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The map label for this gene is hemB [H]

Identifier: 17232217

GI number: 17232217

Start: 5632502

End: 5633512

Strand: Reverse

Name: hemB [H]

Synonym: all4725

Alternate gene names: 17232217

Gene position: 5633512-5632502 (Counterclockwise)

Preceding gene: 17232218

Following gene: 17232216

Centisome position: 87.83

GC content: 46.49

Gene sequence:

>1011_bases
ATGTCAGTTGAAAATTCATCTACCGCCAAACCATTGAACCTGTTGCAACGCCCCCGTCGGTTGCGTCGGACTGCAACACT
GAGGCGGATGGTGCGGGAAACTACCCTGACAGTGGATGATTTGATTTATCCGATGTTTGTCATGGAAGGAGAGGGGCAGA
AAGTAGAAATTACTTCCATGCCAGGATGTTATCGCTACTCCCTAGATTTGTTGCTCAAAGAGATAGCCGAAGTATCACAG
CTAGGAATTCCGGCGATCGCACTTTTCCCTGTCATCTCCGAAAATAAGAAAGATGACATCGGTGCAGAAAGCTACAACCC
AGAGGGATTAGTACAGCAAACAGTCAAAGCCATTAAACAAGCAGTTCCCGATATTGTTGTGATCACTGACGTAGCCCTTG
ACCCCTTCACCACACATGGACACGATGGTTTAGTTGATGAAAACGGCACAATCTTAAATGACCCCACAGTGGAAATGTTA
GTGAAAATGGCACTTTCCCAAGCCGCCGCCGGTACAGATTTTGTTGCCCCTTCCGACATGATGGACGGCAGAATTGGCGC
AATCCGTCAAGCCTTAGATGCAGAAGGCTACATCAATGTAGGGATTTTGGCATACTCCGCTAAATACGCCTCCGCCTATT
ACGGCCCCTTTCGGGATGCGTTAGATTCCGCCCCCAAATTTGGCGACAAAAAAACCTATCAAATGGATGCAGCCAACGCC
AGAGAAGCAATTAAAGAAGTAGAACTAGATATTGTCGAAGGTGCAGATATTGTTATGGTAAAACCTGCCCTAGCTTACCT
AGATATCATTCATCAAGTCCAGCAAGCTACCCAGTTACCAGTTGCAGCCTACAACGTCAGTGGCGAATACGCCATGATCA
AAGCTGCGGCTCAAATGGGTTGGATTAATGAAAAACAAGTGATTTTGGAATCTTTAACCAGCATGAAACGCGCCGGCGCA
GATTTAATTCTCACCTACTTTGCCAAAGAAGTAGCACTGATGTTGCTTTAG

Upstream 100 bases:

>100_bases
AGATCCCCGACTTTTTAAAAAAGTCGGGGATCTGAGCGTTCCTACAACACAAAATGAACGGCTTCCATTATGATAATGGT
TATCAATCTTGTGAAGTCTT

Downstream 100 bases:

>100_bases
ACGTGGAGGGCAGAGGGGCAAGGGGGGCAAATAACAACTGACAACTGACAACTAACAAAATGACCAAAAAAACCGACTTA
GCTATTGTTGGCGCAGGGCC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSVENSSTAKPLNLLQRPRRLRRTATLRRMVRETTLTVDDLIYPMFVMEGEGQKVEITSMPGCYRYSLDLLLKEIAEVSQ
LGIPAIALFPVISENKKDDIGAESYNPEGLVQQTVKAIKQAVPDIVVITDVALDPFTTHGHDGLVDENGTILNDPTVEML
VKMALSQAAAGTDFVAPSDMMDGRIGAIRQALDAEGYINVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANA
REAIKEVELDIVEGADIVMVKPALAYLDIIHQVQQATQLPVAAYNVSGEYAMIKAAAQMGWINEKQVILESLTSMKRAGA
DLILTYFAKEVALMLL

Sequences:

>Translated_336_residues
MSVENSSTAKPLNLLQRPRRLRRTATLRRMVRETTLTVDDLIYPMFVMEGEGQKVEITSMPGCYRYSLDLLLKEIAEVSQ
LGIPAIALFPVISENKKDDIGAESYNPEGLVQQTVKAIKQAVPDIVVITDVALDPFTTHGHDGLVDENGTILNDPTVEML
VKMALSQAAAGTDFVAPSDMMDGRIGAIRQALDAEGYINVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANA
REAIKEVELDIVEGADIVMVKPALAYLDIIHQVQQATQLPVAAYNVSGEYAMIKAAAQMGWINEKQVILESLTSMKRAGA
DLILTYFAKEVALMLL
>Mature_335_residues
SVENSSTAKPLNLLQRPRRLRRTATLRRMVRETTLTVDDLIYPMFVMEGEGQKVEITSMPGCYRYSLDLLLKEIAEVSQL
GIPAIALFPVISENKKDDIGAESYNPEGLVQQTVKAIKQAVPDIVVITDVALDPFTTHGHDGLVDENGTILNDPTVEMLV
KMALSQAAAGTDFVAPSDMMDGRIGAIRQALDAEGYINVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANAR
EAIKEVELDIVEGADIVMVKPALAYLDIIHQVQQATQLPVAAYNVSGEYAMIKAAAQMGWINEKQVILESLTSMKRAGAD
LILTYFAKEVALMLL

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=300, Percent_Identity=41.6666666666667, Blast_Score=252, Evalue=3e-67,
Organism=Escherichia coli, GI87081728, Length=320, Percent_Identity=48.75, Blast_Score=302, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=39.7394136807818, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21358291, Length=305, Percent_Identity=37.0491803278689, Blast_Score=228, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36769; Mature: 36638

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVENSSTAKPLNLLQRPRRLRRTATLRRMVRETTLTVDDLIYPMFVMEGEGQKVEITSM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCCEEEEECC
PGCYRYSLDLLLKEIAEVSQLGIPAIALFPVISENKKDDIGAESYNPEGLVQQTVKAIKQ
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AVPDIVVITDVALDPFTTHGHDGLVDENGTILNDPTVEMLVKMALSQAAAGTDFVAPSDM
HCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCHH
MDGRIGAIRQALDAEGYINVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANA
CCCHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHCCHHHHHHHCCCCCCCCCEEEECHHHH
REAIKEVELDIVEGADIVMVKPALAYLDIIHQVQQATQLPVAAYNVSGEYAMIKAAAQMG
HHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHC
WINEKQVILESLTSMKRAGADLILTYFAKEVALMLL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVENSSTAKPLNLLQRPRRLRRTATLRRMVRETTLTVDDLIYPMFVMEGEGQKVEITSM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCCEEEEECC
PGCYRYSLDLLLKEIAEVSQLGIPAIALFPVISENKKDDIGAESYNPEGLVQQTVKAIKQ
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AVPDIVVITDVALDPFTTHGHDGLVDENGTILNDPTVEMLVKMALSQAAAGTDFVAPSDM
HCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCHH
MDGRIGAIRQALDAEGYINVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANA
CCCHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHCCHHHHHHHCCCCCCCCCEEEECHHHH
REAIKEVELDIVEGADIVMVKPALAYLDIIHQVQQATQLPVAAYNVSGEYAMIKAAAQMG
HHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHC
WINEKQVILESLTSMKRAGADLILTYFAKEVALMLL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]