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The map label for this gene is spkF [H]

Identifier: 17231198

GI number: 17231198

Start: 4475153

End: 4476793

Strand: Direct

Name: spkF [H]

Synonym: alr3706

Alternate gene names: 17231198

Gene position: 4475153-4476793 (Clockwise)

Preceding gene: 17231197

Following gene: 17231199

Centisome position: 69.77

GC content: 43.14

Gene sequence:

>1641_bases
GTGCTACAGCTGTTAGATCGTTATGTGCCACTACAGACTTTGGGTGCGGGGGGTTTTGCACAAATTTATACAGTCTGGGA
TGAGAAGACCCAAACGGAAAAAGTTCTAAAGGTATTGATAGAAGATTCTCCCAAGGCGCTGGAATTATTTACTCAAGAGG
CAGAAGTTTTAGTTCGGTTACGCCATCCTGGTGTCCCTAAAGTTGAGGCTGATGGTCATTTTCAAGTTAATTTATCCAAT
CCCAAGCCGCGCCAACTACCTTGTCTGGTGATGGAAAAAATTAACGGGCCGACTTTGGAGGAAATGTTAAATAAGTATCC
CCAAGGATGTCCAGAAAATTTGGTATTAAACTGGTTAACCCAAGCAATAAAAATCTTACAAGAATTACATAAGCATCAAA
TTATACATCGTGATATCAAGCCTTCCAATTTGATGTTACGCACTCCTTCCCCTAGTGTACCTACACCCCCAGGGGGAACA
GGCTGGGAACAATTAGTTTTAATTGATTTCGGTGGGGCAAAACAATTTAATACTGGAAGACAGCGCCAAGAATCAAGTTC
TACAAGGTTATTTTCTTCTGGTTACAGTCCACCAGAACAAGTTACCGGTGGGCATATCGGGCCGAGTGTTGATTTTTATG
CTCTCGGTCGAACGATGATTGAATTACTCACAGGTAAGTATCCCCCAGAGTTAGAAGATCCTCAGACAGGGGTTTTGCAA
TGGCGTAATAGAGTTACTATCAGACCTGAGTTGGCAGATTTACTAGATGAGATGGTGCAAGAGGATGTGCGATCGCGTCC
CACTAGTGCGGCTATAATTCAAAAACGGTTAGCAAAAATTAACCAGCCAGCTTCAGGACAGAACAGTTTCCAGCAGTTCT
TAACACAGGTTGCTAATCAACTAACACTATTAAATCAATCTACTGAGCAAGTTTTCAGCAACTTGGGACAAACCTTAGGT
AAAATCTTGCGGTGGATTGCAAAGACAATAGTGCAGATCATTACAGCTTGTTTTGCCACTATTTGGGCAATGCTGCTAAC
TGGTCTTGGTGCGAGTGTAGGCACGATCGCTGGATTTATTTTGGCATATCGCACAAACTTAGGCGATCGCTTAGTCGAAT
TTATCGCCGGTCAATTACCCGAATTAATAACTAACCCTGAATCAGGATTCGGTGCAGAAATTATCGTATTTGCCGCCGCA
GGTTTAGGTACAGCCTGGGGACTGACAGCATCCGGGTGTTTTGCCCAACGACGGCGCTTTTTAGTTGCCTCATTCATGGG
AATAATCAGCTACGCCTTTGGCTGGTTATTGTGGCAAATCATTACATCGACCGCAGATAGCGGTGAAGGTTTGGTAGGAG
CAACCGCCATATCTGTATTTTTATTAGCTCTAAGTATGGGTTTCCGTAGCCATCACATAGTTTATGCCATGATTGGCTCA
TTTGGAACAGCGATATTTGTGGCAATTTTGATAGTTTTAGGTTTTCCCACCACTGTTTTACAATTTTCTAGTCGTCACCT
CTGGTCAGAATTATCCTTGCCTATCATCTTTTTTAGCTCTGTCGGCATTTTGATGAGCTTTTGGTTAGGCATAAGCTACT
ACCTAATTGTGCCAGGATTGCGGTTTTTGGGTTGGCGGTAG

Upstream 100 bases:

>100_bases
CTTGGTATACCGTTTTTCTGGGGTTCACTGCATAAATCCTGACTGTCAACGTCCCTACCCCCAGCCCTGGGGTAACAAAT
TTTGTAACAGCTGTGGCACA

Downstream 100 bases:

>100_bases
GGGAAAACTAATGACAACTGACAACTGACCATTGATCAAAATTAAGACCCCCTGACTGGTTATTTATATCTAGTCAGGGG
GCTACTATAGGTGATAGACT

Product: serine/threonine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRLRHPGVPKVEADGHFQVNLSN
PKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLTQAIKILQELHKHQIIHRDIKPSNLMLRTPSPSVPTPPGGT
GWEQLVLIDFGGAKQFNTGRQRQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLQ
WRNRVTIRPELADLLDEMVQEDVRSRPTSAAIIQKRLAKINQPASGQNSFQQFLTQVANQLTLLNQSTEQVFSNLGQTLG
KILRWIAKTIVQIITACFATIWAMLLTGLGASVGTIAGFILAYRTNLGDRLVEFIAGQLPELITNPESGFGAEIIVFAAA
GLGTAWGLTASGCFAQRRRFLVASFMGIISYAFGWLLWQIITSTADSGEGLVGATAISVFLLALSMGFRSHHIVYAMIGS
FGTAIFVAILIVLGFPTTVLQFSSRHLWSELSLPIIFFSSVGILMSFWLGISYYLIVPGLRFLGWR

Sequences:

>Translated_546_residues
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRLRHPGVPKVEADGHFQVNLSN
PKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLTQAIKILQELHKHQIIHRDIKPSNLMLRTPSPSVPTPPGGT
GWEQLVLIDFGGAKQFNTGRQRQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLQ
WRNRVTIRPELADLLDEMVQEDVRSRPTSAAIIQKRLAKINQPASGQNSFQQFLTQVANQLTLLNQSTEQVFSNLGQTLG
KILRWIAKTIVQIITACFATIWAMLLTGLGASVGTIAGFILAYRTNLGDRLVEFIAGQLPELITNPESGFGAEIIVFAAA
GLGTAWGLTASGCFAQRRRFLVASFMGIISYAFGWLLWQIITSTADSGEGLVGATAISVFLLALSMGFRSHHIVYAMIGS
FGTAIFVAILIVLGFPTTVLQFSSRHLWSELSLPIIFFSSVGILMSFWLGISYYLIVPGLRFLGWR
>Mature_546_residues
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRLRHPGVPKVEADGHFQVNLSN
PKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLTQAIKILQELHKHQIIHRDIKPSNLMLRTPSPSVPTPPGGT
GWEQLVLIDFGGAKQFNTGRQRQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLQ
WRNRVTIRPELADLLDEMVQEDVRSRPTSAAIIQKRLAKINQPASGQNSFQQFLTQVANQLTLLNQSTEQVFSNLGQTLG
KILRWIAKTIVQIITACFATIWAMLLTGLGASVGTIAGFILAYRTNLGDRLVEFIAGQLPELITNPESGFGAEIIVFAAA
GLGTAWGLTASGCFAQRRRFLVASFMGIISYAFGWLLWQIITSTADSGEGLVGATAISVFLLALSMGFRSHHIVYAMIGS
FGTAIFVAILIVLGFPTTVLQFSSRHLWSELSLPIIFFSSVGILMSFWLGISYYLIVPGLRFLGWR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI299758415, Length=258, Percent_Identity=28.6821705426357, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI41352712, Length=258, Percent_Identity=28.6821705426357, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI299758411, Length=226, Percent_Identity=29.646017699115, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI225637562, Length=150, Percent_Identity=32, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI41281753, Length=150, Percent_Identity=32, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI225637560, Length=150, Percent_Identity=32, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI37596297, Length=227, Percent_Identity=27.7533039647577, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI120659785, Length=269, Percent_Identity=27.5092936802974, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI19923468, Length=269, Percent_Identity=27.5092936802974, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI120659782, Length=269, Percent_Identity=27.5092936802974, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI120659787, Length=227, Percent_Identity=29.0748898678414, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4503427, Length=224, Percent_Identity=27.6785714285714, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI153281169, Length=224, Percent_Identity=27.6785714285714, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI115529463, Length=269, Percent_Identity=26.3940520446097, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI32698688, Length=224, Percent_Identity=25.8928571428571, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI225735561, Length=291, Percent_Identity=24.3986254295533, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI5031689, Length=267, Percent_Identity=26.5917602996255, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI32483399, Length=296, Percent_Identity=25.3378378378378, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI4502557, Length=216, Percent_Identity=29.1666666666667, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI42794769, Length=290, Percent_Identity=26.2068965517241, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI156105707, Length=268, Percent_Identity=25.3731343283582, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI156105705, Length=268, Percent_Identity=25.3731343283582, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI57222269, Length=225, Percent_Identity=25.7777777777778, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI62241001, Length=222, Percent_Identity=27.4774774774775, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI153945765, Length=224, Percent_Identity=25.8928571428571, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17565634, Length=225, Percent_Identity=30.2222222222222, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17543412, Length=283, Percent_Identity=24.7349823321555, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320102, Length=238, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325053, Length=264, Percent_Identity=26.8939393939394, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI161076714, Length=227, Percent_Identity=30.3964757709251, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI85724948, Length=221, Percent_Identity=27.1493212669683, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85724946, Length=221, Percent_Identity=27.1493212669683, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737415, Length=221, Percent_Identity=27.1493212669683, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552377, Length=221, Percent_Identity=27.1493212669683, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552375, Length=221, Percent_Identity=27.1493212669683, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24653590, Length=303, Percent_Identity=26.0726072607261, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653588, Length=303, Percent_Identity=26.0726072607261, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653592, Length=303, Percent_Identity=26.0726072607261, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653586, Length=303, Percent_Identity=26.0726072607261, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17864254, Length=288, Percent_Identity=25.3472222222222, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644584, Length=288, Percent_Identity=25.3472222222222, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644586, Length=288, Percent_Identity=25.3472222222222, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI85724764, Length=245, Percent_Identity=27.3469387755102, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI85724762, Length=245, Percent_Identity=27.3469387755102, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI85724760, Length=245, Percent_Identity=27.3469387755102, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI85724758, Length=245, Percent_Identity=27.3469387755102, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI85724756, Length=245, Percent_Identity=27.3469387755102, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221378052, Length=288, Percent_Identity=25.3472222222222, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442 [H]

Pfam domain/function: PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 60300; Mature: 60300

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00108 PROTEIN_KINASE_ST ; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRL
CHHHHHHHCCHHHCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RHPGVPKVEADGHFQVNLSNPKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLT
CCCCCCCEECCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
QAIKILQELHKHQIIHRDIKPSNLMLRTPSPSVPTPPGGTGWEQLVLIDFGGAKQFNTGR
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCH
QRQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLQ
HHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
WRNRVTIRPELADLLDEMVQEDVRSRPTSAAIIQKRLAKINQPASGQNSFQQFLTQVANQ
HCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LTLLNQSTEQVFSNLGQTLGKILRWIAKTIVQIITACFATIWAMLLTGLGASVGTIAGFI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LAYRTNLGDRLVEFIAGQLPELITNPESGFGAEIIVFAAAGLGTAWGLTASGCFAQRRRF
HHHHHCHHHHHHHHHHHHCHHHHCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHH
LVASFMGIISYAFGWLLWQIITSTADSGEGLVGATAISVFLLALSMGFRSHHIVYAMIGS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FGTAIFVAILIVLGFPTTVLQFSSRHLWSELSLPIIFFSSVGILMSFWLGISYYLIVPGL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
RFLGWR
HHHCCC
>Mature Secondary Structure
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRL
CHHHHHHHCCHHHCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RHPGVPKVEADGHFQVNLSNPKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLT
CCCCCCCEECCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
QAIKILQELHKHQIIHRDIKPSNLMLRTPSPSVPTPPGGTGWEQLVLIDFGGAKQFNTGR
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCH
QRQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLQ
HHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
WRNRVTIRPELADLLDEMVQEDVRSRPTSAAIIQKRLAKINQPASGQNSFQQFLTQVANQ
HCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LTLLNQSTEQVFSNLGQTLGKILRWIAKTIVQIITACFATIWAMLLTGLGASVGTIAGFI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LAYRTNLGDRLVEFIAGQLPELITNPESGFGAEIIVFAAAGLGTAWGLTASGCFAQRRRF
HHHHHCHHHHHHHHHHHHCHHHHCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHH
LVASFMGIISYAFGWLLWQIITSTADSGEGLVGATAISVFLLALSMGFRSHHIVYAMIGS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FGTAIFVAILIVLGFPTTVLQFSSRHLWSELSLPIIFFSSVGILMSFWLGISYYLIVPGL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
RFLGWR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12168951; 8905231 [H]