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The map label for this gene is gcvT

Identifier: 17232101

GI number: 17232101

Start: 5510983

End: 5512113

Strand: Reverse

Name: gcvT

Synonym: all4609

Alternate gene names: 17232101

Gene position: 5512113-5510983 (Counterclockwise)

Preceding gene: 17232105

Following gene: 17232100

Centisome position: 85.94

GC content: 45.71

Gene sequence:

>1131_bases
GTGGCTAATCAAAAAGATACTGCCGAAACCTTAGCGAGAACCCCTTTGTATCAACTGGGTGTAGAACTCAAAGCCCGCTT
GACCAGCTTTGGCGGGTGGGAAATGCCAGTACAATTTAGTGGGATCACCCGCGAACACGAAGCAGTAAGAAACGCTGCTG
GGATGTTTGACATTTCTCACATGGGTAAATTCACCCTCCAAGGTAAAAACCTCATTTCTCAACTCCAAGGTTTAGTTCCT
TCAGATTTAAGTAGGTTGCAACCAGGACAAGCCCAATATACCGTGTTGTTAAACCCCCAAGGAGGAATCATCGACGATAT
TATTGTCTACTACCAAGGTGAAGACAACACTGGTACACAACAGGCATTTATTATCGTCAATGCAGCCACCACTAGTAAAG
ACAAAGCATGGATACTGTCACACCTCGACCAAAATCAGGTGCAATTCCAAGACATATCACCAGCAAAAGTCTTAATCGCC
ATTCAAGGGCCAAAAGCTATCGGCTATCTCCAGCCTTTTGTGCAGCAAAACTTACAACCAATCAAAGCCTTTGGACATCT
AGAAGCAACAGTACTAGGTCAAGCAGGTTTTATAGCCCGTACAGGTTATACCGGGGAAGATGGCTTTGAGATTTTGGTAG
ACCCAGAAGTAGGGGTAGAGTTATGGCGTAGTTTATATGATGCAGGTGTCATTCCCTGTGGCTTAGGTGCAAGAGATACC
CTGAGGCTAGAAGCAGCTATGGCGCTTTACGGTCAAGACATCGATGACAACACCACTCCTCTAGAAGCTGGGTTAGGGTG
GTTAGTTCATTTGGATACCAAAGGAGATTTTATTGGTCGGTCGGTTTTAGAACAACAAAAGGCTACAGGAGTACAACGCC
GACTTATAGGTTTGCAAACCCAAGGACGTAACATCGCCCGTCATGGCTACCAAGTTCTCTCAGACGGTAAAGTAGTAGGC
GGAGTGACTAGCGGCACTCTATCACCTACACTGGGTTATCCTGTTGCTTTAGCCTACGTCCCTAGCAAACTAGCGAAAGT
TGGTCAACCGCTAGAAGTCGAAATTCGTGGTAAAGCATACCCAGCTGTTGTAGTTAAGCGACCCTTTTATCGTTCAAGTA
ATAAGGGTTAG

Upstream 100 bases:

>100_bases
AGTGGGTCAGAAATTATTCCCTATGTCTTACTCCCTATTAATTGAAACCATCACGTAGGATATTAAATGTTGAAGTGCGA
TCGCATAAGCAAAACTATCT

Downstream 100 bases:

>100_bases
AAAATCGTGATTAGGGTAAGCAAAGGGGTTGAAGAGGGAAAATTTGGCCTATCTCCAGCCCCCAATCTAAAAACCAATGT
TGACCTACTGAATGTGTTGT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MANQKDTAETLARTPLYQLGVELKARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISHMGKFTLQGKNLISQLQGLVP
SDLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNTGTQQAFIIVNAATTSKDKAWILSHLDQNQVQFQDISPAKVLIA
IQGPKAIGYLQPFVQQNLQPIKAFGHLEATVLGQAGFIARTGYTGEDGFEILVDPEVGVELWRSLYDAGVIPCGLGARDT
LRLEAAMALYGQDIDDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVQRRLIGLQTQGRNIARHGYQVLSDGKVVG
GVTSGTLSPTLGYPVALAYVPSKLAKVGQPLEVEIRGKAYPAVVVKRPFYRSSNKG

Sequences:

>Translated_376_residues
MANQKDTAETLARTPLYQLGVELKARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISHMGKFTLQGKNLISQLQGLVP
SDLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNTGTQQAFIIVNAATTSKDKAWILSHLDQNQVQFQDISPAKVLIA
IQGPKAIGYLQPFVQQNLQPIKAFGHLEATVLGQAGFIARTGYTGEDGFEILVDPEVGVELWRSLYDAGVIPCGLGARDT
LRLEAAMALYGQDIDDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVQRRLIGLQTQGRNIARHGYQVLSDGKVVG
GVTSGTLSPTLGYPVALAYVPSKLAKVGQPLEVEIRGKAYPAVVVKRPFYRSSNKG
>Mature_375_residues
ANQKDTAETLARTPLYQLGVELKARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISHMGKFTLQGKNLISQLQGLVPS
DLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNTGTQQAFIIVNAATTSKDKAWILSHLDQNQVQFQDISPAKVLIAI
QGPKAIGYLQPFVQQNLQPIKAFGHLEATVLGQAGFIARTGYTGEDGFEILVDPEVGVELWRSLYDAGVIPCGLGARDTL
RLEAAMALYGQDIDDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVQRRLIGLQTQGRNIARHGYQVLSDGKVVGG
VTSGTLSPTLGYPVALAYVPSKLAKVGQPLEVEIRGKAYPAVVVKRPFYRSSNKG

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=369, Percent_Identity=36.5853658536585, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI257796258, Length=355, Percent_Identity=35.7746478873239, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI257796254, Length=366, Percent_Identity=34.1530054644809, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI257796256, Length=309, Percent_Identity=36.8932038834951, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI24797151, Length=383, Percent_Identity=29.5039164490862, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=28.7037037037037, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=28.7037037037037, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI194306651, Length=320, Percent_Identity=26.5625, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1789272, Length=373, Percent_Identity=41.0187667560322, Blast_Score=250, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17560118, Length=379, Percent_Identity=33.245382585752, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI32563613, Length=349, Percent_Identity=26.9340974212034, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71994052, Length=377, Percent_Identity=24.6684350132626, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994045, Length=377, Percent_Identity=24.6684350132626, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320222, Length=385, Percent_Identity=36.1038961038961, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI20129441, Length=377, Percent_Identity=36.8700265251989, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI28571104, Length=286, Percent_Identity=27.972027972028, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20130091, Length=351, Percent_Identity=26.4957264957265, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_NOSS1 (Q8YNF7)

Other databases:

- EMBL:   BA000019
- PIR:   AI2381
- RefSeq:   NP_488649.1
- ProteinModelPortal:   Q8YNF7
- SMR:   Q8YNF7
- STRING:   Q8YNF7
- GeneID:   1108210
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all4609
- NMPDR:   fig|103690.1.peg.4916
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- PhylomeDB:   Q8YNF7
- ProtClustDB:   PRK00389
- BioCyc:   NSP103690:ALL4609-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 40775; Mature: 40644

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQKDTAETLARTPLYQLGVELKARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISH
CCCCHHHHHHHHHCCHHHHCHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCEEHHH
MGKFTLQGKNLISQLQGLVPSDLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNTGTQ
CCCEEECHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCE
QAFIIVNAATTSKDKAWILSHLDQNQVQFQDISPAKVLIAIQGPKAIGYLQPFVQQNLQP
EEEEEEEECCCCCCHHHHHHHCCCCCEEEECCCCEEEEEEEECCCHHHHHHHHHHCCCHH
IKAFGHLEATVLGQAGFIARTGYTGEDGFEILVDPEVGVELWRSLYDAGVIPCGLGARDT
HHHHCCCEEEEECCCCEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCH
LRLEAAMALYGQDIDDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVQRRLIGLQT
HHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QGRNIARHGYQVLSDGKVVGGVTSGTLSPTLGYPVALAYVPSKLAKVGQPLEVEIRGKAY
CCCHHHHHCHHHHCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCC
PAVVVKRPFYRSSNKG
CEEEEECCCCCCCCCC
>Mature Secondary Structure 
ANQKDTAETLARTPLYQLGVELKARLTSFGGWEMPVQFSGITREHEAVRNAAGMFDISH
CCCHHHHHHHHHCCHHHHCHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCEEHHH
MGKFTLQGKNLISQLQGLVPSDLSRLQPGQAQYTVLLNPQGGIIDDIIVYYQGEDNTGTQ
CCCEEECHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCE
QAFIIVNAATTSKDKAWILSHLDQNQVQFQDISPAKVLIAIQGPKAIGYLQPFVQQNLQP
EEEEEEEECCCCCCHHHHHHHCCCCCEEEECCCCEEEEEEEECCCHHHHHHHHHHCCCHH
IKAFGHLEATVLGQAGFIARTGYTGEDGFEILVDPEVGVELWRSLYDAGVIPCGLGARDT
HHHHCCCEEEEECCCCEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCH
LRLEAAMALYGQDIDDNTTPLEAGLGWLVHLDTKGDFIGRSVLEQQKATGVQRRLIGLQT
HHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QGRNIARHGYQVLSDGKVVGGVTSGTLSPTLGYPVALAYVPSKLAKVGQPLEVEIRGKAY
CCCHHHHHCHHHHCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCC
PAVVVKRPFYRSSNKG
CEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840