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The map label for this gene is prk [H]

Identifier: 17231615

GI number: 17231615

Start: 4966719

End: 4967723

Strand: Direct

Name: prk [H]

Synonym: alr4123

Alternate gene names: 17231615

Gene position: 4966719-4967723 (Clockwise)

Preceding gene: 17231611

Following gene: 161353738

Centisome position: 77.44

GC content: 43.78

Gene sequence:

>1005_bases
ATGACAACTAAGCCGGAACGCGTGGTACTGATTGGAGTAGCCGGAGACTCCGGGTGCGGTAAATCTACGTTTTTGCGTCG
TCTGATAGATTTATTTGGTGAAGAGTTTATGACGGTCATCTGTTTAGATGACTACCATTCTTTGGATCGTAAACAACGTA
AAGAAACTGGAATCACCGCACTTGACCCCAGGGCCAACAATTTTGACCTGATGTATGAGCAGATCAAAGCGCTCAAAGAA
GGGCAAACGATTAATAAGCCGATTTATAACCACGAAACCGGCCTAATTGATCCACCTGAGATAGTAAAGCCAAATCACAT
TGTAGTGGTTGAGGGTTTACACCCTCTATATGATGAACGGGTGAGATCGCTCCTCGATTTCAGCGTCTACTTTGACATCA
GCGATGAAGTCAAAATTGCTTGGAAAATCCAGCGTGATATGGCAGAAAGAGGTCATCGCTACGAAGACGTTCTAGCGGCC
ATCAATTCTCGTAAGCCAGATTTTCAAAAATATATCGAACCTCAAAGAGAATTCGCCGATGTGGTGCTACAAGTACTACC
CACCAACTTAATCAAGGATGATACAGAACGTAAAGTCCTACGGGTGCGGATGTTACAACGGGAAGGAAAAGAAGGTTTTG
AACCCGCTTACCTGTTTGATGAAGGTTCAACAATTAACTGGACTCCTTGCGGACGTAAGCTTACCTGTTCTTACCCAGGA
ATGCAGTTATACTACGGTTCCGATGTTTACTACGGTCGCTATGTCTCAGTTCTAGAGGTGGATGGTCAATTTGACAACCT
CGAAGAAGTAATCTACATCGAAACCCACCTCAGCAATACATCTACTAAGTATCAAGGTGAGTTAACTCAGCTGTTACTCC
AACACCGTGAATATCCCGGTTCAAATAACGGAACTGGTTTTTTCCAAGTATTAACAGGTTTGAAAATGCGTGCTGCTTAC
GAGCGCTTGACAACAAAGGAAGCCAAACTAGCAGTTCAGGTTTAA

Upstream 100 bases:

>100_bases
GTAGCAAGAACGCAGGACAAACCTATGGGGTAAACTCCTGGCTTCACATTCTGCTGTGTGAAAAATTATTGATTGACACA
TTTAGTATCTGAGGAGATTT

Downstream 100 bases:

>100_bases
TACAGCAGTTTTTGTGTCAAAACTTCTGGGGTACTGACGAGTACCCCTTTTTTTGTATCCATGAAAACATATACAACCTA
TGGATAATTTCAGTAAATTA

Product: phosphoribulokinase

Products: NA

Alternate protein names: PRK; PRKase; Phosphopentokinase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTTKPERVVLIGVAGDSGCGKSTFLRRLIDLFGEEFMTVICLDDYHSLDRKQRKETGITALDPRANNFDLMYEQIKALKE
GQTINKPIYNHETGLIDPPEIVKPNHIVVVEGLHPLYDERVRSLLDFSVYFDISDEVKIAWKIQRDMAERGHRYEDVLAA
INSRKPDFQKYIEPQREFADVVLQVLPTNLIKDDTERKVLRVRMLQREGKEGFEPAYLFDEGSTINWTPCGRKLTCSYPG
MQLYYGSDVYYGRYVSVLEVDGQFDNLEEVIYIETHLSNTSTKYQGELTQLLLQHREYPGSNNGTGFFQVLTGLKMRAAY
ERLTTKEAKLAVQV

Sequences:

>Translated_334_residues
MTTKPERVVLIGVAGDSGCGKSTFLRRLIDLFGEEFMTVICLDDYHSLDRKQRKETGITALDPRANNFDLMYEQIKALKE
GQTINKPIYNHETGLIDPPEIVKPNHIVVVEGLHPLYDERVRSLLDFSVYFDISDEVKIAWKIQRDMAERGHRYEDVLAA
INSRKPDFQKYIEPQREFADVVLQVLPTNLIKDDTERKVLRVRMLQREGKEGFEPAYLFDEGSTINWTPCGRKLTCSYPG
MQLYYGSDVYYGRYVSVLEVDGQFDNLEEVIYIETHLSNTSTKYQGELTQLLLQHREYPGSNNGTGFFQVLTGLKMRAAY
ERLTTKEAKLAVQV
>Mature_333_residues
TTKPERVVLIGVAGDSGCGKSTFLRRLIDLFGEEFMTVICLDDYHSLDRKQRKETGITALDPRANNFDLMYEQIKALKEG
QTINKPIYNHETGLIDPPEIVKPNHIVVVEGLHPLYDERVRSLLDFSVYFDISDEVKIAWKIQRDMAERGHRYEDVLAAI
NSRKPDFQKYIEPQREFADVVLQVLPTNLIKDDTERKVLRVRMLQREGKEGFEPAYLFDEGSTINWTPCGRKLTCSYPGM
QLYYGSDVYYGRYVSVLEVDGQFDNLEEVIYIETHLSNTSTKYQGELTQLLLQHREYPGSNNGTGFFQVLTGLKMRAAYE
RLTTKEAKLAVQV

Specific function: Pyrimidine salvage pathway. [C]

COG id: COG0572

COG function: function code F; Uridine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoribulokinase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=187, Percent_Identity=26.7379679144385, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI57863312, Length=187, Percent_Identity=26.7379679144385, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI18699734, Length=195, Percent_Identity=25.6410256410256, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI13899253, Length=199, Percent_Identity=26.1306532663317, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87082034, Length=193, Percent_Identity=32.1243523316062, Blast_Score=100, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17539892, Length=180, Percent_Identity=29.4444444444444, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17539894, Length=180, Percent_Identity=29.4444444444444, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71981181, Length=192, Percent_Identity=29.1666666666667, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324339, Length=176, Percent_Identity=26.7045454545455, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221458995, Length=188, Percent_Identity=27.6595744680851, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24649624, Length=188, Percent_Identity=27.6595744680851, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45550449, Length=180, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573516, Length=180, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573514, Length=180, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573512, Length=180, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006082
- InterPro:   IPR006083 [H]

Pfam domain/function: PF00485 PRK [H]

EC number: =2.7.1.19 [H]

Molecular weight: Translated: 38455; Mature: 38324

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKPERVVLIGVAGDSGCGKSTFLRRLIDLFGEEFMTVICLDDYHSLDRKQRKETGITA
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCHHHEEEEEECCHHHHHHHHHHHCCCEE
LDPRANNFDLMYEQIKALKEGQTINKPIYNHETGLIDPPEIVKPNHIVVVEGLHPLYDER
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHH
VRSLLDFSVYFDISDEVKIAWKIQRDMAERGHRYEDVLAAINSRKPDFQKYIEPQREFAD
HHHHHCEEEEEECCCCEEEEEEEHHHHHHCCCHHHHHHHHHHCCCCCHHHHHCHHHHHHH
VVLQVLPTNLIKDDTERKVLRVRMLQREGKEGFEPAYLFDEGSTINWTPCGRKLTCSYPG
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCEEEECCCC
MQLYYGSDVYYGRYVSVLEVDGQFDNLEEVIYIETHLSNTSTKYQGELTQLLLQHREYPG
EEEEECCCEEECEEEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
SNNGTGFFQVLTGLKMRAAYERLTTKEAKLAVQV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
>Mature Secondary Structure 
TTKPERVVLIGVAGDSGCGKSTFLRRLIDLFGEEFMTVICLDDYHSLDRKQRKETGITA
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCHHHEEEEEECCHHHHHHHHHHHCCCEE
LDPRANNFDLMYEQIKALKEGQTINKPIYNHETGLIDPPEIVKPNHIVVVEGLHPLYDER
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHH
VRSLLDFSVYFDISDEVKIAWKIQRDMAERGHRYEDVLAAINSRKPDFQKYIEPQREFAD
HHHHHCEEEEEECCCCEEEEEEEHHHHHHCCCHHHHHHHHHHCCCCCHHHHHCHHHHHHH
VVLQVLPTNLIKDDTERKVLRVRMLQREGKEGFEPAYLFDEGSTINWTPCGRKLTCSYPG
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCEEEECCCC
MQLYYGSDVYYGRYVSVLEVDGQFDNLEEVIYIETHLSNTSTKYQGELTQLLLQHREYPG
EEEEECCCEEECEEEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
SNNGTGFFQVLTGLKMRAAYERLTTKEAKLAVQV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1660882; 8905231 [H]