLGVEPNDPLGELRNVANFVLQQLVEDMHWRRVFEIMFNKCEFVE
HHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DTSPILKRQQESFEEGLARLTHIIGQAARRGQLPPDLDVPLAVAHFHASFGGIMGDYLFY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PDASSLAVKRERFVDACIDTLKYSPALRLAQPVVAEACA
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVRRTKEEALETRNRILDAAEEVFYVRGVARTSLSDIAQAAGVTRGAIYWHFRNKADVFA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
AMCERVKLPMETLCSPLGVEPNDPLGELRNVANFVLQQLVEDMHWRRVFEIMFNKCEFVE
HHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DTSPILKRQQESFEEGLARLTHIIGQAARRGQLPPDLDVPLAVAHFHASFGGIMGDYLFY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PDASSLAVKRERFVDACIDTLKYSPALRLAQPVVAEACA
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]