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The map label for this gene is bvdR [H]

Identifier: 17231641

GI number: 17231641

Start: 4993218

End: 4994186

Strand: Direct

Name: bvdR [H]

Synonym: alr4149

Alternate gene names: 17231641

Gene position: 4993218-4994186 (Clockwise)

Preceding gene: 17231639

Following gene: 17231642

Centisome position: 77.85

GC content: 42.83

Gene sequence:

>969_bases
GTGGGTATAGTTGGGACTGGGTATGCAGCAAAACTGAGGGCAGAAGCCTTTTTAGAGGATGAGCGATCGCACCTAGTCGC
CATAGCGGGTAGTAAACTGGAGCGAACCCAGACTTTCGCGCAAGCTTACCAAGCTGAAGTGATAACTGGCTGGCAACAGT
TAGTAGAGCGAGAAGATATAGATTTAGTGGTAATTTGTACAATTAATCGTGATCATGGTGCGATCGCCCGTGCTGCCCTA
ACTGCTGGCAAACACGTAATTGTAGAATATCCCTTATCTGTAGATTTAACTGAAGCTGAAGAACTGATTGCCTTAGCCAA
AACACAGCAAAAATTACTCCACGTCGAACACATTGAACTTTTAGGTGGCTTACATCAAGCTTTAAAGCAAAATTTAGATA
AAGTAGGTCATCTCTTTTACGTGCGCTACAGCACCATCAATCCTCAAAACCCTGCACCCCGAAAGTGGACTTATAACCAC
GCAATGTTTGGTTTTCCCTTAATTGGCGCACTTTCCCGTCTGCATCGTTTGACAGATTTATTTGGTAAAGTCTTTACAGT
TAACTGCCATCAACGGTATTGGGAAATAGAACCAGAATATTACCAGACCTGTTTTTGCATGACTCAACTGTGCTTTACTA
GTGGATTATTAGCCCAAGTGATTTACGGTAAAGGTGAAAGTTTGTGGCAACCAGAACGCAAGTTTGAAGTTCATGGTGAC
AATGGTGCTTTAATTTTTGACGGGGATACAGGATTTTTCATCCAATCAGGGGAAAGCACACCTGTAGAATTGGGTACTCG
TCGGGGATTATTTGCCAAAGACACAAGTATGGTGTTAGACCATATCTTTGATGGCGCTCCTTTGTACGTCACCCCGGAAG
AAAGCTTGTATACCCTAAGAGTTGCTGATGCTGCTCAAAGAGCCGCACAGATGGGAATAACTATATTTTTGACAGATAAG
CTAAATTAA

Upstream 100 bases:

>100_bases
GCTTTTTTCATAAATGATCATTGATCACTGTGGTTGGTAGCAGGACTGGTGAGGATTATATTAAGAGTCGGAGGCAGCTT
TGGCAGAAGCAAAAATACGT

Downstream 100 bases:

>100_bases
ATTTCATGAAAACCGAGTTCATCGTTATCTTATCCCAACGCGAAATAGAAAAAATGCGGCAAGCGGGACGCTTGGCGGCT
AAACTTCTGCAACATCTTGA

Product: biliverdin reductase

Products: biliverdin; NADH; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MGIVGTGYAAKLRAEAFLEDERSHLVAIAGSKLERTQTFAQAYQAEVITGWQQLVEREDIDLVVICTINRDHGAIARAAL
TAGKHVIVEYPLSVDLTEAEELIALAKTQQKLLHVEHIELLGGLHQALKQNLDKVGHLFYVRYSTINPQNPAPRKWTYNH
AMFGFPLIGALSRLHRLTDLFGKVFTVNCHQRYWEIEPEYYQTCFCMTQLCFTSGLLAQVIYGKGESLWQPERKFEVHGD
NGALIFDGDTGFFIQSGESTPVELGTRRGLFAKDTSMVLDHIFDGAPLYVTPEESLYTLRVADAAQRAAQMGITIFLTDK
LN

Sequences:

>Translated_322_residues
MGIVGTGYAAKLRAEAFLEDERSHLVAIAGSKLERTQTFAQAYQAEVITGWQQLVEREDIDLVVICTINRDHGAIARAAL
TAGKHVIVEYPLSVDLTEAEELIALAKTQQKLLHVEHIELLGGLHQALKQNLDKVGHLFYVRYSTINPQNPAPRKWTYNH
AMFGFPLIGALSRLHRLTDLFGKVFTVNCHQRYWEIEPEYYQTCFCMTQLCFTSGLLAQVIYGKGESLWQPERKFEVHGD
NGALIFDGDTGFFIQSGESTPVELGTRRGLFAKDTSMVLDHIFDGAPLYVTPEESLYTLRVADAAQRAAQMGITIFLTDK
LN
>Mature_321_residues
GIVGTGYAAKLRAEAFLEDERSHLVAIAGSKLERTQTFAQAYQAEVITGWQQLVEREDIDLVVICTINRDHGAIARAALT
AGKHVIVEYPLSVDLTEAEELIALAKTQQKLLHVEHIELLGGLHQALKQNLDKVGHLFYVRYSTINPQNPAPRKWTYNHA
MFGFPLIGALSRLHRLTDLFGKVFTVNCHQRYWEIEPEYYQTCFCMTQLCFTSGLLAQVIYGKGESLWQPERKFEVHGDN
GALIFDGDTGFFIQSGESTPVELGTRRGLFAKDTSMVLDHIFDGAPLYVTPEESLYTLRVADAAQRAAQMGITIFLTDKL
N

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Homo sapiens, GI33589854, Length=270, Percent_Identity=27.4074074074074, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87081947, Length=117, Percent_Identity=37.6068376068376, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.3.1.24

Molecular weight: Translated: 36107; Mature: 35976

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIVGTGYAAKLRAEAFLEDERSHLVAIAGSKLERTQTFAQAYQAEVITGWQQLVEREDI
CCEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DLVVICTINRDHGAIARAALTAGKHVIVEYPLSVDLTEAEELIALAKTQQKLLHVEHIEL
CEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGGLHQALKQNLDKVGHLFYVRYSTINPQNPAPRKWTYNHAMFGFPLIGALSRLHRLTDL
HHHHHHHHHHHHHHHCEEEEEEEEECCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHH
FGKVFTVNCHQRYWEIEPEYYQTCFCMTQLCFTSGLLAQVIYGKGESLWQPERKFEVHGD
HHCEEEEEECHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
NGALIFDGDTGFFIQSGESTPVELGTRRGLFAKDTSMVLDHIFDGAPLYVTPEESLYTLR
CCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEE
VADAAQRAAQMGITIFLTDKLN
EHHHHHHHHHCCEEEEEEECCC
>Mature Secondary Structure 
GIVGTGYAAKLRAEAFLEDERSHLVAIAGSKLERTQTFAQAYQAEVITGWQQLVEREDI
CEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DLVVICTINRDHGAIARAALTAGKHVIVEYPLSVDLTEAEELIALAKTQQKLLHVEHIEL
CEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGGLHQALKQNLDKVGHLFYVRYSTINPQNPAPRKWTYNHAMFGFPLIGALSRLHRLTDL
HHHHHHHHHHHHHHHCEEEEEEEEECCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHH
FGKVFTVNCHQRYWEIEPEYYQTCFCMTQLCFTSGLLAQVIYGKGESLWQPERKFEVHGD
HHCEEEEEECHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
NGALIFDGDTGFFIQSGESTPVELGTRRGLFAKDTSMVLDHIFDGAPLYVTPEESLYTLR
CCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEE
VADAAQRAAQMGITIFLTDKLN
EHHHHHHHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: bilirubin; NAD+; NADP+

Specific reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]