Click here to switch to the map view.

The map label for this gene is lysS [H]

Identifier: 17231563

GI number: 17231563

Start: 4899267

End: 4900952

Strand: Reverse

Name: lysS [H]

Synonym: all4071

Alternate gene names: 17231563

Gene position: 4900952-4899267 (Counterclockwise)

Preceding gene: 17231565

Following gene: 17231562

Centisome position: 76.41

GC content: 43.89

Gene sequence:

>1686_bases
ATGTCGGAAGAAGATATCCGTGCCGCTAGGCTGGAGAAAGTAGAACAACTCAAGCAGCTAGGGACTAACCCCTATGCTTA
CCGTTGGGAGTCTACTCATCACGCCGCCCAATTGCAAGAAAAATTTGCTGATTTAACCAGTGGTGAAGAAGTCGAGACAG
AAGTTGCCATTGCCGGACGCATTATGGCGCGTCGCGTTTTCGGTAAATTGGCTTTCTTCACCTTGGAGGATGAAACAGGC
ACTATTCAGCTTTATTTAGAGAAAAATCGTATCCAAGAAAGCATGGCAGAAATTGATGCCAATGCTTTTAATCATCTCAA
ACAACTCACCGATGTAGGGGATATTCTGGGAGCCAAGGGAACAATAAAACGGACTGAAAAGGGCGAGTTATCGGTTTACG
TCAAAGAATATACCATCCTCACCAAATCCCTACTGCCGCTACCCGACAAGTGGCATGGGTTAACGGATGTTGCCAAACGC
TACCGTCAACGCTACGTTGATTTGATTGTTAACCCCGAAGTCCGCCAAACTTTCCGCCGTCGCGCCCAAATCACGGCCGG
GATTCGCCGCTATTTGGAACAAAGGGATTTTCTAGAGATTGAAACCCCTGTTTTACAAAGTGAAGCCGGCGGTGCTGATG
CGCGTCCCTTCGTCACTTACCACAACACCTTAGAAATGGAGTTGTATCTACGAATAGCAACAGAACTCCACCTCAAGCGG
TTGATTGTCGGTGGTTTTGAAAAGGTGTTTGAATTGGGGCGAATTTTCCGTAATGAAGGGATTTCCACCAGACACAACCC
TGAATTTACCTCAATTGAAGTTTATCAAGCCTACGCCGACTACAACGATATGATGGCTCTAACAGAAGGTATTATCACCA
CTGTGGCCCAAGATGTACTCGGCACACTGCAAATTACCTACCAAGGCGAAACGGTAGATTTGACACCACCTTGGCGACGG
GTGACAATGCACGATTTAGTAAAAGAATATACAGGATTGGATTTCCATTCTTTCCAAACACTAGAAGAAGCGAAATCAGC
AGGTAAAAATGCTGGGATTCCTGGTGTAGATGAAGCCCAAACTATAGGTAAAATCCTGAATTTAGCATTTGAAGAAAAGG
TAGAAACAAAGTTAATTCAGCCTACCTTTGTAATTGATTATCCTGTGGAAATTTCGCCATTAGCTAAACCTCACCGTTCT
CAACCTGGGTTAGTAGAAAGATTTGAATTATTCATAGTCGGGCGGGAGACTGCGAATAGTTTCTCAGAATTAACAGATCC
CATCGACCAAAGAGAACGCCTAGAAGCCCAAGCAGCCAAAAAAGCCGCCGGTGACTTAGAAGCCCAAGGTGTAGATGAAG
ACTTCTTGACTGCGTTGGAATACGGGATGCCACCTACAGGAGGTTTAGGTATTGGGATTGATCGGTTAGTCATGTTATTA
ACTGATTCTGCCAGTATTCGGGATGTGATTGCTTTCCCTTTACTCAAACCAGAAGGCAGCTTTATTAAGGCATATCGCTA
TGAGCCAACAACTCAAACACTGACTCTTGAATTTGATAGTGGAAGTATTTACGAATATTTCAAAGTACCGCTTACTGTTA
AAGAAGAATTAGACAATGCACCGTCTAAGGGTCAATATTTCCATAAGTTTATTAAAGGGCAATTCAAGTATGAACAATTG
AGTTGA

Upstream 100 bases:

>100_bases
CTCCACAAATCATAAAAATTCTTCCCCAATTTCCAATCCCTACTCCCTAATCCCTAATCCCTATTTATAATTAATCTTGC
CCTCTGAATAGTTCGTTACC

Downstream 100 bases:

>100_bases
TCGAATTAAGTAGAAAATAAGATTTAAAAATAACGCGACCTCTGACCGATTTAAGCCGTGGGTTTGACGTTTTGGAGGTC
AGCGATATTTTTAACAATCT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MSEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVETEVAIAGRIMARRVFGKLAFFTLEDETG
TIQLYLEKNRIQESMAEIDANAFNHLKQLTDVGDILGAKGTIKRTEKGELSVYVKEYTILTKSLLPLPDKWHGLTDVAKR
YRQRYVDLIVNPEVRQTFRRRAQITAGIRRYLEQRDFLEIETPVLQSEAGGADARPFVTYHNTLEMELYLRIATELHLKR
LIVGGFEKVFELGRIFRNEGISTRHNPEFTSIEVYQAYADYNDMMALTEGIITTVAQDVLGTLQITYQGETVDLTPPWRR
VTMHDLVKEYTGLDFHSFQTLEEAKSAGKNAGIPGVDEAQTIGKILNLAFEEKVETKLIQPTFVIDYPVEISPLAKPHRS
QPGLVERFELFIVGRETANSFSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLL
TDSASIRDVIAFPLLKPEGSFIKAYRYEPTTQTLTLEFDSGSIYEYFKVPLTVKEELDNAPSKGQYFHKFIKGQFKYEQL
S

Sequences:

>Translated_561_residues
MSEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVETEVAIAGRIMARRVFGKLAFFTLEDETG
TIQLYLEKNRIQESMAEIDANAFNHLKQLTDVGDILGAKGTIKRTEKGELSVYVKEYTILTKSLLPLPDKWHGLTDVAKR
YRQRYVDLIVNPEVRQTFRRRAQITAGIRRYLEQRDFLEIETPVLQSEAGGADARPFVTYHNTLEMELYLRIATELHLKR
LIVGGFEKVFELGRIFRNEGISTRHNPEFTSIEVYQAYADYNDMMALTEGIITTVAQDVLGTLQITYQGETVDLTPPWRR
VTMHDLVKEYTGLDFHSFQTLEEAKSAGKNAGIPGVDEAQTIGKILNLAFEEKVETKLIQPTFVIDYPVEISPLAKPHRS
QPGLVERFELFIVGRETANSFSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLL
TDSASIRDVIAFPLLKPEGSFIKAYRYEPTTQTLTLEFDSGSIYEYFKVPLTVKEELDNAPSKGQYFHKFIKGQFKYEQL
S
>Mature_560_residues
SEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVETEVAIAGRIMARRVFGKLAFFTLEDETGT
IQLYLEKNRIQESMAEIDANAFNHLKQLTDVGDILGAKGTIKRTEKGELSVYVKEYTILTKSLLPLPDKWHGLTDVAKRY
RQRYVDLIVNPEVRQTFRRRAQITAGIRRYLEQRDFLEIETPVLQSEAGGADARPFVTYHNTLEMELYLRIATELHLKRL
IVGGFEKVFELGRIFRNEGISTRHNPEFTSIEVYQAYADYNDMMALTEGIITTVAQDVLGTLQITYQGETVDLTPPWRRV
TMHDLVKEYTGLDFHSFQTLEEAKSAGKNAGIPGVDEAQTIGKILNLAFEEKVETKLIQPTFVIDYPVEISPLAKPHRSQ
PGLVERFELFIVGRETANSFSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLLT
DSASIRDVIAFPLLKPEGSFIKAYRYEPTTQTLTLEFDSGSIYEYFKVPLTVKEELDNAPSKGQYFHKFIKGQFKYEQLS

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=504, Percent_Identity=43.0555555555556, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI194272210, Length=504, Percent_Identity=43.0555555555556, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI45439306, Length=468, Percent_Identity=25.2136752136752, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI40789249, Length=250, Percent_Identity=26, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790571, Length=515, Percent_Identity=48.3495145631068, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1789256, Length=493, Percent_Identity=49.8985801217039, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI87082379, Length=321, Percent_Identity=33.3333333333333, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1788173, Length=293, Percent_Identity=27.3037542662116, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17535925, Length=517, Percent_Identity=43.5203094777563, Blast_Score=403, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17535927, Length=517, Percent_Identity=43.5203094777563, Blast_Score=403, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71994340, Length=517, Percent_Identity=43.5203094777563, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17551876, Length=477, Percent_Identity=23.2704402515723, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32566633, Length=303, Percent_Identity=23.7623762376238, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=514, Percent_Identity=41.2451361867704, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324256, Length=501, Percent_Identity=31.5369261477046, Blast_Score=193, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6323011, Length=494, Percent_Identity=25.9109311740891, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325153, Length=260, Percent_Identity=23.8461538461538, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24640849, Length=523, Percent_Identity=42.4474187380497, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24640851, Length=523, Percent_Identity=42.4474187380497, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI17136276, Length=475, Percent_Identity=22.9473684210526, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24584738, Length=335, Percent_Identity=23.5820895522388, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 63677; Mature: 63546

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVETEVAIAGR
CCCHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IMARRVFGKLAFFTLEDETGTIQLYLEKNRIQESMAEIDANAFNHLKQLTDVGDILGAKG
HHHHHHHHHEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TIKRTEKGELSVYVKEYTILTKSLLPLPDKWHGLTDVAKRYRQRYVDLIVNPEVRQTFRR
CCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHH
RAQITAGIRRYLEQRDFLEIETPVLQSEAGGADARPFVTYHNTLEMELYLRIATELHLKR
HHHHHHHHHHHHHHCCCEEECCCHHHCCCCCCCCCCEEEECCEEEEEHHHHHHHHHHHHH
LIVGGFEKVFELGRIFRNEGISTRHNPEFTSIEVYQAYADYNDMMALTEGIITTVAQDVL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHCHHHHHHHHHHHHHHHHHHHH
GTLQITYQGETVDLTPPWRRVTMHDLVKEYTGLDFHSFQTLEEAKSAGKNAGIPGVDEAQ
HEEEEEEECCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
TIGKILNLAFEEKVETKLIQPTFVIDYPVEISPLAKPHRSQPGLVERFELFIVGRETANS
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHEEEEEEEEECHHHHH
FSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLL
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TDSASIRDVIAFPLLKPEGSFIKAYRYEPTTQTLTLEFDSGSIYEYFKVPLTVKEELDNA
CCCCHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEECCEEEHHHHCCC
PSKGQYFHKFIKGQFKYEQLS
CCCHHHHHHHHCCCCCHHCCC
>Mature Secondary Structure 
SEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVETEVAIAGR
CCHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IMARRVFGKLAFFTLEDETGTIQLYLEKNRIQESMAEIDANAFNHLKQLTDVGDILGAKG
HHHHHHHHHEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TIKRTEKGELSVYVKEYTILTKSLLPLPDKWHGLTDVAKRYRQRYVDLIVNPEVRQTFRR
CCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHH
RAQITAGIRRYLEQRDFLEIETPVLQSEAGGADARPFVTYHNTLEMELYLRIATELHLKR
HHHHHHHHHHHHHHCCCEEECCCHHHCCCCCCCCCCEEEECCEEEEEHHHHHHHHHHHHH
LIVGGFEKVFELGRIFRNEGISTRHNPEFTSIEVYQAYADYNDMMALTEGIITTVAQDVL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHCHHHHHHHHHHHHHHHHHHHH
GTLQITYQGETVDLTPPWRRVTMHDLVKEYTGLDFHSFQTLEEAKSAGKNAGIPGVDEAQ
HEEEEEEECCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
TIGKILNLAFEEKVETKLIQPTFVIDYPVEISPLAKPHRSQPGLVERFELFIVGRETANS
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHEEEEEEEEECHHHHH
FSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLL
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TDSASIRDVIAFPLLKPEGSFIKAYRYEPTTQTLTLEFDSGSIYEYFKVPLTVKEELDNA
CCCCHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEECCEEEHHHHCCC
PSKGQYFHKFIKGQFKYEQLS
CCCHHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA