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The map label for this gene is hisA [H]

Identifier: 17231998

GI number: 17231998

Start: 5397008

End: 5397781

Strand: Reverse

Name: hisA [H]

Synonym: all4506

Alternate gene names: 17231998

Gene position: 5397781-5397008 (Counterclockwise)

Preceding gene: 17231999

Following gene: 17231995

Centisome position: 84.16

GC content: 46.25

Gene sequence:

>774_bases
ATGGATGTAATTCCAGCAATTGATTTACTAGCAGGTCGTTGTGTGCGACTCTATCAGGGAGACTACGATCGCTCACAAGT
GTTTAGCGAAAATCCTGTTGATGTTGCTAAACAGTGGGTAGATGAGGGTGCAACACGTCTGCACATAGTAGATTTAGATG
GTGCAAAAGCAGGTAAAGTAGTAAATCTAGGAGCAATTGAAGCGATCGCTCAAGCTATTTCTATACCGATTGAAATTGGT
GGCGGATTGCGCGATCGTTCTAGTGTGGAACAGGTGTTTAATTTAGGTGTACAGTGGGCAATTCTCGGTACTGTCGCCGT
AGAACAACCCCAGCTTGTACAAGAACTCTGTCAACAATACCCCGGACAAATTATTATCGGTATTGATGCCCGTAACGGAC
TAGTAGCTACTCGTGGTTGGTTGGAAACATCTGAGGTTTTAGCCACTCAATTGGCTATACAGATGCAGGAAATGGGTGCA
GCAGCCATCATTTATACAGATATCCACCGTGACGGGACTCTTGCAGGCCCGAATTTAGACGCACTACGAGAACTAGCAGC
AGCCATTTCCATCCCTGTGATTGCATCTGGTGGGGTGAGTTCTGTCACCGATTTGTTGAGTTTGTTGGCGTTGGAACCCC
AAGGCGTGACAGGTGTGATTGTGGGACGTGCATTGTATACGGGTGATATTAGCTTAAAAGAGGCATTGCAGGCGATCGGC
CCAGGACGTATTCAAGACATACCACCGAATTTAGACTTCTCTTCCTTTGCTTAA

Upstream 100 bases:

>100_bases
TGGGTTTCGCACAAGCTATCAGACAACTAAAAGCGAAAAACTAAATCGGGATTTGCACAAAATTGGCACTCTTCATGGCA
TTAAATACAGGGGAATTGAG

Downstream 100 bases:

>100_bases
GATAATTCAACTTGAGGCTAATGGTGTTTGCGTAGGGTCTTTACAAGATACTATGTGAACACAAAGATCACCTGTAAACT
GCCATAGTATTTTTTAATTT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MDVIPAIDLLAGRCVRLYQGDYDRSQVFSENPVDVAKQWVDEGATRLHIVDLDGAKAGKVVNLGAIEAIAQAISIPIEIG
GGLRDRSSVEQVFNLGVQWAILGTVAVEQPQLVQELCQQYPGQIIIGIDARNGLVATRGWLETSEVLATQLAIQMQEMGA
AAIIYTDIHRDGTLAGPNLDALRELAAAISIPVIASGGVSSVTDLLSLLALEPQGVTGVIVGRALYTGDISLKEALQAIG
PGRIQDIPPNLDFSSFA

Sequences:

>Translated_257_residues
MDVIPAIDLLAGRCVRLYQGDYDRSQVFSENPVDVAKQWVDEGATRLHIVDLDGAKAGKVVNLGAIEAIAQAISIPIEIG
GGLRDRSSVEQVFNLGVQWAILGTVAVEQPQLVQELCQQYPGQIIIGIDARNGLVATRGWLETSEVLATQLAIQMQEMGA
AAIIYTDIHRDGTLAGPNLDALRELAAAISIPVIASGGVSSVTDLLSLLALEPQGVTGVIVGRALYTGDISLKEALQAIG
PGRIQDIPPNLDFSSFA
>Mature_257_residues
MDVIPAIDLLAGRCVRLYQGDYDRSQVFSENPVDVAKQWVDEGATRLHIVDLDGAKAGKVVNLGAIEAIAQAISIPIEIG
GGLRDRSSVEQVFNLGVQWAILGTVAVEQPQLVQELCQQYPGQIIIGIDARNGLVATRGWLETSEVLATQLAIQMQEMGA
AAIIYTDIHRDGTLAGPNLDALRELAAAISIPVIASGGVSSVTDLLSLLALEPQGVTGVIVGRALYTGDISLKEALQAIG
PGRIQDIPPNLDFSSFA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=241, Percent_Identity=34.4398340248963, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1788336, Length=243, Percent_Identity=24.6913580246914, Blast_Score=78, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 27173; Mature: 27173

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVIPAIDLLAGRCVRLYQGDYDRSQVFSENPVDVAKQWVDEGATRLHIVDLDGAKAGKV
CCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCE
VNLGAIEAIAQAISIPIEIGGGLRDRSSVEQVFNLGVQWAILGTVAVEQPQLVQELCQQY
EEHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHC
PGQIIIGIDARNGLVATRGWLETSEVLATQLAIQMQEMGAAAIIYTDIHRDGTLAGPNLD
CCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHH
ALRELAAAISIPVIASGGVSSVTDLLSLLALEPQGVTGVIVGRALYTGDISLKEALQAIG
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHHHHHHC
PGRIQDIPPNLDFSSFA
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDVIPAIDLLAGRCVRLYQGDYDRSQVFSENPVDVAKQWVDEGATRLHIVDLDGAKAGKV
CCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCE
VNLGAIEAIAQAISIPIEIGGGLRDRSSVEQVFNLGVQWAILGTVAVEQPQLVQELCQQY
EEHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHC
PGQIIIGIDARNGLVATRGWLETSEVLATQLAIQMQEMGAAAIIYTDIHRDGTLAGPNLD
CCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHH
ALRELAAAISIPVIASGGVSSVTDLLSLLALEPQGVTGVIVGRALYTGDISLKEALQAIG
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHHHHHHC
PGRIQDIPPNLDFSSFA
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA