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The map label for this gene is map [C]

Identifier: 17231642

GI number: 17231642

Start: 4994192

End: 4994962

Strand: Direct

Name: map [C]

Synonym: alr4150

Alternate gene names: 17231642

Gene position: 4994192-4994962 (Clockwise)

Preceding gene: 17231641

Following gene: 17231643

Centisome position: 77.87

GC content: 46.82

Gene sequence:

>771_bases
ATGAAAACCGAGTTCATCGTTATCTTATCCCAACGCGAAATAGAAAAAATGCGGCAAGCGGGACGCTTGGCGGCTAAACT
TCTGCAACATCTTGAGCCATTGGTGAAGCCAGGGGTGAGTACTCTGGAACTGAATGATGAAGCTGAACGTTGGACACAAG
CACATGGAGCTAAAAGCGCTCCTCTGGGTTATAAGGGTTTCCCCAAGTCAATTTGTACCAGCGTCAATGAAGTGATCTGT
CACGGGATTCCCAACGCCAAGCAGATTCTTAAAGATGGTGACATTATTAACATTGATGTGACACCAATTGTTGATGGCTA
CCACGGCGACACATCCAAAACCTTTATTGTGGGCAATGCTGCTCCCAAAATCAAGAAGCTGGTGGAAGTAACGCAGGAGT
GCTTACATTTAGGGATTGCAGAAGTTAAACCAGGAGCAAAGATAGGTGATATCGGCGCAGCAATTCAAGAGTATGCTGAG
GCTGAGGGCTTCTCTGTGGTGCGCGACTTTGTGGGACATGGTATCAGTAATATTTTCCATACAGCACCAGATGTACCTCA
CTACGGCACACGAGGGAAAGGCAAGCGCCTGCGTCCAGGGATGGTATTTACCATTGAGCCAATGATTAATGAAGGGACTT
ACGAAGTCGAGATGTTAGGTGATGGGTGGACAGCCGTAACACGCGATCGCAAGCTATCAGCCCAGTTTGAACACACCATC
GTAGTTACAGAAGATGGCGTAGAAATTCTTACTTTACCTGAAAGTGAGTAA

Upstream 100 bases:

>100_bases
CGGAAGAAAGCTTGTATACCCTAAGAGTTGCTGATGCTGCTCAAAGAGCCGCACAGATGGGAATAACTATATTTTTGACA
GATAAGCTAAATTAAATTTC

Downstream 100 bases:

>100_bases
ATAAAGGTTTTTTACTATGCAATCTCCAGAGAAAATAGATCCAACATGGGAAGATAGCGTCATTGATAGCTTTATTAGCT
TTGTCAGATCATACGATGGC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MKTEFIVILSQREIEKMRQAGRLAAKLLQHLEPLVKPGVSTLELNDEAERWTQAHGAKSAPLGYKGFPKSICTSVNEVIC
HGIPNAKQILKDGDIINIDVTPIVDGYHGDTSKTFIVGNAAPKIKKLVEVTQECLHLGIAEVKPGAKIGDIGAAIQEYAE
AEGFSVVRDFVGHGISNIFHTAPDVPHYGTRGKGKRLRPGMVFTIEPMINEGTYEVEMLGDGWTAVTRDRKLSAQFEHTI
VVTEDGVEILTLPESE

Sequences:

>Translated_256_residues
MKTEFIVILSQREIEKMRQAGRLAAKLLQHLEPLVKPGVSTLELNDEAERWTQAHGAKSAPLGYKGFPKSICTSVNEVIC
HGIPNAKQILKDGDIINIDVTPIVDGYHGDTSKTFIVGNAAPKIKKLVEVTQECLHLGIAEVKPGAKIGDIGAAIQEYAE
AEGFSVVRDFVGHGISNIFHTAPDVPHYGTRGKGKRLRPGMVFTIEPMINEGTYEVEMLGDGWTAVTRDRKLSAQFEHTI
VVTEDGVEILTLPESE
>Mature_256_residues
MKTEFIVILSQREIEKMRQAGRLAAKLLQHLEPLVKPGVSTLELNDEAERWTQAHGAKSAPLGYKGFPKSICTSVNEVIC
HGIPNAKQILKDGDIINIDVTPIVDGYHGDTSKTFIVGNAAPKIKKLVEVTQECLHLGIAEVKPGAKIGDIGAAIQEYAE
AEGFSVVRDFVGHGISNIFHTAPDVPHYGTRGKGKRLRPGMVFTIEPMINEGTYEVEMLGDGWTAVTRDRKLSAQFEHTI
VVTEDGVEILTLPESE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=51.004016064257, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=45.5284552845528, Blast_Score=212, Evalue=3e-55,
Organism=Escherichia coli, GI1786364, Length=252, Percent_Identity=56.3492063492063, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI1789275, Length=272, Percent_Identity=26.1029411764706, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=48.582995951417, Blast_Score=232, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6323273, Length=247, Percent_Identity=46.9635627530364, Blast_Score=234, Evalue=8e-63,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=50.8130081300813, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=47.1311475409836, Blast_Score=224, Evalue=4e-59,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27977; Mature: 27977

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTEFIVILSQREIEKMRQAGRLAAKLLQHLEPLVKPGVSTLELNDEAERWTQAHGAKSA
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCC
PLGYKGFPKSICTSVNEVICHGIPNAKQILKDGDIINIDVTPIVDGYHGDTSKTFIVGNA
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEECEEECCCCCCCCCEEEEECC
APKIKKLVEVTQECLHLGIAEVKPGAKIGDIGAAIQEYAEAEGFSVVRDFVGHGISNIFH
CHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHH
TAPDVPHYGTRGKGKRLRPGMVFTIEPMINEGTYEVEMLGDGWTAVTRDRKLSAQFEHTI
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCEEEEE
VVTEDGVEILTLPESE
EEECCCEEEEECCCCC
>Mature Secondary Structure
MKTEFIVILSQREIEKMRQAGRLAAKLLQHLEPLVKPGVSTLELNDEAERWTQAHGAKSA
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCC
PLGYKGFPKSICTSVNEVICHGIPNAKQILKDGDIINIDVTPIVDGYHGDTSKTFIVGNA
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEECEEECCCCCCCCCEEEEECC
APKIKKLVEVTQECLHLGIAEVKPGAKIGDIGAAIQEYAEAEGFSVVRDFVGHGISNIFH
CHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHH
TAPDVPHYGTRGKGKRLRPGMVFTIEPMINEGTYEVEMLGDGWTAVTRDRKLSAQFEHTI
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCEEEEE
VVTEDGVEILTLPESE
EEECCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]