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The map label for this gene is cobC [H]

Identifier: 17232398

GI number: 17232398

Start: 5852102

End: 5852740

Strand: Reverse

Name: cobC [H]

Synonym: all4906

Alternate gene names: 17232398

Gene position: 5852740-5852102 (Counterclockwise)

Preceding gene: 17232408

Following gene: 17232396

Centisome position: 91.25

GC content: 42.72

Gene sequence:

>639_bases
ATGACACTCAATTTATATTTACTGCGACATGGAGAAACTACTTTTAGTCAAAGTGGTAATTTCTGCGGTAAAACTGATGC
AGACTTGACCTCTGAAGGGGTGCAGATGGCAGAGAGTTTTGCCGATGTTTATCAAAAACTGAAATGGGAAGCGGTTTATG
CTAGCCCGATGAAGCGCACAATTGCCACAGCCAAACCATTTTGTGATGCAATTGGTATGGAAATGCGGTTGCGTGACGGA
CTTAGAGAAGGTAGTTACGGCGAATGGGAAACCAAAAGTAAATCCTTTGCCCAAGAGAATTACGCCCAAAACTATGTAAA
ATGGTTGACAGAACCCGCTTGGAATGCACCAATAGGTGGAGAAACGGCGGTAGATATTGCAAACCGTTCTATGCCTGTAA
TTGCGGAAATTCAGGAAAAATATCCCCAAGGTAATGTCTTAGTAGTTTCCCATAAAGCCACGATTCGGATTATGCTTTGC
AGCTTACTAGGAATTGATTTGGGACGCTATCGCTATCGGGTGAATATTTTGGTCGCGTCGGTAAGTATGGTAAAATTTGA
CGTTAATGGCCCTTTATTAGAAATATTAGGCGATCGCCATCATATACCCGATCATATTCGCTCTCGTCCGGGAACATAA

Upstream 100 bases:

>100_bases
TGGTTGATTGACTTTTTTGGTTGATTACTTTGTCCGGCTGTTACATACTCAATTGTGAGATTGATGGTAGTTTATTTTTG
CACAGACTCCTTTATCCCAT

Downstream 100 bases:

>100_bases
CAGTCTCTACTAGTAGTTTGCCCAGAAATTATCAGACTTGTCCGAAAACTCCAAAGCCCAGGGACACCTATTTCTAGTGC
GACAATTTTTAAATAGCGAC

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTLNLYLLRHGETTFSQSGNFCGKTDADLTSEGVQMAESFADVYQKLKWEAVYASPMKRTIATAKPFCDAIGMEMRLRDG
LREGSYGEWETKSKSFAQENYAQNYVKWLTEPAWNAPIGGETAVDIANRSMPVIAEIQEKYPQGNVLVVSHKATIRIMLC
SLLGIDLGRYRYRVNILVASVSMVKFDVNGPLLEILGDRHHIPDHIRSRPGT

Sequences:

>Translated_212_residues
MTLNLYLLRHGETTFSQSGNFCGKTDADLTSEGVQMAESFADVYQKLKWEAVYASPMKRTIATAKPFCDAIGMEMRLRDG
LREGSYGEWETKSKSFAQENYAQNYVKWLTEPAWNAPIGGETAVDIANRSMPVIAEIQEKYPQGNVLVVSHKATIRIMLC
SLLGIDLGRYRYRVNILVASVSMVKFDVNGPLLEILGDRHHIPDHIRSRPGT
>Mature_211_residues
TLNLYLLRHGETTFSQSGNFCGKTDADLTSEGVQMAESFADVYQKLKWEAVYASPMKRTIATAKPFCDAIGMEMRLRDGL
REGSYGEWETKSKSFAQENYAQNYVKWLTEPAWNAPIGGETAVDIANRSMPVIAEIQEKYPQGNVLVVSHKATIRIMLCS
LLGIDLGRYRYRVNILVASVSMVKFDVNGPLLEILGDRHHIPDHIRSRPGT

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Homo sapiens, GI64762406, Length=161, Percent_Identity=31.6770186335404, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI64762445, Length=161, Percent_Identity=31.6770186335404, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1786857, Length=174, Percent_Identity=25.2873563218391, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1790856, Length=208, Percent_Identity=26.9230769230769, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 23806; Mature: 23674

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNLYLLRHGETTFSQSGNFCGKTDADLTSEGVQMAESFADVYQKLKWEAVYASPMKRT
CEEEEEEEECCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATAKPFCDAIGMEMRLRDGLREGSYGEWETKSKSFAQENYAQNYVKWLTEPAWNAPIGG
HHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ETAVDIANRSMPVIAEIQEKYPQGNVLVVSHKATIRIMLCSLLGIDLGRYRYRVNILVAS
CHHEECCCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCHHHEEEEEEEEEEE
VSMVKFDVNGPLLEILGDRHHIPDHIRSRPGT
EEEEEEECCCCHHHHHCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
TLNLYLLRHGETTFSQSGNFCGKTDADLTSEGVQMAESFADVYQKLKWEAVYASPMKRT
EEEEEEEECCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATAKPFCDAIGMEMRLRDGLREGSYGEWETKSKSFAQENYAQNYVKWLTEPAWNAPIGG
HHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ETAVDIANRSMPVIAEIQEKYPQGNVLVVSHKATIRIMLCSLLGIDLGRYRYRVNILVAS
CHHEECCCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCHHHEEEEEEEEEEE
VSMVKFDVNGPLLEILGDRHHIPDHIRSRPGT
EEEEEEECCCCHHHHHCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]