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The map label for this gene is gor

Identifier: 17232460

GI number: 17232460

Start: 5930094

End: 5931473

Strand: Reverse

Name: gor

Synonym: all4968

Alternate gene names: 17232460

Gene position: 5931473-5930094 (Counterclockwise)

Preceding gene: 17232461

Following gene: 17232459

Centisome position: 92.48

GC content: 45.22

Gene sequence:

>1380_bases
ATGACTTTTGATTATGACTTGTTTGTAATTGGTGCTGGTTCTGGTGGTTTGGCTGCTTCTAAACGAGCTGCTAGCTATGG
CGCAAAAGTAGCGATCGCCGAAAATGATTTAGTGGGTGGAACCTGTGTCATTCGGGGTTGTGTACCCAAAAAACTCATGG
TTTATGGTTCTCACTTTCCCGCTTTATTCGAGGATGCAGCAGGCTATGGTTGGCAAGTCGGTAAGGCAGAATTAAATTGG
GAACATTTCATTACATCTATAGATAAGGAAGTCCGGCGACTATCCCAACTGCACATCAGCTTTCTAGAAAAAGCCGGGGT
AGAACTGATCTCTGGTCGTGCTACTTTGGTAGATAATCACACAGTAGAAGTAGGCGAGCGTAAATTTACCGCCGATAAAA
TTTTAATTGCCGTTGGTGGTCGTCCCATCAAACCAGAGTTGCCAGGGATGGAATATGGCATCACCTCCAACGAAATTTTT
CACCTAAAAACCCAACCAAAACACATCGCTATCATTGGTTCTGGTTACATCGGTACAGAATTTGCCGGAATCATGCGTGG
TTTGGGTTCACAAGTCACCCAAATTACCAGAGGTGACAAAATTCTCAAAGGTTTTGATGAAGACATCCGCACCGAAATTC
AAGAAGGGATGACAAATCACGGTATTCGGATTATTCCTAAAAACGTAGTTACAGCTATTGAACAAGTACCAGAAGGTTTG
AAAATAAGTTTATCTGGTGAAGACCAAGAACCAATCATTGCCGATGTATTTTTAGTAGCTACAGGACGGGTTCCCAACGT
AGATGGTTTAGGTCTGGAAAATGCTGGTGTTGATGTTGTTGACAGTTCTATAGAGGGGCCAGGATACAGCACCATGAATG
CCATTGCAGTGAACGAATACAGCCAAACCAGCCAACCCAATATCTATGCTGTTGGTGATGTTACAGACCGCTTAAACCTC
ACTCCCGTAGCCATTGGTGAAGGTCGCGCCTTCGCCGACAGTGAATTTGGCAACAACCGCCGAGAATTTAGCCACGAAAC
TATTGCTACTGCTGTATTCTCTAACCCACAAGCCTCTACAGTCGGACTAACGGAAGCCGAAGCACGGGCAAAACTCGGTG
ATGATGCCGTCACAATATACCGCACCCGCTTCCGCCCCATGTATCACAGTTTCACAGGCAAACAAGAGCGCATAATGATG
AAATTAGTGGTTGATACCAAAACCGACAAAGTTTTAGGCGCTCACATGGTGGGTGAAAATGCTGCTGAAATTATCCAAGG
TGTAGCGATCGCTGTCAAAATGGGAGCAACCAAAAAAGACTTCGATGCTACCGTTGGCATTCATCCCTCCTCCGCCGAGG
AATTTGTCACTATGCGATGA

Upstream 100 bases:

>100_bases
ATGAAAGGTAATAGGGGAGGAACTGATGACTGTTGACAACTGACAATTGACAAATAACAACTGTTACATTAAATATCAGC
AAATAGTATGTTAGGTTATT

Downstream 100 bases:

>100_bases
AGTAAGTAGGAAGCAGGGAGCAGGGGAAAGAAAATTGACAACTGTACAGACGCGATTAATCGCGTCTCTGAGCAATGACC
AAATACATCTACCTCCACGG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTFDYDLFVIGAGSGGLAASKRAASYGAKVAIAENDLVGGTCVIRGCVPKKLMVYGSHFPALFEDAAGYGWQVGKAELNW
EHFITSIDKEVRRLSQLHISFLEKAGVELISGRATLVDNHTVEVGERKFTADKILIAVGGRPIKPELPGMEYGITSNEIF
HLKTQPKHIAIIGSGYIGTEFAGIMRGLGSQVTQITRGDKILKGFDEDIRTEIQEGMTNHGIRIIPKNVVTAIEQVPEGL
KISLSGEDQEPIIADVFLVATGRVPNVDGLGLENAGVDVVDSSIEGPGYSTMNAIAVNEYSQTSQPNIYAVGDVTDRLNL
TPVAIGEGRAFADSEFGNNRREFSHETIATAVFSNPQASTVGLTEAEARAKLGDDAVTIYRTRFRPMYHSFTGKQERIMM
KLVVDTKTDKVLGAHMVGENAAEIIQGVAIAVKMGATKKDFDATVGIHPSSAEEFVTMR

Sequences:

>Translated_459_residues
MTFDYDLFVIGAGSGGLAASKRAASYGAKVAIAENDLVGGTCVIRGCVPKKLMVYGSHFPALFEDAAGYGWQVGKAELNW
EHFITSIDKEVRRLSQLHISFLEKAGVELISGRATLVDNHTVEVGERKFTADKILIAVGGRPIKPELPGMEYGITSNEIF
HLKTQPKHIAIIGSGYIGTEFAGIMRGLGSQVTQITRGDKILKGFDEDIRTEIQEGMTNHGIRIIPKNVVTAIEQVPEGL
KISLSGEDQEPIIADVFLVATGRVPNVDGLGLENAGVDVVDSSIEGPGYSTMNAIAVNEYSQTSQPNIYAVGDVTDRLNL
TPVAIGEGRAFADSEFGNNRREFSHETIATAVFSNPQASTVGLTEAEARAKLGDDAVTIYRTRFRPMYHSFTGKQERIMM
KLVVDTKTDKVLGAHMVGENAAEIIQGVAIAVKMGATKKDFDATVGIHPSSAEEFVTMR
>Mature_458_residues
TFDYDLFVIGAGSGGLAASKRAASYGAKVAIAENDLVGGTCVIRGCVPKKLMVYGSHFPALFEDAAGYGWQVGKAELNWE
HFITSIDKEVRRLSQLHISFLEKAGVELISGRATLVDNHTVEVGERKFTADKILIAVGGRPIKPELPGMEYGITSNEIFH
LKTQPKHIAIIGSGYIGTEFAGIMRGLGSQVTQITRGDKILKGFDEDIRTEIQEGMTNHGIRIIPKNVVTAIEQVPEGLK
ISLSGEDQEPIIADVFLVATGRVPNVDGLGLENAGVDVVDSSIEGPGYSTMNAIAVNEYSQTSQPNIYAVGDVTDRLNLT
PVAIGEGRAFADSEFGNNRREFSHETIATAVFSNPQASTVGLTEAEARAKLGDDAVTIYRTRFRPMYHSFTGKQERIMMK
LVVDTKTDKVLGAHMVGENAAEIIQGVAIAVKMGATKKDFDATVGIHPSSAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family

Homologues:

Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=40.8119658119658, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI22035672, Length=482, Percent_Identity=35.6846473029046, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI33519430, Length=485, Percent_Identity=33.4020618556701, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI33519428, Length=485, Percent_Identity=33.4020618556701, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI33519426, Length=485, Percent_Identity=33.4020618556701, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI148277065, Length=485, Percent_Identity=33.4020618556701, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI148277071, Length=485, Percent_Identity=33.4020618556701, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI291045266, Length=484, Percent_Identity=32.0247933884297, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI291045268, Length=484, Percent_Identity=30.5785123966942, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI91199540, Length=472, Percent_Identity=27.7542372881356, Blast_Score=152, Evalue=5e-37,
Organism=Escherichia coli, GI1789915, Length=461, Percent_Identity=41.2147505422993, Blast_Score=311, Evalue=6e-86,
Organism=Escherichia coli, GI87082354, Length=465, Percent_Identity=28.3870967741935, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=27.9220779220779, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI87081717, Length=461, Percent_Identity=27.765726681128, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789065, Length=257, Percent_Identity=24.5136186770428, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71983419, Length=460, Percent_Identity=41.7391304347826, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI71983429, Length=460, Percent_Identity=41.7391304347826, Blast_Score=295, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=33.8204592901879, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71982272, Length=493, Percent_Identity=33.8742393509128, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI32565766, Length=469, Percent_Identity=28.3582089552239, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=38.3966244725738, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=28.1183932346723, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=26.0416666666667, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640553, Length=481, Percent_Identity=36.5904365904366, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24640549, Length=481, Percent_Identity=36.5904365904366, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24640551, Length=481, Percent_Identity=36.5904365904366, Blast_Score=272, Evalue=3e-73,
Organism=Drosophila melanogaster, GI17737741, Length=481, Percent_Identity=34.3035343035343, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI21358499, Length=471, Percent_Identity=29.2993630573248, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): GSHR_NOSS1 (P48638)

Other databases:

- EMBL:   X89712
- EMBL:   BA000019
- PIR:   AH2426
- PIR:   I39477
- RefSeq:   NP_489008.1
- ProteinModelPortal:   P48638
- SMR:   P48638
- STRING:   P48638
- GeneID:   1108569
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all4968
- NMPDR:   fig|103690.1.peg.5275
- eggNOG:   COG1249
- HOGENOM:   HBG515043
- OMA:   VNEYSQT
- PhylomeDB:   P48638
- ProtClustDB:   PRK06116
- BioCyc:   NSP103690:ALL4968-MONOMER
- GO:   GO:0005737
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327
- Gene3D:   G3DSA:3.30.390.30
- PRINTS:   PR00368
- TIGRFAMs:   TIGR01424

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim; SSF55424 FAD/NAD-linked_reductase_dimer

EC number: =1.8.1.7

Molecular weight: Translated: 49479; Mature: 49348

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: ACT_SITE 448-448

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDYDLFVIGAGSGGLAASKRAASYGAKVAIAENDLVGGTCVIRGCVPKKLMVYGSHFP
CCEEEEEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCEEEEECCCCC
ALFEDAAGYGWQVGKAELNWEHFITSIDKEVRRLSQLHISFLEKAGVELISGRATLVDNH
HHHHHCCCCCEEECCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECC
TVEVGERKFTADKILIAVGGRPIKPELPGMEYGITSNEIFHLKTQPKHIAIIGSGYIGTE
EEECCCEEECCCEEEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCEEEEEECCCCHHH
FAGIMRGLGSQVTQITRGDKILKGFDEDIRTEIQEGMTNHGIRIIPKNVVTAIEQVPEGL
HHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCHHHCCEEEECHHHHHHHHHCCCCC
KISLSGEDQEPIIADVFLVATGRVPNVDGLGLENAGVDVVDSSIEGPGYSTMNAIAVNEY
EEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECC
SQTSQPNIYAVGDVTDRLNLTPVAIGEGRAFADSEFGNNRREFSHETIATAVFSNPQAST
CCCCCCCEEEEECCCCCCCCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHEECCCCCCE
VGLTEAEARAKLGDDAVTIYRTRFRPMYHSFTGKQERIMMKLVVDTKTDKVLGAHMVGEN
ECCCHHHHHHHCCCCEEEEEEECCCHHHHHCCCCHHEEEEEEEEECCCCCEEEHHHCCCC
AAEIIQGVAIAVKMGATKKDFDATVGIHPSSAEEFVTMR
HHHHHHHEEEEEEECCCCCCCCEEEECCCCCHHHHEECC
>Mature Secondary Structure 
TFDYDLFVIGAGSGGLAASKRAASYGAKVAIAENDLVGGTCVIRGCVPKKLMVYGSHFP
CEEEEEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCEEEEECCCCC
ALFEDAAGYGWQVGKAELNWEHFITSIDKEVRRLSQLHISFLEKAGVELISGRATLVDNH
HHHHHCCCCCEEECCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECC
TVEVGERKFTADKILIAVGGRPIKPELPGMEYGITSNEIFHLKTQPKHIAIIGSGYIGTE
EEECCCEEECCCEEEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCEEEEEECCCCHHH
FAGIMRGLGSQVTQITRGDKILKGFDEDIRTEIQEGMTNHGIRIIPKNVVTAIEQVPEGL
HHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCHHHCCEEEECHHHHHHHHHCCCCC
KISLSGEDQEPIIADVFLVATGRVPNVDGLGLENAGVDVVDSSIEGPGYSTMNAIAVNEY
EEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECC
SQTSQPNIYAVGDVTDRLNLTPVAIGEGRAFADSEFGNNRREFSHETIATAVFSNPQAST
CCCCCCCEEEEECCCCCCCCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHEECCCCCCE
VGLTEAEARAKLGDDAVTIYRTRFRPMYHSFTGKQERIMMKLVVDTKTDKVLGAHMVGEN
ECCCHHHHHHHCCCCEEEEEEECCCHHHHHCCCCHHEEEEEEEEECCCCCEEEHHHCCCC
AAEIIQGVAIAVKMGATKKDFDATVGIHPSSAEEFVTMR
HHHHHHHEEEEEEECCCCCCCCEEEECCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840