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The map label for this gene is hisS [H]

Identifier: 17232504

GI number: 17232504

Start: 5984215

End: 5985603

Strand: Reverse

Name: hisS [H]

Synonym: all5012

Alternate gene names: 17232504

Gene position: 5985603-5984215 (Counterclockwise)

Preceding gene: 17232505

Following gene: 17232503

Centisome position: 93.32

GC content: 38.8

Gene sequence:

>1389_bases
ATGGCAAAAAACGACAAAATTAACTTCTCAACTCCTAGCGGCTTTCCCGAATTTCTGCCCAGCGAAAAGCGCTTAGAATT
ATATTTACTAGATACCATCCGTAGAGTTTATGAAAGCTATGGATTTACACCTATTGAAACTCCCGCAGTTGAACGCTTGG
AAGTACTACAAGCCAAAGGTAATCAAGGGGACAATATTATTTATGGTCTTGAGCCAATTCTCCCACCAAATCGCCAAGCA
GAAAAAGATAAATCAGGAGACACGGGTTCAGAAGCCAGAGCTTTAAAATTTGACCAAACTGTGCCTTTAGCCGCTTATAT
TGCTCGTCATTTAAATGATTTAACTTTCCCTTTTGCTCGTTATCAAATGGACGTGGTTTTTCGCGGGGAACGGGCTAAGG
ATGGGAGATTTCGTCAATTTCGCCAGTGTGATATCGATGTAGTTGGACGAGAAAAACTCAGTTTGCTTTATGATGCTCAA
ATGCCAGCAATTATCACCGAAATATTTGAGGCAGTTAATATTGGTGATTTTGTAATTCGTATCAATAATCGGAAAGTTTT
AACAGGATTTTTCCAATCTTTAAATATATCAGAAACTCAAATTAAATCTTGTATTAGCATTATCGATAATCTCGAAAAAA
TCGGTGAAGCTAAAGTTAAATTAGAGTTAGAGAAAGAAGGTATTAACCCAGAGCAAACACAAAAAATTATAGATTTTGTT
AAAATTGATGGTAGCGTTGACGATGTATTAGATAAACTCAAACATCTTTCACAAACACTGCCAGAATCAGAGCAATTTAA
TTTAGGTGTCAGCGAATTAGAAACAGTAATTACAGGGGTGCGTAACCTGGGAGTGCCTGACAAACGCTTTTGTATTGATT
TGGCGATCGCTCGTGGCCTAAACTACTATACAGGCACAGTTTATGAAACCACTCTCATCGGCCATGAAGCTTTAGGTAGT
ATCTGTTCAGGTGGCAGATACGAAGAATTAGTTGGTACATTTATCGGTGAAAAAATGCCCGGTGTGGGTATTTCTATCGG
CTTAACTCGCTTAATTAGTCGCTTACTGAAAGCAGGGATTCTTAACACTTTACCACCAACACCAGCCCAGGTAGTGGTAG
TAAATATGCAGGATGAACTAATGCCAACTTATCTAAAAGTATCGCAACAGTTACGGCAAGCAGGGCTGAATGTAATTACA
AACTTTGAAAAACGCCAGTTAGGTAAACAATTTCAAGCAGCCGATAAACAAGGTATTAGATTTTGTGTCATCATCGGTGC
TGATGAAGCCGCAGCACAAAAATCATCCCTCAAAGATTTACAATCAGGCGAACAGGTAGAAGTCGCCTTAGCAGATTTAG
CTGAAGAAATTAAACGTAGGTTGACCTAA

Upstream 100 bases:

>100_bases
ATGCTTTTATCTATTGGAATACAACTTTCTGAAAAAATAAAATGGTAGGGGTGCAAACTTTTGCGCCCCTATCAAGTTTA
AATTTCACAAAAATAGACGC

Downstream 100 bases:

>100_bases
TTAAAAATCTTCTCTTTTCTGTGCCTCTGTTATGGAATAATCTATTTCTCAACATGAAGCACAGACAAAAACTTAGTTCT
ACACTATCAAAATATATGGA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAKNDKINFSTPSGFPEFLPSEKRLELYLLDTIRRVYESYGFTPIETPAVERLEVLQAKGNQGDNIIYGLEPILPPNRQA
EKDKSGDTGSEARALKFDQTVPLAAYIARHLNDLTFPFARYQMDVVFRGERAKDGRFRQFRQCDIDVVGREKLSLLYDAQ
MPAIITEIFEAVNIGDFVIRINNRKVLTGFFQSLNISETQIKSCISIIDNLEKIGEAKVKLELEKEGINPEQTQKIIDFV
KIDGSVDDVLDKLKHLSQTLPESEQFNLGVSELETVITGVRNLGVPDKRFCIDLAIARGLNYYTGTVYETTLIGHEALGS
ICSGGRYEELVGTFIGEKMPGVGISIGLTRLISRLLKAGILNTLPPTPAQVVVVNMQDELMPTYLKVSQQLRQAGLNVIT
NFEKRQLGKQFQAADKQGIRFCVIIGADEAAAQKSSLKDLQSGEQVEVALADLAEEIKRRLT

Sequences:

>Translated_462_residues
MAKNDKINFSTPSGFPEFLPSEKRLELYLLDTIRRVYESYGFTPIETPAVERLEVLQAKGNQGDNIIYGLEPILPPNRQA
EKDKSGDTGSEARALKFDQTVPLAAYIARHLNDLTFPFARYQMDVVFRGERAKDGRFRQFRQCDIDVVGREKLSLLYDAQ
MPAIITEIFEAVNIGDFVIRINNRKVLTGFFQSLNISETQIKSCISIIDNLEKIGEAKVKLELEKEGINPEQTQKIIDFV
KIDGSVDDVLDKLKHLSQTLPESEQFNLGVSELETVITGVRNLGVPDKRFCIDLAIARGLNYYTGTVYETTLIGHEALGS
ICSGGRYEELVGTFIGEKMPGVGISIGLTRLISRLLKAGILNTLPPTPAQVVVVNMQDELMPTYLKVSQQLRQAGLNVIT
NFEKRQLGKQFQAADKQGIRFCVIIGADEAAAQKSSLKDLQSGEQVEVALADLAEEIKRRLT
>Mature_461_residues
AKNDKINFSTPSGFPEFLPSEKRLELYLLDTIRRVYESYGFTPIETPAVERLEVLQAKGNQGDNIIYGLEPILPPNRQAE
KDKSGDTGSEARALKFDQTVPLAAYIARHLNDLTFPFARYQMDVVFRGERAKDGRFRQFRQCDIDVVGREKLSLLYDAQM
PAIITEIFEAVNIGDFVIRINNRKVLTGFFQSLNISETQIKSCISIIDNLEKIGEAKVKLELEKEGINPEQTQKIIDFVK
IDGSVDDVLDKLKHLSQTLPESEQFNLGVSELETVITGVRNLGVPDKRFCIDLAIARGLNYYTGTVYETTLIGHEALGSI
CSGGRYEELVGTFIGEKMPGVGISIGLTRLISRLLKAGILNTLPPTPAQVVVVNMQDELMPTYLKVSQQLRQAGLNVITN
FEKRQLGKQFQAADKQGIRFCVIIGADEAAAQKSSLKDLQSGEQVEVALADLAEEIKRRLT

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=473, Percent_Identity=33.4038054968288, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI15029520, Length=481, Percent_Identity=30.3534303534304, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI65287717, Length=459, Percent_Identity=20.2614379084967, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788861, Length=473, Percent_Identity=24.7357293868922, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71993693, Length=485, Percent_Identity=29.0721649484536, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI71993686, Length=453, Percent_Identity=30.242825607064, Blast_Score=171, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6325290, Length=474, Percent_Identity=29.957805907173, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24643061, Length=489, Percent_Identity=30.4703476482618, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24643059, Length=508, Percent_Identity=29.5275590551181, Blast_Score=202, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 51521; Mature: 51390

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNDKINFSTPSGFPEFLPSEKRLELYLLDTIRRVYESYGFTPIETPAVERLEVLQAKG
CCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
NQGDNIIYGLEPILPPNRQAEKDKSGDTGSEARALKFDQTVPLAAYIARHLNDLTFPFAR
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCHHH
YQMDVVFRGERAKDGRFRQFRQCDIDVVGREKLSLLYDAQMPAIITEIFEAVNIGDFVIR
EEEEEEEECCCCCCCHHHHHHHCCCEEECHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
INNRKVLTGFFQSLNISETQIKSCISIIDNLEKIGEAKVKLELEKEGINPEQTQKIIDFV
ECCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHH
KIDGSVDDVLDKLKHLSQTLPESEQFNLGVSELETVITGVRNLGVPDKRFCIDLAIARGL
HCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
NYYTGTVYETTLIGHEALGSICSGGRYEELVGTFIGEKMPGVGISIGLTRLISRLLKAGI
CCCCCCEEEEHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LNTLPPTPAQVVVVNMQDELMPTYLKVSQQLRQAGLNVITNFEKRQLGKQFQAADKQGIR
HCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCE
FCVIIGADEAAAQKSSLKDLQSGEQVEVALADLAEEIKRRLT
EEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKNDKINFSTPSGFPEFLPSEKRLELYLLDTIRRVYESYGFTPIETPAVERLEVLQAKG
CCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
NQGDNIIYGLEPILPPNRQAEKDKSGDTGSEARALKFDQTVPLAAYIARHLNDLTFPFAR
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCHHH
YQMDVVFRGERAKDGRFRQFRQCDIDVVGREKLSLLYDAQMPAIITEIFEAVNIGDFVIR
EEEEEEEECCCCCCCHHHHHHHCCCEEECHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
INNRKVLTGFFQSLNISETQIKSCISIIDNLEKIGEAKVKLELEKEGINPEQTQKIIDFV
ECCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHH
KIDGSVDDVLDKLKHLSQTLPESEQFNLGVSELETVITGVRNLGVPDKRFCIDLAIARGL
HCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
NYYTGTVYETTLIGHEALGSICSGGRYEELVGTFIGEKMPGVGISIGLTRLISRLLKAGI
CCCCCCEEEEHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LNTLPPTPAQVVVVNMQDELMPTYLKVSQQLRQAGLNVITNFEKRQLGKQFQAADKQGIR
HCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCE
FCVIIGADEAAAQKSSLKDLQSGEQVEVALADLAEEIKRRLT
EEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA