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The map label for this gene is glkA [H]

Identifier: 17232494

GI number: 17232494

Start: 5974840

End: 5975775

Strand: Reverse

Name: glkA [H]

Synonym: all5002

Alternate gene names: 17232494

Gene position: 5975775-5974840 (Counterclockwise)

Preceding gene: 17232495

Following gene: 17232491

Centisome position: 93.17

GC content: 46.37

Gene sequence:

>936_bases
ATGACTTCTGCTGTGGTGGTTTGGTGTGAGGAATTGAATGTGGGGAATTCTCAAGTAATTGGCATTGACTTGGGGGGAAC
AGCAATTAAATTGGGGCGATTTAGCAAAGATGGGACTTGTTCACAATCTTTGACTGTGGCGACTCCCCAACCAGCAACCC
CGGAAGCGGTTTTTCTGGTCATGGTGGATGCGATCGCGCAAATTGACCCAGATAATGAAACTATAGCTATTGGTGTGGGT
ACTCCTGGCCCGGCTGATGCTCAAGGACGCATTGCTCAAATTGCTATTAACTTACCGCAATGGGAAAATGTACCTTTGGC
GGATTGGTTAGAAGCGAAAACTAACAAGCCGACAGTAATTGAAAATGATGCCAACTGTGCGGGAATCGCTGAGGCTTGGT
TAGGAGCCGGTCGCCACTGCCAAAACTTTATCATGTTAACTTTGGGGACTGGTGTTGGTGGCGCAATTTTTTTAGATGGC
AAATTATTTGTCGGACATCGTGGCGCAGCTGGTGAACTGGGACTAATTACACTCCAACCCGATGGCCCTATGTGTAAAAG
CGGCAACCCTGGTTCTTTAGAGCAGTACACTTCCATTAAAGCTATTCGTCGCCTGACTGGTAAAGAACCTGCGGAATTAG
GTATGCTAGCTCAAGCTGGAGATCCAGAAGCCTTACAATTTTGGCAAGAATACGGACAAAATTTAGGTATAGGTTTAACG
AGTTTAATTTATGTTCTCACACCACAGGCGATCGTGCTTGGCGGTGGTGTAAGTGCCAGCTGTGAATTTTTCTTACCAAC
TCTCAAAGCCGAAATCGAAAAGCGAGTTATGTCCACATCTCGCGCAGGGTTACAAATCTTGCCAGCAGAGTTAGGTAACT
CAGCCGGAATGGTAGGCGCAGCAAGATTAGCTTGGGAAAAGTTTGGTAATTGGTAA

Upstream 100 bases:

>100_bases
ACTGAGAACTTAGAATTTTTTGGCCCAGAAATCCCAAAAAGCTAATATGCTTTTGTGAAATACCCTAAATGGGTAATTAT
CGTCAGCTTCATCAAAGCTG

Downstream 100 bases:

>100_bases
TGGGTGATTCAAAACTATTGACTATCGACTAAGAAAAAGAATGTCCTGTGGTTTTTTGGACGTATTGCAAAACTTTCTTA
TAAGAATCTGGGCTACTGAC

Product: sugar kinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTSAVVVWCEELNVGNSQVIGIDLGGTAIKLGRFSKDGTCSQSLTVATPQPATPEAVFLVMVDAIAQIDPDNETIAIGVG
TPGPADAQGRIAQIAINLPQWENVPLADWLEAKTNKPTVIENDANCAGIAEAWLGAGRHCQNFIMLTLGTGVGGAIFLDG
KLFVGHRGAAGELGLITLQPDGPMCKSGNPGSLEQYTSIKAIRRLTGKEPAELGMLAQAGDPEALQFWQEYGQNLGIGLT
SLIYVLTPQAIVLGGGVSASCEFFLPTLKAEIEKRVMSTSRAGLQILPAELGNSAGMVGAARLAWEKFGNW

Sequences:

>Translated_311_residues
MTSAVVVWCEELNVGNSQVIGIDLGGTAIKLGRFSKDGTCSQSLTVATPQPATPEAVFLVMVDAIAQIDPDNETIAIGVG
TPGPADAQGRIAQIAINLPQWENVPLADWLEAKTNKPTVIENDANCAGIAEAWLGAGRHCQNFIMLTLGTGVGGAIFLDG
KLFVGHRGAAGELGLITLQPDGPMCKSGNPGSLEQYTSIKAIRRLTGKEPAELGMLAQAGDPEALQFWQEYGQNLGIGLT
SLIYVLTPQAIVLGGGVSASCEFFLPTLKAEIEKRVMSTSRAGLQILPAELGNSAGMVGAARLAWEKFGNW
>Mature_310_residues
TSAVVVWCEELNVGNSQVIGIDLGGTAIKLGRFSKDGTCSQSLTVATPQPATPEAVFLVMVDAIAQIDPDNETIAIGVGT
PGPADAQGRIAQIAINLPQWENVPLADWLEAKTNKPTVIENDANCAGIAEAWLGAGRHCQNFIMLTLGTGVGGAIFLDGK
LFVGHRGAAGELGLITLQPDGPMCKSGNPGSLEQYTSIKAIRRLTGKEPAELGMLAQAGDPEALQFWQEYGQNLGIGLTS
LIYVLTPQAIVLGGGVSASCEFFLPTLKAEIEKRVMSTSRAGLQILPAELGNSAGMVGAARLAWEKFGNW

Specific function: Required for glucose repression of many different genes [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=283, Percent_Identity=26.5017667844523, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI298566325, Length=266, Percent_Identity=27.4436090225564, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI190014632, Length=266, Percent_Identity=27.4436090225564, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4885285, Length=266, Percent_Identity=27.4436090225564, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786891, Length=305, Percent_Identity=26.2295081967213, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787363, Length=301, Percent_Identity=28.2392026578073, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787878, Length=244, Percent_Identity=25.8196721311475, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790522, Length=299, Percent_Identity=26.4214046822742, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081733, Length=302, Percent_Identity=26.8211920529801, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082230, Length=244, Percent_Identity=28.2786885245902, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082127, Length=215, Percent_Identity=23.2558139534884, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 32585; Mature: 32454

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAVVVWCEELNVGNSQVIGIDLGGTAIKLGRFSKDGTCSQSLTVATPQPATPEAVFLV
CCCEEEEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHH
MVDAIAQIDPDNETIAIGVGTPGPADAQGRIAQIAINLPQWENVPLADWLEAKTNKPTVI
HHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEE
ENDANCAGIAEAWLGAGRHCQNFIMLTLGTGVGGAIFLDGKLFVGHRGAAGELGLITLQP
ECCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCEEEEECCCCCCCEEEEEECC
DGPMCKSGNPGSLEQYTSIKAIRRLTGKEPAELGMLAQAGDPEALQFWQEYGQNLGIGLT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCEEECCCCHHHHHHHHHHCCCCCCCHH
SLIYVLTPQAIVLGGGVSASCEFFLPTLKAEIEKRVMSTSRAGLQILPAELGNSAGMVGA
HHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCHHH
ARLAWEKFGNW
HHHHHHHHCCC
>Mature Secondary Structure 
TSAVVVWCEELNVGNSQVIGIDLGGTAIKLGRFSKDGTCSQSLTVATPQPATPEAVFLV
CCEEEEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHH
MVDAIAQIDPDNETIAIGVGTPGPADAQGRIAQIAINLPQWENVPLADWLEAKTNKPTVI
HHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEE
ENDANCAGIAEAWLGAGRHCQNFIMLTLGTGVGGAIFLDGKLFVGHRGAAGELGLITLQP
ECCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCEEEEECCCCCCCEEEEEECC
DGPMCKSGNPGSLEQYTSIKAIRRLTGKEPAELGMLAQAGDPEALQFWQEYGQNLGIGLT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCEEECCCCHHHHHHHHHHCCCCCCCHH
SLIYVLTPQAIVLGGGVSASCEFFLPTLKAEIEKRVMSTSRAGLQILPAELGNSAGMVGA
HHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCHHH
ARLAWEKFGNW
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1435260; 12000953 [H]