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The map label for this gene is merA [H]

Identifier: 17231429

GI number: 17231429

Start: 4754386

End: 4755855

Strand: Direct

Name: merA [H]

Synonym: alr3937

Alternate gene names: 17231429

Gene position: 4754386-4755855 (Clockwise)

Preceding gene: 17231428

Following gene: 17231430

Centisome position: 74.13

GC content: 42.31

Gene sequence:

>1470_bases
ATGACTATTGACTACGATGTCGTGATTATTGGCGGCAGTCTCGCAGGACGCTATGCCGCCCTTACCGCCACCCAAATGGG
GGCTAAAGTGGCATTGGTAGAATCCCAGCTAAATAACAGTTTGATTGTTCACCAAGCCATAGGGGAAATTGCCAACCTAA
CCCAAAATTTGCATAATTTGGCTGGCTGTGGCATCGATGCTGTACACCCTGATACTTCTGAAAAGTGCCAAATTTCCCTA
AAATGGGCAGCAGCATTGTTTTCGGCTCAAGGTATTGCCGCTAACGTCCAAGAACAAATGTCTCTTGCTCACTTGTCAGC
CCAAGGAGTCGATGTCATTGTTGACAGTGGACAATTTCAACGCTCACCCCATTTAGCTTTTGTTGTAGGTCAGCGCCTAC
TACGCGGTCGCACTTATCTACTTGCTAGTGGTTCCCTACCAGCAATTCCCAAAATTGAAGGATTACAAGCTACCGACTAC
CTGACACCAGCAAATATTTGGCAATATTTATACAAACAACATTCTCCATCTTCGGAACTACCCCAAAATTGGGTAATTAT
TGGCGGTACTCCTCAAAGCATCGAAATATCGCAAACTTTAGCCAGACTGGGTTGCAGTATCACTTTGGTAGTTAAATCTC
TTCATCTTCTACCTCAGCTTGACCCAGAAATTGCCCAGTTGCTTCAAGCACAGTTAGAAATCGATGGTGTACGCATCCTA
ACTCAAAAAATGGTGACACAAGTCAAGCGAATCGACGATAAAAAATGGGTTCAGGCAGGAGAAAAAGCAATAGAAGCTGA
TGAGATTCTAGTAGCAATTGGCCAGAAACCAAATATTGAATCTTTGAATTTGCCAGAAGTAGGAGTGAAATGGCAGCAGC
ATCGTTTACTGGTCAACGAAAAACTACAGACTACCAATCACCGAATTTATGCTTGTGGTGATGTCATTTGCGGTTACGAC
TTGCCTAACGTAGCTAATTACGAAGCTCGAATTGCTTTGAACAATGCTCTGTTTCTTCCCAGGTTGCAAGTTAATTACCA
AAATACTCCTTGGGCGATATTATCCCACCCAACTTTAGCCCAGGTTGGGGTGACGGAGAACCAGGCAAAACGCCAATTTA
GTCAACAAGAAGTTATCGTCTTGAGGCATTACTATAAATCCATAGCAGCAGCCCAACTGAAAAATGAAATTACAGGTATT
TGTAAATTAGTGGTGCTAGGCAACGGAAAAATTTTAGGAGCTACTATATTTAGTACACAAGCCAGAGAGTTAATTAATCT
CATTGCTTTGGCAATGTCTCGCAATATTTCTGTCAAACACTTAGGGAATTTATCTGCTGTCTATCCAAGTTTCTCAGAAC
TTTTAGAACAAACAGCACGAGATTTTAGCCAACACAGGTTCAATAACAACACAGCTTGGCAAGATTGGTTGGAGAATCTC
TTTTATTTGCGCCGTAATTGGAATTTGTGA

Upstream 100 bases:

>100_bases
GCGTCGCCGTCCGTTCTCACACAGACAATCAACGCTTAACAAAAGCACTAAGCGCAATAGTCCAAAACTCTTTTGACCAC
TGACTACTGACCAATGACTA

Downstream 100 bases:

>100_bases
ATGTTCGCTCCTCTTCTCATGAGGCTGAAAATACTAAACTGTCATACTCTGTTGGCAAAAGTAAAAAATTATACTTAATA
AATTTTCAAGAAAATCATGA

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MTIDYDVVIIGGSLAGRYAALTATQMGAKVALVESQLNNSLIVHQAIGEIANLTQNLHNLAGCGIDAVHPDTSEKCQISL
KWAAALFSAQGIAANVQEQMSLAHLSAQGVDVIVDSGQFQRSPHLAFVVGQRLLRGRTYLLASGSLPAIPKIEGLQATDY
LTPANIWQYLYKQHSPSSELPQNWVIIGGTPQSIEISQTLARLGCSITLVVKSLHLLPQLDPEIAQLLQAQLEIDGVRIL
TQKMVTQVKRIDDKKWVQAGEKAIEADEILVAIGQKPNIESLNLPEVGVKWQQHRLLVNEKLQTTNHRIYACGDVICGYD
LPNVANYEARIALNNALFLPRLQVNYQNTPWAILSHPTLAQVGVTENQAKRQFSQQEVIVLRHYYKSIAAAQLKNEITGI
CKLVVLGNGKILGATIFSTQARELINLIALAMSRNISVKHLGNLSAVYPSFSELLEQTARDFSQHRFNNNTAWQDWLENL
FYLRRNWNL

Sequences:

>Translated_489_residues
MTIDYDVVIIGGSLAGRYAALTATQMGAKVALVESQLNNSLIVHQAIGEIANLTQNLHNLAGCGIDAVHPDTSEKCQISL
KWAAALFSAQGIAANVQEQMSLAHLSAQGVDVIVDSGQFQRSPHLAFVVGQRLLRGRTYLLASGSLPAIPKIEGLQATDY
LTPANIWQYLYKQHSPSSELPQNWVIIGGTPQSIEISQTLARLGCSITLVVKSLHLLPQLDPEIAQLLQAQLEIDGVRIL
TQKMVTQVKRIDDKKWVQAGEKAIEADEILVAIGQKPNIESLNLPEVGVKWQQHRLLVNEKLQTTNHRIYACGDVICGYD
LPNVANYEARIALNNALFLPRLQVNYQNTPWAILSHPTLAQVGVTENQAKRQFSQQEVIVLRHYYKSIAAAQLKNEITGI
CKLVVLGNGKILGATIFSTQARELINLIALAMSRNISVKHLGNLSAVYPSFSELLEQTARDFSQHRFNNNTAWQDWLENL
FYLRRNWNL
>Mature_488_residues
TIDYDVVIIGGSLAGRYAALTATQMGAKVALVESQLNNSLIVHQAIGEIANLTQNLHNLAGCGIDAVHPDTSEKCQISLK
WAAALFSAQGIAANVQEQMSLAHLSAQGVDVIVDSGQFQRSPHLAFVVGQRLLRGRTYLLASGSLPAIPKIEGLQATDYL
TPANIWQYLYKQHSPSSELPQNWVIIGGTPQSIEISQTLARLGCSITLVVKSLHLLPQLDPEIAQLLQAQLEIDGVRILT
QKMVTQVKRIDDKKWVQAGEKAIEADEILVAIGQKPNIESLNLPEVGVKWQQHRLLVNEKLQTTNHRIYACGDVICGYDL
PNVANYEARIALNNALFLPRLQVNYQNTPWAILSHPTLAQVGVTENQAKRQFSQQEVIVLRHYYKSIAAAQLKNEITGIC
KLVVLGNGKILGATIFSTQARELINLIALAMSRNISVKHLGNLSAVYPSFSELLEQTARDFSQHRFNNNTAWQDWLENLF
YLRRNWNL

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=489, Percent_Identity=26.5848670756646, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI50301238, Length=478, Percent_Identity=23.8493723849372, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI22035672, Length=336, Percent_Identity=24.4047619047619, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI33519430, Length=342, Percent_Identity=20.7602339181287, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI33519428, Length=342, Percent_Identity=20.7602339181287, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI33519426, Length=342, Percent_Identity=20.7602339181287, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI148277065, Length=342, Percent_Identity=20.7602339181287, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI148277071, Length=342, Percent_Identity=20.7602339181287, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789915, Length=355, Percent_Identity=26.7605633802817, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=23.9035087719298, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082354, Length=475, Percent_Identity=23.7894736842105, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786307, Length=487, Percent_Identity=22.5872689938398, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32565766, Length=495, Percent_Identity=24.8484848484848, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71983429, Length=329, Percent_Identity=26.7477203647416, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983419, Length=329, Percent_Identity=26.7477203647416, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17557007, Length=484, Percent_Identity=21.2809917355372, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982272, Length=338, Percent_Identity=20.7100591715976, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=489, Percent_Identity=24.7443762781186, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6325166, Length=287, Percent_Identity=25.0871080139373, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24640551, Length=483, Percent_Identity=25.879917184265, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=25.879917184265, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=25.879917184265, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21358499, Length=493, Percent_Identity=25.3549695740365, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17737741, Length=492, Percent_Identity=24.390243902439, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 54138; Mature: 54007

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDYDVVIIGGSLAGRYAALTATQMGAKVALVESQLNNSLIVHQAIGEIANLTQNLHNL
CEEEEEEEEECCCCCCCHHHHHHHHCCCEEEEEHHHCCCCEEHHHHHHHHHHHHHHHHHH
AGCGIDAVHPDTSEKCQISLKWAAALFSAQGIAANVQEQMSLAHLSAQGVDVIVDSGQFQ
HCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCC
RSPHLAFVVGQRLLRGRTYLLASGSLPAIPKIEGLQATDYLTPANIWQYLYKQHSPSSEL
CCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
PQNWVIIGGTPQSIEISQTLARLGCSITLVVKSLHLLPQLDPEIAQLLQAQLEIDGVRIL
CCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
TQKMVTQVKRIDDKKWVQAGEKAIEADEILVAIGQKPNIESLNLPEVGVKWQQHRLLVNE
HHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
KLQTTNHRIYACGDVICGYDLPNVANYEARIALNNALFLPRLQVNYQNTPWAILSHPTLA
HHHCCCCEEEEECCEEECCCCCCCCCCEEEEEECCEEEEEEEEEECCCCCEEEECCCCCE
QVGVTENQAKRQFSQQEVIVLRHYYKSIAAAQLKNEITGICKLVVLGNGKILGATIFSTQ
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEHHHHH
ARELINLIALAMSRNISVKHLGNLSAVYPSFSELLEQTARDFSQHRFNNNTAWQDWLENL
HHHHHHHHHHHHHCCCCHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FYLRRNWNL
HHHHHCCCC
>Mature Secondary Structure 
TIDYDVVIIGGSLAGRYAALTATQMGAKVALVESQLNNSLIVHQAIGEIANLTQNLHNL
EEEEEEEEECCCCCCCHHHHHHHHCCCEEEEEHHHCCCCEEHHHHHHHHHHHHHHHHHH
AGCGIDAVHPDTSEKCQISLKWAAALFSAQGIAANVQEQMSLAHLSAQGVDVIVDSGQFQ
HCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCC
RSPHLAFVVGQRLLRGRTYLLASGSLPAIPKIEGLQATDYLTPANIWQYLYKQHSPSSEL
CCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
PQNWVIIGGTPQSIEISQTLARLGCSITLVVKSLHLLPQLDPEIAQLLQAQLEIDGVRIL
CCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
TQKMVTQVKRIDDKKWVQAGEKAIEADEILVAIGQKPNIESLNLPEVGVKWQQHRLLVNE
HHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
KLQTTNHRIYACGDVICGYDLPNVANYEARIALNNALFLPRLQVNYQNTPWAILSHPTLA
HHHCCCCEEEEECCEEECCCCCCCCCCEEEEEECCEEEEEEEEEECCCCCEEEECCCCCE
QVGVTENQAKRQFSQQEVIVLRHYYKSIAAAQLKNEITGICKLVVLGNGKILGATIFSTQ
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEHHHHH
ARELINLIALAMSRNISVKHLGNLSAVYPSFSELLEQTARDFSQHRFNNNTAWQDWLENL
HHHHHHHHHHHHHCCCCHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FYLRRNWNL
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]