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The map label for this gene is ilvG [H]

Identifier: 17232105

GI number: 17232105

Start: 5514172

End: 5516070

Strand: Reverse

Name: ilvG [H]

Synonym: all4613

Alternate gene names: 17232105

Gene position: 5516070-5514172 (Counterclockwise)

Preceding gene: 17232106

Following gene: 17232101

Centisome position: 86.0

GC content: 47.29

Gene sequence:

>1899_bases
GTGACTGTGAGCTTGCCTTCCCCGACTAGTCCCTCACAAACAGAGAAACATACTCAGTCTGTTAATTCGCCATCGGTGGT
TGTGACACCACAACGGGTAACTGGTGGCTTCGCGCTACTTGATAGCCTGCTGCGCCACGGCGTTGAGTATATCTTTGGTT
ATCCTGGTGGGGCGATTCTGCCGATTTATGATGATCTGTATAAGGTGGAAGCAACTGGCAGCCTTAAACATATTCTAGTG
AGACACGAACAAGGAGCAGCTCATGCTGCTGATGGTTATGCTCGTGCAACCGGAAAAGTAGGTGTATGCTTTGGTACTTC
TGGGCCTGGGGCAACTAACTTGGTAACAGGTATCGCTACAGCCTACATGGATTCAATTCCAATGGTGATTGTTACTGGGC
AAGTACCCCGGAAAATGATCGGTACAGATGCGTTCCAAGAAACCGATATCTACGGTATTACTCTACCCATTGTTAAGCAC
TCCTATGTAGTGCGTGACCCCCAAGACATGGCGCGAATTGTGGCAGAAGCATTCCACATAGCCAGCACAGGCCGTCCAGG
GCCAGTGTTGATTGATGTGCCGAAAGATGTGGCTTTTGAACAATTTGATTATGTACCTGTAGAACCAGGTTCAATTAAAT
TACGCGGATATCGCCCCACGGTGAAGGGAAATCCACGCCAAATTAACGCCGCGATTGAATTGATCCGCGAAAGCCGTCGT
CCTTTACTATACGTTGGTGGTGGGGCGATCGCATCTGGCGCTCATGCAGAAATTCAAGAACTCGCCGAGTTATTTAATAT
CCCCGTCACTACCACCCTAATGGGTATCGGGGCTTTTGATGAACACCATCCTTTATCCTTGGGGATGTTGGGGATGCACG
GCACAGCTTACGCTAACTTTGCTGTGACTGATTGTGATTTATTGATTTGCGTGGGTGCTAGGTTTGATGACCGTGTTACT
GGCAAATTAGATGAGTTTGCTTCTCGTGCCAAAGTCATTCACATCGATATTGACCCCGCCGAAGTTGGTAAAAACCGCAT
TCCTGAAGTCCCCATTGTTGGCGATGTGCGGAAAGTCTTACTTGATTTATTACGTCGTTGCAAACAAACAAGTGCCAAAA
CTACCCCCAACCAAAACCAAGAATGGCTTAACTTAATTAACCGTTGGCGGGAGGATTACCCCCTAGTAGTTCCCCAGCAT
CCAGACAGCATTCCCCCACAAGAAGTGATTGTGGAAGTCGGTAGTCAAGCCCCCCACGCCTTCTACACCACTGATGTTGG
TCAACATCAAATGTGGGCAGCCCAATTCCTCAAAAATGGCCCCCGGCGTTGGATTTCTAGCGCAGGCTTGGGAACTATGG
GTTTTGGTTTACCTGCCGCAATTGGCGCTAAAGTAGCTTTCCCAGATGAACAAGTAATCTGTATTAGCGGTGATGCCAGT
TTCCAAATGTGTCTGCAAGAGCTTGGTACTGCTGCACAATATAAGATAAATGTCAAGACTGTAATTCTAAATAACGGCTG
GCAAGGGATGGTACGCCAATGGCAACAAGCATTCCACGGCGAGCGCTACTCCTGCTCAAATATGGAAGTAGGGATGCCAG
ATGTAGAGTTATTGGCACAAGCCTACGGCATTAAGGGTATTGTAGTCACTCACAGAGAGCAATTGAAAGATGCGATCGCT
CAAATGTTAGCCTACGATGGCCCAGTTATTTTAGATGTTCGCGTCACAAAAGACGAGAATTGCTATCCTATGGTAGCTCC
TGGTAAGAGTAATGCTCAAATGATTGGTTTACCGAAGCAACCACCAAAGACCAGTGTCGAACCAGTTTATTGCAGCCATT
GTGGCACGTCAAATTTACCAAATCACAATTTCTGTTCTGAATGTGGGACTAAGTTGTAA

Upstream 100 bases:

>100_bases
AAAGAAATTTAATTCATAATTTGATTGAACTTTTCTATTAATATTGAATTACTGACTACAGAATTCCCGCATTAACTTAG
CTATCATCTGAGGTTTGACC

Downstream 100 bases:

>100_bases
TTCATTTGCAGTTATATAAGTGATTTTGATGACGCAGGGTTTTATGTACTCTGCGTTTTTTCTTTTTCAACACAGAGGAA
CGCTATAGCTGGGGACTGGG

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MTVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAILPIYDDLYKVEATGSLKHILV
RHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIATAYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKH
SYVVRDPQDMARIVAEAFHIASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRR
PLLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANFAVTDCDLLICVGARFDDRVT
GKLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVLLDLLRRCKQTSAKTTPNQNQEWLNLINRWREDYPLVVPQH
PDSIPPQEVIVEVGSQAPHAFYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDAS
FQMCLQELGTAAQYKINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAQAYGIKGIVVTHREQLKDAIA
QMLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQPPKTSVEPVYCSHCGTSNLPNHNFCSECGTKL

Sequences:

>Translated_632_residues
MTVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAILPIYDDLYKVEATGSLKHILV
RHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIATAYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKH
SYVVRDPQDMARIVAEAFHIASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRR
PLLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANFAVTDCDLLICVGARFDDRVT
GKLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVLLDLLRRCKQTSAKTTPNQNQEWLNLINRWREDYPLVVPQH
PDSIPPQEVIVEVGSQAPHAFYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDAS
FQMCLQELGTAAQYKINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAQAYGIKGIVVTHREQLKDAIA
QMLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQPPKTSVEPVYCSHCGTSNLPNHNFCSECGTKL
>Mature_631_residues
TVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAILPIYDDLYKVEATGSLKHILVR
HEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIATAYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKHS
YVVRDPQDMARIVAEAFHIASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRRP
LLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANFAVTDCDLLICVGARFDDRVTG
KLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVLLDLLRRCKQTSAKTTPNQNQEWLNLINRWREDYPLVVPQHP
DSIPPQEVIVEVGSQAPHAFYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDASF
QMCLQELGTAAQYKINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAQAYGIKGIVVTHREQLKDAIAQ
MLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQPPKTSVEPVYCSHCGTSNLPNHNFCSECGTKL

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=597, Percent_Identity=26.9681742043551, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI93004078, Length=555, Percent_Identity=26.3063063063063, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI87081685, Length=569, Percent_Identity=46.3971880492091, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1790104, Length=576, Percent_Identity=42.5347222222222, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1786717, Length=558, Percent_Identity=34.7670250896057, Blast_Score=319, Evalue=4e-88,
Organism=Escherichia coli, GI1787096, Length=547, Percent_Identity=28.3363802559415, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1788716, Length=552, Percent_Identity=27.1739130434783, Blast_Score=175, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17531301, Length=580, Percent_Identity=26.551724137931, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17531299, Length=591, Percent_Identity=26.2267343485618, Blast_Score=149, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17542570, Length=541, Percent_Identity=26.2476894639556, Blast_Score=142, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6323755, Length=618, Percent_Identity=42.2330097087379, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6320816, Length=516, Percent_Identity=25, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6321524, Length=511, Percent_Identity=26.027397260274, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323163, Length=513, Percent_Identity=24.1715399610136, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323073, Length=511, Percent_Identity=24.26614481409, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19922626, Length=578, Percent_Identity=26.4705882352941, Blast_Score=169, Evalue=7e-42,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 68684; Mature: 68552

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAIL
CEECCCCCCCCCHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHCCCCEEEECCCCEEE
PIYDDLYKVEATGSLKHILVRHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIAT
EEECCEEEEECCCCEEEEEEECCCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHH
AYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKHSYVVRDPQDMARIVAEAFHI
HHHCCCCEEEEECCCCHHHHCCCCCCCCCEEEEEEEEEECEEEEECHHHHHHHHHHHHHH
ASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRR
HCCCCCCCEEEECCCCCCHHHCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCC
PLLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANF
CEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCEEEEEECCCCEEEEE
AVTDCDLLICVGARFDDRVTGKLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVL
EEECCEEEEEECCCCCCCCCCCHHHHHCCCEEEEEECCHHHHCCCCCCCCCCHHHHHHHH
LDLLRRCKQTSAKTTPNQNQEWLNLINRWREDYPLVVPQHPDSIPPQEVIVEVGSQAPHA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCCCCCCE
FYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDAS
EEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHCCEEECCCCEEEEEECCCH
FQMCLQELGTAAQYKINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAQ
HHHHHHHHCCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHH
AYGIKGIVVTHREQLKDAIAQMLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQ
HHCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCEEECCCCC
PPKTSVEPVYCSHCGTSNLPNHNFCSECGTKL
CCCCCCCCEEECCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
TVSLPSPTSPSQTEKHTQSVNSPSVVVTPQRVTGGFALLDSLLRHGVEYIFGYPGGAIL
EECCCCCCCCCHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHCCCCEEEECCCCEEE
PIYDDLYKVEATGSLKHILVRHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIAT
EEECCEEEEECCCCEEEEEEECCCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHH
AYMDSIPMVIVTGQVPRKMIGTDAFQETDIYGITLPIVKHSYVVRDPQDMARIVAEAFHI
HHHCCCCEEEEECCCCHHHHCCCCCCCCCEEEEEEEEEECEEEEECHHHHHHHHHHHHHH
ASTGRPGPVLIDVPKDVAFEQFDYVPVEPGSIKLRGYRPTVKGNPRQINAAIELIRESRR
HCCCCCCCEEEECCCCCCHHHCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCC
PLLYVGGGAIASGAHAEIQELAELFNIPVTTTLMGIGAFDEHHPLSLGMLGMHGTAYANF
CEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCEEEEEECCCCEEEEE
AVTDCDLLICVGARFDDRVTGKLDEFASRAKVIHIDIDPAEVGKNRIPEVPIVGDVRKVL
EEECCEEEEEECCCCCCCCCCCHHHHHCCCEEEEEECCHHHHCCCCCCCCCCHHHHHHHH
LDLLRRCKQTSAKTTPNQNQEWLNLINRWREDYPLVVPQHPDSIPPQEVIVEVGSQAPHA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCCCCCCE
FYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAAIGAKVAFPDEQVICISGDAS
EEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHCCEEECCCCEEEEEECCCH
FQMCLQELGTAAQYKINVKTVILNNGWQGMVRQWQQAFHGERYSCSNMEVGMPDVELLAQ
HHHHHHHHCCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHH
AYGIKGIVVTHREQLKDAIAQMLAYDGPVILDVRVTKDENCYPMVAPGKSNAQMIGLPKQ
HHCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCEEECCCCC
PPKTSVEPVYCSHCGTSNLPNHNFCSECGTKL
CCCCCCCCEEECCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512571 [H]