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The map label for this gene is adk

Identifier: 17231688

GI number: 17231688

Start: 5041199

End: 5041753

Strand: Reverse

Name: adk

Synonym: all4196

Alternate gene names: 17231688

Gene position: 5041753-5041199 (Counterclockwise)

Preceding gene: 17231689

Following gene: 17231687

Centisome position: 78.61

GC content: 46.13

Gene sequence:

>555_bases
GTGACGCGACTAATCTTCTTGGGGCCGCCGGGAGCAGGTAAAGGAACACAAGCTCAAATTTTGGCTGAACATTTACATAT
TCCGCATATTTCCACTGGGGACATATTGCGGCAAGCCATGAAAGAGCAAACTCCCTTGGGAATCAAAGCTCAAAGCTATG
TAGATAGTGGCGAGTTGGTTCCTGATCAGTTAGTGCAAGACTTGGTAGAAGAGCGTCTTGAGCAAGCAGATGCTAAATCT
GGTTGGATATTGGATGGTTTCCCTCGTAAAGTCACACAAGCGGCTTTTCTGGAAGAATTGCTGCAAAAAACTGGTCAAGG
TGGCGAAAGAGTAGTCAATTTGGATGCGGCAGATGATGTCGTGGTAGCACGGTTGTTATCCAGAGGCAGGAAAGATGACA
CCGAAGAGGTAATTCGTCGCCGCCTGGAAATTTACCGCAGCGATACTGCACCCTTGATTGATTATTATAGCGATCGCCAA
AAACTTCTAACCATCAATGGCGACCAGTCCCAAGAAGAAGTCACTCACGAATTGAAAGCAACTTTAGGTTCATAA

Upstream 100 bases:

>100_bases
CAACTTCATTGCTAATTCTGGTTGGTGTGGCAATTGAGACAGCTAAACAAGTCCAAACTTACGTTATTTCTCAGCGTTAT
GAAGGAATGGTGAAACAATA

Downstream 100 bases:

>100_bases
CTAGCCCAAAAAGTCCAGGGGATAGAGTTTAGGGACTGTACCTAGTCCCCAGTACCCAATCCCCAGTTCCCTGTCACTGA
AAGATGTTGTCAAATTTAGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK 1; ATP-AMP transphosphorylase 1

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MTRLIFLGPPGAGKGTQAQILAEHLHIPHISTGDILRQAMKEQTPLGIKAQSYVDSGELVPDQLVQDLVEERLEQADAKS
GWILDGFPRKVTQAAFLEELLQKTGQGGERVVNLDAADDVVVARLLSRGRKDDTEEVIRRRLEIYRSDTAPLIDYYSDRQ
KLLTINGDQSQEEVTHELKATLGS

Sequences:

>Translated_184_residues
MTRLIFLGPPGAGKGTQAQILAEHLHIPHISTGDILRQAMKEQTPLGIKAQSYVDSGELVPDQLVQDLVEERLEQADAKS
GWILDGFPRKVTQAAFLEELLQKTGQGGERVVNLDAADDVVVARLLSRGRKDDTEEVIRRRLEIYRSDTAPLIDYYSDRQ
KLLTINGDQSQEEVTHELKATLGS
>Mature_183_residues
TRLIFLGPPGAGKGTQAQILAEHLHIPHISTGDILRQAMKEQTPLGIKAQSYVDSGELVPDQLVQDLVEERLEQADAKSG
WILDGFPRKVTQAAFLEELLQKTGQGGERVVNLDAADDVVVARLLSRGRKDDTEEVIRRRLEIYRSDTAPLIDYYSDRQK
LLTINGDQSQEEVTHELKATLGS

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=33.6492890995261, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=33.6492890995261, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI4502011, Length=187, Percent_Identity=33.6898395721925, Blast_Score=106, Evalue=9e-24,
Organism=Homo sapiens, GI28144897, Length=189, Percent_Identity=32.8042328042328, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI28144899, Length=189, Percent_Identity=32.8042328042328, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI19923437, Length=203, Percent_Identity=29.064039408867, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI310110345, Length=200, Percent_Identity=30, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI53832003, Length=200, Percent_Identity=30, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI8051579, Length=200, Percent_Identity=30, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI53832001, Length=200, Percent_Identity=30, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI7706497, Length=190, Percent_Identity=31.0526315789474, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI22749187, Length=195, Percent_Identity=27.6923076923077, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=38.2488479262673, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17552384, Length=185, Percent_Identity=36.7567567567568, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=35.6756756756757, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17533833, Length=166, Percent_Identity=33.1325301204819, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=30.9782608695652, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=202, Percent_Identity=28.7128712871287, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25147457, Length=183, Percent_Identity=24.0437158469945, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=31.4553990610329, Blast_Score=121, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=33.8383838383838, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=28.9617486338798, Blast_Score=95, Evalue=6e-21,
Organism=Drosophila melanogaster, GI22026816, Length=201, Percent_Identity=33.8308457711443, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17737899, Length=201, Percent_Identity=31.8407960199005, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24645822, Length=201, Percent_Identity=31.8407960199005, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=30.2702702702703, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=30.2702702702703, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17647141, Length=180, Percent_Identity=29.4444444444444, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24663208, Length=180, Percent_Identity=29.4444444444444, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24582962, Length=178, Percent_Identity=26.9662921348315, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD1_NOSS1 (Q8YPJ8)

Other databases:

- EMBL:   BA000019
- PIR:   AE2330
- RefSeq:   NP_488236.1
- ProteinModelPortal:   Q8YPJ8
- SMR:   Q8YPJ8
- STRING:   Q8YPJ8
- GeneID:   1107798
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all4196
- NMPDR:   fig|103690.1.peg.4503
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   TRLMEYY
- ProtClustDB:   PRK02496
- BioCyc:   NSP103690:ALL4196-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20442; Mature: 20311

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLIFLGPPGAGKGTQAQILAEHLHIPHISTGDILRQAMKEQTPLGIKAQSYVDSGELV
CCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCC
PDQLVQDLVEERLEQADAKSGWILDGFPRKVTQAAFLEELLQKTGQGGERVVNLDAADDV
HHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
VVARLLSRGRKDDTEEVIRRRLEIYRSDTAPLIDYYSDRQKLLTINGDQSQEEVTHELKA
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
TLGS
HHCC
>Mature Secondary Structure 
TRLIFLGPPGAGKGTQAQILAEHLHIPHISTGDILRQAMKEQTPLGIKAQSYVDSGELV
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCC
PDQLVQDLVEERLEQADAKSGWILDGFPRKVTQAAFLEELLQKTGQGGERVVNLDAADDV
HHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
VVARLLSRGRKDDTEEVIRRRLEIYRSDTAPLIDYYSDRQKLLTINGDQSQEEVTHELKA
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
TLGS
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840